CY1116989T1 - C-28 αμινες c-3 τροποποιημενων παραγωγων βετουλινικου οξεος ως αναστολεις hiv ωριμανσης - Google Patents

C-28 αμινες c-3 τροποποιημενων παραγωγων βετουλινικου οξεος ως αναστολεις hiv ωριμανσης

Info

Publication number
CY1116989T1
CY1116989T1 CY20151101099T CY151101099T CY1116989T1 CY 1116989 T1 CY1116989 T1 CY 1116989T1 CY 20151101099 T CY20151101099 T CY 20151101099T CY 151101099 T CY151101099 T CY 151101099T CY 1116989 T1 CY1116989 T1 CY 1116989T1
Authority
CY
Cyprus
Prior art keywords
amines
modified
compound
formula
hiv patients
Prior art date
Application number
CY20151101099T
Other languages
Greek (el)
English (en)
Inventor
Alicia Regueiro-Ren
Jacob Swidorski
Sing-Yuen Sit
Yan Chen
Jie Chen
Nicholas A Meanwell
Zheng Liu
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of CY1116989T1 publication Critical patent/CY1116989T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CY20151101099T 2011-01-31 2015-12-01 C-28 αμινες c-3 τροποποιημενων παραγωγων βετουλινικου οξεος ως αναστολεις hiv ωριμανσης CY1116989T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161437870P 2011-01-31 2011-01-31
EP12702946.0A EP2670764B1 (en) 2011-01-31 2012-01-27 C-28 amines of c-3 modified betulinic acid derivatives as hiv maturation inhibitors

Publications (1)

Publication Number Publication Date
CY1116989T1 true CY1116989T1 (el) 2017-04-05

Family

ID=45567146

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20151101099T CY1116989T1 (el) 2011-01-31 2015-12-01 C-28 αμινες c-3 τροποποιημενων παραγωγων βετουλινικου οξεος ως αναστολεις hiv ωριμανσης

Country Status (19)

Country Link
US (1) US8748415B2 (enExample)
EP (1) EP2670764B1 (enExample)
JP (1) JP6000283B2 (enExample)
CN (1) CN103339141B (enExample)
BR (1) BR112014010105A2 (enExample)
CA (1) CA2826257A1 (enExample)
CY (1) CY1116989T1 (enExample)
DK (1) DK2670764T3 (enExample)
EA (1) EA023578B1 (enExample)
ES (1) ES2552512T3 (enExample)
HR (1) HRP20151212T1 (enExample)
HU (1) HUE026371T2 (enExample)
MX (1) MX2013008359A (enExample)
PL (1) PL2670764T3 (enExample)
PT (1) PT2670764E (enExample)
RS (1) RS54352B1 (enExample)
SI (1) SI2670764T1 (enExample)
SM (1) SMT201500303B (enExample)
WO (1) WO2012106188A1 (enExample)

