CY1111576T1 - Υποκατεστημενα παραγωγα μεθυλενο αμιδης ως ρυθμιστες των φωσφατασων πρωτεϊνης τυροσινης(ptps) - Google Patents
Υποκατεστημενα παραγωγα μεθυλενο αμιδης ως ρυθμιστες των φωσφατασων πρωτεϊνης τυροσινης(ptps)Info
- Publication number
- CY1111576T1 CY1111576T1 CY20111100576T CY111100576T CY1111576T1 CY 1111576 T1 CY1111576 T1 CY 1111576T1 CY 20111100576 T CY20111100576 T CY 20111100576T CY 111100576 T CY111100576 T CY 111100576T CY 1111576 T1 CY1111576 T1 CY 1111576T1
- Authority
- CY
- Cyprus
- Prior art keywords
- amide derivatives
- substituted methylene
- methylene amide
- ptps
- present
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/56—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having carbon atoms of carboxamide groups bound to carbon atoms of carboxyl groups, e.g. oxamides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Abstract
Η παρούσα εφεύρεση αναφέρεται σε υποκατεστημένα παράγωγα μεθυλένο αμίδης του χημικού τύπου (I) και στη χρήση αυτών στην αντιμετώπιση και/ή στη πρόληψη μεταβολικών διαταραχών που μεσολαβούνται από την αντοχή στην ινσουλίνη ή την υπεργλυκαιμία, που περιλαμβάνουν το σακχαρώδη διαβήτη τύπου I και/ή II, τη διαταραγμένη ανοχή στη γλυκόζη, την αντοχή στην ινσουλίνη, την υπερλιπιδαιμία, την υπερτριγλυκεριδαιμία, την υπερχοληστερολαιμία, τη παχυσαρκία, το σύνδρομο πολυκυστικών ωοθηκών (PCOS). Συγκεκριμένα, η παρούσα εφεύρεση αναφέρεται στη χρήση των υποκατεστημένων παραγώγων μεθυλένο αμίδης του χημικού τύπου (I) για τη ρύθμιση, ιδιαιτέρως την αναστολή της δραστηριότητας των PTPs. Επίσης η παρούσα εφεύρεση αναφέρεται σε μια μέθοδο αντιμετώπισης του διαβήτη τύπου II, της παχυσαρκίας και ρύθμισης της όρεξης στα θηλαστικά. Η παρούσα εφεύρεση αναφέρεται επιπλέον σε καινοτόμα υποκατεστημένα παράγωγα μεθυλένο αμίδης και στη μέθοδο παρασκευής αυτών. Χημικός τύπος (I).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02100078 | 2002-01-29 | ||
EP02100410 | 2002-04-25 | ||
EP03734697A EP1470102B1 (en) | 2002-01-29 | 2003-01-27 | Substituted methylene amide derivatives as modulators of protein tyrosine phosphatases (ptps) |
Publications (1)
Publication Number | Publication Date |
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CY1111576T1 true CY1111576T1 (el) | 2015-10-07 |
Family
ID=27664997
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20111100576T CY1111576T1 (el) | 2002-01-29 | 2011-06-16 | Υποκατεστημενα παραγωγα μεθυλενο αμιδης ως ρυθμιστες των φωσφατασων πρωτεϊνης τυροσινης(ptps) |
Country Status (24)
Country | Link |
---|---|
US (1) | US7592477B2 (el) |
EP (1) | EP1470102B1 (el) |
JP (2) | JP4828793B2 (el) |
KR (1) | KR100922041B1 (el) |
CN (1) | CN100410236C (el) |
AT (1) | ATE510817T1 (el) |
AU (1) | AU2003239296B2 (el) |
BR (1) | BR0307394A (el) |
CA (1) | CA2472021C (el) |
CY (1) | CY1111576T1 (el) |
DK (1) | DK1470102T3 (el) |
EA (1) | EA012260B1 (el) |
HK (1) | HK1073649A1 (el) |
HR (1) | HRP20040612A2 (el) |
IL (1) | IL163144A (el) |
MX (1) | MXPA04007253A (el) |
NO (1) | NO329742B1 (el) |
PL (1) | PL207295B1 (el) |
PT (1) | PT1470102E (el) |
RS (1) | RS51865B (el) |
SI (1) | SI1470102T1 (el) |
UA (1) | UA82661C2 (el) |
WO (1) | WO2003064376A1 (el) |
ZA (1) | ZA200405179B (el) |
