CY1112664T1 - Μεθοδος κλωνοποιησης συγγενων αντισωματων - Google Patents
Μεθοδος κλωνοποιησης συγγενων αντισωματωνInfo
- Publication number
- CY1112664T1 CY1112664T1 CY20111101105T CY111101105T CY1112664T1 CY 1112664 T1 CY1112664 T1 CY 1112664T1 CY 20111101105 T CY20111101105 T CY 20111101105T CY 111101105 T CY111101105 T CY 111101105T CY 1112664 T1 CY1112664 T1 CY 1112664T1
- Authority
- CY
- Cyprus
- Prior art keywords
- linking
- procedure
- generation
- methods
- relates
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Gram-positive bacteria
- C07K16/1282—Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/143—Multiplexing, i.e. use of multiple primers or probes in a single reaction, usually for simultaneously analyse of multiple analysis
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Virology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200700316 | 2007-03-01 | ||
| US90477207P | 2007-03-05 | 2007-03-05 | |
| EP08706942A EP2121920B1 (en) | 2007-03-01 | 2008-02-27 | Method for cloning cognate antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1112664T1 true CY1112664T1 (el) | 2016-02-10 |
Family
ID=38561767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20111101105T CY1112664T1 (el) | 2007-03-01 | 2011-11-16 | Μεθοδος κλωνοποιησης συγγενων αντισωματων |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US8283294B2 (https=) |
| EP (1) | EP2121920B1 (https=) |
| JP (1) | JP5669397B2 (https=) |
| KR (1) | KR20090118993A (https=) |
| CN (1) | CN101622346A (https=) |
| AT (1) | ATE521704T1 (https=) |
| AU (1) | AU2008221119B2 (https=) |
| BR (1) | BRPI0808171A2 (https=) |
| CA (1) | CA2677771A1 (https=) |
| CY (1) | CY1112664T1 (https=) |
| DK (1) | DK2121920T3 (https=) |
| ES (1) | ES2369946T3 (https=) |
| HR (1) | HRP20110686T1 (https=) |
| IL (1) | IL199773A0 (https=) |
| MX (1) | MX2009008908A (https=) |
| NZ (1) | NZ578851A (https=) |
| PL (1) | PL2121920T3 (https=) |
| PT (1) | PT2121920E (https=) |
| RU (1) | RU2459868C2 (https=) |
| SI (1) | SI2121920T1 (https=) |
| TW (1) | TW200911986A (https=) |
| WO (1) | WO2008104184A2 (https=) |
| ZA (1) | ZA200905831B (https=) |
Families Citing this family (69)
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| BRPI0808551B1 (pt) | 2007-03-01 | 2022-04-05 | Symphogen A/S | Composições de anticorpo para o receptor do fator de crescimento antiepidérmico recombinante, molécula de ligação bi-específica e composição farmacêutica que os compreende |
| JP2008289483A (ja) * | 2007-05-25 | 2008-12-04 | Symphogen As | 真核生物系において発現可能な形質転換体のスクリーニング |
| DE102007037215A1 (de) * | 2007-08-07 | 2009-02-12 | Robert Bosch Gmbh | Stellorgan |
| WO2010000864A1 (en) * | 2008-07-04 | 2010-01-07 | Novo Nordisk A/S | Method for producing monoclonal antibodies |
| CN102137928A (zh) * | 2008-08-29 | 2011-07-27 | 西福根有限公司 | 克隆禽源抗体的方法 |
| WO2010022736A2 (en) | 2008-08-29 | 2010-03-04 | Symphogen A/S | Recombinant anti-epidermal growth factor receptor antibody compositions |
| US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| EP2364368B1 (en) * | 2008-11-07 | 2014-01-15 | Sequenta, Inc. | Methods of monitoring conditions by sequence analysis |
| US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
| US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
| US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
| US8691510B2 (en) * | 2008-11-07 | 2014-04-08 | Sequenta, Inc. | Sequence analysis of complex amplicons |
