CY1107134T1 - Μεθοδος καθαρισμου για βακτηριακη κυτολυσινη - Google Patents
Μεθοδος καθαρισμου για βακτηριακη κυτολυσινηInfo
- Publication number
- CY1107134T1 CY1107134T1 CY20081100036T CY081100036T CY1107134T1 CY 1107134 T1 CY1107134 T1 CY 1107134T1 CY 20081100036 T CY20081100036 T CY 20081100036T CY 081100036 T CY081100036 T CY 081100036T CY 1107134 T1 CY1107134 T1 CY 1107134T1
- Authority
- CY
- Cyprus
- Prior art keywords
- cytolysin
- cleaning
- bacterial cytolysin
- detergent
- binding
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Otolaryngology (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Η παρούσα εφεύρεση αφορά μέθοδο για καθαρισμό βακτηριακών κυτολυσινών, όπως πνευμονοκοκκικής πνευμολυσίνης. Ένα απλό στάδιο χρωματογραφίας δίδει εξαιρετικό καθαρισμό της κυτολυσίνης, με σύνδεση διαλυτής συσσωματωμένης κυτολυσίνης, προς ένα υδρόφοβο υλικό χρωματογραφίας αλληλεπίδρασης, παρουσία απορρυπαντικού και υψηλής συγκέντρωσης άλατος.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0305792A GB0305792D0 (en) | 2003-03-13 | 2003-03-13 | Purification Process |
GB0305791A GB0305791D0 (en) | 2003-03-13 | 2003-03-13 | Detoxification process |
EP04719447A EP1601689B1 (en) | 2003-03-13 | 2004-03-11 | Purification process for bacterial cytolysin |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1107134T1 true CY1107134T1 (el) | 2012-10-24 |
Family
ID=32992596
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081100036T CY1107134T1 (el) | 2003-03-13 | 2008-01-10 | Μεθοδος καθαρισμου για βακτηριακη κυτολυσινη |
Country Status (23)
Country | Link |
---|---|
US (3) | US8084235B2 (el) |
EP (1) | EP1601689B1 (el) |
JP (2) | JP4597123B2 (el) |
KR (1) | KR101052996B1 (el) |
CN (1) | CN101818185B (el) |
AU (2) | AU2004219910B2 (el) |
BR (1) | BRPI0408094A (el) |
CA (2) | CA2518669C (el) |
CY (1) | CY1107134T1 (el) |
DE (1) | DE602004010376T2 (el) |
DK (1) | DK1601689T3 (el) |
EG (1) | EG24449A (el) |
ES (1) | ES2295836T3 (el) |
HK (1) | HK1086013A1 (el) |
IL (1) | IL210984A0 (el) |
IS (1) | IS2587B (el) |
MA (1) | MA27666A1 (el) |
MX (1) | MXPA05009579A (el) |
NO (1) | NO336672B1 (el) |
NZ (1) | NZ541969A (el) |
PT (1) | PT1601689E (el) |
RU (1) | RU2340627C2 (el) |
WO (1) | WO2004081515A2 (el) |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101818185B (zh) | 2003-03-13 | 2016-05-25 | 葛兰素史密丝克莱恩生物有限公司 | 纯化细菌溶细胞素的方法 |
GB0421083D0 (en) * | 2004-09-22 | 2004-10-27 | Glaxosmithkline Biolog Sa | Purification process |
EP1863502B1 (en) | 2005-03-23 | 2018-09-12 | Sonoma Pharmaceuticals, Inc. | Method of treating skin ulcers using oxidative reductive potential water solution |
EP1896062B1 (en) | 2005-06-27 | 2010-03-31 | GlaxoSmithKline Biologicals S.A. | Immunogenic composition |
NO346529B1 (no) | 2005-12-22 | 2022-09-26 | Glaxosmithkline Biologicals Sa | Bruk av et immunogenpreparat for småbarn, omfattende 22F sakkaridkonjugat |
GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
CA2637197C (en) | 2006-01-20 | 2017-01-31 | Oculus Innovative Sciences, Inc. | Methods of treating or preventing peritonitis with oxidative reductive potential water solution |
PL2066344T3 (pl) | 2006-09-07 | 2011-10-31 | Glaxosmithkline Biologicals Sa | Skojarzona szczepionka zawierająca inaktywowany wirus polio |
RU2487890C2 (ru) * | 2007-04-16 | 2013-07-20 | МинерваКС Апс | Слитый белок, способный индуцировать защитный иммунитет против стрептококка группы в, и вакцина, содержащая такой белок |