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Publication number | Priority date | Publication date | Assignee | Title |
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PT1656139E (pt) * | 2003-07-21 | 2011-11-04 | Merck Serono Sa | Arildicarboxamidas |
WO2005012280A1 (en) * | 2003-07-21 | 2005-02-10 | Applied Research Systems Ars Holding N.V. | Alkynyl aryl carboxamides |
ATE381529T1 (de) | 2003-10-13 | 2008-01-15 | Serono Lab | Verfahren zur herstellung von para-phenylalkynyl benzaldehyden |
EA011811B1 (ru) * | 2004-02-27 | 2009-06-30 | Лаборатуар Сероно Са | Применение производных метиленамида при лечении сердечно-сосудистых нарушений |
AU2005231980B2 (en) * | 2004-04-07 | 2011-09-08 | Merck Serono Sa | 1,1'-(1,2-ethynediyl)bis-benzene derivatives as PTP 1-B inhibitors |
CN1942428A (zh) | 2004-04-13 | 2007-04-04 | 默克公司 | Cetp抑制剂 |
US7517991B2 (en) * | 2004-10-12 | 2009-04-14 | Bristol-Myers Squibb Company | N-sulfonylpiperidine cannabinoid receptor 1 antagonists |
WO2007009959A1 (en) * | 2005-07-15 | 2007-01-25 | Laboratoires Serono S.A. | Glepp-1 inhibitors in the treatment of autoimmune and/or inflammatory disorders |
WO2007028145A2 (en) * | 2005-09-02 | 2007-03-08 | Dara Biosciences, Inc. | Agents and methods for reducing protein tyrosine phosphatase 1b activity in the central nervous system |
US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
JP5773560B2 (ja) | 2006-02-09 | 2015-09-02 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | Cetp阻害剤のポリマー製剤 |
JP2009526773A (ja) * | 2006-02-13 | 2009-07-23 | ラボラトワール セローノ ソシエテ アノニム | 細菌感染症治療のためのスルホンアミド誘導体 |
WO2008044731A1 (fr) * | 2006-10-12 | 2008-04-17 | Institute Of Medicinal Molecular Design. Inc. | Dérivé d'acide n-phényloxamidique |
US8633245B2 (en) * | 2008-04-11 | 2014-01-21 | Institute Of Medicinal Molecular Design, Inc. | PAI-1 inhibitor |
EP2602839A1 (en) | 2010-08-05 | 2013-06-12 | Idemitsu Kosan Co., Ltd. | Organic electroluminescent element |
CN102512407B (zh) * | 2011-11-23 | 2014-05-21 | 中山大学 | 一种β-苯丙氨酸类化合物作为醛糖还原酶抑制剂的应用 |
EP2917194B1 (en) * | 2012-11-06 | 2017-09-27 | Eli Lilly and Company | Novel benzyl sulfonamide compounds useful as mogat-2 inhibitors |
US10647664B2 (en) * | 2013-08-16 | 2020-05-12 | Duke University | Substituted hydroxamic acid compounds |
JP7454573B2 (ja) * | 2018-11-23 | 2024-03-22 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | インスリン抵抗性を処置するためのshp2阻害剤の使用 |
CN115297860A (zh) * | 2020-04-06 | 2022-11-04 | 普渡研究基金会 | 新型n-芳基草氨酸 |
CN114478522B (zh) * | 2022-01-25 | 2023-07-28 | 山东大学 | 一种吡啶并咪唑类衍生物及其制备方法与应用 |
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EP1123928A4 (en) * | 1998-10-20 | 2005-02-16 | Takeda Pharmaceutical | 1,5-BENZODIAZEPINE COMPOUNDS, PROCESS FOR PRODUCING THE SAME, AND MEDICAMENT |
JP2003509429A (ja) * | 1999-09-10 | 2003-03-11 | ノボ ノルディスク アクティーゼルスカブ | タンパク質チロシンホスファターゼ(ptpアーゼ)のモジュレーター |
WO2002018321A2 (en) * | 2000-08-29 | 2002-03-07 | Abbott Laboratories | Amino(oxo)acetic acid protein tyrosine phosphatase inhibitors |
US6627767B2 (en) * | 2000-08-29 | 2003-09-30 | Abbott Laboratories | Amino(oxo) acetic acid protein tyrosine phosphatase inhibitors |
WO2002100396A1 (en) | 2001-06-07 | 2002-12-19 | Wyeth | COMBINATION OF A PTPase INHIBITOR AND A THIAZOLIDINEDIONE AGENT |
