JP6000283B2 - Ｈｉｖ成熟阻害剤としてのｃ−３修飾ベツリン酸誘導体のｃ−２８アミン - Google Patents
Ｈｉｖ成熟阻害剤としてのｃ−３修飾ベツリン酸誘導体のｃ−２８アミン Download PDFInfo
- Publication number
- JP6000283B2 JP6000283B2 JP2013551360A JP2013551360A JP6000283B2 JP 6000283 B2 JP6000283 B2 JP 6000283B2 JP 2013551360 A JP2013551360 A JP 2013551360A JP 2013551360 A JP2013551360 A JP 2013551360A JP 6000283 B2 JP6000283 B2 JP 6000283B2
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- methyl
- cyclopenta
- pentamethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 0 CC(C)([C@]1CC2)C(c(cc3)ccc3C(O)=O)=CC[C@]1(C)[C@@](CC1)[C@]2(C)[C@@]2(C)[C@]1[C@@]([C@@](CC1)C(C)=C)[C@@]1(C*)CC2 Chemical compound CC(C)([C@]1CC2)C(c(cc3)ccc3C(O)=O)=CC[C@]1(C)[C@@](CC1)[C@]2(C)[C@@]2(C)[C@]1[C@@]([C@@](CC1)C(C)=C)[C@@]1(C*)CC2 0.000 description 7
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- FEGKZTVSOPPFSN-BHVYCOFMSA-N CC(C)([C@@H]1CC2)C(c(cc3)ccc3C(O)=O)=CC[C@]1(C)[C@@H](CC1)[C@]2(C)[C@@]2(C)[C@H]1[C@@H]([C@@H](CC1)C(C)=C)[C@@]1(CNCCC(NC)=O)CC2 Chemical compound CC(C)([C@@H]1CC2)C(c(cc3)ccc3C(O)=O)=CC[C@]1(C)[C@@H](CC1)[C@]2(C)[C@@]2(C)[C@H]1[C@@H]([C@@H](CC1)C(C)=C)[C@@]1(CNCCC(NC)=O)CC2 FEGKZTVSOPPFSN-BHVYCOFMSA-N 0.000 description 1
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- XVUGIRZZANVASX-YLNVBRMASA-N CC(CNC[C@@](CC[C@H]1C(C)=C)(CC2)[C@H]1[C@@H](CC1)[C@]2(C)[C@](C)(CC2)[C@H]1[C@]1(C)[C@@H]2C(C)(C)C(c(cc2)ccc2C(O)=O)=CC1)CN(CCC1)C1=O Chemical compound CC(CNC[C@@](CC[C@H]1C(C)=C)(CC2)[C@H]1[C@@H](CC1)[C@]2(C)[C@](C)(CC2)[C@H]1[C@]1(C)[C@@H]2C(C)(C)C(c(cc2)ccc2C(O)=O)=CC1)CN(CCC1)C1=O XVUGIRZZANVASX-YLNVBRMASA-N 0.000 description 1
- OFKULFWRBUXWKQ-PQYYYUBBSA-N CCC([C@H](CC1)[C@H]([C@H]2CC3)[C@@]1(CNCCC(N(C)C)=O)CC[C@@]2(C)[C@](C)(CC1)[C@H]3[C@]2(C)[C@@H]1C(C)(C)C(c(cc1)ccc1C(O)=O)=CC2)=C Chemical compound CCC([C@H](CC1)[C@H]([C@H]2CC3)[C@@]1(CNCCC(N(C)C)=O)CC[C@@]2(C)[C@](C)(CC1)[C@H]3[C@]2(C)[C@@H]1C(C)(C)C(c(cc1)ccc1C(O)=O)=CC2)=C OFKULFWRBUXWKQ-PQYYYUBBSA-N 0.000 description 1
- OLQUNWGZDAWVKP-WCENMHOUSA-N CCN(CC)CCNC[C@@](CC[C@H]1C(C)=C)(CC2)[C@H]1[C@@H](CC1)[C@]2(C)[C@](C)(CC2)[C@H]1[C@]1(C)[C@@H]2C(C)(C)C(c(cc2)ccc2C(O)=O)=CC1 Chemical compound CCN(CC)CCNC[C@@](CC[C@H]1C(C)=C)(CC2)[C@H]1[C@@H](CC1)[C@]2(C)[C@](C)(CC2)[C@H]1[C@]1(C)[C@@H]2C(C)(C)C(c(cc2)ccc2C(O)=O)=CC1 OLQUNWGZDAWVKP-WCENMHOUSA-N 0.000 description 1
- VUYOLIKWIVQHBC-UHFFFAOYSA-N CN(C(CCC1)=O)C1=O Chemical compound CN(C(CCC1)=O)C1=O VUYOLIKWIVQHBC-UHFFFAOYSA-N 0.000 description 1
- LFHMKODCPPOLIB-UHFFFAOYSA-N CN(CC1)CCC1(F)F Chemical compound CN(CC1)CCC1(F)F LFHMKODCPPOLIB-UHFFFAOYSA-N 0.000 description 1
- AXGLXFHGUWLXGU-UHFFFAOYSA-N CN(CC1)CCS1(=O)=[O]CN(CC1)CC1(F)F Chemical compound CN(CC1)CCS1(=O)=[O]CN(CC1)CC1(F)F AXGLXFHGUWLXGU-UHFFFAOYSA-N 0.000 description 1
- SECXISVLQFMRJM-UHFFFAOYSA-N CN(CCC1)C1=O Chemical compound CN(CCC1)C1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 1
- GGYVTHJIUNGKFZ-UHFFFAOYSA-N CN(CCCC1)C1=O Chemical compound CN(CCCC1)C1=O GGYVTHJIUNGKFZ-UHFFFAOYSA-N 0.000 description 1
- AVFZOVWCLRSYKC-UHFFFAOYSA-N CN1CCCC1 Chemical compound CN1CCCC1 AVFZOVWCLRSYKC-UHFFFAOYSA-N 0.000 description 1
- PAMIQIKDUOTOBW-UHFFFAOYSA-N CN1CCCCC1 Chemical compound CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 description 1