| US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| ES2726702T3 (es) | 2009-01-15 | 2019-10-08 | Adaptive Biotechnologies Corp | Perfilado de la inmunidad adaptativa y métodos para la generación de anticuerpos monoclonales |
| US9079942B2 (en) * | 2009-02-09 | 2015-07-14 | Epitomics, Inc. | CDR-anchored amplification method |
| ES2570460T3 (es) * | 2009-02-20 | 2016-05-18 | Hoffmann La Roche | Método de obtención de ácido nucleico que codifica inmunoglobulina |
| US20100317539A1 (en) * | 2009-06-12 | 2010-12-16 | Guo-Liang Yu | Library of Engineered-Antibody Producing Cells |
| WO2010151416A1 (en) | 2009-06-25 | 2010-12-29 | Fred Hutchinson Cancer Research Center | Method of measuring adaptive immunity |
| US8293483B2 (en) * | 2009-09-11 | 2012-10-23 | Epitomics, Inc. | Method for identifying lineage-related antibodies |
| US9043160B1 (en) | 2009-11-09 | 2015-05-26 | Sequenta, Inc. | Method of determining clonotypes and clonotype profiles |
| DE102010037622B4 (de) | 2010-09-17 | 2012-07-12 | Lophius Biosciences Gmbh | Verfahren zum Nachweis, Differenzieren und Quantifizieren von T-Zellpopulationen mittels der Reverse Transkription quantitativen Real-Time PCR (RT-qPCR) Technologie |
| CA2814047C (en) | 2010-10-08 | 2017-11-14 | President And Fellows Of Harvard College | High-throughput immune sequencing |
| US9155802B2 (en) | 2010-11-01 | 2015-10-13 | Symphogen A/S | Pan-HER antibody composition |
| JP5920835B2 (ja) | 2010-12-01 | 2016-05-18 | 田辺三菱製薬株式会社 | 無細胞翻訳系でＦａｂを提示しうるポリヌクレオチド構築物ならびにそれを用いたＦａｂの製造方法およびスクリーニング方法 |
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| CN103732738A (zh) * | 2011-04-28 | 2014-04-16 | 小利兰斯坦福大学托管委员会 | 与样品相关的多核苷酸的鉴定 |
| US10385475B2 (en) | 2011-09-12 | 2019-08-20 | Adaptive Biotechnologies Corp. | Random array sequencing of low-complexity libraries |
| BR112014004566A2 (pt) * | 2011-09-21 | 2017-06-13 | Hoffmann La Roche | método de amplificação e quantificação de cadeias leve e pesada de igg cognato, método de obtenção de anticorpo monoclonal, métodos de produção de fragmento de fab de imunoglobulina e de imunoglobulina, ácido nucleico e kit |
| EP2768982A4 (en) | 2011-10-21 | 2015-06-03 | Adaptive Biotechnologies Corp | QUANTIFICATION OF ADAPTIVE IMMUNOCELL GENOMES IN A COMPLEX MIX OF CELLS |
| US9824179B2 (en) | 2011-12-09 | 2017-11-21 | Adaptive Biotechnologies Corp. | Diagnosis of lymphoid malignancies and minimal residual disease detection |
| US9499865B2 (en) | 2011-12-13 | 2016-11-22 | Adaptive Biotechnologies Corp. | Detection and measurement of tissue-infiltrating lymphocytes |
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| EP3372694A1 (en) | 2012-03-05 | 2018-09-12 | Adaptive Biotechnologies Corporation | Determining paired immune receptor chains from frequency matched subunits |
| WO2013164689A2 (en) | 2012-05-02 | 2013-11-07 | Lantto, Johan | Humanized pan-her antibody compositions |
| HUE029357T2 (en) | 2012-05-08 | 2017-02-28 | Adaptive Biotechnologies Corp | Preparations and devices for measuring and calibrating amplification distortion in multiplex PCR reactions |
| EP2861760B1 (en) | 2012-06-15 | 2020-01-01 | The Board of Regents of The University of Texas System | High throughput sequencing of multiple transcripts of a single cell |
| EP3330384B1 (en) | 2012-10-01 | 2019-09-25 | Adaptive Biotechnologies Corporation | Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization |
