CY1110106T1 - Φαρμακοτεχνικες μορφες για την παρατεταμενη απελευθερωση ιντερφερονων και θεραπευτικες εφαρμογες αυτων - Google Patents

Φαρμακοτεχνικες μορφες για την παρατεταμενη απελευθερωση ιντερφερονων και θεραπευτικες εφαρμογες αυτων

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Publication number
CY1110106T1
CY1110106T1 CY20101100278T CY101100278T CY1110106T1 CY 1110106 T1 CY1110106 T1 CY 1110106T1 CY 20101100278 T CY20101100278 T CY 20101100278T CY 101100278 T CY101100278 T CY 101100278T CY 1110106 T1 CY1110106 T1 CY 1110106T1
Authority
CY
Cyprus
Prior art keywords
ifn
active agent
release
physiological
duration
Prior art date
Application number
CY20101100278T
Other languages
English (en)
Inventor
Gauthier Pouliquen
Rémi Meyrueix
Olivier Soula
Original Assignee
Flamel Technologies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flamel Technologies filed Critical Flamel Technologies
Publication of CY1110106T1 publication Critical patent/CY1110106T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/66—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells
    • A61K47/665—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells the pre-targeting system, clearing therapy or rescue therapy involving biotin-(strept) avidin systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Nanotechnology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Η παρούσα εφεύρεση αφορά νέες φαρμακοτεχνικές μορφές με βάση σταθερά και υγρά υδατικά κολλοειδή εναιωρήματα για την παρατεταμένη απελευθέρωση ιντερφερόνης IFN- (και ενός ή περισσοτέρων άλλων προαιρετικών δραστικών συστατικών), καθώς επίσης τις εφαρμογές, ιδιαιτέρως θεραπευτικές, αυτών των φαρμακοτεχνικών μορφών. Ο σκοπός της εφεύρεσης είναι να προτείνει μία ρευστή φαρμακοτεχνική μορφή για την παρατεταμένη απελευθέρωση ιντερφερόνης(ων) (και ενός ή περισσοτέρων ενδεχομένως δραστικών συστατικών), έτσι ώστε μετά από παρεντερική ένεση, ο χρόνος απελευθέρωσης ιντερφερόνης in vivo είναι αυξημένος σημαντικά, ενώ η κορύφωση συγκέντρωσης πλάσματος αυτής είναι μειωμένη. Επιπλέον, η εν λόγω φαρμακοτεχνική μορφή πρέπει να είναι σταθερή στην φύλαξη και επιπλέον, βιοσυμβατή, μη-τοξική, βιοαποικοδομήσιμη, μη-ανοσογονική και καλώς ανεκτή τοπικώς. Σύμφωνα με την εφεύρεση, η φαρμακοτεχνική μορφή είναι χαμηλού ιξώδους υδατικό κολλοειδές εναιώρημα υπομικρονικών σωματιδίων υδατοδιαλυτου, βιοαποικοδομήσιμου πολυμερούς ΡΟ που φέρει υδρόφοβες ομάδες (GH). Τα προαναφερθέντα σωματίδια συνδυάζονται με μη-ομοιοπολικό τρόπο με τουλάχιστον μία ιντερφερόνη (και ένα ή περισσότερα άλλα ενδεχόμενα δραστικά συστατικά) και σχηματίζει μία πηκτοποιημένη αποθήκη επί της θέσης ένεσης, αυτή δε η πήκτωση προκαλείται με μία πρωτεΐνη που υπάρχει σε φυσιολογικό μέσο.
CY20101100278T 2003-11-21 2010-03-22 Φαρμακοτεχνικες μορφες για την παρατεταμενη απελευθερωση ιντερφερονων και θεραπευτικες εφαρμογες αυτων CY1110106T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0350886A FR2862541B1 (fr) 2003-11-21 2003-11-21 Formulations pharmaceutiques pour la liberation prolongee d'interferons et leurs applications therapeutiques
EP04805848A EP1689426B1 (fr) 2003-11-21 2004-11-19 Formulations pharmaceutiques pour la liberation prolongee d'interferons et leurs applications therapeutiques

Publications (1)

