CY1116008T1 - Διαδικασια για την παρασκευη των ν-υποκατεστημενων 2-κυανοπυρρολιδινων - Google Patents
Διαδικασια για την παρασκευη των ν-υποκατεστημενων 2-κυανοπυρρολιδινωνInfo
- Publication number
- CY1116008T1 CY1116008T1 CY20151100168T CY151100168T CY1116008T1 CY 1116008 T1 CY1116008 T1 CY 1116008T1 CY 20151100168 T CY20151100168 T CY 20151100168T CY 151100168 T CY151100168 T CY 151100168T CY 1116008 T1 CY1116008 T1 CY 1116008T1
- Authority
- CY
- Cyprus
- Prior art keywords
- preparation
- reaction
- resulting compound
- substituted
- cyanopyrrolidines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pyrrole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Η παρούσα εφεύρεση σχετίζεται με μία διαδικασία για την παρασκευή μίας Ν-(Ν΄-υποκατεστημένης γλυκυλο)-2-κυανο-πυρρολιδίνης η οποία περιλαμβάνει τουλάχιστον (α) την αντίδραση, παρουσία διμεθυλοφορμαμιδίου, μίας ένωσης με τον τύπο (V) όπου, ανεξάρτητα το ένα από το άλλο, το Χ1 και το Χ3 είναι αλογόνο, το Χ2 είναι αλογόνο, OH, O-C(=O)-CH2X3, -O-SO2-(C1-8) αλκύλιο ή -O-SO2-(αρύλιο) με το L-προλιναμίδιο, και στη συνέχεια με (β) την αντίδραση της ένωσης που προκύπτει χωρίς καθαρισμό με έναν παράγοντα αφυδρογόνωσης, και στη συνέχεια με (γ) την αντίδραση, παρουσία μίας βάσης, της ένωσης που προκύπτει χωρίς καθαρισμό με μία κατάλληλη αμίνη και (δ) την ανάκτηση της ένωσης που προκύπτει σε ελεύθερη μορφή ή στη μορφή ενός όξινου άλατος προσθήκης.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0308854A GB0308854D0 (en) | 2003-04-16 | 2003-04-16 | Organic compounds |
| GB0311836A GB0311836D0 (en) | 2003-05-22 | 2003-05-22 | Process for the manufacture of organic compounds |
| EP04727557.3A EP1620396B1 (en) | 2003-04-16 | 2004-04-15 | Process for the preparation of n-substituted 2-cyanopyrrolidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1116008T1 true CY1116008T1 (el) | 2017-01-25 |
Family
ID=33301223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20151100168T CY1116008T1 (el) | 2003-04-16 | 2015-02-18 | Διαδικασια για την παρασκευη των ν-υποκατεστημενων 2-κυανοπυρρολιδινων |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US7375238B2 (el) |
| EP (1) | EP1620396B1 (el) |
| JP (1) | JP4672647B2 (el) |
| KR (1) | KR101192538B1 (el) |
| AR (1) | AR044019A1 (el) |
| AU (2) | AU2004230245B2 (el) |
| BR (1) | BRPI0409471B8 (el) |
| CA (1) | CA2520128C (el) |
| CL (1) | CL2004000804A1 (el) |
| CO (1) | CO5700735A2 (el) |
| CY (1) | CY1116008T1 (el) |
| DK (1) | DK1620396T3 (el) |
| EC (1) | ECSP056093A (el) |
| ES (1) | ES2531084T3 (el) |
| HK (1) | HK1087695A1 (el) |
| HR (1) | HRP20150163T1 (el) |
| IL (1) | IL170887A (el) |
| IS (1) | IS2979B (el) |
| MA (1) | MA27765A1 (el) |
| MX (1) | MXPA05011073A (el) |
| MY (1) | MY139476A (el) |
| NO (1) | NO333251B1 (el) |
| NZ (1) | NZ542899A (el) |
| PE (2) | PE20081293A1 (el) |
| PL (1) | PL1620396T3 (el) |
| PT (1) | PT1620396E (el) |
| RU (1) | RU2369598C2 (el) |
| SG (1) | SG160212A1 (el) |
| SI (1) | SI1620396T1 (el) |
| TW (1) | TWI359135B (el) |
