HK1043320A1 - Vla-1的一種阻塞性單系抗體，以及其治療炎性失調的功用 - Google Patents

Vla-1的一種阻塞性單系抗體，以及其治療炎性失調的功用

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Publication number
HK1043320A1
HK1043320A1 HK02105185.2A HK02105185A HK1043320A1 HK 1043320 A1 HK1043320 A1 HK 1043320A1 HK 02105185 A HK02105185 A HK 02105185A HK 1043320 A1 HK1043320 A1 HK 1043320A1
Authority
HK
Hong Kong
Prior art keywords
vla
treatment
monoclonal antibody
inflammatory disorders
blocking monoclonal
Prior art date
Application number
HK02105185.2A
Other languages
English (en)
Inventor
De Fougerolles Antonin
Gotwals Philip
Lobb Roy
Koteliansky Victor
Original Assignee
Biogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Inc filed Critical Biogen Inc
Publication of HK1043320A1 publication Critical patent/HK1043320A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/565—Complementarity determining region [CDR]
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HK02105185.2A 1999-06-01 2002-07-12 Vla-1的一種阻塞性單系抗體，以及其治療炎性失調的功用 HK1043320A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13703899P 1999-06-01 1999-06-01
US18533600P 2000-02-29 2000-02-29
PCT/US2000/015004 WO2000072881A1 (en) 1999-06-01 2000-06-01 A blocking monoclonal antibody to vla-1 and its use for the treatment of inflammatory disorders

Publications (1)

Publication Number Publication Date
HK1043320A1 true HK1043320A1 (zh) 2002-09-13

Family

ID=26834850

Family Applications (2)

Application Number Title Priority Date Filing Date
HK02105185.2A HK1043320A1 (zh) 1999-06-01 2002-07-12 Vla-1的一種阻塞性單系抗體，以及其治療炎性失調的功用
HK11108559.3A HK1154352A1 (zh) 1999-06-01 2011-08-15 人類α -結構域的 的單克隆封閉抗體及其在炎性病症的治療中的應用

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK11108559.3A HK1154352A1 (zh) 1999-06-01 2011-08-15 人類α -結構域的 的單克隆封閉抗體及其在炎性病症的治療中的應用

Country Status (28)

Country Link
US (5) US6955810B2 (zh)
EP (3) EP1181054A1 (zh)
JP (6) JP4817503B2 (zh)
CN (1) CN1309419C (zh)
AU (2) AU783989B2 (zh)
BG (1) BG65579B1 (zh)
BR (1) BR0011250A (zh)
CA (1) CA2375827C (zh)
CY (1) CY1116042T1 (zh)
CZ (1) CZ300710B6 (zh)
DK (2) DK2314315T3 (zh)
EA (1) EA011384B1 (zh)
EE (1) EE200100651A (zh)
ES (2) ES2557768T3 (zh)
GE (1) GEP20063774B (zh)
HK (2) HK1043320A1 (zh)
HU (1) HUP0202568A3 (zh)
IL (2) IL146508A0 (zh)
IS (1) IS6179A (zh)
MX (1) MXPA01012388A (zh)
NO (1) NO20015864L (zh)
NZ (1) NZ515686A (zh)
PT (2) PT1488806E (zh)
SI (2) SI1488806T1 (zh)
SK (1) SK17232001A3 (zh)
TR (1) TR200103432T2 (zh)
WO (1) WO2000072881A1 (zh)
YU (1) YU85501A (zh)

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WO2009135953A2 (en) * 2008-05-09 2009-11-12 Ablynx Nv Amino acid sequences directed against integrins and uses thereof
CN107596365A (zh) * 2010-06-18 2018-01-19 埃克斯生物科技公司 关节炎治疗
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