EP2142211A1 (en) | 2007-05-02 | 2010-01-13 | GlaxoSmithKline Biologicals S.A. | Vaccine |
SI2167121T1 (sl) | 2007-06-26 | 2015-12-31 | Glaxosmithkline Biologicals S.A. | Cepivo, ki obsega kapsularne polisaharidne konjugate Streptococcusa pneumoniae |
KR20110009157A (ko) | 2008-04-16 | 2011-01-27 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 |
AU2009286769A1 (en) * | 2008-08-28 | 2010-03-04 | Glaxosmithkline Biologicals S.A. | Vaccine |
EP2424562B1 (en) | 2009-04-30 | 2015-10-07 | Coley Pharmaceutical Group, Inc. | Pneumococcal vaccine and uses thereof |
US8668911B2 (en) | 2009-05-14 | 2014-03-11 | The Regents Of The University Of Michigan | Streptococcus vaccine compositions and methods of using the same |
KR101781229B1 (ko) | 2009-06-15 | 2017-09-22 | 오클루스 이노바티브 사이언시즈 인코포레이티드 | 차아염소산을 함유하는 용액 및 그의 사용 방법 |
PT2473605T (pt) | 2009-09-03 | 2018-05-28 | Pfizer Vaccines Llc | Vacina pcsk9 |
HUE034251T2 (en) | 2009-10-30 | 2018-02-28 | Glaxosmithkline Biologicals Sa | Purification of type 5 and type 8 capsular saccharides from Staphylococcus aureus |
GB201003924D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Immunogenic composition |
WO2012131504A1 (en) | 2011-03-02 | 2012-10-04 | Pfizer Inc. | Pcsk9 vaccine |
ES2742823T3 (es) * | 2011-04-22 | 2020-02-17 | Wyeth Llc | Composiciones relacionadas con una toxina mutante de Clostridium difficile y sus procedimientos |
AR086405A1 (es) | 2011-05-17 | 2013-12-11 | Glaxosmithkline Biolog Sa | Vacuna de streptococcus pneumoniae |
ES2763415T3 (es) | 2012-09-19 | 2020-05-28 | Univ Osaka | Vacuna neumocócica que contiene proteína A superficial neumocócica |
AU2013352723B2 (en) * | 2012-11-30 | 2017-01-05 | Bioneer Corporation | Apparatus for automatically preparing cell-free proteins and method for preparing proteins using same |
WO2015095868A1 (en) | 2013-12-20 | 2015-06-25 | Wake Forest University Health Sciences | Methods and compositions for increasing protective antibody levels induced by pneumococcal polysaccharide vaccines |
ES2820824T3 (es) | 2014-01-21 | 2021-04-22 | Pfizer | Composiciones inmunogénicas que comprenden antígenos sacáridos capsulares conjugados y usos de las mismas |
HRP20231504T1 (hr) | 2014-01-21 | 2024-03-01 | Pfizer Inc. | Polisaharidi kapsule iz bakterije streptococcus pneumoniae i njihovi konjugati |
US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
PT3096783T (pt) | 2014-01-21 | 2021-08-16 | Pfizer | Polissacáridos capsulares de streptococcus pneumoniae e conjugados dos mesmos |
ES2930318T3 (es) | 2014-02-14 | 2022-12-09 | Pfizer | Conjugados glucoproteicos inmunogénicos |
BR112017013891B1 (pt) | 2015-01-15 | 2024-01-30 | Pfizer Inc | Composições imunogênicas para uso em vacinas pneumocócicas |
US9218427B1 (en) * | 2015-01-21 | 2015-12-22 | Maana, Inc. | Dynamic semantic models having multiple indices |
WO2016168815A1 (en) * | 2015-04-16 | 2016-10-20 | Iventprise LLC | Bordetella pertussis immunogenic vaccine compositions |
TWI720448B (zh) | 2015-07-21 | 2021-03-01 | 美商輝瑞股份有限公司 | 包含經共軛之莢膜糖抗原的致免疫性組成物、包含該致免疫性組成物之套組及彼等之用途 |
GB201518684D0 (en) | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Vaccine |
US10786561B2 (en) | 2015-11-20 | 2020-09-29 | Pfizer Inc. | Immunogenic compositions for use in pneumococcal vaccines |
GB201603029D0 (en) * | 2016-02-22 | 2016-04-06 | Glaxosmithkline Biolog Sa | Vaccine |
