CY1122516T1 - Ετοιμες προς χρηση διατυπωσεις κετορολακης - Google Patents
Ετοιμες προς χρηση διατυπωσεις κετορολακηςInfo
- Publication number
- CY1122516T1 CY1122516T1 CY20191101153T CY191101153T CY1122516T1 CY 1122516 T1 CY1122516 T1 CY 1122516T1 CY 20191101153 T CY20191101153 T CY 20191101153T CY 191101153 T CY191101153 T CY 191101153T CY 1122516 T1 CY1122516 T1 CY 1122516T1
- Authority
- CY
- Cyprus
- Prior art keywords
- ketorolak
- ready
- use formulations
- pharmaceutically acceptable
- ketorolac
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- OZWKMVRBQXNZKK-UHFFFAOYSA-N ketorolac Chemical compound OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 OZWKMVRBQXNZKK-UHFFFAOYSA-N 0.000 abstract 1
- 229960004752 ketorolac Drugs 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40538410P | 2010-10-21 | 2010-10-21 | |
| US201161481602P | 2011-05-02 | 2011-05-02 | |
| PCT/US2011/057284 WO2012054831A2 (en) | 2010-10-21 | 2011-10-21 | Ready to use ketorolac formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1122516T1 true CY1122516T1 (el) | 2021-01-27 |
Family
ID=45973506
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20191101153T CY1122516T1 (el) | 2010-10-21 | 2019-11-06 | Ετοιμες προς χρηση διατυπωσεις κετορολακης |
Country Status (19)
| Country | Link |
|---|---|
| US (5) | US9421191B2 (https=) |
| EP (3) | EP4190327A1 (https=) |
| JP (1) | JP6013346B2 (https=) |
| KR (4) | KR20140012029A (https=) |
| CN (2) | CN108703948A (https=) |
| CA (1) | CA2814805C (https=) |
| CY (1) | CY1122516T1 (https=) |
| DK (1) | DK2616064T3 (https=) |
| ES (2) | ES2753981T3 (https=) |
| HR (1) | HRP20191994T1 (https=) |
| HU (1) | HUE045889T2 (https=) |
| LT (1) | LT2616064T (https=) |
| MX (1) | MX346879B (https=) |
| PL (1) | PL2616064T3 (https=) |
| PT (1) | PT2616064T (https=) |
| RS (1) | RS59526B1 (https=) |
| SI (1) | SI2616064T1 (https=) |
| SM (1) | SMT201900656T1 (https=) |
| WO (1) | WO2012054831A2 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2616064T (lt) | 2010-10-21 | 2019-11-25 | Rtu Pharmaceuticals Llc | Parengtos naudoti ketorolako kompozicijos |
| US10098872B1 (en) | 2013-07-22 | 2018-10-16 | William Bradley Worthington | Analgesic formulations and methods for reduced postoperative nausea and vomiting and enhanced postoperative pain relief |
| US11992484B2 (en) | 2013-07-22 | 2024-05-28 | Hutchison Health, Llc | Analgesic formulations and methods for reduced postoperative nausea and vomiting and enhanced postoperative pain relief |
| US11559521B2 (en) * | 2013-07-22 | 2023-01-24 | William Bradley Worthington | Analgesic formulations and methods for reduced postoperative nausea and vomiting and enhanced postoperative pain relief |
| US11992485B2 (en) | 2013-07-22 | 2024-05-28 | Hutchison Health, Llc | Analgesic formulations and methods for reduced postoperative nausea and vomiting and enhanced postoperative pain relief |
| CA3042642A1 (en) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| CN103830171B (zh) * | 2014-03-04 | 2015-11-18 | 鲁南制药集团股份有限公司 | 一种酮咯酸氨丁三醇注射液及其制备方法 |
| CA2955229C (en) | 2014-07-17 | 2020-03-10 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
| AU2015336065A1 (en) | 2014-10-20 | 2017-05-04 | Pharmaceutical Manufacturing Research Services, Inc. | Extended release abuse deterrent liquid fill dosage form |
| MY191574A (en) * | 2015-02-10 | 2022-06-30 | Axsome Therapeutics Inc | Pharmaceutical compositions comprising meloxicam |
| IT201600075246A1 (it) * | 2016-07-19 | 2018-01-19 | Jointherapeutics S R L | Composizioni comprendenti una matrice polisaccaridica per il rilascio controllato di principi attivi. |
| EP4467600A3 (en) * | 2017-05-10 | 2025-03-12 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| FR3101917B1 (fr) | 2019-10-09 | 2022-07-15 | Ifp Energies Now | Système de refroidissement à radiateur unique |
| CN110812325B (zh) * | 2019-11-13 | 2022-04-05 | 鲁南制药集团股份有限公司 | 一种提高酮咯酸氨丁三醇注射液存储稳定性的方法 |
| CN119818450A (zh) * | 2020-05-19 | 2025-04-15 | 南京海融医药科技股份有限公司 | 一种左酮咯酸的药物组合物及其制备方法 |
| CN114159384B (zh) * | 2021-02-07 | 2023-04-07 | 南京锐志生物医药有限公司 | 一种化学性质稳定的低刺激性酮咯酸氨丁三醇注射液 |
| TWI857310B (zh) * | 2021-06-24 | 2024-10-01 | 大陸商上海雲晟研新生物科技有限公司 | 酮咯酸胺丁三醇的液體組合物、其製備方法及應用 |
| CN113384524B (zh) * | 2021-07-05 | 2025-08-12 | 四川尚锐生物医药有限公司 | 一种稳定的酮咯酸氨丁三醇注射液的制备方法 |
| CN114191384A (zh) * | 2021-12-20 | 2022-03-18 | 成都倍特药业股份有限公司 | 一种即用型酮咯酸氨丁三醇和氢溴酸依他佐辛组合液体制剂 |
