CY1113625T1 - Μεθοδος για την παραγωγη συμπυκνωμενων παραγωγων της πιπεραζιν-2-ονης καθως και ενδιαμεσα προϊοντα της μεθοδου - Google Patents
Μεθοδος για την παραγωγη συμπυκνωμενων παραγωγων της πιπεραζιν-2-ονης καθως και ενδιαμεσα προϊοντα της μεθοδουInfo
- Publication number
- CY1113625T1 CY1113625T1 CY20121101215T CY121101215T CY1113625T1 CY 1113625 T1 CY1113625 T1 CY 1113625T1 CY 20121101215 T CY20121101215 T CY 20121101215T CY 121101215 T CY121101215 T CY 121101215T CY 1113625 T1 CY1113625 T1 CY 1113625T1
- Authority
- CY
- Cyprus
- Prior art keywords
- products
- piperazine
- producing concentrated
- intermediate products
- derivatives
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- IWELDVXSEVIIGI-UHFFFAOYSA-N piperazin-2-one Chemical compound O=C1CNCCN1 IWELDVXSEVIIGI-UHFFFAOYSA-N 0.000 title abstract 2
- 239000013067 intermediate product Substances 0.000 title 1
- 239000000047 product Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004058337A DE102004058337A1 (de) | 2004-12-02 | 2004-12-02 | Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten |
| EP05823799A EP1819706B1 (de) | 2004-12-02 | 2005-11-29 | Verfahren zur herstellung von annelierten piperazin-2-on derivaten sowie zwischenprodukte des verfahrens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1113625T1 true CY1113625T1 (el) | 2016-06-22 |
Family
ID=35923724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20121101215T CY1113625T1 (el) | 2004-12-02 | 2012-12-12 | Μεθοδος για την παραγωγη συμπυκνωμενων παραγωγων της πιπεραζιν-2-ονης καθως και ενδιαμεσα προϊοντα της μεθοδου |
Country Status (34)
| Country | Link |
|---|---|
| US (9) | US7238807B2 (OSRAM) |
| EP (2) | EP1819706B1 (OSRAM) |
| JP (1) | JP5164574B2 (OSRAM) |
| KR (2) | KR101395591B1 (OSRAM) |
| CN (3) | CN101065381B (OSRAM) |
| AR (1) | AR053100A1 (OSRAM) |
| AU (1) | AU2005311308B2 (OSRAM) |
| BR (1) | BRPI0518601A2 (OSRAM) |
| CA (1) | CA2588857C (OSRAM) |
| CL (1) | CL2013002895A1 (OSRAM) |
| CY (1) | CY1113625T1 (OSRAM) |
| DE (1) | DE102004058337A1 (OSRAM) |
| DK (2) | DK2436685T3 (OSRAM) |
| EA (1) | EA012624B1 (OSRAM) |
| ES (2) | ES2548680T3 (OSRAM) |
| HR (1) | HRP20120980T1 (OSRAM) |
| HU (1) | HUE027689T2 (OSRAM) |
| IL (1) | IL183568A (OSRAM) |
| ME (1) | ME01470B (OSRAM) |
| MX (1) | MX2007006549A (OSRAM) |
| MY (1) | MY147459A (OSRAM) |
| NO (1) | NO20072283L (OSRAM) |
| NZ (1) | NZ556182A (OSRAM) |
| PE (2) | PE20090488A1 (OSRAM) |
| PL (2) | PL2436685T3 (OSRAM) |
| PT (1) | PT1819706E (OSRAM) |
| RS (1) | RS52533B (OSRAM) |
| SG (2) | SG141461A1 (OSRAM) |
| SI (1) | SI1819706T1 (OSRAM) |
| TW (1) | TWI362391B (OSRAM) |
| UA (1) | UA89390C2 (OSRAM) |
| UY (1) | UY29233A1 (OSRAM) |
| WO (1) | WO2006058876A1 (OSRAM) |
| ZA (1) | ZA200703368B (OSRAM) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6861422B2 (en) * | 2003-02-26 | 2005-03-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions |
| DE102004029784A1 (de) * | 2004-06-21 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel |
| DE102004033670A1 (de) * | 2004-07-09 | 2006-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel |
| US7759485B2 (en) * | 2004-08-14 | 2010-07-20 | Boehringer Ingelheim International Gmbh | Process for the manufacture of dihydropteridinones |