| WO2015160439A2 (en) | 2014-04-17 | 2015-10-22 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| CN103074349B (zh) * | 2012-11-07 | 2014-10-15 | 杭州鸿运华宁生物医药工程有限公司 | 巢式一步法rt-pcr从单个b细胞扩增鼠源抗体重链和轻链可变区基因全序列的方法 |
| JP6456350B2 (ja) * | 2013-03-11 | 2019-01-23 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | キメラ主要組織適合複合体（ｍｈｃ）クラスｉｉ分子を発現する遺伝子導入マウス |
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| RU2687044C2 (ru) | 2013-05-31 | 2019-05-06 | Дженентек, Инк. | Антитела против стеночной тейхоевой кислоты и их конъюгаты |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| WO2015134787A2 (en) | 2014-03-05 | 2015-09-11 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
| CA2966201A1 (en) | 2014-10-29 | 2016-05-06 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
| US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| AU2015353581A1 (en) | 2014-11-25 | 2017-06-15 | Adaptive Biotechnologies Corporation | Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing |
| HK1243931A1 (zh) | 2014-12-03 | 2018-07-27 | F. Hoffmann-La Roche Ag | 抗金黄色葡萄球菌抗体利福霉素缀合物及其用途 |
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| US10513733B2 (en) | 2015-03-23 | 2019-12-24 | Board Of Regents, The University Of Texas System | High throughout sequencing of paired VH and VL transcripts from B cells secreting antigen-specific antibodies |
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| CN109972209B (zh) * | 2019-01-18 | 2022-05-03 | 南开大学 | 基于乳液pcr的一步法将单链抗体库重排为全长抗体库的方法 |
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| SI1583830T1 (sl) | 2003-01-07 | 2006-12-31 | Symphogen As | Postopek za pripravo rekombinantnih poliklonskih proteinov |
| US20060275766A1 (en) | 2003-01-07 | 2006-12-07 | Haurum John S | Method for manufacturing recombinant polyclonal proteins |
| US20050090453A1 (en) * | 2003-01-15 | 2005-04-28 | Solbec Pharmaceuticals Co., Ltd. | Methods of modulating IL-6 |
| US20060228350A1 (en) * | 2003-08-18 | 2006-10-12 | Medimmune, Inc. | Framework-shuffling of antibodies |
| RU2392324C2 (ru) * | 2003-09-18 | 2010-06-20 | Симфоген А/С | Способ связывания интересующих последовательностей |
| TWI333977B (en) * | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
| WO2005052139A2 (en) | 2003-11-19 | 2005-06-09 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Method of inducing memory b cell development and terminal differentiation |
| US8288109B2 (en) | 2004-07-20 | 2012-10-16 | Symphogen A/S | Procedure for structural characterization of a recombinant polyclonal protein or a polyclonal cell line |
| EA014182B1 (ru) | 2004-07-20 | 2010-10-29 | Симфоген А/С | КОМПОЗИЦИЯ ПОЛИКЛОНАЛЬНЫХ АНТИ-RhD АНТИТЕЛ, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЕ КОМПОЗИЦИИ |
| US20060094645A1 (en) * | 2004-10-06 | 2006-05-04 | Oliver Lawless | Method for defining and treating chemically-induced immune disorders using tumor necrosis factor (TFNalpha), interleukin-1 (lL-1), and interleulin-6R(lL-6R) antagonists |
| EP1910513B1 (en) * | 2005-07-01 | 2016-08-10 | John Schrader | Methods of isolating antibody secreting cells from blood samples of immunized animals and generating monoclonal antibodies from said antibody secreting cells. |
| US7850965B2 (en) | 2005-12-05 | 2010-12-14 | Symphogen A/S | Anti-orthopoxvirus recombinant polyclonal antibody |
| WO2007101441A1 (en) | 2006-03-06 | 2007-09-13 | Symphogen A/S | Recombinant polyclonal antibody for treatment of respiratory syncytial virus infections |
