CY1219A - Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof and process for their manufacture - Google Patents

Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof and process for their manufacture

Info

Publication number
CY1219A
CY1219A CY1219A CY121978A CY1219A CY 1219 A CY1219 A CY 1219A CY 1219 A CY1219 A CY 1219A CY 121978 A CY121978 A CY 121978A CY 1219 A CY1219 A CY 1219A
Authority
CY
Cyprus
Prior art keywords
phthalazin
manufacture
pharmaceutical compositions
acid derivatives
enzyme inhibitory
Prior art date
Application number
CY1219A
Other languages
English (en)
Inventor
David Robert Brittain
Robin Wood
Original Assignee
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ici Plc filed Critical Ici Plc
Publication of CY1219A publication Critical patent/CY1219A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CY1219A 1977-12-29 1978-12-01 Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof and process for their manufacture CY1219A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5414277 1977-12-29

Publications (1)

Publication Number Publication Date
CY1219A true CY1219A (en) 1984-04-06

Family

ID=10470067

Family Applications (1)

Application Number Title Priority Date Filing Date
CY1219A CY1219A (en) 1977-12-29 1978-12-01 Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof and process for their manufacture

Country Status (31)

Country Link
US (2) US4251528A (cs)
EP (1) EP0002895B1 (cs)
JP (2) JPS5495582A (cs)
AT (1) AT365581B (cs)
AU (1) AU516264B2 (cs)
BG (1) BG34336A3 (cs)
CA (1) CA1107732A (cs)
CS (1) CS241015B2 (cs)
CY (1) CY1219A (cs)
DD (1) DD141021A5 (cs)
DE (1) DE2861170D1 (cs)
DK (1) DK151253C (cs)
ES (1) ES476496A1 (cs)
FI (1) FI64357C (cs)
GR (1) GR65303B (cs)
HK (1) HK22484A (cs)
HU (1) HU182585B (cs)
IE (1) IE47592B1 (cs)
IL (1) IL56099A0 (cs)
IN (1) IN150196B (cs)
IT (1) IT1110885B (cs)
MY (1) MY8500359A (cs)
NO (1) NO154346C (cs)
NZ (1) NZ189034A (cs)
PH (1) PH15435A (cs)
PL (1) PL118443B1 (cs)
PT (1) PT68956A (cs)
SG (1) SG68683G (cs)
SU (3) SU1087075A3 (cs)
YU (3) YU41607B (cs)
ZW (1) ZW24978A1 (cs)

