CY1116919T1 - Διαδικασια παρασκευης οξινης θειικης αταζαναβιρης και καινοτομων μορφων - Google Patents
Διαδικασια παρασκευης οξινης θειικης αταζαναβιρης και καινοτομων μορφωνInfo
- Publication number
- CY1116919T1 CY1116919T1 CY20151101005T CY151101005T CY1116919T1 CY 1116919 T1 CY1116919 T1 CY 1116919T1 CY 20151101005 T CY20151101005 T CY 20151101005T CY 151101005 T CY151101005 T CY 151101005T CY 1116919 T1 CY1116919 T1 CY 1116919T1
- Authority
- CY
- Cyprus
- Prior art keywords
- atazanavir
- hydrogen sulfate
- preparation
- crystals
- sulfur
- Prior art date
Links
- AXRYRYVKAWYZBR-UHFFFAOYSA-N Atazanavir Natural products C=1C=C(C=2N=CC=CC=2)C=CC=1CN(NC(=O)C(NC(=O)OC)C(C)(C)C)CC(O)C(NC(=O)C(NC(=O)OC)C(C)(C)C)CC1=CC=CC=C1 AXRYRYVKAWYZBR-UHFFFAOYSA-N 0.000 title abstract 7
- 108010019625 Atazanavir Sulfate Proteins 0.000 title abstract 7
- 229960003277 atazanavir Drugs 0.000 title abstract 7
- AXRYRYVKAWYZBR-GASGPIRDSA-N atazanavir Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)[C@@H](O)CN(CC=1C=CC(=CC=1)C=1N=CC=CC=1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C1=CC=CC=C1 AXRYRYVKAWYZBR-GASGPIRDSA-N 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 229910052717 sulfur Inorganic materials 0.000 title 1
- 239000011593 sulfur Substances 0.000 title 1
- QAOWNCQODCNURD-UHFFFAOYSA-M hydrogensulfate Chemical compound OS([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 abstract 4
- 239000013078 crystal Substances 0.000 abstract 3
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 3
- 239000012458 free base Substances 0.000 abstract 2
- 229940122440 HIV protease inhibitor Drugs 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- -1 ethanol sulphate triethanolate Chemical compound 0.000 abstract 1
- 239000004030 hiv protease inhibitor Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/127—Preparation from compounds containing pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56804304P | 2004-05-04 | 2004-05-04 | |
| US60753304P | 2004-09-07 | 2004-09-07 | |
| US11/119,558 US7829720B2 (en) | 2004-05-04 | 2005-05-02 | Process for preparing atazanavir bisulfate and novel forms |
| EP05744537.1A EP1755596B9 (en) | 2004-05-04 | 2005-05-03 | Process for preparing atazanavir bisulfate and novel forms |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1116919T1 true CY1116919T1 (el) | 2017-04-05 |
Family
ID=35310244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20151101005T CY1116919T1 (el) | 2004-05-04 | 2015-11-10 | Διαδικασια παρασκευης οξινης θειικης αταζαναβιρης και καινοτομων μορφων |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US7829720B2 (https=) |
| EP (3) | EP2669273A1 (https=) |
| JP (1) | JP5086069B2 (https=) |
| KR (1) | KR101153606B1 (https=) |
| AU (2) | AU2005240622B2 (https=) |
| BR (1) | BRPI0509595B8 (https=) |
| CA (2) | CA2777216A1 (https=) |
| CY (1) | CY1116919T1 (https=) |
| DK (1) | DK1755596T5 (https=) |
| ES (1) | ES2552219T3 (https=) |
| HR (1) | HRP20150962T2 (https=) |
| HU (1) | HUE026242T2 (https=) |
| IL (1) | IL178965A (https=) |
| MX (1) | MXPA06012612A (https=) |