| CN114432240A (zh) * | 2022-03-04 | 2022-05-06 | 郑州市中心医院 | 一种稳定不刺激的酮咯酸氨丁三醇注射液及其制备方法 |
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| US4089969A (en) | 1976-07-14 | 1978-05-16 | Syntex (U.S.A.) Inc. | 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof |
| US5214052A (en) | 1987-07-28 | 1993-05-25 | Mitsubishi Kasei Corporation | Method for dissolving arginineamides and pharmaceutical compositions containing them |
| PT948965E (pt) | 1997-07-11 | 2004-08-31 | Toray Industries | Composicoes medicinais estaveis contendo um derivado de 4,5-epoximorfinano |
| US6608073B1 (en) | 1998-10-14 | 2003-08-19 | New Millennium Pharmaceutical Research, Inc. | Intranasal codeine for the rapid suppression of cough and rapid relief of pain |
| WO2000057851A2 (en) | 1999-03-26 | 2000-10-05 | Pozen Inc. | High potency dihydroergotamine compositions |
| US20040022787A1 (en) * | 2000-07-03 | 2004-02-05 | Robert Cohen | Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID |
| US6509027B2 (en) * | 2001-02-12 | 2003-01-21 | Supergen, Inc. | Injectable pharmaceutical composition comprising coated particles of camptothecin |
| US20030191187A1 (en) * | 2002-04-01 | 2003-10-09 | Lee Fang Yu | Injectable pharmaceutical composition containing a non-steroidal anti-inflammatory drug and method for preparing the same |
| US20040105881A1 (en) | 2002-10-11 | 2004-06-03 | Gregor Cevc | Aggregates with increased deformability, comprising at least three amphipats, for improved transport through semi-permeable barriers and for the non-invasive drug application in vivo, especially through the skin |
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| KR20070084211A (ko) * | 2004-10-15 | 2007-08-24 | 유서홍 | 약제학적 화합물의 독성을 감소시키기 위한 방법 및 조성물 |
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| US20090239836A1 (en) | 2008-03-24 | 2009-09-24 | Mary Lee Ciolkowski | Multifunctional Ophthalmic Compositions |
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| KR20190031592A (ko) * | 2010-07-19 | 2019-03-26 | 바이오젠 체사피크 엘엘씨 | 글리부리드 및 다른 약물의 정맥내 투여를 위한 방법 |
| EP2596112A4 (en) | 2010-07-21 | 2015-01-21 | Cumberland Pharmaceuticals Inc | ACETYCYSTEIN COMPOSITIONS AND USE METHOD THEREFOR |
| LT2616064T (lt) | 2010-10-21 | 2019-11-25 | Rtu Pharmaceuticals Llc | Parengtos naudoti ketorolako kompozicijos |
-
2011
- 2011-10-21 LT LT11835216T patent/LT2616064T/lt unknown
- 2011-10-21 SM SM20190656T patent/SMT201900656T1/it unknown
- 2011-10-21 JP JP2013535115A patent/JP6013346B2/ja active Active
- 2011-10-21 PL PL11835216T patent/PL2616064T3/pl unknown
- 2011-10-21 SI SI201131812T patent/SI2616064T1/sl unknown
- 2011-10-21 DK DK11835216T patent/DK2616064T3/da active
- 2011-10-21 EP EP22195395.3A patent/EP4190327A1/en not_active Withdrawn
- 2011-10-21 HU HUE11835216A patent/HUE045889T2/hu unknown
- 2011-10-21 ES ES11835216T patent/ES2753981T3/es active Active
- 2011-10-21 US US13/278,703 patent/US9421191B2/en active Active
- 2011-10-21 KR KR1020137009935A patent/KR20140012029A/ko not_active Ceased
- 2011-10-21 HR HRP20191994TT patent/HRP20191994T1/hr unknown
- 2011-10-21 KR KR1020187027505A patent/KR102114568B1/ko active Active
- 2011-10-21 ES ES19189949T patent/ES2933198T3/es active Active
- 2011-10-21 RS RS20191421A patent/RS59526B1/sr unknown
- 2011-10-21 EP EP19189949.1A patent/EP3632432B1/en active Active
- 2011-10-21 PT PT118352160T patent/PT2616064T/pt unknown
- 2011-10-21 CN CN201810988217.6A patent/CN108703948A/zh active Pending
- 2011-10-21 KR KR1020197019855A patent/KR20190085561A/ko not_active Ceased
- 2011-10-21 MX MX2013004393A patent/MX346879B/es active IP Right Grant
- 2011-10-21 CA CA2814805A patent/CA2814805C/en active Active
- 2011-10-21 EP EP11835216.0A patent/EP2616064B1/en active Active
- 2011-10-21 KR KR1020207013936A patent/KR102307601B1/ko active Active
- 2011-10-21 WO PCT/US2011/057284 patent/WO2012054831A2/en not_active Ceased
- 2011-10-21 CN CN201180050372XA patent/CN103167800A/zh active Pending
-
2016
- 2016-07-15 US US15/211,560 patent/US9962371B2/en active Active
-
2018
- 2018-04-06 US US15/946,865 patent/US10278959B2/en active Active
- 2018-12-07 US US16/213,250 patent/US11116750B2/en active Active
-
2019
- 2019-11-06 CY CY20191101153T patent/CY1122516T1/el unknown
-
2021
- 2021-08-09 US US17/396,890 patent/US20220023260A1/en active Pending
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