CY1110615T1 - Βελτιωμενο συστημα διαδερμικης χορηγησης αντισυλληπτικου και μεθοδος - Google Patents
Βελτιωμενο συστημα διαδερμικης χορηγησης αντισυλληπτικου και μεθοδοςInfo
- Publication number
- CY1110615T1 CY1110615T1 CY20101100276T CY101100276T CY1110615T1 CY 1110615 T1 CY1110615 T1 CY 1110615T1 CY 20101100276 T CY20101100276 T CY 20101100276T CY 101100276 T CY101100276 T CY 101100276T CY 1110615 T1 CY1110615 T1 CY 1110615T1
- Authority
- CY
- Cyprus
- Prior art keywords
- adhesive
- estrogen
- dispersed
- intercontinual
- administration
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
Abstract
Περιγράφεται ένα διαδερμικό σύστημα χορήγησης αντισυλληπτικού (TCDS), για τον έλεγχο γονιμότητας για γυναίκες, το οποίο περιέχει μια στρώση φόδρας και μια γειτονική συγκολλητική πολυμερή μήτρα απορρόφησης, εντός της οποίας είναι διασπαρμένες οι ελάχιστες αποτελεσματικές ημερήσιες δόσεις ενός οιστρογόνου και μιας προγεστίνης και απελευθερώνονται για διαδερμική απορρόφηση. Σήμερον προτιμάται η χρήση συνθετικού οιστρογόνονου, αιθινυλ εστραδιόλης και της συνθετικής προγεστίνης λεβονοργεστρέλης. Μαζί με αυτούς τους δύο στεροειδείς παράγοντες αντισύλληψης ένας συνδυασμός χημικών παραγόντων ενίσχυσης διαπέρασης του δέρματος, συμπεριλαμβανομένου καπρικού οξέος, που έχουν αναμιχθεί σε ειδικές αναλογίες βάρους, που κυμαίνονται από 2,0:1:1:0,8 έως 6:1:1:0,8 έχουν διασπαρεί ομοιογενώς εντός της συγκολλητικής πολυμερούς μήτρας. Η εφεύρεση δίδει επίσης μια μέθοδο ελέγχου γονιμότητας, η οποία χρησιμοποιεί το διαδερμικό σύστημα χορήγησης αντισυλληπτικού.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16753599P | 1999-11-24 | 1999-11-24 | |
EP00980651A EP1242012B1 (en) | 1999-11-24 | 2000-11-22 | Improved transdermal contraceptive delivery system and process |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1110615T1 true CY1110615T1 (el) | 2015-04-29 |
Family
ID=22607771
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20101100276T CY1110615T1 (el) | 1999-11-24 | 2010-03-22 | Βελτιωμενο συστημα διαδερμικης χορηγησης αντισυλληπτικου και μεθοδος |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP1242012B1 (el) |
JP (2) | JP4841781B2 (el) |
KR (1) | KR100758757B1 (el) |
CN (1) | CN1399533A (el) |
AR (1) | AR030037A1 (el) |
AT (1) | ATE453374T1 (el) |
AU (2) | AU784196B2 (el) |
BR (1) | BR0015802B1 (el) |
CA (1) | CA2391430C (el) |
CY (1) | CY1110615T1 (el) |
DE (1) | DE60043621D1 (el) |
DK (1) | DK1242012T3 (el) |
ES (1) | ES2338860T3 (el) |
IL (1) | IL149655A0 (el) |
MX (1) | MXPA02005224A (el) |
NO (1) | NO331218B1 (el) |
NZ (1) | NZ518723A (el) |
PT (1) | PT1242012E (el) |
TW (1) | TWI253350B (el) |
WO (1) | WO2001037770A1 (el) |
ZA (1) | ZA200203525B (el) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7384650B2 (en) * | 1999-11-24 | 2008-06-10 | Agile Therapeutics, Inc. | Skin permeation enhancement composition for transdermal hormone delivery system |
US7045145B1 (en) | 1999-11-24 | 2006-05-16 | Agile Therapeutics, Inc. | Transdermal contraceptive delivery system and process |