| NO (1) | NO341013B1 (https=) |
| PL (1) | PL1755596T3 (https=) |
| PT (1) | PT1755596E (https=) |
| RS (1) | RS54284B1 (https=) |
| SI (1) | SI1755596T1 (https=) |
| WO (1) | WO2005108349A2 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200534879A (en) * | 2004-03-25 | 2005-11-01 | Bristol Myers Squibb Co | Coated tablet formulation and method |
| US7829720B2 (en) | 2004-05-04 | 2010-11-09 | Bristol-Myers Squibb Company | Process for preparing atazanavir bisulfate and novel forms |
| US20050256314A1 (en) * | 2004-05-04 | 2005-11-17 | Soojin Kim | Process employing controlled crystallization in forming crystals of a pharmaceutical |
| TWI354569B (en) | 2004-05-28 | 2011-12-21 | Bristol Myers Squibb Co | Coated tablet formulation and method |
| US7642049B2 (en) * | 2006-06-30 | 2010-01-05 | Bristol-Myers Squibb Company | Method for identifying HIV-1 protease inhibitors with reduced metabolic affects through detection of human resistin polymorphisms |
| AR066972A1 (es) * | 2007-06-12 | 2009-09-23 | Concert Pharmaceuticals Inc | Derivados azapeptidicos |
| ES2360336T3 (es) * | 2007-06-22 | 2011-06-03 | Bristol-Myers Squibb Company | Composiciones en comprimidos que contienen atazanavir. |
| DK2170292T3 (da) * | 2007-06-22 | 2014-04-07 | Bristol Myers Squibb Holdings Ireland | Atazanavirholdige sammensætninger i tabletform |
| EP2178512B1 (en) * | 2007-06-22 | 2011-03-09 | Bristol-Myers Squibb Company | Tableted compositions containing atazanavir |
| SI2178513T1 (sl) * | 2007-06-22 | 2011-05-31 | Bristol Myers Squibb Co | Tabletni sestavki vsebujoäśi atazanavir |
| WO2010079497A2 (en) * | 2009-01-12 | 2010-07-15 | Hetero Research Foundation | Novel polymorph of atazanavir sulfate |
| WO2011027324A1 (en) | 2009-09-03 | 2011-03-10 | Ranbaxy Laboratories Limited | Polymorphic forms of atazanavir sulfate |
| IN2012DN03377A (https=) | 2009-10-26 | 2015-10-23 | Merck Sharp & Dohme | |
| EP2555757B1 (en) | 2010-04-09 | 2016-05-25 | Bristol-Myers Squibb Holdings Ireland | Atazanavir sulfate formulations with improved ph effect |
| WO2012041488A1 (en) | 2010-09-28 | 2012-04-05 | Ratiopharm Gmbh | Dry processing of atazanavir |
| WO2013014633A1 (en) | 2011-07-27 | 2013-01-31 | Ranbaxy Laboratories Limited | Process for preparation of atazanavir or its bisulfate salt |
| US8461347B2 (en) | 2011-08-05 | 2013-06-11 | Scinopharm Taiwan, Ltd. | Process for preparing form A of atazanavir sulfate |
| WO2014030173A2 (en) * | 2012-08-24 | 2014-02-27 | Laurus Labs Private Limited | An improved process for the preparation of atazanavir bisulfate |
| WO2014036690A1 (zh) * | 2012-09-04 | 2014-03-13 | 上海迪赛诺化学制药有限公司 | 制备阿扎那韦硫酸氢盐a型结晶的方法 |
| CA2900705A1 (en) | 2013-02-12 | 2014-08-21 | Cipla Limited | Process for preparing atazanavir sulphate |
| CN114763336A (zh) * | 2021-01-14 | 2022-07-19 | 威智医药有限公司 | 一种硫酸阿扎那韦晶型的生产方法 |
| CN115215792A (zh) * | 2022-06-27 | 2022-10-21 | 江西富祥药业股份有限公司 | 一种制备阿扎那韦或其硫酸盐的方法 |
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| US658435A (en) * | 1900-03-22 | 1900-09-25 | William T Ginn | Coal-digger. |
