CY1110469T1 - Συνθεσεις και μεθοδοι για θεραπεια ενος οπισθιου τμηματος ενος ματιου - Google Patents

Συνθεσεις και μεθοδοι για θεραπεια ενος οπισθιου τμηματος ενος ματιου

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Publication number
CY1110469T1
CY1110469T1 CY20091100549T CY091100549T CY1110469T1 CY 1110469 T1 CY1110469 T1 CY 1110469T1 CY 20091100549 T CY20091100549 T CY 20091100549T CY 091100549 T CY091100549 T CY 091100549T CY 1110469 T1 CY1110469 T1 CY 1110469T1
Authority
CY
Cyprus
Prior art keywords
component
eye
corticosteroid
composition
viscosity
Prior art date
Application number
CY20091100549T
Other languages
English (en)
Inventor
Robert T Lyons
James N Chang
John T Trogden
Scott M Whitcup
Original Assignee
Allergan, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan, Inc. filed Critical Allergan, Inc.
Publication of CY1110469T1 publication Critical patent/CY1110469T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)

Abstract

Παρέχονται συνθέσεις και μέθοδοι για χρήση τέτοιων συνθέσεων για έγχυση μέσα στα οπίσθια τμήματα ματιών ανθρώπων και ζώων. Τέτοιες συνθέσεις περιλαμβάνουν σωματίδια κορτικοστεροειδούς συστατικού που είναι παρόν σε μια θεραπευτικά αποτελεσματική ποσότητα, ένα συστατικό επαγωγής ιξώδους και ένα υδάτινο συστατικό φορέα. Οι συνθέσεις έχουν ιξώδη τουλάχιστο περίπου 10 cps ή περίπου 100 cps σε μια ταχύτητα διάτμησης 0.1/δευτερόλεπτο. Σε μια προτιμούμενη πραγματοποίηση, το ιξώδες είναι στο εύρος από περίπου 140,000 cps έως περίπου 300,000 cps. Οι συνθέσεις πλεονεκτικά θέτουν σε αιώρηση τα σωματίδια για παρατεταμένες χρονικές περιόδους.
CY20091100549T 2003-11-12 2009-05-22 Συνθεσεις και μεθοδοι για θεραπεια ενος οπισθιου τμηματος ενος ματιου CY1110469T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US51923703P 2003-11-12 2003-11-12
US53006203P 2003-12-16 2003-12-16
US10/966,764 US20050101582A1 (en) 2003-11-12 2004-10-14 Compositions and methods for treating a posterior segment of an eye
EP04810635A EP1682185B1 (en) 2003-11-12 2004-11-08 Compositions and methods for treating a posterior segment of an eye

Publications (1)

Publication Number Publication Date
CY1110469T1 true CY1110469T1 (el) 2015-04-29

Family

ID=34557415

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20091100549T CY1110469T1 (el) 2003-11-12 2009-05-22 Συνθεσεις και μεθοδοι για θεραπεια ενος οπισθιου τμηματος ενος ματιου
CY20101100788T CY1110758T1 (el) 2003-11-12 2010-08-27 Συνθεσεις και μεθοδοι για θεραπεια ενος οπισθιου τμηματος ενος ματιου

Family Applications After (1)

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CY20101100788T CY1110758T1 (el) 2003-11-12 2010-08-27 Συνθεσεις και μεθοδοι για θεραπεια ενος οπισθιου τμηματος ενος ματιου

Country Status (19)

Country Link
US (3) US20050101582A1 (el)
EP (2) EP1682185B1 (el)
JP (2) JP5437563B2 (el)
KR (1) KR20060113709A (el)
CN (1) CN105748407A (el)
AT (2) ATE424220T1 (el)
AU (2) AU2004289300B2 (el)
BR (1) BRPI0416506A (el)
CA (1) CA2545878C (el)
CY (2) CY1110469T1 (el)
DE (2) DE602004027773D1 (el)
DK (2) DK1682185T3 (el)
ES (2) ES2321305T3 (el)
NZ (1) NZ546699A (el)
PL (2) PL1682185T3 (el)
PT (2) PT1997497E (el)
SI (2) SI1997497T1 (el)
TW (1) TWI362264B (el)
WO (1) WO2005046641A2 (el)

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EP1997497B1 (en) 2010-06-16
EP1997497A2 (en) 2008-12-03
US20140051671A1 (en) 2014-02-20
JP5437563B2 (ja) 2014-03-12
DE602004027773D1 (de) 2010-07-29
SI1682185T1 (sl) 2009-06-30
CN105748407A (zh) 2016-07-13
US8569272B2 (en) 2013-10-29
KR20060113709A (ko) 2006-11-02
US20050101582A1 (en) 2005-05-12
AU2009222473B2 (en) 2012-03-29
CA2545878A1 (en) 2005-05-26
PT1997497E (pt) 2010-07-27
JP2012021011A (ja) 2012-02-02
ATE424220T1 (de) 2009-03-15
AU2004289300A1 (en) 2005-05-26
PL1682185T3 (pl) 2009-07-31
AU2009222473A1 (en) 2009-10-15
US20080269181A1 (en) 2008-10-30
JP2007510744A (ja) 2007-04-26
ES2345018T3 (es) 2010-09-13
AU2004289300B2 (en) 2009-07-16
ATE471159T1 (de) 2010-07-15
EP1997497A3 (en) 2009-05-13
DK1997497T3 (da) 2010-09-13
TWI362264B (en) 2012-04-21
JP5592321B2 (ja) 2014-09-17
SI1997497T1 (sl) 2010-08-31
PT1682185E (pt) 2009-04-22
CA2545878C (en) 2010-01-12
DE602004019801D1 (de) 2009-04-16
EP1682185A2 (en) 2006-07-26
DK1682185T3 (da) 2009-04-20
BRPI0416506A (pt) 2007-01-09
PL213709B1 (pl) 2013-04-30
WO2005046641A3 (en) 2005-11-24
PL380453A1 (pl) 2007-02-05
EP1682185B1 (en) 2009-03-04
US9265775B2 (en) 2016-02-23
WO2005046641A2 (en) 2005-05-26
NZ546699A (en) 2009-07-31
CY1110758T1 (el) 2015-06-10
ES2321305T3 (es) 2009-06-04
TW200528114A (en) 2005-09-01

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