HUP0302174A2 - Eljárás királisan tiszta N-(transz-4-izopropil-ciklohexilkarbonil)-D-fenilalanin (Nateglinid) és kristálymódosulatainak előállítására, valamint a G kristálymódosulata - Google Patents

Eljárás királisan tiszta N-(transz-4-izopropil-ciklohexilkarbonil)-D-fenilalanin (Nateglinid) és kristálymódosulatainak előállítására, valamint a G kristálymódosulata

Info

Publication number
HUP0302174A2
HUP0302174A2 HU0302174A HUP0302174A HUP0302174A2 HU P0302174 A2 HUP0302174 A2 HU P0302174A2 HU 0302174 A HU0302174 A HU 0302174A HU P0302174 A HUP0302174 A HU P0302174A HU P0302174 A2 HUP0302174 A2 HU P0302174A2
Authority
HU
Hungary
Prior art keywords
nateglinide
trans
chirally pure
cyclohexylcarbonyl
alanine
Prior art date
Application number
HU0302174A
Other languages
English (en)
Inventor
Mária Gazdag
Tibor Gizur
Béla Hegedűs
Attila Szemző
Gábor Tárkányi
József Törley
Zoltánné Babják Mónika Zsoldos
Original Assignee
Richter Gedeon Vegyészeti Gyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyészeti Gyár Rt. filed Critical Richter Gedeon Vegyészeti Gyár Rt.
Priority to HU0302174A priority Critical patent/HU227073B1/hu
Publication of HUP0302174D0 publication Critical patent/HUP0302174D0/hu
Priority to EP10181014A priority patent/EP2264001A1/en
Priority to EP10181081A priority patent/EP2264002A1/en
Priority to JP2006518379A priority patent/JP2007526890A/ja
Priority to PCT/HU2004/000073 priority patent/WO2005005373A1/en
Priority to EA200700896A priority patent/EA011409B1/ru
Priority to EP04743732A priority patent/EP1651591A1/en
Priority to YUP-2005/0980A priority patent/RS20050980A/sr
Priority to EA200700897A priority patent/EA010569B1/ru
Priority to EA200600230A priority patent/EA008883B1/ru
Priority to US10/564,017 priority patent/US7767847B2/en
Publication of HUP0302174A2 publication Critical patent/HUP0302174A2/hu
Priority to US12/755,572 priority patent/US20100256414A1/en
Publication of HU227073B1 publication Critical patent/HU227073B1/hu
Priority to JP2011006521A priority patent/JP2011098975A/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány tárgya <G< kristálymódosulatú, (I) képletű N--(transz-4-izopropilciklohexánkarbonil)-D-fenilalanin (nateglinid) és előállításieljárása, továbbá eljárás <H< kristálymódosulatú nateglinidelőállítására alacsonyabb olvadáspontú módosulatokból, és eljáráskirálisan tiszta nateglinid. előállítására a II. képletű vegyület aholR jelentése: rövid szénláncú (C1-C4) alkilcsoport vagy hidrogénatom;lúgos kezelése majd a kapott alkáli sóból sav célszerű hozzáadássaltörténő felszabadítás útján. Ó
HU0302174A 2003-07-10 2003-07-10 Eljárás királisan tiszta N-(transz-4-izopropil-ciklohexilkarbonil)-D-fenil-alanin (nateglinid) és kristálymódosulatainak elõállítására, valamint a G-kristálymódosulata HU227073B1 (hu)

Priority Applications (13)

