CY1111168T1 - Παραγωγο βενζιμιδαζολιου και χρηση αυτου - Google Patents

Παραγωγο βενζιμιδαζολιου και χρηση αυτου

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Publication number
CY1111168T1
CY1111168T1 CY20101101173T CY101101173T CY1111168T1 CY 1111168 T1 CY1111168 T1 CY 1111168T1 CY 20101101173 T CY20101101173 T CY 20101101173T CY 101101173 T CY101101173 T CY 101101173T CY 1111168 T1 CY1111168 T1 CY 1111168T1
Authority
CY
Cyprus
Prior art keywords
methyl
petroleum product
oxo
pharmaceutical agent
dioxol
Prior art date
Application number
CY20101101173T
Other languages
English (en)
Inventor
Takanobu Kuroita
Mami Ojima
Junko Ban
Original Assignee
Takeda Pharmaceutical Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Company Limited filed Critical Takeda Pharmaceutical Company Limited
Publication of CY1111168T1 publication Critical patent/CY1111168T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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Abstract

Η παρούσα εφεύρεση παρέχει (5-μεθυλο-2-οξο-1,3-διοξολ-4-υλ)μεθυλο 2-κυκλο-προπυλο-1 - {[2' -(5-οξο-4,5-διυδρο-1,2,4-οξαδια-ζολ-3-υλ)διφαινυλ-4-υλ] μεθυλο} -1Η-βενζιμιδαζολ-7-καρβοξυλικό εστέρα που αντιπροσωπεύεται από τον τύπο: που έχει ανώτερες ιδιότητες ως φαρμακευτικός παράγοντας, ένα άλας αυτής, έναν κρύσταλλο αυτής, έναν φαρμακευτικό παράγοντα που περιέχει την ένωση, κλπ.
CY20101101173T 2005-03-30 2010-12-20 Παραγωγο βενζιμιδαζολιου και χρηση αυτου CY1111168T1 (el)

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WO2008096829A1 (ja) 2007-02-07 2008-08-14 Kyowa Hakko Kirin Co., Ltd. ３環系化合物
JP5635491B2 (ja) * 2008-07-31 2014-12-03 武田薬品工業株式会社 固形医薬組成物
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KR101275092B1 (ko) * 2011-05-19 2013-06-17 한미정밀화학주식회사 아질사르탄의 개선된 제조방법
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JP6281735B2 (ja) * 2013-03-19 2018-02-21 トーアエイヨー株式会社 急性心不全治療薬の評価方法、及び、急性心不全モデルの作製方法

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BRPI0608944A2 (pt) 2010-11-16
RU2007139928A (ru) 2009-05-10
PE20061195A1 (es) 2006-12-21
GEP20115138B (en) 2011-01-10
PT1863801E (pt) 2010-11-19
US20090054502A1 (en) 2009-02-26
JP2008534434A (ja) 2008-08-28
MEP33308A (en) 2010-10-10
RS20080510A (en) 2009-07-15
IL185726A (en) 2012-07-31
HRP20080552A2 (en) 2009-03-31
CR9432A (es) 2008-02-04
WO2006107062A3 (en) 2006-12-14
AU2006231418A1 (en) 2006-10-12
JP2011190265A (ja) 2011-09-29
EP1863801B1 (en) 2010-09-29
NO20075399L (no) 2007-12-19
DK1863801T3 (da) 2010-11-15
MY146254A (en) 2012-07-31
HK1115584A1 (en) 2008-12-05
AR055755A1 (es) 2007-09-05
WO2006107062A2 (en) 2006-10-12
KR20070116648A (ko) 2007-12-10
RU2407742C2 (ru) 2010-12-27
DE602006017183D1 (de) 2010-11-11
AU2006231418B2 (en) 2011-10-13
SI1863801T1 (sl) 2010-12-31
EP1863801A2 (en) 2007-12-12
US20120172401A1 (en) 2012-07-05
HRP20080552A9 (en) 2009-08-31
IL185726A0 (en) 2008-01-06
NZ562887A (en) 2010-10-29
CA2602624A1 (en) 2006-10-12
TW200724539A (en) 2007-07-01
PL1863801T3 (pl) 2011-03-31
MA29438B1 (fr) 2008-05-02
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