CN101065381B - 稠合的哌嗪-2-酮衍生物的制备方法及所述方法的中间体 - Google Patents

稠合的哌嗪-2-酮衍生物的制备方法及所述方法的中间体 Download PDF

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Publication number
CN101065381B
CN101065381B CN2005800406546A CN200580040654A CN101065381B CN 101065381 B CN101065381 B CN 101065381B CN 2005800406546 A CN2005800406546 A CN 2005800406546A CN 200580040654 A CN200580040654 A CN 200580040654A CN 101065381 B CN101065381 B CN 101065381B
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compound
solvent
formula
reaction
hydrogen
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CN101065381A (zh
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阿迪尔·杜兰
冈特·林茨
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Boehringer Ingelheim International GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN2005800406546A 2004-12-02 2005-11-29 稠合的哌嗪-2-酮衍生物的制备方法及所述方法的中间体 Expired - Fee Related CN101065381B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004058337A DE102004058337A1 (de) 2004-12-02 2004-12-02 Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
DE102004058337.4 2004-12-02
PCT/EP2005/056291 WO2006058876A1 (de) 2004-12-02 2005-11-29 Verfahren zur herstellung von annelierten piperazin-2-on derivaten sowie zwischenprodukte des verfahrens

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN2010105934512A Division CN102070637B (zh) 2004-12-02 2005-11-29 稠合的哌嗪-2-酮衍生物的制备方法
CN201010593286.0A Division CN102093361B (zh) 2004-12-02 2005-11-29 稠合的哌嗪-2-酮衍生物的制备方法

Publications (2)

Publication Number Publication Date
CN101065381A CN101065381A (zh) 2007-10-31
CN101065381B true CN101065381B (zh) 2011-03-30

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CN2005800406546A Expired - Fee Related CN101065381B (zh) 2004-12-02 2005-11-29 稠合的哌嗪-2-酮衍生物的制备方法及所述方法的中间体
CN201010593286.0A Expired - Fee Related CN102093361B (zh) 2004-12-02 2005-11-29 稠合的哌嗪-2-酮衍生物的制备方法
CN2010105934512A Expired - Fee Related CN102070637B (zh) 2004-12-02 2005-11-29 稠合的哌嗪-2-酮衍生物的制备方法

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CN201010593286.0A Expired - Fee Related CN102093361B (zh) 2004-12-02 2005-11-29 稠合的哌嗪-2-酮衍生物的制备方法
CN2010105934512A Expired - Fee Related CN102070637B (zh) 2004-12-02 2005-11-29 稠合的哌嗪-2-酮衍生物的制备方法

Country Status (34)

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US (9) US7238807B2 (OSRAM)
EP (2) EP1819706B1 (OSRAM)
JP (1) JP5164574B2 (OSRAM)
KR (2) KR101395591B1 (OSRAM)
CN (3) CN101065381B (OSRAM)
AR (1) AR053100A1 (OSRAM)
AU (1) AU2005311308B2 (OSRAM)
BR (1) BRPI0518601A2 (OSRAM)
CA (1) CA2588857C (OSRAM)
CL (1) CL2013002895A1 (OSRAM)
CY (1) CY1113625T1 (OSRAM)
DE (1) DE102004058337A1 (OSRAM)
DK (2) DK2436685T3 (OSRAM)
EA (1) EA012624B1 (OSRAM)
ES (2) ES2548680T3 (OSRAM)
HR (1) HRP20120980T1 (OSRAM)
HU (1) HUE027689T2 (OSRAM)
IL (1) IL183568A (OSRAM)
ME (1) ME01470B (OSRAM)
MX (1) MX2007006549A (OSRAM)
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NO (1) NO20072283L (OSRAM)
NZ (1) NZ556182A (OSRAM)
PE (2) PE20090488A1 (OSRAM)
PL (2) PL2436685T3 (OSRAM)
PT (1) PT1819706E (OSRAM)
RS (1) RS52533B (OSRAM)
SG (2) SG141461A1 (OSRAM)
SI (1) SI1819706T1 (OSRAM)
TW (1) TWI362391B (OSRAM)
UA (1) UA89390C2 (OSRAM)
UY (1) UY29233A1 (OSRAM)
WO (1) WO2006058876A1 (OSRAM)
ZA (1) ZA200703368B (OSRAM)