| US4026897A (en) | 1974-01-31 | 1977-05-31 | Otsuka Pharmaceutical Company | 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-hydroxycarbostyril derivatives |
| US3980637A (en) | 1975-03-17 | 1976-09-14 | Bristol-Myers Company | Production of amoxicillin |
| DE3403329A1 (de) * | 1984-02-01 | 1985-08-01 | Horst Dr. 4019 Monheim Zerbe | Pharmazeutisches produkt in form von pellets mit kontinuierlicher, verzoegerter wirkstoffabgabe |
| JPS6186211A (ja) | 1984-10-04 | 1986-05-01 | 日本碍子株式会社 | セラミックス複合構造体及びその製造法 |
| FR2623810B2 (fr) * | 1987-02-17 | 1992-01-24 | Sanofi Sa | Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant |
| US5158777A (en) * | 1990-02-16 | 1992-10-27 | E. R. Squibb & Sons, Inc. | Captopril formulation providing increased duration of activity |
| CA2068402C (en) * | 1991-06-14 | 1998-09-22 | Michael R. Hoy | Taste mask coatings for preparation of chewable pharmaceutical tablets |
| US5428048A (en) * | 1993-11-08 | 1995-06-27 | American Home Products Corporation | Aryl-N-hydroxyureas as inhibitors of 5-lipoxygenase and anto-arteriosclerotic agents |
| GB9407386D0 (en) * | 1994-04-14 | 1994-06-08 | Smithkline Beecham Plc | Pharmaceutical formulation |
| TW483763B (en) * | 1994-09-02 | 2002-04-21 | Astra Ab | Pharmaceutical composition comprising of ramipril and dihydropyridine compound |
| US5849911A (en) * | 1996-04-22 | 1998-12-15 | Novartis Finance Corporation | Antivirally active heterocyclic azahexane derivatives |
| KR100486051B1 (ko) * | 1996-04-22 | 2005-09-09 | 노파르티스 아게 | 항바이러스활성헤테로시클릭아자헥산유도체 |
| GB9715896D0 (en) | 1997-07-28 | 1997-10-01 | Sca Packaging Ltd | Containers |
| US6087383A (en) | 1998-01-20 | 2000-07-11 | Bristol-Myers Squibb Company | Bisulfate salt of HIV protease inhibitor |
| FR2779726B1 (fr) * | 1998-06-15 | 2001-05-18 | Sanofi Sa | Forme polymorphe de l'hydrogenosulfate de clopidogrel |
| CA2368023A1 (en) * | 1999-03-22 | 2000-09-28 | Guixue Yu | Fused pyridopyridazine inhibitors of cgmp phosphodiesterase |
| US6414002B1 (en) * | 1999-09-22 | 2002-07-02 | Bristol-Myers Squibb Company | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method |
| US6949259B1 (en) | 1999-11-11 | 2005-09-27 | Kyorin Pharmaceutical Co., Ltd. | Solid preparations for oral use |
| PT1741446E (pt) | 2000-01-21 | 2008-05-09 | Novartis Pharma Ag | Combinações incluindo inibidores da dipeptidilpeptidase-iv e agentes anti-diabéticos |
| US6254888B1 (en) * | 2000-01-28 | 2001-07-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method for coating pharmaceutical dosage forms |
| US6395767B2 (en) * | 2000-03-10 | 2002-05-28 | Bristol-Myers Squibb Company | Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method |
| CZ20011726A3 (cs) | 2000-05-26 | 2002-02-13 | Pfizer Products Inc. | Způsob reakční krystalizace, který umoľňuje řídit velikost částic |
| IL145106A0 (en) | 2000-08-30 | 2002-06-30 | Pfizer Prod Inc | Intermittent administration of a geowth hormone secretagogue |
| US6670344B2 (en) * | 2000-09-14 | 2003-12-30 | Bristol-Myers Squibb Company | Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di- amino acid salts, and mono- and di-amino acid ester salts |