DE10159120B4 (de) * | 2001-12-01 | 2006-08-17 | Lts Lohmann Therapie-Systeme Ag | Steroidhormonhaltige transdermale therapeutische Systeme enthaltend Propylenglycolmonocaprylat und seine Verwendung |
PL219030B1 (pl) | 2003-02-21 | 2015-03-31 | Schering Ag | Transdermalny system terapeutyczny w postaci plastra odporny na działanie promieniowania UV |
JP2006525358A (ja) * | 2003-05-02 | 2006-11-09 | ドゥラメド ファーマシューティカルズ, インコーポレイテッド | 長期周期避妊養生法を利用するホルモン治療の方法 |
UA84303C2 (ru) * | 2003-10-28 | 2008-10-10 | Новен Фармасьютикалз, Инк. | Система для трансдермальной доставки лечебного средства |
UA89766C2 (en) | 2003-12-12 | 2010-03-10 | Байер Шеринг Фарма Акциенгезельшафт | Transdermal delivery system of gestodene |
US8668925B2 (en) | 2003-12-12 | 2014-03-11 | Bayer Intellectual Property Gmbh | Transdermal delivery of hormones without the need of penetration enhancers |
US20050202073A1 (en) | 2004-03-09 | 2005-09-15 | Mylan Technologies, Inc. | Transdermal systems containing multilayer adhesive matrices to modify drug delivery |
US9205062B2 (en) | 2004-03-09 | 2015-12-08 | Mylan Pharmaceuticals, Inc. | Transdermal systems containing multilayer adhesive matrices to modify drug delivery |
CN1313084C (zh) * | 2004-11-05 | 2007-05-02 | 郑会义 | 一种透皮避孕药传送体系及制备方法 |
CN1318032C (zh) * | 2005-01-24 | 2007-05-30 | 浙江大学 | 炔雌醇透皮吸收贴片 |
US8962013B2 (en) | 2005-05-02 | 2015-02-24 | Bayer Intellectual Property Gmbh | Multi-layered transdermal system with triazine UV absorber |
US20080075779A1 (en) * | 2006-09-27 | 2008-03-27 | Chappa Ralph A | Additives And Methods For Enhancing Active Agent Elution Kinetics |
GB0809905D0 (en) * | 2008-06-02 | 2008-07-09 | Secr Defence | A Transdermal drug delivery device |
WO2011048613A2 (en) | 2009-10-12 | 2011-04-28 | Lyka Labs Limited | Emergency contraceptive |
US20110236462A1 (en) | 2010-03-28 | 2011-09-29 | Shaked Ze Ev | Intravaginal drug delivery device |
DE102010040299A1 (de) | 2010-09-06 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Transdermale therapeutische Systeme mit kristallisationsinhibierender Schutzfolie (Release Liner) |
US10028858B2 (en) | 2011-07-11 | 2018-07-24 | Medicines360 | Intrauterine systems, IUD insertion devices, and related methods and kits therefor |
CA2854164C (en) * | 2011-11-04 | 2021-04-13 | Agile Therapeutics, Inc. | Dermal delivery compositions and methods |
US9144553B2 (en) | 2012-12-21 | 2015-09-29 | Teikoku Pharma Usa, Inc. | Compositions and methods for transdermal delivery of hormones and other medicinal agents |
US9314470B2 (en) | 2012-12-28 | 2016-04-19 | Noven Pharmaceuticals, Inc. | Transdermal drug delivery systems for levonorgestrel and ethinyl estradiol |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3632740A (en) * | 1968-06-13 | 1972-01-04 | Johnson & Johnson | Topical device for the therapeutic management of dermatological lesions with steroids |
JPS5843368B2 (ja) * | 1980-10-30 | 1983-09-27 | 日東電工株式会社 | 消炎鎮痛貼付剤 |
US5023084A (en) * | 1986-12-29 | 1991-06-11 | Rutgers, The State University Of New Jersey | Transdermal estrogen/progestin dosage unit, system and process |