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IE47592B1 (en) * 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
CA1143733A (en) * 1979-07-31 1983-03-29 Masao Yoshida Producing 7-alkoxycarbonyl-6,8-dimethyl-4- hydroxymethyl-1-phthalazone and intermediates
US4762839A (en) * 1985-06-06 1988-08-09 Tanabe Seiyaku Co., Ltd. Quinazolinone copmpounds useful for the prophyloxis and treatment of diabetic complications
ES2032749T3 (es) * 1985-11-07 1993-03-01 Pfizer Inc. Acidos oxoftalazinil-aceticos heterociclicos.
JPS63132889A (ja) * 1986-11-21 1988-06-04 Tanabe Seiyaku Co Ltd キナゾリノン誘導体
WO1993013092A1 (en) * 1986-11-24 1993-07-08 Reinhard Sarges Imidazolidinedione derivatives
GB8704569D0 (en) 1987-02-26 1987-04-01 Ici America Inc Therapeutic agent
JPH0676391B2 (ja) * 1987-06-09 1994-09-28 フアイザー・インコーポレイテツド ベンゾチアゾール等の複素環側鎖を有するオキソフタラジニル酢酸類の製造方法
US4868301A (en) * 1987-06-09 1989-09-19 Pfizer Inc. Processes and intermediates for the preparation of oxophthalazinyl acetic acids having benzothiazole or other heterocyclic side chains
EP0315249A1 (en) * 1987-11-02 1989-05-10 Merck & Co. Inc. Phthalazineacetic acid composition and tablet
DK607188A (da) * 1987-11-02 1989-06-22 Merck & Co Inc Tablet indeholdende en phthalazineddikesyreforbindelse
US4880928A (en) * 1987-12-21 1989-11-14 Merck & Co., Inc. Process for the preparation of 3-((4-bromo-2-fluorophenyl)methyl)-3,4-dihydro-4-oxo-1-phthalazine-acetic acid
US4904782A (en) * 1988-02-29 1990-02-27 Pfizer Inc. Process for the production of phthalazineacetic acid ester derivatives and a novel intermediate
US4940791A (en) * 1988-02-29 1990-07-10 Pfizer Inc. Process for the production of phthalazineacetic acid ester derivatives and a novel hydrazine containing intermediate
US4996204A (en) * 1989-05-11 1991-02-26 Pfizer Inc. Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors
US4954629A (en) * 1989-05-11 1990-09-04 Pfizer Inc. Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof
EP0397930A1 (en) * 1989-05-18 1990-11-22 Merck & Co. Inc. Process for the preparation of 3-[(4-bromo-2-fluorophenyl) methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid
FR2647676A1 (fr) * 1989-06-05 1990-12-07 Union Pharma Scient Appl Nouveaux derives de pyridazinone, leurs procedes de preparation, medicaments les contenant, utiles notamment comme inhibiteurs de l'aldose reductase
US5304557A (en) * 1989-12-15 1994-04-19 Pfizer Inc. Substituted oxoophthalazinyl acetic acids and analogs thereof
US5037831A (en) * 1990-05-21 1991-08-06 American Home Products Corporation Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors
FR2682108B1 (fr) * 1991-10-07 1994-01-07 Lipha Acide 3,4-dihydro-4-oxo-3(prop-2-enyl)-1-phtalazineacetiques et derives, leurs preparations et medicaments les contenant.
JP2789134B2 (ja) * 1992-09-28 1998-08-20 ファイザー・インク． 糖尿病の合併症を制御する置換ピリミジン類
AU5455194A (en) * 1992-11-02 1994-05-24 Merck & Co., Inc. Substituted phthalazinones as nerotensin antagonists
CH683965A5 (it) * 1993-02-19 1994-06-30 Limad Marketing Exp & Imp Composti della classe dei ftalidrazidici come sostanza attiva in agenti antinfiammatori ed antitossici.
AU7195594A (en) * 1993-07-26 1995-02-20 Fujisawa Pharmaceutical Co., Ltd. Oxophthalazines for treating cachexia
US6696407B1 (en) 1997-03-21 2004-02-24 The Regents Of The University Of California Huntington's disease treatment comprising administering aldose reductase inhibitors to increase striatal CNTF
WO1998042324A2 (en) * 1997-03-21 1998-10-01 The Regents Of The University Of California Methods for modulating neurotrophic factor-associated activity using aldose reductase inhibitors
ES2321162T3 (es) * 1997-04-15 2009-06-03 Csir Compuestos y composiciones farmaceuticas que tienen actividad supresora del apetito.
CN1205207C (zh) 1998-03-31 2005-06-08 药品发现学会公司 取代的吲哚链烷酸
TNSN99224A1 (fr) 1998-12-01 2005-11-10 Inst For Pharm Discovery Inc Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique
GB2396815B (en) * 1999-10-27 2004-09-08 Phytopharm Plc A composition comprising a pregnenone derivative and an NSAID
DE19963607B4 (de) * 1999-12-23 2005-12-15 Schering Ag Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen
GB2363985B (en) 2000-06-30 2004-09-29 Phytopharm Plc Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
MXPA03004871A (es) * 2000-11-30 2003-08-19 Pfizer Prod Inc Combinacion de agonistas de gaba e inhibidores de aldosa-reductasa.
DE60204611T2 (de) 2001-02-28 2006-05-11 Pfizer Products Inc., Groton Sulfonyl-pyridazinon-derivate zur Verwendung als Aldose-reduktase-inhibitoren
IL156462A0 (en) * 2001-03-30 2004-01-04 Pfizer Prod Inc Pyridazinone aldose reductase inhibitors
JP2004528344A (ja) * 2001-04-30 2004-09-16 ファイザー・プロダクツ・インク アルドースレダクターゼ阻害薬とシクロオキシゲナーゼ−２阻害薬の併用
AU761191B2 (en) 2001-05-24 2003-05-29 Pfizer Products Inc. Therapies for tissue damage resulting from ischemia
WO2003092696A1 (en) * 2002-04-30 2003-11-13 Novartis Ag Method for decreasing capillary permeability in the retina
MXPA05001011A (es) * 2002-07-26 2005-06-08 Inst For Pharm Discovery Inc Derivado de acidos indolalcanoicos substituidos y formulaciones que lo contienen para uso en tratamiento de complicaciones diabeticas.
US7572910B2 (en) * 2003-02-20 2009-08-11 Pfizer, Inc. Pyridazinone aldose reductase inhibitors
US20110092566A1 (en) * 2004-11-19 2011-04-21 Srivastava Satish K Treatment of cancer with aldose reductase inhibitors
JP4838582B2 (ja) * 2004-12-27 2011-12-14 岐阜プラスチック工業株式会社 台車用本体
US8877717B2 (en) 2007-03-12 2014-11-04 Zadec Aps Anti-diabetic extract of rooibos
EP2139330B1 (en) * 2007-03-23 2014-09-24 The Board of Regents of The University of Texas System Methods involving aldose reductase inhibitors
US20090270490A1 (en) * 2008-04-24 2009-10-29 The Board Of Regents Of The University Of Texas System Methods involving aldose reductase inhibition
EP2654749B1 (en) 2010-12-23 2017-05-10 The Board of Regents of The University of Texas System Methods for treating copd
MX2015007608A (es) * 2012-12-14 2016-04-13 Phusis Therapeutics Inc Metodos y composiciones para inhibir cnksr1.
US10227356B2 (en) 2015-04-20 2019-03-12 Phusis Therapeutics, Inc. Compounds, compositions and methods for inhibiting CNKSR1
US12090142B2 (en) 2018-02-22 2024-09-17 Board Of Regents, The University Of Texas System Combination therapy for the treatment of cancer
KR20210068495A (ko) * 2018-10-04 2021-06-09 닛토덴코 가부시키가이샤 내열 이형 시트 및 열 압착 방법
JP6751974B1 (ja) * 2019-10-16 2020-09-09 株式会社コバヤシ 離型フィルム及び離型フィルムの製造方法

