JP4817503B2 - Ｖｌａ−１に対するブロッキングモノクローナル抗体および炎症性障害の処置のためのその使用 - Google Patents

Ｖｌａ−１に対するブロッキングモノクローナル抗体および炎症性障害の処置のためのその使用 Download PDF

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JP4817503B2
JP4817503B2 JP2000620987A JP2000620987A JP4817503B2 JP 4817503 B2 JP4817503 B2 JP 4817503B2 JP 2000620987 A JP2000620987 A JP 2000620987A JP 2000620987 A JP2000620987 A JP 2000620987A JP 4817503 B2 JP4817503 B2 JP 4817503B2
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antibody
composition
mab
day
human
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JP2004500328A (ja
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アントニン デフォージェロレス，
フィリップ ゴットウォールズ，
ロイ ラブ，
ビクター コテリアンスキー，
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Biogen Inc
Biogen MA Inc
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Biogen Inc
Biogen Idec Inc
Biogen Idec MA Inc
Biogen MA Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2842—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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JP2000620987A 1999-06-01 2000-06-01 Ｖｌａ−１に対するブロッキングモノクローナル抗体および炎症性障害の処置のためのその使用 Expired - Lifetime JP4817503B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13703899P 1999-06-01 1999-06-01
US60/137,038 1999-06-01
US18533600P 2000-02-29 2000-02-29
US60/185,336 2000-02-29
PCT/US2000/015004 WO2000072881A1 (en) 1999-06-01 2000-06-01 A blocking monoclonal antibody to vla-1 and its use for the treatment of inflammatory disorders

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2007136041A Division JP2007277253A (ja) 1999-06-01 2007-05-22 Ｖｌａ−１に対するブロッキングモノクローナル抗体および炎症性障害の処置のためのその使用
JP2011116366A Division JP5623335B2 (ja) 1999-06-01 2011-05-24 Ｖｌａ−１に対するブロッキングモノクローナル抗体および炎症性障害の処置のためのその使用

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JP2004500328A JP2004500328A (ja) 2004-01-08
JP4817503B2 true JP4817503B2 (ja) 2011-11-16

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JP2000620987A Expired - Lifetime JP4817503B2 (ja) 1999-06-01 2000-06-01 Ｖｌａ−１に対するブロッキングモノクローナル抗体および炎症性障害の処置のためのその使用
JP2007136041A Pending JP2007277253A (ja) 1999-06-01 2007-05-22 Ｖｌａ−１に対するブロッキングモノクローナル抗体および炎症性障害の処置のためのその使用
JP2011116366A Expired - Lifetime JP5623335B2 (ja) 1999-06-01 2011-05-24 Ｖｌａ−１に対するブロッキングモノクローナル抗体および炎症性障害の処置のためのその使用
JP2012130177A Pending JP2012176983A (ja) 1999-06-01 2012-06-07 Ｖｌａ−１に対するブロッキングモノクローナル抗体および炎症性障害の処置のためのその使用
JP2014165702A Expired - Lifetime JP5960762B2 (ja) 1999-06-01 2014-08-18 Ｖｌａ−１に対するブロッキングモノクローナル抗体および炎症性障害の処置のためのその使用
JP2016060029A Withdrawn JP2016121184A (ja) 1999-06-01 2016-03-24 Ｖｌａ−１に対するブロッキングモノクローナル抗体および炎症性障害の処置のためのその使用

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JP2007136041A Pending JP2007277253A (ja) 1999-06-01 2007-05-22 Ｖｌａ−１に対するブロッキングモノクローナル抗体および炎症性障害の処置のためのその使用
JP2011116366A Expired - Lifetime JP5623335B2 (ja) 1999-06-01 2011-05-24 Ｖｌａ−１に対するブロッキングモノクローナル抗体および炎症性障害の処置のためのその使用
JP2012130177A Pending JP2012176983A (ja) 1999-06-01 2012-06-07 Ｖｌａ−１に対するブロッキングモノクローナル抗体および炎症性障害の処置のためのその使用
JP2014165702A Expired - Lifetime JP5960762B2 (ja) 1999-06-01 2014-08-18 Ｖｌａ−１に対するブロッキングモノクローナル抗体および炎症性障害の処置のためのその使用
JP2016060029A Withdrawn JP2016121184A (ja) 1999-06-01 2016-03-24 Ｖｌａ−１に対するブロッキングモノクローナル抗体および炎症性障害の処置のためのその使用

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US (5) US6955810B2 (enExample)
EP (3) EP1181054A1 (enExample)
JP (6) JP4817503B2 (enExample)
CN (1) CN1309419C (enExample)
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Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1181054A1 (en) * 1999-06-01 2002-02-27 Biogen, Inc. A blocking monoclonal antibody to vla-1 and its use for the treatment of inflammatory disorders
EP1423431B1 (en) 2001-04-13 2010-06-16 Biogen Idec MA Inc. Antibodies to vla-1
AU2003215298A1 (en) * 2002-02-14 2003-09-04 Biogen, Inc. Alpha1beta1 antagonists for treatment of atherosclerosis
BR0315054A (pt) * 2002-11-01 2005-08-16 Boys Town Nat Res Hospital Ligando induzìvel para a integrina alfa 1 beta 1 e empregos
WO2005004800A2 (en) * 2003-06-20 2005-01-20 Morehouse School Of Medicine Trypanosome derived apoptotic factors (taf)
WO2005057755A1 (en) * 2003-12-09 2005-06-23 Electrotechnologies Selem, Inc. Polyphase claw-pole machines with a segmented magnetic circuit
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