EP0721348B1 (en) * | 1993-09-29 | 1999-09-01 | Alza Corporation | Monoglyceride/lactate ester permeation enhancer |
EP0742011B1 (en) * | 1994-11-17 | 2002-07-24 | Toray Industries, Inc. | Percutaneously absorbable preparation |
PL181582B1 (pl) * | 1995-06-07 | 2001-08-31 | Ortho Mcneil Pharm Inc | Plaster na skóre do zapobiegania owulacji u kobiety oraz plaster na skóre do przeprowadzania hormonalnej terapii substytucyjnej PL PL PL PL PL PL PL PL |
US5762956A (en) * | 1996-04-24 | 1998-06-09 | Rutgers, The State University Of New Jersey | Transdermal contraceptive delivery system and process |
-
2000
- 2000-11-22 JP JP2001539387A patent/JP4841781B2/ja not_active Expired - Fee Related
- 2000-11-22 DK DK00980651.4T patent/DK1242012T3/da active
- 2000-11-22 PT PT00980651T patent/PT1242012E/pt unknown
- 2000-11-22 EP EP00980651A patent/EP1242012B1/en not_active Expired - Lifetime
- 2000-11-22 CN CN00816271A patent/CN1399533A/zh active Pending
- 2000-11-22 MX MXPA02005224A patent/MXPA02005224A/es active IP Right Grant
- 2000-11-22 KR KR1020027006580A patent/KR100758757B1/ko active IP Right Grant
- 2000-11-22 AU AU17883/01A patent/AU784196B2/en not_active Ceased
- 2000-11-22 NZ NZ518723A patent/NZ518723A/en not_active IP Right Cessation
- 2000-11-22 BR BRPI0015802-0B1A patent/BR0015802B1/pt not_active IP Right Cessation
- 2000-11-22 ES ES00980651T patent/ES2338860T3/es not_active Expired - Lifetime
- 2000-11-22 AT AT00980651T patent/ATE453374T1/de active
- 2000-11-22 WO PCT/US2000/032043 patent/WO2001037770A1/en active IP Right Grant
- 2000-11-22 CA CA002391430A patent/CA2391430C/en not_active Expired - Fee Related
- 2000-11-22 IL IL14965500A patent/IL149655A0/xx not_active IP Right Cessation
- 2000-11-22 DE DE60043621T patent/DE60043621D1/de not_active Expired - Lifetime
- 2000-11-23 AR ARP000106197A patent/AR030037A1/es not_active Application Discontinuation
-
2001
- 2001-01-03 TW TW089124926A patent/TWI253350B/zh not_active IP Right Cessation
-
2002
- 2002-05-03 ZA ZA200203525A patent/ZA200203525B/xx unknown
- 2002-05-22 NO NO20022420A patent/NO331218B1/no not_active IP Right Cessation
-
2006
- 2006-05-09 AU AU2006201918A patent/AU2006201918B2/en not_active Ceased
-
2010
- 2010-03-22 CY CY20101100276T patent/CY1110615T1/el unknown
-
2011
- 2011-07-25 JP JP2011161744A patent/JP2011231125A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP4841781B2 (ja) | 2011-12-21 |
BR0015802A (pt) | 2003-06-24 |
PT1242012E (pt) | 2010-03-31 |
JP2011231125A (ja) | 2011-11-17 |
BR0015802B1 (pt) | 2014-04-29 |
NO331218B1 (no) | 2011-11-07 |
CA2391430A1 (en) | 2001-05-31 |
NO20022420L (no) | 2002-07-18 |
ZA200203525B (en) | 2003-07-18 |
AR030037A1 (es) | 2003-08-13 |
AU2006201918B2 (en) | 2009-07-30 |
TWI253350B (en) | 2006-04-21 |
NZ518723A (en) | 2004-04-30 |
KR100758757B1 (ko) | 2007-09-14 |
DE60043621D1 (de) | 2010-02-11 |
NO20022420D0 (no) | 2002-05-22 |
JP2003533434A (ja) | 2003-11-11 |
KR20020072280A (ko) | 2002-09-14 |
AU784196B2 (en) | 2006-02-23 |
EP1242012B1 (en) | 2009-12-30 |