EA011811B1 (ru) * | 2004-02-27 | 2009-06-30 | Лаборатуар Сероно Са | Применение производных метиленамида при лечении сердечно-сосудистых нарушений |
-
2003
- 2003-01-27 BR BR0307394-7A patent/BR0307394A/pt not_active IP Right Cessation
- 2003-01-27 CN CNB038070367A patent/CN100410236C/zh not_active Expired - Fee Related
- 2003-01-27 CA CA2472021A patent/CA2472021C/en not_active Expired - Fee Related
- 2003-01-27 US US10/501,344 patent/US7592477B2/en not_active Expired - Fee Related
- 2003-01-27 DK DK03734697.0T patent/DK1470102T3/da active
- 2003-01-27 PL PL371198A patent/PL207295B1/pl not_active IP Right Cessation
- 2003-01-27 EP EP03734697A patent/EP1470102B1/en not_active Expired - Lifetime
- 2003-01-27 UA UA20040706337A patent/UA82661C2/uk unknown
- 2003-01-27 AT AT03734697T patent/ATE510817T1/de active
- 2003-01-27 PT PT03734697T patent/PT1470102E/pt unknown
- 2003-01-27 MX MXPA04007253A patent/MXPA04007253A/es active IP Right Grant
- 2003-01-27 RS YU65304A patent/RS51865B/sr unknown
- 2003-01-27 SI SI200332010T patent/SI1470102T1/sl unknown
- 2003-01-27 AU AU2003239296A patent/AU2003239296B2/en not_active Ceased
- 2003-01-27 WO PCT/EP2003/000808 patent/WO2003064376A1/en active Application Filing
- 2003-01-27 KR KR1020047011772A patent/KR100922041B1/ko not_active IP Right Cessation
- 2003-01-27 JP JP2003564000A patent/JP4828793B2/ja not_active Expired - Fee Related
- 2003-01-27 EA EA200400882A patent/EA012260B1/ru not_active IP Right Cessation
-
2004
- 2004-06-29 ZA ZA2004/05179A patent/ZA200405179B/en unknown
- 2004-07-06 HR HR20040612A patent/HRP20040612A2/xx not_active Application Discontinuation
- 2004-07-22 IL IL163144A patent/IL163144A/en not_active IP Right Cessation
- 2004-08-24 NO NO20043520A patent/NO329742B1/no not_active IP Right Cessation
-
2005
- 2005-08-30 HK HK05107572A patent/HK1073649A1/xx not_active IP Right Cessation
-
2011
- 2011-06-16 CY CY20111100576T patent/CY1111576T1/el unknown
- 2011-06-30 JP JP2011146082A patent/JP2011256174A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
RS51865B (sr) | 2012-02-29 |
KR100922041B1 (ko) | 2009-10-19 |
CA2472021C (en) | 2012-08-14 |
BR0307394A (pt) | 2004-11-09 |
IL163144A (en) | 2012-07-31 |
US7592477B2 (en) | 2009-09-22 |
ATE510817T1 (de) | 2011-06-15 |
NO20043520L (no) | 2004-10-05 |
DK1470102T3 (da) | 2011-06-20 |
ZA200405179B (en) | 2005-08-31 |
CN100410236C (zh) | 2008-08-13 |
EA200400882A1 (ru) | 2005-04-28 |
WO2003064376A1 (en) | 2003-08-07 |
NO329742B1 (no) | 2010-12-13 |
EA012260B1 (ru) | 2009-08-28 |
EP1470102A1 (en) | 2004-10-27 |
MXPA04007253A (es) | 2004-10-29 |
KR20040104953A (ko) | 2004-12-13 |
SI1470102T1 (sl) | 2011-08-31 |
PL371198A1 (en) | 2005-06-13 |
CN1633410A (zh) | 2005-06-29 |
HK1073649A1 (en) | 2005-10-14 |
JP2011256174A (ja) | 2011-12-22 |
PL207295B1 (pl) | 2010-11-30 |
US20050124656A1 (en) | 2005-06-09 |
AU2003239296B2 (en) | 2008-10-23 |
HRP20040612A2 (en) | 2005-04-30 |
JP4828793B2 (ja) | 2011-11-30 |
EP1470102B1 (en) | 2011-05-25 |
UA82661C2 (uk) | 2008-05-12 |
JP2005516061A (ja) | 2005-06-02 |
PT1470102E (pt) | 2011-06-06 |
CA2472021A1 (en) | 2003-08-07 |
RS65304A (en) | 2007-02-05 |
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