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JPS5116430B2 (cs) * 1971-08-05 1976-05-24
GB1398549A (en) * 1972-11-06 1975-06-25 Boots Co Ltd Phthalazine derivatives and their use in pharmaceutical compo sitions
AR205004A1 (es) * 1973-10-30 1976-03-31 Ishikawa M Procedimiento para preparar derivados de 6,8-dialquil-7-alcoxi-carbonil-4-hidroximetil-1-ftalazona y la 7,8-lactona
DE2451117A1 (de) * 1973-10-31 1975-05-22 Boots Co Ltd Therapeutisch wirksame verbindungen
IE43079B1 (en) * 1975-03-20 1980-12-17 Ici Ltd Quinolone derivatives
GB1502312A (en) 1975-03-20 1978-03-01 Ici Ltd Quinolone derivatives
JPS5214788A (en) * 1975-07-21 1977-02-03 Fuji Photo Film Co Ltd Process for preparing phthalazinone and its derivatives
NL7702763A (nl) * 1976-03-18 1977-09-20 Takio Shimamoto En Masayuki Is Werkwijze voor de bereiding van thromboxaan- -antagonisten en van preparaten die deze stof- fen bevatten.
IE47592B1 (en) * 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
US4293553A (en) * 1978-08-11 1981-10-06 Masayuki Ishikawa 1-Phthalazone derivatives, and use thereof

Also Published As

Publication number Publication date
CA1107732A (en) 1981-08-25
AT365581B (de) 1982-01-25
IN150196B (cs) 1982-08-14
EP0002895B1 (en) 1981-10-14
US4393062A (en) 1983-07-12
DK541878A (da) 1979-06-30
ES476496A1 (es) 1979-04-16
NZ189034A (en) 1981-11-19
YU42807B (en) 1988-12-31
YU42054B (en) 1988-04-30
CS241015B2 (en) 1986-03-13
JPH0262532B2 (cs) 1990-12-26
NO154346B (no) 1986-05-26
NO784397L (no) 1979-07-02
AU516264B2 (en) 1981-05-28
HK22484A (en) 1984-03-23
GR65303B (en) 1980-08-01
DK151253B (da) 1987-11-16
IL56099A0 (en) 1979-01-31
SG68683G (en) 1984-08-03
YU232182A (en) 1983-01-21
IE782337L (en) 1979-06-29
EP0002895A1 (en) 1979-07-11
NO154346C (no) 1986-09-03
FI783844A (fi) 1979-06-30
SU1087075A3 (ru) 1984-04-15
DE2861170D1 (en) 1981-12-24
BG34336A3 (en) 1983-08-15
PH15435A (en) 1983-01-18
SU1272984A3 (ru) 1986-11-23
JPS6326110B2 (cs) 1988-05-27
ZW24978A1 (en) 1980-10-22
FI64357C (fi) 1983-11-10
JPS63119469A (ja) 1988-05-24
IE47592B1 (en) 1984-05-02
YU232082A (en) 1983-01-21
JPS5495582A (en) 1979-07-28
DD141021A5 (de) 1980-04-09
YU41607B (en) 1987-12-31
PL118443B1 (en) 1981-10-31
US4251528A (en) 1981-02-17
MY8500359A (en) 1985-12-31
FI64357B (fi) 1983-07-29
IT7852480A0 (it) 1978-12-28
HU182585B (en) 1984-02-28
AU4204078A (en) 1979-07-05
IT1110885B (it) 1986-01-06
SU1072803A3 (ru) 1984-02-07
PT68956A (en) 1979-01-01
DK151253C (da) 1988-05-16
ATA937678A (de) 1981-06-15
YU312778A (en) 1983-01-21

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