| BRPI0808551B1 (pt) | 2007-03-01 | 2022-04-05 | Symphogen A/S | Composições de anticorpo para o receptor do fator de crescimento antiepidérmico recombinante, molécula de ligação bi-específica e composição farmacêutica que os compreende |
| JP2010534057A (ja) | 2007-03-06 | 2010-11-04 | シムフォゲン・アクティーゼルスカブ | 呼吸器合胞体ウイルス感染症を治療するための組換え抗体 |
| MX2009012526A (es) | 2007-05-25 | 2009-12-09 | Symphogen As | Metodo para fabricar una proteina policlonal recombinante. |
| CA2695309A1 (en) | 2007-09-07 | 2009-03-12 | Symphogen A/S | Methods for recombinant manufacturing of anti-rsv antibodies |
| CN102137928A (zh) | 2008-08-29 | 2011-07-27 | 西福根有限公司 | 克隆禽源抗体的方法 |
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2008
- 2008-02-27 DK DK08706942.3T patent/DK2121920T3/da active
- 2008-02-27 MX MX2009008908A patent/MX2009008908A/es active IP Right Grant
- 2008-02-27 PL PL08706942T patent/PL2121920T3/pl unknown
- 2008-02-27 PT PT08706942T patent/PT2121920E/pt unknown
- 2008-02-27 RU RU2009136342/10A patent/RU2459868C2/ru not_active IP Right Cessation
- 2008-02-27 AT AT08706942T patent/ATE521704T1/de active
- 2008-02-27 KR KR1020097020517A patent/KR20090118993A/ko not_active Ceased
- 2008-02-27 BR BRPI0808171-9A2A patent/BRPI0808171A2/pt not_active IP Right Cessation
- 2008-02-27 AU AU2008221119A patent/AU2008221119B2/en active Active
- 2008-02-27 CA CA002677771A patent/CA2677771A1/en not_active Abandoned
- 2008-02-27 CN CN200880006843A patent/CN101622346A/zh active Pending
- 2008-02-27 NZ NZ578851A patent/NZ578851A/en not_active IP Right Cessation
- 2008-02-27 SI SI200830415T patent/SI2121920T1/sl unknown
- 2008-02-27 HR HR20110686T patent/HRP20110686T1/hr unknown
- 2008-02-27 WO PCT/DK2008/050048 patent/WO2008104184A2/en not_active Ceased
- 2008-02-27 ES ES08706942T patent/ES2369946T3/es active Active
- 2008-02-27 JP JP2009551103A patent/JP5669397B2/ja active Active
- 2008-02-27 EP EP08706942A patent/EP2121920B1/en active Active
- 2008-02-29 TW TW097107003A patent/TW200911986A/zh unknown
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2009
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2011
- 2011-11-16 CY CY20111101105T patent/CY1112664T1/el unknown
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2012
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Also Published As
| Publication number | Publication date |
|---|---|
| DK2121920T3 (da) | 2011-11-21 |
| HRP20110686T1 (hr) | 2011-10-31 |
| BRPI0808171A2 (pt) | 2014-08-05 |
| HK1133905A1 (en) | 2010-04-09 |
| JP2010535150A (ja) | 2010-11-18 |
| CN101622346A (zh) | 2010-01-06 |
| WO2008104184A2 (en) | 2008-09-04 |
| ZA200905831B (en) | 2011-02-23 |
| CA2677771A1 (en) | 2008-09-04 |
| AU2008221119A1 (en) | 2008-09-04 |
| KR20090118993A (ko) | 2009-11-18 |
| JP5669397B2 (ja) | 2015-02-12 |
| US8283294B2 (en) | 2012-10-09 |
| SI2121920T1 (sl) | 2011-12-30 |
| US20130023447A1 (en) | 2013-01-24 |
| IL199773A0 (en) | 2010-04-15 |
| US20080227660A1 (en) | 2008-09-18 |
| EP2121920A2 (en) | 2009-11-25 |
| AU2008221119B2 (en) | 2013-11-14 |
| PL2121920T3 (pl) | 2012-01-31 |
| NZ578851A (en) | 2011-09-30 |
| EP2121920B1 (en) | 2011-08-24 |
| MX2009008908A (es) | 2009-08-28 |
| ES2369946T3 (es) | 2011-12-09 |
| WO2008104184A3 (en) | 2008-10-16 |
| PT2121920E (pt) | 2011-10-03 |
| RU2459868C2 (ru) | 2012-08-27 |
| RU2009136342A (ru) | 2011-04-10 |
| ATE521704T1 (de) | 2011-09-15 |
| TW200911986A (en) | 2009-03-16 |
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