Publication Number Publication Date
CY1110106T1 true CY1110106T1 (el) 2015-01-14

Family

ID=34531383

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100278T CY1110106T1 (el) 2003-11-21 2010-03-22 Φαρμακοτεχνικες μορφες για την παρατεταμενη απελευθερωση ιντερφερονων και θεραπευτικες εφαρμογες αυτων

Country Status (22)

Country Link
US (1) US20070269517A1 (el)
EP (1) EP1689426B1 (el)
JP (1) JP2007511587A (el)
KR (1) KR20060111594A (el)
CN (1) CN1889971A (el)
AT (1) ATE453400T1 (el)
AU (1) AU2004292370B2 (el)
BR (1) BRPI0416766A (el)
CA (1) CA2546677A1 (el)
CY (1) CY1110106T1 (el)
DE (1) DE602004024920D1 (el)
DK (1) DK1689426T3 (el)
ES (1) ES2339119T3 (el)
FR (1) FR2862541B1 (el)
IL (1) IL175805A (el)
MX (1) MXPA06005716A (el)
PL (1) PL1689426T3 (el)
PT (1) PT1689426E (el)
SI (1) SI1689426T1 (el)
TW (1) TW200517141A (el)
WO (1) WO2005051417A1 (el)
ZA (1) ZA200603959B (el)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2862536B1 (fr) * 2003-11-21 2007-11-23 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques
FR2862535B1 (fr) * 2003-11-21 2007-11-23 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee d'interleukines et leurs applications therapeutiques
FR2904219B1 (fr) * 2006-07-28 2010-08-13 Flamel Tech Sa Microparticules a base de copolymere amphiphile et de principe(s) actif(s) a liberation modifiee et formulations pharmaceutiques en contenant
FR2910318B1 (fr) * 2006-12-20 2009-07-03 Flamel Technologies Sa Dispersion de polyaminoacides dans une phase lipidique continue.
FR2915684B1 (fr) * 2007-05-03 2011-01-14 Flamel Tech Sa Particules a base de polyelectrolytes et de principe actif a liberation modifiee et formulations pharmaceutiques contenant ces particules
JP4829351B2 (ja) * 2010-02-05 2011-12-07 ナノキャリア株式会社 易崩壊型ポリマーミセル組成物
CN101893619B (zh) * 2010-02-10 2013-11-13 上海蓝怡科技有限公司 改进乳胶悬浊液稳定性的方法
ES2563737T3 (es) 2011-05-20 2016-03-16 Ares Trading S.A. Composiciones de IFN-beta, métodos de preparación y usos de las mismas
FR2975301B1 (fr) 2011-05-20 2013-05-24 Flamel Tech Sa Composition comprenant un interferon alpha
TW201427681A (zh) * 2013-01-07 2014-07-16 Superlab Far East Ltd 用空間構象改變的重組干擾素治療腫瘤的方法

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Also Published As

Publication number Publication date
ES2339119T3 (es) 2010-05-17
BRPI0416766A (pt) 2007-02-27
CA2546677A1 (fr) 2005-06-09
FR2862541B1 (fr) 2007-04-20
EP1689426A1 (fr) 2006-08-16
EP1689426B1 (fr) 2009-12-30
DK1689426T3 (da) 2010-05-10
FR2862541A1 (fr) 2005-05-27
PT1689426E (pt) 2010-03-30
DE602004024920D1 (de) 2010-02-11
ZA200603959B (en) 2008-03-26
WO2005051417A1 (fr) 2005-06-09
US20070269517A1 (en) 2007-11-22
TW200517141A (en) 2005-06-01
SI1689426T1 (sl) 2010-05-31
AU2004292370B2 (en) 2010-12-02
IL175805A0 (en) 2006-10-05
PL1689426T3 (pl) 2010-06-30
MXPA06005716A (es) 2006-08-23
JP2007511587A (ja) 2007-05-10
CN1889971A (zh) 2007-01-03
IL175805A (en) 2013-10-31
ATE453400T1 (de) 2010-01-15
AU2004292370A1 (en) 2005-06-09
KR20060111594A (ko) 2006-10-27

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