CY1109903T1 - Αμινοπεπτιδαση β2324 - Google Patents
Αμινοπεπτιδαση β2324Info
- Publication number
- CY1109903T1 CY1109903T1 CY20091101111T CY091101111T CY1109903T1 CY 1109903 T1 CY1109903 T1 CY 1109903T1 CY 20091101111 T CY20091101111 T CY 20091101111T CY 091101111 T CY091101111 T CY 091101111T CY 1109903 T1 CY1109903 T1 CY 1109903T1
- Authority
- CY
- Cyprus
- Prior art keywords
- polypeptide
- aminopeptidase
- sequence
- gene
- native
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/185—Escherichia
- C12R2001/19—Escherichia coli
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
- Detergent Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32235001P | 2001-09-13 | 2001-09-13 | |
| EP02761635A EP1432793B1 (en) | 2001-09-13 | 2002-09-12 | Aminopeptidase b2324 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1109903T1 true CY1109903T1 (el) | 2014-09-10 |
Family
ID=23254494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20091101111T CY1109903T1 (el) | 2001-09-13 | 2009-10-26 | Αμινοπεπτιδαση β2324 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US6921659B2 (enExample) |
| EP (1) | EP1432793B1 (enExample) |
| JP (2) | JP4831932B2 (enExample) |
| KR (2) | KR100956907B1 (enExample) |
| CN (1) | CN100552023C (enExample) |
| AT (1) | ATE440134T1 (enExample) |
| AU (1) | AU2002326884B2 (enExample) |
| BR (1) | BR0212886A (enExample) |
| CA (1) | CA2460309C (enExample) |
| CY (1) | CY1109903T1 (enExample) |
| DE (1) | DE60233417D1 (enExample) |
| DK (1) | DK1432793T3 (enExample) |
| ES (1) | ES2329880T3 (enExample) |
| HU (3) | HU225430B1 (enExample) |
| IL (2) | IL160658A0 (enExample) |
| MX (1) | MXPA04002326A (enExample) |
| NZ (2) | NZ531516A (enExample) |
| PL (1) | PL206286B1 (enExample) |
| PT (1) | PT1432793E (enExample) |
| WO (1) | WO2003023030A2 (enExample) |
| ZA (1) | ZA200401752B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL206286B1 (pl) | 2001-09-13 | 2010-07-30 | Genentech Incgenentech Inc | Komórka Gram-ujemnej bakterii, sposób wytwarzania heterologicznego peptydu, sposób zapobiegania odcinaniu N-końcowego aminokwasu, sposób odcinania N-końcowego aminokwasu i sposób wytwarzania skróconego polipeptydu |
| ES2527291T3 (es) | 2004-03-11 | 2015-01-22 | Genentech, Inc. | Proceso para la producción de polipéptidos |
| WO2010077806A1 (en) | 2008-12-15 | 2010-07-08 | Greenlight Biosciences, Inc. | Methods for control of flux in metabolic pathways |
| CN105132387A (zh) * | 2008-12-22 | 2015-12-09 | 绿光生物科学公司 | 用于制造化合物的组合物和方法 |
| US8956833B2 (en) | 2010-05-07 | 2015-02-17 | Greenlight Biosciences, Inc. | Methods for control of flux in metabolic pathways through enzyme relocation |
| US8916358B2 (en) | 2010-08-31 | 2014-12-23 | Greenlight Biosciences, Inc. | Methods for control of flux in metabolic pathways through protease manipulation |
| KR20150010932A (ko) | 2011-09-09 | 2015-01-29 | 그린라이트 바이오사이언시스, 아이엔씨. | 카바페넴의 무세포 제조법 |
| WO2015021058A2 (en) | 2013-08-05 | 2015-02-12 | Greenlight Biosciences, Inc. | Engineered proteins with a protease cleavage site |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| BR112017020690A2 (pt) | 2015-03-30 | 2018-06-26 | Greenlight Biosciences Inc | produção livre de células de ácido ribonucleico |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| SG11201808721YA (en) | 2016-04-06 | 2018-11-29 | Greenlight Biosciences Inc | Cell-free production of ribonucleic acid |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CN106967658B (zh) * | 2017-02-23 | 2020-09-15 | 郑州大学 | 一种提高Fab抗体表达量的方法 |
| JP7792196B2 (ja) | 2017-10-11 | 2025-12-25 | グリーンライト バイオサイエンシーズ インコーポレーテッド | ヌクレオシド三リン酸およびリボ核酸の生成のための方法および組成物 |
| US11471497B1 (en) | 2019-03-13 | 2022-10-18 | David Gordon Bermudes | Copper chelation therapeutics |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
| US12537071B1 (en) | 2020-07-22 | 2026-01-27 | David Gordon Bermudes | Bacteria having boolean control pathways expressing therapeutic proteins including immunotherapeutic cytotoxins |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0489711B1 (en) | 1984-08-16 | 2003-10-01 | Savient Pharmaceuticals, Inc. | Method for producing human growth hormone |
| WO1986007380A1 (fr) * | 1985-06-04 | 1986-12-18 | Takeda Chemical Industries, Ltd. | Procede de preparation de polypeptides |
| US4865974A (en) * | 1985-09-20 | 1989-09-12 | Cetus Corporation | Bacterial methionine N-terminal peptidase |
