CY1120908T1 - Μεθοδοι και συστηματα για τον καθαρισμο της μη συμπλεγμενης νευροτοξινης της αλλαντιασης - Google Patents

Μεθοδοι και συστηματα για τον καθαρισμο της μη συμπλεγμενης νευροτοξινης της αλλαντιασης

Info

Publication number
CY1120908T1
CY1120908T1 CY181100988T CY181100988T CY1120908T1 CY 1120908 T1 CY1120908 T1 CY 1120908T1 CY 181100988 T CY181100988 T CY 181100988T CY 181100988 T CY181100988 T CY 181100988T CY 1120908 T1 CY1120908 T1 CY 1120908T1
Authority
CY
Cyprus
Prior art keywords
methods
systems
neurotoxin
chealth
cleansing
Prior art date
Application number
CY181100988T
Other languages
English (en)
Inventor
Curtis L Ruegg
Original Assignee
Revance Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43879799&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1120908(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Revance Therapeutics Inc filed Critical Revance Therapeutics Inc
Publication of CY1120908T1 publication Critical patent/CY1120908T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Παρουσιάζονται μέθοδοι και συστήματα για τον χρωματογραφικό καθαρισμό μιας νευροτοξίνης της αλλαντίασης. Αυτές οι μέθοδοι και τα συστήματα καθιστούν δυνατό τον αποτελεσματικό καθαρισμό μιας μη συμπλεγμένης μορφής της νευροτοξίνης της αλλαντίασης με υψηλό καθαρισμό και απόδοση, η οποία μπορεί να χρησιμοποιηθεί ως ενεργό συστατικό φαρμακευτικών σκευασμάτων.
CY181100988T 2009-10-21 2018-09-25 Μεθοδοι και συστηματα για τον καθαρισμο της μη συμπλεγμενης νευροτοξινης της αλλαντιασης CY1120908T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25381009P 2009-10-21 2009-10-21
PCT/US2010/053389 WO2011050072A1 (en) 2009-10-21 2010-10-20 Methods and systems for purifying non-complexed botulinum neurotoxin

Publications (1)

Publication Number Publication Date
CY1120908T1 true CY1120908T1 (el) 2019-12-11

Family

ID=43879799

Family Applications (1)

Application Number Title Priority Date Filing Date
CY181100988T CY1120908T1 (el) 2009-10-21 2018-09-25 Μεθοδοι και συστηματα για τον καθαρισμο της μη συμπλεγμενης νευροτοξινης της αλλαντιασης

Country Status (23)

Country Link
US (5) US20110092682A1 (el)
EP (1) EP2490986B2 (el)
JP (1) JP5951490B2 (el)
KR (1) KR101819129B1 (el)
CN (2) CN104961812B (el)
AU (1) AU2010310749B2 (el)
BR (1) BR112012009227A2 (el)
CA (1) CA2773396C (el)
CO (1) CO6551670A2 (el)
CY (1) CY1120908T1 (el)
DK (1) DK2490986T4 (el)
ES (1) ES2688065T3 (el)
HK (2) HK1175453A1 (el)
HR (1) HRP20181869T1 (el)
HU (1) HUE041599T2 (el)
IL (2) IL218532A (el)
LT (1) LT2490986T (el)
MX (3) MX2012004703A (el)
PL (1) PL2490986T3 (el)
PT (1) PT2490986T (el)
RS (1) RS58006B1 (el)
SI (1) SI2490986T1 (el)
WO (1) WO2011050072A1 (el)

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KR102463881B1 (ko) 2016-10-04 2022-11-07 (주)메디톡스 보툴리눔 독소 함유 용액으로부터 보툴리눔 독소를 분리하는 방법
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CN113056478A (zh) * 2018-12-21 2021-06-29 一般财团法人阪大微生物病研究会 肉毒毒素的制造方法
KR102516203B1 (ko) * 2019-04-15 2023-03-30 (주)제테마 보툴리눔 독소의 제조방법
KR102516204B1 (ko) * 2019-04-15 2023-03-30 (주)제테마 보툴리눔 독소의 정제방법
US10851363B1 (en) * 2019-05-22 2020-12-01 Boke Zhang Multilayer nano-cell containing biomolecules
KR20230009178A (ko) * 2021-07-08 2023-01-17 주식회사 파마리서치바이오 비-독소 단백질이 제거된 클로스트리디움 보툴리눔 신경독소 단백질의 정제방법
KR102512757B1 (ko) * 2021-07-22 2023-03-22 (주)이니바이오 정제 수율이 향상된 보툴리눔 독소 복합체 정제방법

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Also Published As

Publication number Publication date
EP2490986B2 (en) 2024-04-24
AU2010310749A1 (en) 2012-03-29
IL248486A0 (en) 2016-12-29
KR101819129B1 (ko) 2018-02-28
AU2010310749B2 (en) 2016-02-11
PT2490986T (pt) 2018-11-13
ES2688065T3 (es) 2018-10-30
HK1215951A1 (zh) 2016-09-30
DK2490986T4 (da) 2024-06-17
US20150322419A1 (en) 2015-11-12
US9469849B2 (en) 2016-10-18
JP2013508388A (ja) 2013-03-07
CN104961812A (zh) 2015-10-07
CN102666396A (zh) 2012-09-12
US20120196349A1 (en) 2012-08-02
EP2490986A4 (en) 2013-11-13
EP2490986B1 (en) 2018-08-08
MX2012004703A (es) 2012-06-08
JP5951490B2 (ja) 2016-07-13
BR112012009227A2 (pt) 2016-08-23
CN102666396B (zh) 2015-05-13
IL218532A (en) 2016-10-31
DK2490986T3 (en) 2018-11-05
US20110092682A1 (en) 2011-04-21
SI2490986T1 (sl) 2018-12-31
IL218532A0 (en) 2012-07-31
CA2773396C (en) 2020-12-15
US11466262B2 (en) 2022-10-11
MX365496B (es) 2019-06-05
HK1175453A1 (en) 2013-07-05
PL2490986T3 (pl) 2019-03-29
US20170029795A1 (en) 2017-02-02
CN104961812B (zh) 2019-08-20
CA2773396A1 (en) 2011-04-28
CO6551670A2 (es) 2012-10-31
EP2490986A1 (en) 2012-08-29
HRP20181869T1 (hr) 2019-01-11
LT2490986T (lt) 2018-11-26
KR20120099431A (ko) 2012-09-10
HUE041599T2 (hu) 2019-05-28
RS58006B1 (sr) 2019-02-28
US20200277591A1 (en) 2020-09-03
MX2019006519A (es) 2019-09-18
WO2011050072A1 (en) 2011-04-28

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