| US20060058311A1 (en) | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
| US7728134B2 (en) * | 2004-08-14 | 2010-06-01 | Boehringer Ingelheim International Gmbh | Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament |
| US20060074088A1 (en) * | 2004-08-14 | 2006-04-06 | Boehringer Ingelheim International Gmbh | Dihydropteridinones for the treatment of cancer diseases |
| US20060035903A1 (en) * | 2004-08-14 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Storage stable perfusion solution for dihydropteridinones |
| EP1630163A1 (de) * | 2004-08-25 | 2006-03-01 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| EP1632493A1 (de) * | 2004-08-25 | 2006-03-08 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| DE102004058337A1 (de) | 2004-12-02 | 2006-06-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten |
| US7439358B2 (en) | 2006-02-08 | 2008-10-21 | Boehringer Ingelheim International Gmbh | Specific salt, anhydrous and crystalline form of a dihydropteridione derivative |
| AU2007215221C1 (en) | 2006-02-14 | 2013-05-30 | Vertex Pharmaceuticals Incorporated | Dihydrodiazepines useful as inhibitors of protein kinases |
| JP4958461B2 (ja) * | 2006-03-30 | 2012-06-20 | 富士フイルム株式会社 | 近赤外吸収色素含有硬化性組成物 |
| KR20090104920A (ko) | 2007-02-01 | 2009-10-06 | 아스트라제네카 아베 | Ｈｓｐ90 억제제로서 5,6,7,8-테트라히드로프테리딘 유도체 |
| EP3098223A1 (en) * | 2007-08-03 | 2016-11-30 | Boehringer Ingelheim International GmbH | Crystalline form of a dihydropteridione derivative |
| EP2100894A1 (en) | 2008-03-12 | 2009-09-16 | 4Sc Ag | Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors |
| CN102020643A (zh) | 2009-09-22 | 2011-04-20 | 上海恒瑞医药有限公司 | 二氢喋啶酮类衍生物、其制备方法及其在医药上的应用 |
| SG179206A1 (en) | 2009-09-25 | 2012-04-27 | Vertex Pharma | Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors |
| NZ599342A (en) | 2009-09-25 | 2014-04-30 | Vertex Pharma | Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors |
| US8546566B2 (en) | 2010-10-12 | 2013-10-01 | Boehringer Ingelheim International Gmbh | Process for manufacturing dihydropteridinones and intermediates thereof |
| US9358233B2 (en) | 2010-11-29 | 2016-06-07 | Boehringer Ingelheim International Gmbh | Method for treating acute myeloid leukemia |
| EP2678342B1 (en) | 2011-02-25 | 2015-01-07 | Takeda Pharmaceutical Company Limited | N-substituted oxazinopteridines and oxazinopteridinones |
| US9370535B2 (en) | 2011-05-17 | 2016-06-21 | Boehringer Ingelheim International Gmbh | Method for treatment of advanced solid tumors |
| UY34893A (es) | 2012-07-10 | 2014-02-28 | Takeda Pharmaceutical | Derivados de azaindol |
| WO2015011236A1 (en) | 2013-07-26 | 2015-01-29 | Boehringer Ingelheim International Gmbh | Treatment of myelodysplastic syndrome |
| AR099052A1 (es) | 2014-01-09 | 2016-06-29 | Takeda Pharmaceuticals Co | Derivados de azaindol |
| US9867831B2 (en) | 2014-10-01 | 2018-01-16 | Boehringer Ingelheim International Gmbh | Combination treatment of acute myeloid leukemia and myelodysplastic syndrome |
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| CA2517020C (en) | 2003-02-26 | 2012-06-26 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Dihydropteridinones, method for the production and use thereof in the form of drugs |