| ATE122391T1 (de) | 1987-01-30 | 1995-05-15 | Harvard College | Periplasmische protease-mutanten von escherichia coli. |
| US4946783A (en) * | 1987-01-30 | 1990-08-07 | President And Fellows Of Harvard College | Periplasmic protease mutants of Escherichia coli |
| JPH01181796A (ja) * | 1988-01-14 | 1989-07-19 | Ajinomoto Co Inc | 組換えｄｎａ法を用いたポリペプチドの製造法 |
| JP2844870B2 (ja) * | 1989-07-21 | 1999-01-13 | 味の素株式会社 | 組み替えｄｎａ法によるポリペプチドの製造法 |
| US5508192A (en) * | 1990-11-09 | 1996-04-16 | Board Of Regents, The University Of Texas System | Bacterial host strains for producing proteolytically sensitive polypeptides |
| US5304472A (en) * | 1992-11-20 | 1994-04-19 | Genentech, Inc. | Method of controlling polypeptide production in bacterial cells |
| US5573923A (en) * | 1993-12-22 | 1996-11-12 | Eli Lilly And Company | Method for removing N-terminal dipeptides from precursor polypeptides with immobilized dipeptidylaminopeptidase from dictyostelium discoideum |
| US6127144A (en) * | 1993-12-23 | 2000-10-03 | Cangene Corporation | Method for expression of proteins in bacterial host cells |
| US5789199A (en) * | 1994-11-03 | 1998-08-04 | Genentech, Inc. | Process for bacterial production of polypeptides |
| US5639635A (en) * | 1994-11-03 | 1997-06-17 | Genentech, Inc. | Process for bacterial production of polypeptides |
| KR100369839B1 (ko) * | 1997-02-28 | 2003-06-12 | 주식회사 엘지생명과학 | 바실러스리케니포미스균주에서유래한아미노펩티다제,그의제조방법및이를이용한천연형단백질의제조방법 |
| JP2002531121A (ja) * | 1998-12-07 | 2002-09-24 | ノボザイムス アクティーゼルスカブ | Ｎ末端伸長を有するグルコアミラーゼ |
| ES2280211T3 (es) | 1999-04-30 | 2007-09-16 | Pharmacia Corporation | Metodo para eliminar residuos de alanina, situados en extremos terminales de n, a partir de polipeptidos, con una aminopeptidasa procedente de aeromonas. |
| KR100400638B1 (ko) | 2000-12-06 | 2003-10-08 | 주식회사 엘지생명과학 | 재조합 인간 성장호르몬 유사체의 분리방법 |
| PL206286B1 (pl) | 2001-09-13 | 2010-07-30 | Genentech Incgenentech Inc | Komórka Gram-ujemnej bakterii, sposób wytwarzania heterologicznego peptydu, sposób zapobiegania odcinaniu N-końcowego aminokwasu, sposób odcinania N-końcowego aminokwasu i sposób wytwarzania skróconego polipeptydu |
-
2002
- 2002-09-12 PL PL368463A patent/PL206286B1/pl unknown
- 2002-09-12 CA CA2460309A patent/CA2460309C/en not_active Expired - Lifetime
- 2002-09-12 DE DE60233417T patent/DE60233417D1/de not_active Expired - Lifetime
- 2002-09-12 AU AU2002326884A patent/AU2002326884B2/en not_active Expired
- 2002-09-12 BR BR0212886-1A patent/BR0212886A/pt not_active Application Discontinuation
- 2002-09-12 WO PCT/US2002/029015 patent/WO2003023030A2/en not_active Ceased
- 2002-09-12 KR KR1020087030860A patent/KR100956907B1/ko not_active Expired - Lifetime
- 2002-09-12 ES ES02761635T patent/ES2329880T3/es not_active Expired - Lifetime
- 2002-09-12 JP JP2003527095A patent/JP4831932B2/ja not_active Expired - Lifetime
- 2002-09-12 HU HU0600309A patent/HU225430B1/hu unknown
- 2002-09-12 DK DK02761635T patent/DK1432793T3/da active
- 2002-09-12 HU HU0600310A patent/HU225346B1/hu unknown
- 2002-09-12 IL IL16065802A patent/IL160658A0/xx unknown
- 2002-09-12 PT PT02761635T patent/PT1432793E/pt unknown
- 2002-09-12 US US10/243,789 patent/US6921659B2/en not_active Expired - Lifetime
- 2002-09-12 KR KR1020047003708A patent/KR100954641B1/ko not_active Expired - Lifetime
- 2002-09-12 AT AT02761635T patent/ATE440134T1/de active
- 2002-09-12 CN CNB028179846A patent/CN100552023C/zh not_active Expired - Lifetime
- 2002-09-12 MX MXPA04002326A patent/MXPA04002326A/es active IP Right Grant
- 2002-09-12 NZ NZ531516A patent/NZ531516A/xx not_active IP Right Cessation
- 2002-09-12 EP EP02761635A patent/EP1432793B1/en not_active Expired - Lifetime
- 2002-09-12 NZ NZ544964A patent/NZ544964A/en not_active IP Right Cessation
- 2002-09-12 HU HU0401869A patent/HU225243B1/hu unknown
-
2004
- 2004-03-01 IL IL160658A patent/IL160658A/en unknown
- 2004-03-03 ZA ZA2004/01752A patent/ZA200401752B/en unknown
-
2005
- 2005-05-16 US US11/131,035 patent/US7229787B2/en not_active Expired - Lifetime
-
2007
- 2007-04-27 US US11/741,510 patent/US7632658B2/en not_active Expired - Lifetime
-
2009
- 2009-10-26 CY CY20091101111T patent/CY1109903T1/el unknown
-
2011
- 2011-04-20 JP JP2011094093A patent/JP5372061B2/ja not_active Expired - Lifetime
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