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CA2849475A1 (en) 2011-09-21 2013-03-28 Bristol-Myers Squibb Company Novel betulinic acid derivatives with antiviral activity
US8906889B2 (en) 2012-02-15 2014-12-09 Bristol-Myers Squibb Company C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity
US8889854B2 (en) 2012-05-07 2014-11-18 Bristol-Myers Squibb Company C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity
RU2516952C1 (ru) * 2012-11-09 2014-05-20 Леонид Леонидович Клопотенко Фармацевтическая композиция, содержащая инкапсулированную тритерпеновую кислоту или ее производные
RU2519133C1 (ru) * 2012-11-09 2014-06-10 Леонид Леонидович Клопотенко Мазь, содержащая инкапсулированную тритерпеновую кислоту или ее производные
CN103214543B (zh) * 2012-12-25 2015-09-02 中国人民解放军海军医学研究所 新山楂酸衍生物、其制备方法及其在抗肿瘤药物中的应用
US20140221361A1 (en) * 2013-02-06 2014-08-07 Bristol-Myers Squibb Company C-19 modified triterpenoids with hiv maturation inhibitory activity
CN105102468A (zh) 2013-02-25 2015-11-25 百时美施贵宝公司 用于治疗hiv的c-3烷基和烯基修饰的桦木酸衍生物
LT3129392T (lt) 2014-04-11 2020-11-10 VIIV Healthcare UK(No.4) Limited Triterpenoidai, pasižymintys živ brandinimą inhibuojančiu aktyvumu, pakeisti 3-ioje padėtyje nearomatiniu žiedu, turinčiu halogenalkilo pakaitą
US9920090B2 (en) * 2014-06-19 2018-03-20 VIIV Healthcare UK (No.5) Limited Betulinic acid derivatives with HIV maturation inhibitory activity
JP2017533934A (ja) 2014-11-14 2017-11-16 ヴィーブ ヘルスケア ユーケー（ナンバー５）リミテッド Ｃ１７アリール置換ベツリン酸類似体
EP3218387A1 (en) * 2014-11-14 2017-09-20 VIIV Healthcare UK (No.5) Limited Oxolupene derivatives
KR20170092580A (ko) * 2014-11-14 2017-08-11 비브 헬스케어 유케이 (넘버5) 리미티드 연장된 베툴린산 유사체
KR20170135970A (ko) * 2015-04-14 2017-12-08 비브 헬스케어 유케이 (넘버4) 리미티드 Hiv 성숙화 억제제를 생산하는 방법
KR20180028534A (ko) 2015-07-28 2018-03-16 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 Hiv 감염을 예방하거나 치료하기 위한 베투인 유도체
RU2018105352A (ru) * 2015-07-28 2019-08-29 ГлаксоСмитКлайн Интеллекчуал Проперти (N2) Лимитед Производные бетулина для предупреждения или лечения ВИЧ-инфекций
US20180273579A1 (en) 2015-09-24 2018-09-27 Glaxosmithkline Intellectual Property (No.2) Limited Compounds with hiv maturation inhibitory activity
WO2017125870A1 (en) 2016-01-20 2017-07-27 Glaxosmithkline Intellectual Property (No.2) Limited Amine derivatives of lupanes with hiv maturation inhibitory activity
AR107512A1 (es) 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
WO2018002849A1 (en) * 2016-06-30 2018-01-04 VIIV Healthcare UK (No.5) Limited Triterpenoid inhibitors of human immunodeficiency virus replication
CA3075173A1 (en) * 2017-09-13 2019-03-21 Emmyon, Inc. Ursolic acid morpholine and diethanolamine salts
RU2020113341A (ru) 2017-09-14 2021-10-15 Феникс Байотекнолоджи, Инк. Способ и композиция для лечения вирусной инфекции
KR20200083969A (ko) 2017-09-14 2020-07-09 피닉스 바이오테크놀러지 인코포레이티드. 신경학적 상태를 치료하기 위한 방법 및 개선된 신경보호 조성물
US20210347813A1 (en) 2018-04-24 2021-11-11 Viiv Healthcare Uk (No. 5) Limited Compounds with hiv maturation inhibitory activity
PL237998B1 (pl) 2018-05-28 2021-06-28 Narodowy Inst Lekow Fosfonowe pochodne kwasu 3-karboksyacylobetulinowego, sposób ich otrzymywania oraz ich zastosowanie
US10343997B1 (en) 2018-12-04 2019-07-09 King Saud University Ursolic acid derivatives
EP4295854A3 (en) 2020-03-31 2024-04-03 Phoenix Biotechnology, Inc. Method and compositions for treating coronavirus infection
JP7153083B2 (ja) 2020-03-31 2022-10-13 フェニックス・バイオテクノロジー・インコーポレイテッド コロナウイルス感染を治療するための方法および組成物

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SI2576586T1 (sl) * 2010-06-04 2015-11-30 Bristol-Myers Squibb Company C-28 amidi derivatov modificirane c-3 betulinske kisline kot inhibitorji zorenja hiv
CA2801487C (en) * 2010-06-04 2017-12-05 Bristol-Myers Squibb Company Modified c-3 betulinic acid derivatives as hiv maturation inhibitors
AU2012212509B2 (en) * 2011-01-31 2016-01-21 ViiV Healthcare UK (No.4) Limited C-17 and C-3 modified triterpenoids with HIV maturation inhibitory activity

Also Published As

Publication number Publication date
DK2670764T3 (en) 2015-12-07
HUE026371T2 (en) 2016-05-30
EP2670764A1 (en) 2013-12-11
HRP20151212T1 (hr) 2015-12-04
JP2014507422A (ja) 2014-03-27
US8748415B2 (en) 2014-06-10
BR112014010105A2 (pt) 2017-06-13
EA023578B1 (ru) 2016-06-30
SI2670764T1 (sl) 2016-03-31
RS54352B1 (sr) 2016-02-29
WO2012106188A1 (en) 2012-08-09
JP6000283B2 (ja) 2016-09-28
CN103339141A (zh) 2013-10-02
EA201391098A1 (ru) 2013-12-30
CN103339141B (zh) 2016-08-24
SMT201500303B (it) 2016-01-08
PL2670764T3 (pl) 2016-02-29
MX2013008359A (es) 2013-08-27
ES2552512T3 (es) 2015-11-30
EP2670764B1 (en) 2015-09-02
US20130029954A1 (en) 2013-01-31
CA2826257A1 (en) 2012-08-09
PT2670764E (pt) 2015-11-20

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