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| DE102004002557A1 (de) * | 2004-01-17 | 2005-08-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von substituierten Pyrimido(5,4-d)pyrimidinen zur Behandlung von Atemwegserkrankungen |
| DE102004029784A1 (de) * | 2004-06-21 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel |
| DE102004033670A1 (de) * | 2004-07-09 | 2006-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel |
| DE102004034623A1 (de) * | 2004-07-16 | 2006-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 6-Formyl-tetrahydropteridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US7728134B2 (en) * | 2004-08-14 | 2010-06-01 | Boehringer Ingelheim International Gmbh | Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament |
| US20060035903A1 (en) * | 2004-08-14 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Storage stable perfusion solution for dihydropteridinones |
| US20060074088A1 (en) * | 2004-08-14 | 2006-04-06 | Boehringer Ingelheim International Gmbh | Dihydropteridinones for the treatment of cancer diseases |
| US7759485B2 (en) | 2004-08-14 | 2010-07-20 | Boehringer Ingelheim International Gmbh | Process for the manufacture of dihydropteridinones |
| US20060058311A1 (en) | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
| EP1632493A1 (de) * | 2004-08-25 | 2006-03-08 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| EP1630163A1 (de) * | 2004-08-25 | 2006-03-01 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| JP2008510770A (ja) * | 2004-08-26 | 2008-04-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｐｌｋ阻害剤としての新規プテリジノン |
| JP2008510771A (ja) * | 2004-08-27 | 2008-04-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ジヒドロプテリジノン、その製造方法および医薬薬剤としてのその使用 |
| DE102004058337A1 (de) * | 2004-12-02 | 2006-06-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten |
| JP2009503014A (ja) | 2005-08-03 | 2009-01-29 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 呼吸器系疾患の治療におけるジヒドロプテリジノン |
| US7439358B2 (en) * | 2006-02-08 | 2008-10-21 | Boehringer Ingelheim International Gmbh | Specific salt, anhydrous and crystalline form of a dihydropteridione derivative |
| CN101437795A (zh) | 2006-03-07 | 2009-05-20 | 阿斯利康(瑞典)有限公司 | 哌啶衍生物，制备它们的方法，它们作为治疗剂的用途和含有它们的药物组合物 |
| EP3098223A1 (en) | 2007-08-03 | 2016-11-30 | Boehringer Ingelheim International GmbH | Crystalline form of a dihydropteridione derivative |
-
2004
- 2004-12-02 DE DE102004058337A patent/DE102004058337A1/de not_active Withdrawn
-
2005
- 2005-11-22 US US11/284,836 patent/US7238807B2/en not_active Ceased
- 2005-11-29 HU HUE11189691A patent/HUE027689T2/hu unknown
- 2005-11-29 MX MX2007006549A patent/MX2007006549A/es active IP Right Grant
- 2005-11-29 EA EA200701164A patent/EA012624B1/ru not_active IP Right Cessation
- 2005-11-29 AU AU2005311308A patent/AU2005311308B2/en not_active Ceased
- 2005-11-29 EP EP05823799A patent/EP1819706B1/de not_active Expired - Lifetime
- 2005-11-29 SG SG200802431-7A patent/SG141461A1/en unknown
- 2005-11-29 DK DK11189691.6T patent/DK2436685T3/en active
- 2005-11-29 ME MEP-2012-124A patent/ME01470B/me unknown
