ES2111149T3 - Extracto a base de proteinas bacterianas, procedimiento para su preparacion y composicion farmaceutica que lo contiene. - Google Patents

Extracto a base de proteinas bacterianas, procedimiento para su preparacion y composicion farmaceutica que lo contiene.

Info

Publication number
ES2111149T3
ES2111149T3 ES93902023T ES93902023T ES2111149T3 ES 2111149 T3 ES2111149 T3 ES 2111149T3 ES 93902023 T ES93902023 T ES 93902023T ES 93902023 T ES93902023 T ES 93902023T ES 2111149 T3 ES2111149 T3 ES 2111149T3
Authority
ES
Spain
Prior art keywords
extract
preparation
pharmaceutical composition
procedure
bacterial proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93902023T
Other languages
English (en)
Inventor
Jacques Bauer
Pierre Hirt
Adrian Schulthess
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OM LAB SA
Laboratoires OM SA
Original Assignee
OM LAB SA
Laboratoires OM SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by OM LAB SA, Laboratoires OM SA filed Critical OM LAB SA
Application granted granted Critical
Publication of ES2111149T3 publication Critical patent/ES2111149T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/848—Escherichia
    • Y10S435/849—Escherichia coli
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/851—Haemophilus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/852—Klebsiella
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/871—Neisseria
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/885—Streptococcus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

EL EXTRACTO A BASE DE PROTEINAS BACTERIANAS MODIFICADAS COMPORTA UNA MEZCLA DE POLIANIONES BACTERIANOS ACIDOS QUE TIENEN UN PESO MOLECULAR DE 10.000 A 1.000.000 Y U PUNTO ISOELECTRICO COMPRENDIDO ENTRE 2,5 Y 5,5 Y EN EL CUAL LA SUMA PONDERAL DE LOS ACIDOS AMINOS CONSTITUTIVOS REPRESENTA AL MENOS EL 50% DE DICHO EXTRACTO. LA PREPARCION DE ESTE EXTRACTO PROTEINICO COMPORTA EL CULTIVO DE BACTERIAS EN UN MEDIO ACUOSO, DESPUES LA EXTRACCION ALCALINA DE ESTA SUSPENSION BACTERIANA Y LA PURIFICACION DEL EXTRACTO PROTEINICO. LA EXTRACCION ALCALINA ES EFECTUADA EN PRESENCIA DE UNA FUENTE ACUOSA DILUIDA DE IONES OH- Y CON UN PH ESTABLE COMPRENDIDO ENTRE 11 Y 13, EL DESCENSO DE ESTE PH EN EL CURSO DE DICHA EXTRACCION NO ES SUPERIOR A 0,4. EL EXTRACTO PROTEINICO ASI OBTENIDO PUEDE SER UTILIZADO COMO INGREDIENTE ACTIVO EN UNA COMPOSICION FARMACEUTICA.
ES93902023T 1992-02-14 1993-02-03 Extracto a base de proteinas bacterianas, procedimiento para su preparacion y composicion farmaceutica que lo contiene. Expired - Lifetime ES2111149T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH450/92A CH685498A5 (fr) 1992-02-14 1992-02-14 Extrait de macromolécules bactériennes, procédé pour sa préparation et composition pharmaceutique contenant cet extrait.

Publications (1)

Publication Number Publication Date
ES2111149T3 true ES2111149T3 (es) 1998-03-01

Family

ID=4187312

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93902023T Expired - Lifetime ES2111149T3 (es) 1992-02-14 1993-02-03 Extracto a base de proteinas bacterianas, procedimiento para su preparacion y composicion farmaceutica que lo contiene.