CA2391430C (en) | 2009-10-06 |
DK1242012T3 (da) | 2010-04-26 |
MXPA02005224A (es) | 2003-09-25 |
IL149655A0 (en) | 2002-11-10 |
WO2001037770A1 (en) | 2001-05-31 |
EP1242012A4 (en) | 2006-05-31 |
ATE453374T1 (de) | 2010-01-15 |
EP1242012A1 (en) | 2002-09-25 |
AU1788301A (en) | 2001-06-04 |
AU2006201918A1 (en) | 2006-06-01 |
ES2338860T3 (es) | 2010-05-13 |
CN1399533A (zh) | 2003-02-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1110615T1 (el) | Βελτιωμενο συστημα διαδερμικης χορηγησης αντισυλληπτικου και μεθοδος | |
ATE192043T1 (de) | Kombinationspräparat zur kontrazeption | |
KR970701039A (ko) | 성 스테로이드를 함유하는 경피 치료 시스템(Sexual Steroid-Containing Transdermal Therapeutic Systems) | |
Stanczyk et al. | Radioimmunoassay of serum d-norgestrel in women following oral and intravaginal administration | |
CA2626567C (en) | Method of preventive on-demand hormonal contraception | |
EP0782861B1 (en) | Drug compounding ingredients comprising n-substituted-o-toluidine derivative and percutaneously absorbable preparation | |
NO303527B1 (no) | Ïstrogenholdig medikament og anordning for transdermal administrering derav | |
BR9709934A (pt) | Kit de terapia de reposição hormonal e/ou contraceptivo uso de unidades de dosagem diária consistindo essecialmente de um progestogênio e processo de preparação de um sistema de liberação de droga | |
HUP9800863A2 (hu) | Gyógyszerszállító rendszer két vagy több hatóanyaghoz | |
CY1105276T1 (el) | Τριφασικο στοματικο αντισυλληπτικο | |
KR970706001A (ko) | 습식-과립화를 통해 투여단위를 제조하는 방법 (process of making dosage units by wet granulation) | |
DK365887D0 (da) | Kombinationsdoseringsform til hormonbehandling af kvinder i prae-menopausen | |
AR011480A1 (es) | ACIL-ANILIDAS SUSTITUIDAS CON RADICALES (HETERO) CICLICOS, NO ESTEROIDALES, CON ACTIVIDAD GESTÁGENA Y ANDRoGENA MIXTA. | |
DK0680327T3 (da) | Terapeutiske anvendelser af og leveringssystemer for dehydroepiandrosteron | |
KR890011585A (ko) | 경피식 피임약제제형 | |
NO20062945L (no) | Forlenget anvendelseskombinasjon omfattende ostrogener og progestiner | |
KR900005969A (ko) | 게스토덴을 함유하는 경피 투여용 제제 | |
DK0868188T3 (da) | Kontraceptionskit til hunpattedyr bestående af en kombination af gestagen og estrogen | |
DE122007000011I1 (de) | Feste Arzneiformen, enthaltend Clathrate vom steroidalen Sexualhormon Ethinylestradiol | |
Pollow et al. | Gestodene: a novel synthetic progestin—characterization of binding to receptor and serum proteins | |
BRPI0417530A (pt) | liberação transdérmica de hormÈnios sem a necessidade de melhoradores de penetração | |
Moguilewsky et al. | Interrelations between glucocorticoid and progestin receptors | |
Alfaya et al. | Allergic contact dermatitis caused by an ethinylestradiol-norelgestromin transdermal therapeutic system. | |
PE20070555A1 (es) | Uso de valerato de estradiol en combinacion con dienogest para la terapia oral de la hemorragia uterina disfuncional unida con una anticoncepcion oral | |
AR019901A1 (es) | Parche autoadhesivo medicinal para la aplicacion percutanea de un estrogeno en combinacion con un gestageno y su empleo. |