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EP1630163A1 (de) * 2004-08-25 2006-03-01 Boehringer Ingelheim Pharma GmbH & Co.KG Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
EP1632493A1 (de) * 2004-08-25 2006-03-08 Boehringer Ingelheim Pharma GmbH & Co.KG Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE102004058337A1 (de) 2004-12-02 2006-06-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
US7439358B2 (en) 2006-02-08 2008-10-21 Boehringer Ingelheim International Gmbh Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
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JP4958461B2 (ja) * 2006-03-30 2012-06-20 富士フイルム株式会社 近赤外吸収色素含有硬化性組成物
KR20090104920A (ko) 2007-02-01 2009-10-06 아스트라제네카 아베 Ｈｓｐ90 억제제로서 5,6,7,8-테트라히드로프테리딘 유도체
EP3098223A1 (en) * 2007-08-03 2016-11-30 Boehringer Ingelheim International GmbH Crystalline form of a dihydropteridione derivative
EP2100894A1 (en) 2008-03-12 2009-09-16 4Sc Ag Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors
CN102020643A (zh) 2009-09-22 2011-04-20 上海恒瑞医药有限公司 二氢喋啶酮类衍生物、其制备方法及其在医药上的应用
SG179206A1 (en) 2009-09-25 2012-04-27 Vertex Pharma Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors
NZ599342A (en) 2009-09-25 2014-04-30 Vertex Pharma Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors
US8546566B2 (en) 2010-10-12 2013-10-01 Boehringer Ingelheim International Gmbh Process for manufacturing dihydropteridinones and intermediates thereof
US9358233B2 (en) 2010-11-29 2016-06-07 Boehringer Ingelheim International Gmbh Method for treating acute myeloid leukemia
EP2678342B1 (en) 2011-02-25 2015-01-07 Takeda Pharmaceutical Company Limited N-substituted oxazinopteridines and oxazinopteridinones
US9370535B2 (en) 2011-05-17 2016-06-21 Boehringer Ingelheim International Gmbh Method for treatment of advanced solid tumors
UY34893A (es) 2012-07-10 2014-02-28 Takeda Pharmaceutical Derivados de azaindol
WO2015011236A1 (en) 2013-07-26 2015-01-29 Boehringer Ingelheim International Gmbh Treatment of myelodysplastic syndrome
AR099052A1 (es) 2014-01-09 2016-06-29 Takeda Pharmaceuticals Co Derivados de azaindol
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AR053100A1 (es) 2007-04-25
USRE43115E1 (en) 2012-01-17
PL2436685T3 (pl) 2015-11-30
NZ556182A (en) 2009-08-28
HK1158200A1 (en) 2012-07-13
KR20120136414A (ko) 2012-12-18
CA2588857A1 (en) 2006-06-08
WO2006058876A1 (de) 2006-06-08
AU2005311308B2 (en) 2012-04-12
HK1158199A1 (en) 2012-07-13
RS52533B (sr) 2013-04-30
MX2007006549A (es) 2007-06-18
ME01470B (me) 2014-04-20
CL2013002895A1 (es) 2014-03-14
MY147459A (en) 2012-12-14
TW200628471A (en) 2006-08-16
AU2005311308A1 (en) 2006-06-08
HK1113489A1 (en) 2008-10-03
US20070208027A1 (en) 2007-09-06
PL1819706T3 (pl) 2013-03-29
CN102093361B (zh) 2014-05-07
CY1113625T1 (el) 2016-06-22
DK1819706T3 (da) 2013-01-02
EP1819706B1 (de) 2012-09-19
US20060122393A1 (en) 2006-06-08
US7626019B2 (en) 2009-12-01
KR101362131B1 (ko) 2014-02-19
CN102093361A (zh) 2011-06-15
US20070213531A1 (en) 2007-09-13
EA200701164A1 (ru) 2007-12-28
HUE027689T2 (hu) 2021-12-28
CN102070637A (zh) 2011-05-25
ZA200703368B (en) 2008-09-25
CN102070637B (zh) 2012-09-26
PE20061061A1 (es) 2006-11-10
CA2588857C (en) 2013-10-08
TWI362391B (en) 2012-04-21
CN101065381A (zh) 2007-10-31
EP2436685A1 (de) 2012-04-04
US20070213528A1 (en) 2007-09-13
DE102004058337A1 (de) 2006-06-14
SG158848A1 (en) 2010-02-26
US20070213530A1 (en) 2007-09-13
DK2436685T3 (en) 2015-09-14
NO20072283L (no) 2007-06-28
SI1819706T1 (sl) 2013-01-31
US7238807B2 (en) 2007-07-03
US20070213534A1 (en) 2007-09-13
UY29233A1 (es) 2006-07-31
PE20090488A1 (es) 2009-05-27
US20070219369A1 (en) 2007-09-20
BRPI0518601A2 (pt) 2008-11-25
KR101395591B1 (ko) 2014-05-16
PT1819706E (pt) 2012-12-06
EP2436685B1 (de) 2015-07-01
KR20070092252A (ko) 2007-09-12
IL183568A (en) 2015-02-26
JP2008521861A (ja) 2008-06-26
SG141461A1 (en) 2008-04-28
ES2548680T3 (es) 2015-10-20
EA012624B1 (ru) 2009-10-30
HRP20120980T1 (hr) 2012-12-31
US20070213529A1 (en) 2007-09-13
UA89390C2 (ru) 2010-01-25
ES2395829T3 (es) 2013-02-15
EP1819706A1 (de) 2007-08-22
IL183568A0 (en) 2007-09-20
JP5164574B2 (ja) 2013-03-21

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