| US6867300B2 (en) | 2000-11-17 | 2005-03-15 | Bristol-Myers Squibb Company | Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors |
| EP1385486A4 (en) | 2001-04-18 | 2006-05-17 | Nostrum Pharmaceuticals Inc | NEW COATING OF SLOW RELEASE PHARMACEUTICAL COMPOSITION |
| US20050202081A1 (en) | 2002-01-15 | 2005-09-15 | Deepak Bahl | Stable pharmaceutical compositions comprising ace inhibitor(s) |
| KR100456833B1 (ko) | 2002-08-01 | 2004-11-10 | 주식회사 대웅 | 아목시실린 및 클라불라네이트를 함유하는 유핵정 |
| TW200534879A (en) * | 2004-03-25 | 2005-11-01 | Bristol Myers Squibb Co | Coated tablet formulation and method |
| US20050256314A1 (en) * | 2004-05-04 | 2005-11-17 | Soojin Kim | Process employing controlled crystallization in forming crystals of a pharmaceutical |
| US7829720B2 (en) | 2004-05-04 | 2010-11-09 | Bristol-Myers Squibb Company | Process for preparing atazanavir bisulfate and novel forms |
| US20050288343A1 (en) * | 2004-05-19 | 2005-12-29 | Andrew Rusowicz | Process of preparing substituted carbamates and intermediates thereof |
| TWI354569B (en) * | 2004-05-28 | 2011-12-21 | Bristol Myers Squibb Co | Coated tablet formulation and method |
-
2005
- 2005-05-02 US US11/119,558 patent/US7829720B2/en active Active
- 2005-05-03 CA CA2777216A patent/CA2777216A1/en not_active Abandoned
- 2005-05-03 JP JP2007511502A patent/JP5086069B2/ja not_active Expired - Lifetime
- 2005-05-03 HR HRP20150962TT patent/HRP20150962T2/hr unknown
- 2005-05-03 RS RS20150653A patent/RS54284B1/sr unknown
- 2005-05-03 HU HUE05744537A patent/HUE026242T2/en unknown
- 2005-05-03 EP EP20130175944 patent/EP2669273A1/en not_active Withdrawn
- 2005-05-03 AU AU2005240622A patent/AU2005240622B2/en not_active Expired
- 2005-05-03 ES ES05744537.1T patent/ES2552219T3/es not_active Expired - Lifetime
- 2005-05-03 KR KR1020067025370A patent/KR101153606B1/ko not_active Expired - Lifetime
- 2005-05-03 PT PT57445371T patent/PT1755596E/pt unknown
- 2005-05-03 CA CA2565629A patent/CA2565629C/en not_active Expired - Lifetime
- 2005-05-03 EP EP15180557.9A patent/EP2980074A1/en not_active Ceased
- 2005-05-03 SI SI200532001T patent/SI1755596T1/sl unknown
- 2005-05-03 PL PL05744537T patent/PL1755596T3/pl unknown
- 2005-05-03 WO PCT/US2005/015333 patent/WO2005108349A2/en not_active Ceased
- 2005-05-03 DK DK05744537.1T patent/DK1755596T5/en active
- 2005-05-03 EP EP05744537.1A patent/EP1755596B9/en not_active Expired - Lifetime
- 2005-05-03 BR BRPI0509595A patent/BRPI0509595B8/pt not_active IP Right Cessation
- 2005-05-03 MX MXPA06012612A patent/MXPA06012612A/es active IP Right Grant
-
2006
- 2006-10-31 IL IL178965A patent/IL178965A/en active IP Right Grant
- 2006-11-27 NO NO20065441A patent/NO341013B1/no unknown
-
2009
- 2009-01-27 US US12/360,468 patent/US7838678B2/en not_active Expired - Lifetime
-
2010
- 2010-04-16 AU AU2010201538A patent/AU2010201538B2/en not_active Expired
- 2010-10-08 US US12/900,588 patent/US8513428B2/en active Active
-
2015
- 2015-11-10 CY CY20151101005T patent/CY1116919T1/el unknown
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