Country Status (17)

Country Link
US (1) US5424287A (es)
EP (1) EP0580829B1 (es)
JP (1) JPH06507077A (es)
AT (1) ATE160588T1 (es)
BR (1) BR9304205A (es)
CA (1) CA2106854A1 (es)
CH (1) CH685498A5 (es)
CZ (1) CZ282924B6 (es)
DE (1) DE69315388T2 (es)
DK (1) DK0580829T3 (es)
ES (1) ES2111149T3 (es)
GR (1) GR3025882T3 (es)
HU (1) HU215262B (es)
PL (1) PL175058B1 (es)
RO (1) RO117621B1 (es)
SK (1) SK279877B6 (es)
WO (1) WO1993016190A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2703587B1 (fr) 1993-04-06 1995-06-16 Oreal Composition cosmetique coloree.
CA2182388C (en) 1994-02-07 2007-08-07 Metin Colpan Process for producing endotoxin-free or endotoxin-poor nucleic acids and/or oligonucleotides for gene therapy
DE19710255A1 (de) * 1997-03-13 1998-09-17 Henkel Ecolab Gmbh & Co Ohg Verwendung einer Lösung zur Desaktivierung von Endotoxinen
FR2842208B1 (fr) * 2002-07-10 2004-10-22 Lco Sante Extraits membranaires de klebsiella presentant des proprietes avantageuses, et procede de production de ces extraits
JP5386354B2 (ja) * 2006-09-08 2014-01-15 ワイス・エルエルシー アフィニティークロマトグラフィーを使用するタンパク質精製におけるアルギニン洗浄
AU2013200193B2 (en) * 2007-03-05 2015-04-23 Om Pharma Bacterial extract for digestive or urinary tract disorders and process for its preparation
BRPI0808351A2 (pt) * 2007-03-05 2014-07-29 Om Pharma Extrato bacteriano para doenças do trato digestivo ou urinário e proesso para sua preparação.
AU2013202504B2 (en) * 2007-03-05 2014-09-11 Om Pharma Bacterial extract for respiratory disorders and process for its preparation
PL2114421T3 (pl) * 2007-03-05 2018-07-31 Om Pharma Ekstrakt bakteryjny do stosowania względem zaburzeń oddechowych i sposób jego wytwarzania
US20100055082A1 (en) * 2008-09-04 2010-03-04 Jacques Alain Bauer Immunomodulatory extracts from lactobacillus bacteria and methods of manufacturing and use thereof
CN102617703A (zh) * 2012-04-14 2012-08-01 拜明(苏州)生物技术有限公司 一种无需裂解高效提取发酵细菌中外源表达蛋白的方法
JP2014200194A (ja) * 2013-04-04 2014-10-27 浜松ホトニクス株式会社 細胞から細胞小器官又はタンパク質を回収する方法
JP2022525177A (ja) 2019-03-14 2022-05-11 オーエム ファーマ 安定細菌抽出物を作製するプロセス及び医薬としてのその使用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2405298A1 (fr) * 1977-01-27 1979-05-04 Cassenne Lab Sa Nouvelles glycoproteines isolees d'escherichia coli, procede de preparation et application de medicaments
FR2396018A1 (fr) * 1977-07-01 1979-01-26 Cassenne Lab Sa Nouveaux glycopeptides acetyles hydrosolubles extraits de corps microbiens lyses d'escherichia coli, procede de preparation et application a titre de medicaments de ces produits
CH633188A5 (fr) * 1978-05-26 1982-11-30 Om Laboratoires Sa Medicament contre des maladies infectieuses des voies respiratoires.

Also Published As

Publication number Publication date
DK0580829T3 (da) 1998-08-10
CZ282924B6 (cs) 1997-11-12
EP0580829A1 (fr) 1994-02-02
CZ206493A3 (en) 1994-04-13
PL175058B1 (pl) 1998-10-30
DE69315388D1 (de) 1998-01-08
JPH06507077A (ja) 1994-08-11
RO117621B1 (ro) 2002-05-30
SK279877B6 (sk) 1999-05-07
CA2106854A1 (en) 1993-08-15
GR3025882T3 (en) 1998-04-30
CH685498A5 (fr) 1995-07-31
SK111193A3 (en) 1994-03-09
BR9304205A (pt) 1994-08-02
PL301012A1 (en) 1994-04-05
EP0580829B1 (fr) 1997-11-26
WO1993016190A1 (fr) 1993-08-19
HUT70268A (en) 1995-09-28
ATE160588T1 (de) 1997-12-15
US5424287A (en) 1995-06-13
HU215262B (hu) 1998-11-30
DE69315388T2 (de) 1998-05-14
HU9302893D0 (en) 1994-01-28

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