Application Number Priority Date Filing Date Title
HU0302174A HU227073B1 (hu) 2003-07-10 2003-07-10 Eljárás királisan tiszta N-(transz-4-izopropil-ciklohexilkarbonil)-D-fenil-alanin (nateglinid) és kristálymódosulatainak elõállítására, valamint a G-kristálymódosulata
US10/564,017 US7767847B2 (en) 2003-07-10 2004-07-08 Process for the preparation of chirally pure N-(trans-4-is)
EP04743732A EP1651591A1 (en) 2003-07-10 2004-07-08 A process for the preparation of chirally pure n-(trans-4-isopropyl-cyclohexylcarbonyl)-d-phenylalanine and crystalline modifications thereof
EA200700897A EA010569B1 (ru) 2003-07-10 2004-07-08 Способ получения хирально чистой кристаллической модификации натеглинида
JP2006518379A JP2007526890A (ja) 2003-07-10 2004-07-08 キラル純ｎ−（トランス−４−イソプロピル−シクロヘキシルカルボニル）−ｄ−フェニルアラニン及びそれらの結晶構造変性体の生成方法
PCT/HU2004/000073 WO2005005373A1 (en) 2003-07-10 2004-07-08 A process for the preparation of chirally pure n-(trans-4-isopropyl-cyclohexylcarbonyl)-d-phenylalanine and crystalline modifications thereof
EA200700896A EA011409B1 (ru) 2003-07-10 2004-07-08 Способ получения морфологически чистой модификации "н" натеглинида
EP10181014A EP2264001A1 (en) 2003-07-10 2004-07-08 A process for the preparation of chirally pure n-(trans-4-isopropylcyclohexylcarbonyl)-d-phenylalanine and crystalline modifications thereof
YUP-2005/0980A RS20050980A (en) 2003-07-10 2004-07-08 A process for the preparation of chirally pure n-(trans-4-isopropyl-cyclohexylcarbonil)-d-phenylalanine and crystalline modifications thereof
EP10181081A EP2264002A1 (en) 2003-07-10 2004-07-08 A process for the preparation of chirally pure N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine
EA200600230A EA008883B1 (ru) 2003-07-10 2004-07-08 Способ получения хирально чистого n-(транс-4-изопропилциклогексилкарбонил)-d-фенилаланина и его кристаллических модификаций
US12/755,572 US20100256414A1 (en) 2003-07-10 2010-04-07 Process for the preparation of chirally pure nateglinide
JP2011006521A JP2011098975A (ja) 2003-07-10 2011-01-15 キラル純ｎ−（トランス−４−イソプロピル−シクロヘキシルカルボニル）−ｄ−フェニルアラニン及びそれらの結晶構造変性体の生成方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0302174A HU227073B1 (hu) 2003-07-10 2003-07-10 Eljárás királisan tiszta N-(transz-4-izopropil-ciklohexilkarbonil)-D-fenil-alanin (nateglinid) és kristálymódosulatainak elõállítására, valamint a G-kristálymódosulata

Publications (3)

Publication Number Publication Date
HUP0302174D0 HUP0302174D0 (en) 2003-09-29
HUP0302174A2 true HUP0302174A2 (hu) 2005-07-28
HU227073B1 HU227073B1 (hu) 2010-06-28

Family

ID=90001695

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0302174A HU227073B1 (hu) 2003-07-10 2003-07-10 Eljárás királisan tiszta N-(transz-4-izopropil-ciklohexilkarbonil)-D-fenil-alanin (nateglinid) és kristálymódosulatainak elõállítására, valamint a G-kristálymódosulata

Country Status (7)