EA039427B1 (ru) | 2016-08-05 | 2022-01-26 | Санофи Пастер Инк. | Поливалентная пневмококковая полисахаридно-белковая конъюгатная композиция |
KR102437120B1 (ko) | 2016-08-05 | 2022-08-25 | 사노피 파스퇴르 인코포레이티드 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
US20190360013A1 (en) * | 2016-12-02 | 2019-11-28 | President And Fellows Of Harvard College | Processive Template Independent DNA Polymerase Variants |
CN110366428B (zh) | 2016-12-30 | 2024-05-17 | Vaxcyte公司 | 具有非天然氨基酸的多肽-抗原缀合物 |
US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
EP3570879B1 (en) | 2017-01-20 | 2022-03-30 | Pfizer Inc. | Immunogenic compositions for use in pneumococcal vaccines |
KR102650073B1 (ko) | 2017-01-31 | 2024-03-20 | 머크 샤프 앤드 돔 엘엘씨 | 스트렙토코커스 뉴모니아 혈청형 19f 유래의 협막 다당류 단백질 접합체의 제조 방법 |
US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
AU2018280272C1 (en) | 2017-06-10 | 2021-05-06 | Inventprise, Inc. | Multivalent conjugate vaccines with bivalent or multivalent conjugate polysaccharides that provide improved immunogenicity and avidity |
CA3074708A1 (en) | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
CA3084436A1 (en) | 2017-12-06 | 2019-07-18 | Merck Sharp & Dohme Corp. | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
EP3749358A4 (en) | 2018-02-05 | 2022-04-20 | Sanofi Pasteur, Inc. | MULTIVALENT POLYSACCHARIDE-PNEUMOCOCCAL PROTEIN CONJUGATE COMPOSITION |
KR102486891B1 (ko) | 2018-02-05 | 2023-01-10 | 사노피 파스퇴르 인코포레이티드 | 다가 폐렴구균성 다당류-단백질 접합체 조성물 |
CA3096358A1 (en) | 2018-04-18 | 2019-10-24 | Sk Bioscience Co., Ltd. | Streptococcus pneumoniae capsular polysaccharide and immunogenic conjugate thereof |
US11260119B2 (en) | 2018-08-24 | 2022-03-01 | Pfizer Inc. | Escherichia coli compositions and methods thereof |
JP2022512345A (ja) | 2018-12-12 | 2022-02-03 | ファイザー・インク | 免疫原性多重ヘテロ抗原多糖-タンパク質コンジュゲートおよびその使用 |
JP2022513458A (ja) | 2018-12-12 | 2022-02-08 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | O-結合型グリコシル化のための修飾キャリアタンパク質 |
EP3897705A2 (en) | 2018-12-19 | 2021-10-27 | Merck Sharp & Dohme Corp. | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
JP7239509B6 (ja) | 2019-02-22 | 2023-03-28 | ファイザー・インク | 細菌多糖類を精製するための方法 |
WO2020208502A1 (en) | 2019-04-10 | 2020-10-15 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
MX2022001241A (es) | 2019-07-31 | 2022-04-20 | Sanofi Pasteur Inc | Composiciones de conjugados neumococicos multivalentes polisacarido - proteina y metodos para usar los mismos. |
US20230000966A1 (en) | 2019-11-01 | 2023-01-05 | Pfizer Inc. | Escherichia coli compositions and methods thereof |
CA3171864A1 (en) | 2020-02-21 | 2021-08-26 | Pfizer Inc. | Purification of saccharides |
BR112022014555A2 (pt) | 2020-02-23 | 2022-09-20 | Pfizer | Composições de escherichia coli e métodos das mesmas. |
EP4232593A1 (en) | 2020-10-22 | 2023-08-30 | Pfizer Inc. | Methods for purifying bacterial polysaccharides |
MX2023004912A (es) | 2020-10-27 | 2023-05-16 | Pfizer | Composiciones de escherichia coli y metodos de las mismas. |
MX2023005221A (es) | 2020-11-04 | 2023-05-16 | Pfizer | Composiciones inmunogenicas para uso en vacunas neumococicas. |
US20220202923A1 (en) | 2020-12-23 | 2022-06-30 | Pfizer Inc. | E. coli fimh mutants and uses thereof |
TW202245835A (zh) | 2021-02-04 | 2022-12-01 | 美商默沙東有限責任公司 | 用於肺炎球菌結合物疫苗之奈米乳化液佐劑組合物 |