| WO (1) | WO2004092127A1 (el) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR044019A1 (es) | 2003-04-16 | 2005-08-24 | Novartis Ag | Proceso para la preparacion de 2-cianopirrolidinas n-sustituidas |
| EP2165703A3 (en) | 2004-01-20 | 2012-03-28 | Novartis Pharma AG | Direct compression formulation and process |
| GT200600008A (es) | 2005-01-18 | 2006-08-09 | Formulacion de compresion directa y proceso | |
| MX2008001609A (es) * | 2005-08-04 | 2008-02-19 | Novartis Ag | Sales de vildagliptina. |
| JP5165584B2 (ja) * | 2006-11-29 | 2013-03-21 | 田辺三菱製薬株式会社 | Ｎ−（ｎ’−置換グリシル）−２−シアノピロリジン誘導体の製法 |
| WO2008084383A2 (en) * | 2007-01-10 | 2008-07-17 | Medichem, S.A. | Process for preparing vildagliptin |
| CZ2008512A3 (cs) | 2008-08-26 | 2010-03-10 | Zentiva, A. S | Zpusob prípravy vysoce cistého vildagliptinu |
| EA034049B1 (ru) * | 2009-07-31 | 2019-12-23 | КРКА, д.д., НОВО МЕСТО | Гранулят, включающий вилдаглиптин, способ его получения и фармацевтическая композиция |
| HUP0900638A2 (en) * | 2009-10-07 | 2011-05-30 | Egyt Gyogyszervegyeszeti Gyar | Adducts of inorganic salts basea on vildaelitpin applicable for preparation of pharmaceutical compositions |
| IT1400714B1 (it) | 2010-07-06 | 2013-06-28 | Chemelectiva S R L | Processo ed intermedi per la preparazione di un principio attivo. |
| HU231050B1 (hu) | 2010-08-19 | 2020-02-28 | Egis Gyógyszergyár Nyrt. | Eljárás gyógyszerhatóanyag előállítására |
| ITMI20112224A1 (it) * | 2011-12-06 | 2013-06-07 | Chemelectiva S R L | Nuovo processo ed intermedi per la sintesi di vildagliptin |
| IN2012MU01383A (el) * | 2012-05-04 | 2014-02-28 | ||
| CN103922986B (zh) * | 2013-01-16 | 2017-02-15 | 上海彩迩文生化科技有限公司 | 维大列汀及其类似物、中间体及其制备方法和应用 |
| WO2015145467A1 (en) * | 2014-03-28 | 2015-10-01 | Laurus Labs Private Limited | An improved process for preparing vildagliptin |
| WO2021234430A1 (en) | 2020-05-17 | 2021-11-25 | Lotus International Pte. Ltd. | Modified release dosage form comprising vildagliptin and process for manufacturing the same |
| WO2022003405A1 (en) | 2020-07-03 | 2022-01-06 | Savoi Guilherme | One-pot process to obtain a pyrrolidine-2-carbonitrile intermediate compound and industrial scale telescopic process to prepare (2s)-1-[n-(3-hydroxyadamantan-1-yl)glycyl]-2-pyrrolidinecarbonitrile (vildagliptin) using same |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5510369A (en) * | 1994-07-22 | 1996-04-23 | Merck & Co., Inc. | Pyrrolidine thrombin inhibitors |
| TW492957B (en) * | 1996-11-07 | 2002-07-01 | Novartis Ag | N-substituted 2-cyanopyrrolidnes |
| CO5150173A1 (es) * | 1998-12-10 | 2002-04-29 | Novartis Ag | Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv |
| US6380398B2 (en) | 2000-01-04 | 2002-04-30 | Novo Nordisk A/S | Therapeutically active and selective heterocyclic compounds that are inhibitors of the enzyme DPP-IV |
| EP1254113A1 (en) * | 2000-01-24 | 2002-11-06 | Novo Nordisk A/S | N-substituted 2-cyanopyroles and -pyrrolines which are inhibitors of the enzyme dpp-iv |