Country Link
US (2) US7767847B2 (hu)
EP (3) EP1651591A1 (hu)
JP (2) JP2007526890A (hu)
EA (3) EA011409B1 (hu)
HU (1) HU227073B1 (hu)
RS (1) RS20050980A (hu)
WO (1) WO2005005373A1 (hu)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1616886A4 (en) * 2003-02-18 2006-06-14 Konishi Co Ltd CURABLE RESIN, PROCESS FOR PRODUCING THE SAME, AND CURABLE RESIN COMPOSITION
HU227073B1 (hu) 2003-07-10 2010-06-28 Richter Gedeon Nyrt Eljárás királisan tiszta N-(transz-4-izopropil-ciklohexilkarbonil)-D-fenil-alanin (nateglinid) és kristálymódosulatainak elõállítására, valamint a G-kristálymódosulata
KR20130087485A (ko) 2010-06-14 2013-08-06 씨아이피엘에이 엘티디. 나테글리니드의 제조 방법
CN109369443A (zh) * 2018-11-05 2019-02-22 扬子江药业集团江苏海慈生物药业有限公司 一种新的那格列奈h晶型的制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6354321A (ja) * 1985-03-27 1988-03-08 Ajinomoto Co Inc 血糖降下剤
EP0526171B1 (en) 1991-07-30 1997-03-05 Ajinomoto Co., Inc. Crystals of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine and methods for preparing them
ES2291356T3 (es) 2000-10-18 2008-03-01 Ajinomoto Co., Inc. Procedimiento para producir cristales de nateglinida.
CA2478599A1 (en) 2002-03-11 2003-09-18 Novartis Ag Salts of nateglinide
US7411089B2 (en) 2002-04-15 2008-08-12 Ajinomoto Co., Inc. Nateglinide crystals
AU2003242520A1 (en) 2002-04-15 2003-10-27 Novartis Ag Crystal forms of n-(trans-4-isopropylcyclohexylcarbonyl)-d-phenylalanine
CZ2004997A3 (cs) * 2002-04-29 2005-01-12 Biocon Limited Nová forma N-(trans-4-isopropylcyklohexylkarbonyl)-D-fenylalaninu
US6861553B2 (en) 2002-07-03 2005-03-01 Teva Pharmaceuticals Industries Ltd. Process for preparing nateglinide and intermediates thereof
US20050075400A1 (en) * 2002-07-18 2005-04-07 Ronit Yahalomi Polymorphic forms of nateglinide
US7420084B2 (en) 2002-07-18 2008-09-02 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7358390B2 (en) * 2002-07-18 2008-04-15 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7148376B2 (en) * 2002-07-18 2006-12-12 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7534913B2 (en) * 2002-07-18 2009-05-19 Teva Pharmaceutica Industries Ltd. Crystalline form of nateglinide
AU2003253971A1 (en) * 2002-07-18 2004-02-09 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
WO2004018408A1 (en) 2002-08-26 2004-03-04 Glenmark Pharmaceuticals Limited Synthesis and purification of nateglinide
WO2004020396A1 (en) * 2002-08-28 2004-03-11 Dr. Reddy's Laboratories Limited Crystalline form of nateglinide and process for preparation thereof
HU227073B1 (hu) 2003-07-10 2010-06-28 Richter Gedeon Nyrt Eljárás királisan tiszta N-(transz-4-izopropil-ciklohexilkarbonil)-D-fenil-alanin (nateglinid) és kristálymódosulatainak elõállítására, valamint a G-kristálymódosulata
ATE349418T1 (de) 2003-11-26 2007-01-15 A M S A Anonima Materie Sint E Verfahren zur herstellung von nateglinidin der b- form
KR20070009726A (ko) 2004-05-07 2007-01-18 테바 파마슈티컬 인더스트리즈 리미티드 나테글리나이드의 다형태
WO2007113650A2 (en) 2006-04-05 2007-10-11 Cadila Pharmaceuticals Limited A novel and improved process fro the preparation of nateglinide and its polymorph form-h
WO2007135533A1 (en) 2006-05-23 2007-11-29 Aurobindo Pharma Limited Process for preparing nateglinide b-type crystals
WO2008096373A2 (en) 2007-02-06 2008-08-14 Ind-Swift Laboratories Limited Process for synthesizing highly pure nateglinide polymorphs

Also Published As

Publication number Publication date
JP2011098975A (ja) 2011-05-19
EP2264001A1 (en) 2010-12-22
EP2264002A1 (en) 2010-12-22
US7767847B2 (en) 2010-08-03
EA008883B1 (ru) 2007-08-31
EA011409B1 (ru) 2009-02-27
US20100256414A1 (en) 2010-10-07
EA010569B1 (ru) 2008-10-30
JP2007526890A (ja) 2007-09-20
EA200700897A1 (ru) 2007-10-26
EA200600230A1 (ru) 2006-06-30
EA200700896A1 (ru) 2007-10-26
WO2005005373A1 (en) 2005-01-20
US20070043117A1 (en) 2007-02-22
HU227073B1 (hu) 2010-06-28
HUP0302174D0 (en) 2003-09-29
EP1651591A1 (en) 2006-05-03
RS20050980A (en) 2008-04-04

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Legal Events

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HC9A Change of name, address

Owner name: RICHTER GEDEON NYRT., HU

Free format text: FORMER OWNER(S): RICHTER GEDEON VEGYESZETI GYAR RT., HU

MM4A Lapse of definitive patent protection due to non-payment of fees