CY1120525T1 - Κρυσταλλικη (1r,4r)-6'-φθορο-ν,ν-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,b]ινδολ]-4-αμινη - Google Patents
Κρυσταλλικη (1r,4r)-6'-φθορο-ν,ν-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,b]ινδολ]-4-αμινηInfo
- Publication number
- CY1120525T1 CY1120525T1 CY20171100830T CY171100830T CY1120525T1 CY 1120525 T1 CY1120525 T1 CY 1120525T1 CY 20171100830 T CY20171100830 T CY 20171100830T CY 171100830 T CY171100830 T CY 171100830T CY 1120525 T1 CY1120525 T1 CY 1120525T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pyrano
- spiro
- fluoro
- dimethyl
- phenyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11005587 | 2011-07-08 | ||
| EP12748646.2A EP2729470B1 (en) | 2011-07-08 | 2012-07-06 | Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine |
| PCT/EP2012/002839 WO2013007361A1 (en) | 2011-07-08 | 2012-07-06 | Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1120525T1 true CY1120525T1 (el) | 2019-07-10 |
Family
ID=46717800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20171100830T CY1120525T1 (el) | 2011-07-08 | 2017-08-02 | Κρυσταλλικη (1r,4r)-6'-φθορο-ν,ν-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,b]ινδολ]-4-αμινη |
Country Status (23)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2014000297A (es) * | 2011-07-08 | 2014-01-31 | Grünenthal GmbH | (1r,4r)-6´-fluoro-n,n-dimetil-4-fenil-4´,9´dihidro-3´h-espiro[cic lohexan-1,1´-piran[3,4,b]indol]-4-amina cristalina. |
| CA2974578C (en) | 2015-01-23 | 2020-11-17 | Grunenthal Gmbh | Cebranopadol for treating pain in subjects with impaired hepatic and/or impaired renal function |
| US20180021304A1 (en) | 2015-02-02 | 2018-01-25 | Ratiopharm Gmbh | Composition comprising cebranopadol in a dissolved form |
| CN118286209A (zh) | 2016-02-29 | 2024-07-05 | 帕克治疗公司 | 西博帕多的滴定 |
| EP3981759A4 (en) * | 2019-05-21 | 2023-07-19 | Jiangsu Forefront Pharmaceutical Co., Ltd. | NEW CRYSTALLINE FORM OF A SODIUM TREPROSTINIL SALT AND METHOD FOR PREPARING IT |
| CN112254496A (zh) * | 2020-09-25 | 2021-01-22 | 榆林学院 | 一种煤泥收集装置 |
| WO2024129782A1 (en) | 2022-12-12 | 2024-06-20 | Park Therapeutics, Inc. | Regimens and compositions useful for alleviating pain |
| WO2024173714A1 (en) | 2023-02-15 | 2024-08-22 | Park Therapeutics, Inc. | Regimens and compositions useful for alleviating pain |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10252667A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE102005016460A1 (de) * | 2005-04-11 | 2006-10-19 | Grünenthal GmbH | Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit |
| DE102006033109A1 (de) * | 2006-07-18 | 2008-01-31 | Grünenthal GmbH | Substituierte Heteroaryl-Derivate |
| DE102006046745A1 (de) | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
| DK2600851T3 (en) * | 2010-08-04 | 2018-06-25 | Gruenenthal Gmbh | PHARMACEUTICAL DOSAGE FORM CONTAINING 6'-FLUORO- (N-METHYL OR N, N-DIMETHYL -) - 4-PHENYL-4 ', 9'-DIHYDRO-3'H-SPIRO [CYCLOHEXAN-1,1'-PYRANO [3,4, B] INDOL] -4-AMINE FOR TREATMENT OF NEUROPATHIC PAIN |
| MX2014000297A (es) * | 2011-07-08 | 2014-01-31 | Grünenthal GmbH | (1r,4r)-6´-fluoro-n,n-dimetil-4-fenil-4´,9´dihidro-3´h-espiro[cic lohexan-1,1´-piran[3,4,b]indol]-4-amina cristalina. |
-
2012
- 2012-07-06 MX MX2014000297A patent/MX2014000297A/es unknown
- 2012-07-06 JP JP2014517519A patent/JP6276689B2/ja active Active
- 2012-07-06 CA CA2841032A patent/CA2841032C/en active Active
- 2012-07-06 PT PT127486462T patent/PT2729470T/pt unknown
- 2012-07-06 US US13/542,809 patent/US8618156B2/en active Active
- 2012-07-06 ES ES12748646.2T patent/ES2641299T3/es active Active
- 2012-07-06 HU HUE12748646A patent/HUE033043T2/hu unknown
- 2012-07-06 BR BR112014000358A patent/BR112014000358A2/pt not_active IP Right Cessation
- 2012-07-06 EP EP17020200.6A patent/EP3235821B1/en active Active
- 2012-07-06 CN CN201710173425.6A patent/CN106939005A/zh active Pending
- 2012-07-06 DK DK12748646.2T patent/DK2729470T3/en active
- 2012-07-06 LT LTEP12748646.2T patent/LT2729470T/lt unknown
- 2012-07-06 AU AU2012283449A patent/AU2012283449B2/en not_active Ceased
- 2012-07-06 DK DK17020200.6T patent/DK3235821T3/da active
- 2012-07-06 SI SI201231030T patent/SI2729470T1/sl unknown
- 2012-07-06 TW TW101124343A patent/TWI585092B/zh not_active IP Right Cessation
- 2012-07-06 EA EA201400120A patent/EA026750B1/ru not_active IP Right Cessation
- 2012-07-06 RS RS20170921A patent/RS56343B1/sr unknown
- 2012-07-06 CN CN201280032432.XA patent/CN103649094B/zh active Active
- 2012-07-06 AR ARP120102454A patent/AR087081A1/es not_active Application Discontinuation
- 2012-07-06 EP EP12748646.2A patent/EP2729470B1/en active Active
- 2012-07-06 WO PCT/EP2012/002839 patent/WO2013007361A1/en not_active Ceased
- 2012-07-06 PL PL12748646T patent/PL2729470T3/pl unknown
- 2012-07-06 HR HRP20170968TT patent/HRP20170968T1/hr unknown
-
2013
- 2013-03-15 US US13/835,298 patent/US8765800B2/en active Active
-
2014
- 2014-01-06 IL IL230331A patent/IL230331B/en unknown
-
2017
- 2017-01-12 JP JP2017003194A patent/JP6559165B2/ja active Active
- 2017-07-04 AU AU2017204572A patent/AU2017204572B2/en not_active Ceased
- 2017-08-02 CY CY20171100830T patent/CY1120525T1/el unknown
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