CY1116042T1 - Ενα παρεμποδιστικο μονοκλωνικο αντισωμα εναντι της ανθρωπινης αλφα 1 i περιοχης toy vla-1, και η χρηση του για τη θεραπεια φλεγμονωδων διαταραχων - Google Patents
Ενα παρεμποδιστικο μονοκλωνικο αντισωμα εναντι της ανθρωπινης αλφα 1 i περιοχης toy vla-1, και η χρηση του για τη θεραπεια φλεγμονωδων διαταραχωνInfo
- Publication number
- CY1116042T1 CY1116042T1 CY20151100186T CY151100186T CY1116042T1 CY 1116042 T1 CY1116042 T1 CY 1116042T1 CY 20151100186 T CY20151100186 T CY 20151100186T CY 151100186 T CY151100186 T CY 151100186T CY 1116042 T1 CY1116042 T1 CY 1116042T1
- Authority
- CY
- Cyprus
- Prior art keywords
- treatment
- vla
- region
- toy
- traffic
- Prior art date
Links
- 102100025323 Integrin alpha-1 Human genes 0.000 title abstract 2
- 108010041341 Integrin alpha1 Proteins 0.000 title abstract 2
- 108010055795 Integrin alpha1beta1 Proteins 0.000 title abstract 2
- 201000009863 inflammatory diarrhea Diseases 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 230000009454 functional inhibition Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 208000019553 vascular disease Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- Ophthalmology & Optometry (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13703899P | 1999-06-01 | 1999-06-01 | |
| US18533600P | 2000-02-29 | 2000-02-29 | |
| EP10185467.7A EP2314315B1 (en) | 1999-06-01 | 2000-06-01 | A blocking monoclonal antibody to the human alpha1 I-domain of VLA-1, and its use for the treatment of inflammatory disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1116042T1 true CY1116042T1 (el) | 2017-01-25 |
Family
ID=26834850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20151100186T CY1116042T1 (el) | 1999-06-01 | 2015-02-20 | Ενα παρεμποδιστικο μονοκλωνικο αντισωμα εναντι της ανθρωπινης αλφα 1 i περιοχης toy vla-1, και η χρηση του για τη θεραπεια φλεγμονωδων διαταραχων |
Country Status (28)
| Country | Link |
|---|---|
| US (5) | US6955810B2 (enExample) |
| EP (3) | EP1488806B1 (enExample) |
| JP (6) | JP4817503B2 (enExample) |
| CN (1) | CN1309419C (enExample) |
| AU (2) | AU783989B2 (enExample) |
| BG (1) | BG65579B1 (enExample) |
| BR (1) | BR0011250A (enExample) |
| CA (1) | CA2375827C (enExample) |
| CY (1) | CY1116042T1 (enExample) |
| CZ (1) | CZ300710B6 (enExample) |
| DK (2) | DK2314315T3 (enExample) |
| EA (1) | EA011384B1 (enExample) |
| EE (1) | EE200100651A (enExample) |
| ES (2) | ES2529706T3 (enExample) |
| GE (1) | GEP20063774B (enExample) |
| HK (1) | HK1043320A1 (enExample) |
| HU (1) | HUP0202568A3 (enExample) |
| IL (2) | IL146508A0 (enExample) |
| IS (1) | IS6179A (enExample) |
| MX (1) | MXPA01012388A (enExample) |
| NO (1) | NO20015864L (enExample) |
| NZ (1) | NZ515686A (enExample) |
| PT (2) | PT1488806E (enExample) |
| SI (2) | SI2314315T1 (enExample) |
| SK (1) | SK17232001A3 (enExample) |
| TR (1) | TR200103432T2 (enExample) |
| WO (1) | WO2000072881A1 (enExample) |
| YU (1) | YU85501A (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ300710B6 (cs) * | 1999-06-01 | 2009-07-22 | Biogen Idec Ma Inc. | Použití blokující monoklonální protilátky proti VLA-1 pro výrobu farmaceutického prípravku k lécení zánetlivých onemocnení |
| UA83791C2 (ru) | 2001-04-13 | 2008-08-26 | Байоджен Айдек Ма Инк. | Антитело против vla-1, фармацевтическая композиция, которая его содержит, и из применение для лечения индивидуума с иммунологическим расстройством, опосредованным vla-1 |
| WO2003068262A1 (en) * | 2002-02-14 | 2003-08-21 | Biogen, Inc. | Alpha1beta1 antagonists for treatment of atherosclerosis |
| US7348002B2 (en) * | 2002-11-01 | 2008-03-25 | Boys Town National Research Hospital | Inducible ligand for α1β1 integrin and uses |
| WO2005004800A2 (en) * | 2003-06-20 | 2005-01-20 | Morehouse School Of Medicine | Trypanosome derived apoptotic factors (taf) |
| US20080093950A1 (en) * | 2003-12-09 | 2008-04-24 | Electrotechnologies Selem. Inc | Polyphase Claw-Pole Machines With a Segmented Magnetic Circuit |
| US20050136055A1 (en) * | 2003-12-22 | 2005-06-23 | Pfizer Inc | CD40 antibody formulation and methods |
| WO2006124269A2 (en) * | 2005-05-16 | 2006-11-23 | Amgen Fremont Inc. | Human monoclonal antibodies that bind to very late antigen-1 for the treatment of inflammation and other disorders |
| WO2006133286A2 (en) * | 2005-06-07 | 2006-12-14 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Treatment of tnf antagonist-resistant inflammatory disorders and related methods |
| US10119979B2 (en) * | 2006-05-25 | 2018-11-06 | Biogen Ma Inc. | Methods of treating stroke and traumatic brain injury using humanized AQC2 anti-VLA-1 antibodies |
| WO2009135953A2 (en) * | 2008-05-09 | 2009-11-12 | Ablynx Nv | Amino acid sequences directed against integrins and uses thereof |
| JP6324720B2 (ja) * | 2010-06-18 | 2018-05-16 | エックスバイオテク, インコーポレイテッドXbiotech, Inc. | 関節炎治療 |
| US20140017261A1 (en) * | 2011-02-03 | 2014-01-16 | Mark Totoritis | Selection and treatment of subjects |
| NZ629204A (en) | 2012-02-16 | 2016-09-30 | Santarus Inc | Anti-vla1 (cd49a) antibody pharmaceutical compositions |
| EP3655011A4 (en) * | 2017-07-20 | 2021-03-31 | University Of Virginia Patent Foundation | PROCEDURES FOR THE TREATMENT OR PREVENTION OF A NEUROLOGICAL DISORDER OF THE IMMUNE SYSTEM |
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| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| AU600575B2 (en) | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| WO1991010737A1 (en) | 1990-01-11 | 1991-07-25 | Molecular Affinities Corporation | Production of antibodies using gene libraries |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5391481A (en) | 1990-08-31 | 1995-02-21 | The Trustees Of Columbia University | Antibody which is directed against and inhibits collagen binding to a VLA-1 epitope and uses thereof |
| DE69230142T2 (de) | 1991-05-15 | 2000-03-09 | Cambridge Antibody Technology Ltd. | Verfahren zur herstellung von spezifischen bindungspaargliedern |
| EP0590058B1 (en) | 1991-06-14 | 2003-11-26 | Genentech, Inc. | HUMANIZED Heregulin ANTIBODy |
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2000
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