WO2022234405A1 (en) | 2021-05-03 | 2022-11-10 | Pfizer Inc. | Vaccination against bacterial and betacoronavirus infections |
WO2022234416A1 (en) | 2021-05-03 | 2022-11-10 | Pfizer Inc. | Vaccination against pneumoccocal and covid-19 infections |
CA3221074A1 (en) | 2021-05-28 | 2022-12-01 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
EP4346893A2 (en) | 2021-05-28 | 2024-04-10 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
WO2023135515A1 (en) | 2022-01-13 | 2023-07-20 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
WO2023161817A1 (en) | 2022-02-25 | 2023-08-31 | Pfizer Inc. | Methods for incorporating azido groups in bacterial capsular polysaccharides |
WO2023218322A1 (en) | 2022-05-11 | 2023-11-16 | Pfizer Inc. | Process for producing of vaccine formulations with preservatives |
WO2024084397A1 (en) | 2022-10-19 | 2024-04-25 | Pfizer Inc. | Vaccination against pneumoccocal and covid-19 infections |
WO2024110827A1 (en) | 2022-11-21 | 2024-05-30 | Pfizer Inc. | Methods for preparing conjugated capsular saccharide antigens and uses thereof |
US20240181028A1 (en) | 2022-11-22 | 2024-06-06 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
WO2024116096A1 (en) | 2022-12-01 | 2024-06-06 | Pfizer Inc. | Pneumococcal conjugate vaccine formulations |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8807860D0 (en) * | 1988-04-05 | 1988-05-05 | Connaught Lab | Pertussis vaccine |
JP3237842B2 (ja) | 1988-12-16 | 2001-12-10 | オランダ国 | ニューモリシンミュータント及びそれから製造されたニューモコッカルワクチン |
DE4133707A1 (de) * | 1991-10-11 | 1993-04-15 | Behringwerke Ag | Verfahren zur reinigung von streptolysin o, intaktes streptolysin o erhaeltlich nach diesem verfahren und seine verwendung |
GB9216351D0 (en) * | 1992-07-31 | 1992-09-16 | Wellcome Found | Vaccine production |
US5565204A (en) | 1994-08-24 | 1996-10-15 | American Cyanamid Company | Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections |
BR9606987A (pt) * | 1995-01-27 | 1997-11-04 | Genencor Int | Processos para a recuperação de um produto de fermentação desejado a preparação de um pó detergente |
US5877298A (en) * | 1995-05-04 | 1999-03-02 | Connaught Lab | Acellular pertussis vaccines and methods of preparing thereof |
US5667786A (en) * | 1995-06-07 | 1997-09-16 | Novavax, Inc. | Method for treating tumors with a toxin |
KR100619350B1 (ko) * | 1997-07-21 | 2006-09-05 | 박스터 헬쓰케어 에스.에이. | 변형 면역성 뉴멀리신 백신조성물 |
EP1162999B1 (en) * | 1999-03-19 | 2006-11-29 | Glaxosmithkline Biologicals S.A. | Vaccine against Streptococcus pneumoniae |
JP4132694B2 (ja) * | 2000-03-10 | 2008-08-13 | 独立行政法人科学技術振興機構 | 受容体認識部位が保存された生理活性物質の誘導体及びその使用方法 |
GB0022742D0 (en) * | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
CN101818185B (zh) | 2003-03-13 | 2016-05-25 | 葛兰素史密丝克莱恩生物有限公司 | 纯化细菌溶细胞素的方法 |
GB0421083D0 (en) | 2004-09-22 | 2004-10-27 | Glaxosmithkline Biolog Sa | Purification process |
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2004
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- 2004-03-11 CA CA2518669A patent/CA2518669C/en not_active Expired - Fee Related
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- 2004-03-11 BR BRPI0408094-7A patent/BRPI0408094A/pt not_active Application Discontinuation
- 2004-03-11 PT PT04719447T patent/PT1601689E/pt unknown
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- 2004-03-11 DK DK04719447T patent/DK1601689T3/da active
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