- 2005-11-29 KR KR1020127028659A patent/KR101395591B1/ko not_active Expired - Fee Related
- 2005-11-29 RS RS20120519A patent/RS52533B/sr unknown
- 2005-11-29 UY UY29233A patent/UY29233A1/es not_active Application Discontinuation
- 2005-11-29 CA CA2588857A patent/CA2588857C/en not_active Expired - Fee Related
- 2005-11-29 PL PL11189691T patent/PL2436685T3/pl unknown
- 2005-11-29 UA UAA200706986A patent/UA89390C2/ru unknown
- 2005-11-29 EP EP11189691.6A patent/EP2436685B1/de not_active Expired - Lifetime
- 2005-11-29 NZ NZ556182A patent/NZ556182A/en not_active IP Right Cessation
- 2005-11-29 CN CN2005800406546A patent/CN101065381B/zh not_active Expired - Fee Related
- 2005-11-29 SG SG201000003-2A patent/SG158848A1/en unknown
- 2005-11-29 KR KR1020077015136A patent/KR101362131B1/ko not_active Expired - Fee Related
- 2005-11-29 DK DK05823799.1T patent/DK1819706T3/da active
- 2005-11-29 PL PL05823799T patent/PL1819706T3/pl unknown
- 2005-11-29 PT PT58237991T patent/PT1819706E/pt unknown
- 2005-11-29 ES ES11189691.6T patent/ES2548680T3/es not_active Expired - Lifetime
- 2005-11-29 CN CN201010593286.0A patent/CN102093361B/zh not_active Expired - Fee Related
- 2005-11-29 ES ES05823799T patent/ES2395829T3/es not_active Expired - Lifetime
- 2005-11-29 WO PCT/EP2005/056291 patent/WO2006058876A1/de not_active Ceased
- 2005-11-29 JP JP2007543838A patent/JP5164574B2/ja not_active Expired - Lifetime
- 2005-11-29 CN CN2010105934512A patent/CN102070637B/zh not_active Expired - Fee Related
- 2005-11-29 BR BRPI0518601-3A patent/BRPI0518601A2/pt not_active IP Right Cessation
- 2005-11-29 SI SI200531631T patent/SI1819706T1/sl unknown
- 2005-11-29 HR HRP20120980TT patent/HRP20120980T1/hr unknown
- 2005-11-30 PE PE2009000418A patent/PE20090488A1/es not_active Application Discontinuation
- 2005-11-30 MY MYPI20055607A patent/MY147459A/en unknown
- 2005-11-30 PE PE2005001388A patent/PE20061061A1/es not_active Application Discontinuation
- 2005-12-01 TW TW094142312A patent/TWI362391B/zh not_active IP Right Cessation
- 2005-12-02 AR ARP050105040A patent/AR053100A1/es unknown
-
2007
- 2007-04-25 ZA ZA200703368A patent/ZA200703368B/xx unknown
- 2007-05-03 NO NO20072283A patent/NO20072283L/no not_active Application Discontinuation
- 2007-05-16 US US11/749,206 patent/US7626019B2/en active Active
- 2007-05-16 US US11/749,205 patent/US20070213529A1/en not_active Abandoned
- 2007-05-16 US US11/749,212 patent/US20070213530A1/en not_active Abandoned
- 2007-05-16 US US11/749,203 patent/US20070213528A1/en not_active Abandoned
- 2007-05-16 US US11/749,210 patent/US20070213531A1/en not_active Abandoned
- 2007-05-16 US US11/749,207 patent/US20070213534A1/en not_active Abandoned
- 2007-05-16 US US11/749,208 patent/US20070219369A1/en not_active Abandoned
- 2007-05-31 IL IL183568A patent/IL183568A/en not_active IP Right Cessation
-
2010
- 2010-08-05 US US12/850,993 patent/USRE43115E1/en not_active Expired - Lifetime
-
2012
- 2012-12-12 CY CY20121101215T patent/CY1113625T1/el unknown
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2013
- 2013-10-09 CL CL2013002895A patent/CL2013002895A1/es unknown
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