- SJRJJKPEHAURKC-UHFFFAOYSA-N CN1CCOCC1 Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 1
- KDTVWEHAAISPNW-UHFFFAOYSA-N CN1CCSCC1 Chemical compound CN1CCSCC1 KDTVWEHAAISPNW-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161437870P | 2011-01-31 | 2011-01-31 | |
| US61/437,870 | 2011-01-31 | ||
| PCT/US2012/022847 WO2012106188A1 (en) | 2011-01-31 | 2012-01-27 | C-28 amines of c-3 modified betulinic acid derivatives as hiv maturation inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014507422A JP2014507422A (ja) | 2014-03-27 |
| JP2014507422A5 JP2014507422A5 (enExample) | 2015-02-26 |
| JP6000283B2 true JP6000283B2 (ja) | 2016-09-28 |
Family
ID=45567146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013551360A Expired - Fee Related JP6000283B2 (ja) | 2011-01-31 | 2012-01-27 | Ｈｉｖ成熟阻害剤としてのｃ−３修飾ベツリン酸誘導体のｃ−２８アミン |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8748415B2 (enExample) |
| EP (1) | EP2670764B1 (enExample) |
| JP (1) | JP6000283B2 (enExample) |
| CN (1) | CN103339141B (enExample) |
| BR (1) | BR112014010105A2 (enExample) |
| CA (1) | CA2826257A1 (enExample) |
| CY (1) | CY1116989T1 (enExample) |
| DK (1) | DK2670764T3 (enExample) |
| EA (1) | EA023578B1 (enExample) |
| ES (1) | ES2552512T3 (enExample) |
| HR (1) | HRP20151212T1 (enExample) |
| HU (1) | HUE026371T2 (enExample) |
| MX (1) | MX2013008359A (enExample) |
| PL (1) | PL2670764T3 (enExample) |
| PT (1) | PT2670764E (enExample) |
| RS (1) | RS54352B1 (enExample) |
| SI (1) | SI2670764T1 (enExample) |
| SM (1) | SMT201500303B (enExample) |
| WO (1) | WO2012106188A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA023463B1 (ru) | 2011-09-21 | 2016-06-30 | Бристол-Майерс Сквибб Компани | Производные бетулиновой кислоты с противовирусной активностью |
| US8906889B2 (en) * | 2012-02-15 | 2014-12-09 | Bristol-Myers Squibb Company | C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity |
| US8889854B2 (en) * | 2012-05-07 | 2014-11-18 | Bristol-Myers Squibb Company | C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity |
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- 2012-01-27 CA CA2826257A patent/CA2826257A1/en not_active Abandoned
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- 2012-01-27 DK DK12702946.0T patent/DK2670764T3/en active
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| PT2670764E (pt) | 2015-11-20 |
| DK2670764T3 (en) | 2015-12-07 |
| US20130029954A1 (en) | 2013-01-31 |
| PL2670764T3 (pl) | 2016-02-29 |
| CA2826257A1 (en) | 2012-08-09 |
| SI2670764T1 (sl) | 2016-03-31 |
| CN103339141B (zh) | 2016-08-24 |
| HRP20151212T1 (hr) | 2015-12-04 |
| ES2552512T3 (es) | 2015-11-30 |
| CN103339141A (zh) | 2013-10-02 |
| US8748415B2 (en) | 2014-06-10 |
| EP2670764B1 (en) | 2015-09-02 |
| EA023578B1 (ru) | 2016-06-30 |
| EA201391098A1 (ru) | 2013-12-30 |
| HUE026371T2 (en) | 2016-05-30 |
| WO2012106188A1 (en) | 2012-08-09 |
| JP2014507422A (ja) | 2014-03-27 |
| CY1116989T1 (el) | 2017-04-05 |
| BR112014010105A2 (pt) | 2017-06-13 |
| EP2670764A1 (en) | 2013-12-11 |
| MX2013008359A (es) | 2013-08-27 |
| SMT201500303B (it) | 2016-01-08 |
| RS54352B1 (sr) | 2016-02-29 |
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