| TW583185B (en) * | 2000-06-13 | 2004-04-11 | Novartis Ag | N-(substituted glycyl)-2-cyanopyrrolidines and pharmaceutical composition for inhibiting dipeptidyl peptidase-IV (DPP-IV) or for the prevention or treatment of diseases or conditions associated with elevated levels of DPP-IV comprising the same |
| JP2002265439A (ja) * | 2001-03-08 | 2002-09-18 | Mitsubishi Pharma Corp | シアノピロリジン誘導体およびその医薬用途 |
| AR044019A1 (es) | 2003-04-16 | 2005-08-24 | Novartis Ag | Proceso para la preparacion de 2-cianopirrolidinas n-sustituidas |
-
2004
- 2004-04-14 AR ARP040101251A patent/AR044019A1/es not_active Application Discontinuation
- 2004-04-14 PE PE2007000421A patent/PE20081293A1/es not_active Application Discontinuation
- 2004-04-14 PE PE2004000370A patent/PE20050021A1/es not_active Application Discontinuation
- 2004-04-15 MX MXPA05011073A patent/MXPA05011073A/es active IP Right Grant
- 2004-04-15 MY MYPI20041383A patent/MY139476A/en unknown
- 2004-04-15 SG SG200716949-3A patent/SG160212A1/en unknown
- 2004-04-15 JP JP2006505132A patent/JP4672647B2/ja not_active Expired - Lifetime
- 2004-04-15 US US10/552,835 patent/US7375238B2/en not_active Expired - Fee Related
- 2004-04-15 AU AU2004230245A patent/AU2004230245B2/en not_active Ceased
- 2004-04-15 CA CA2520128A patent/CA2520128C/en not_active Expired - Fee Related
- 2004-04-15 DK DK04727557.3T patent/DK1620396T3/en active
- 2004-04-15 KR KR1020057019568A patent/KR101192538B1/ko active IP Right Review Request
- 2004-04-15 WO PCT/EP2004/003980 patent/WO2004092127A1/en active Application Filing
- 2004-04-15 PL PL04727557T patent/PL1620396T3/pl unknown
- 2004-04-15 SI SI200432220T patent/SI1620396T1/sl unknown
- 2004-04-15 NZ NZ542899A patent/NZ542899A/en not_active IP Right Cessation
- 2004-04-15 RU RU2005135331/04A patent/RU2369598C2/ru active
- 2004-04-15 TW TW093110566A patent/TWI359135B/zh not_active IP Right Cessation
- 2004-04-15 BR BRPI0409471A patent/BRPI0409471B8/pt not_active IP Right Cessation
- 2004-04-15 CL CL200400804A patent/CL2004000804A1/es unknown
- 2004-04-15 PT PT04727557T patent/PT1620396E/pt unknown
- 2004-04-15 EP EP04727557.3A patent/EP1620396B1/en not_active Expired - Lifetime
- 2004-04-15 ES ES04727557T patent/ES2531084T3/es not_active Expired - Lifetime
-
2005
- 2005-09-15 IL IL170887A patent/IL170887A/en active IP Right Grant
- 2005-10-12 EC EC2005006093A patent/ECSP056093A/es unknown
- 2005-10-19 MA MA28559A patent/MA27765A1/fr unknown
- 2005-11-03 CO CO05112189A patent/CO5700735A2/es not_active Application Discontinuation
- 2005-11-07 NO NO20055226A patent/NO333251B1/no not_active IP Right Cessation
- 2005-11-10 IS IS8122A patent/IS2979B/is unknown
-
2006
- 2006-07-11 HK HK06107769.8A patent/HK1087695A1/xx not_active IP Right Cessation
-
2008
- 2008-05-22 AU AU2008202278A patent/AU2008202278A1/en not_active Abandoned
-
2015
- 2015-02-10 HR HRP20150163TT patent/HRP20150163T1/hr unknown
- 2015-02-18 CY CY20151100168T patent/CY1116008T1/el unknown
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