US4709017A
(en)
|
1985-06-07 |
1987-11-24 |
President And Fellows Of Harvard College |
Modified toxic vaccines
|
US4950740A
(en)
|
1987-03-17 |
1990-08-21 |
Cetus Corporation |
Recombinant diphtheria vaccines
|
GB8815795D0
(en)
|
1988-07-02 |
1988-08-10 |
Bkl Extrusions Ltd |
Glazing bead
|
NZ230747A
(en)
|
1988-09-30 |
1992-05-26 |
Bror Morein |
Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina
|
DE3841091A1
(de)
|
1988-12-07 |
1990-06-13 |
Behringwerke Ag |
Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung
|
CA2006700A1
(en)
|
1989-01-17 |
1990-07-17 |
Antonello Pessi |
Synthetic peptides and their use as universal carriers for the preparation of immunogenic conjugates suitable for the development of synthetic vaccines
|
EP0482068A1
(en)
|
1989-07-14 |
1992-04-29 |
American Cyanamid Company |
Cytokine and hormone carriers for conjugate vaccines
|
IT1237764B
(it)
|
1989-11-10 |
1993-06-17 |
Eniricerche Spa |
Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici.
|
SE466259B
(sv)
|
1990-05-31 |
1992-01-20 |
Arne Forsgren |
Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal
|
DE69113564T2
(de)
|
1990-08-13 |
1996-05-30 |
American Cyanamid Co |
Faser-Hemagglutinin von Bordetella pertussis als Träger für konjugierten Impfstoff.
|
CA2129899C
(en)
|
1992-02-11 |
2011-01-04 |
James J. Mond |
Dual carrier immunogenic construct
|
IT1262896B
(it)
|
1992-03-06 |
1996-07-22 |
|
Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini.
|
JP3506431B2
(ja)
|
1992-05-06 |
2004-03-15 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
ジフテリア毒素受容体結合領域
|
JP3755890B2
(ja)
|
1992-06-25 |
2006-03-15 |
スミスクライン・ビーチャム・バイオロジカルス(ソシエテ・アノニム) |
アジュバント含有ワクチン組成物
|
IL102687A
(en)
|
1992-07-30 |
1997-06-10 |
Yeda Res & Dev |
Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them
|
DE69434079T2
(de)
|
1993-03-05 |
2005-02-24 |
Wyeth Holdings Corp. |
Plasmid zur Herstellung von CRM-Protein und Diphtherie-Toxin
|
CN1087176C
(zh)
|
1993-03-23 |
2002-07-10 |
史密斯克莱·比奇曼生物公司 |
含有3-o脱酰基单磷酰脂a的疫苗制剂
|
JP3828145B2
(ja)
|
1993-09-22 |
2006-10-04 |
ヘンリー エム.ジャクソン ファウンデイション フォー ザ アドバンスメント オブ ミリタリー メディスン |
免疫原性構成物の製造のための新規シアン化試薬を使った可溶性炭水化物の活性化方法
|
GB9326253D0
(en)
|
1993-12-23 |
1994-02-23 |
Smithkline Beecham Biolog |
Vaccines
|
US5917017A
(en)
|
1994-06-08 |
1999-06-29 |
President And Fellows Of Harvard College |
Diphtheria toxin vaccines bearing a mutated R domain
|
US6455673B1
(en)
|
1994-06-08 |
2002-09-24 |
President And Fellows Of Harvard College |
Multi-mutant diphtheria toxin vaccines
|
ES2267100T5
(es)
|
1994-07-15 |
2011-04-08 |
The University Of Iowa Research Foundation |
Oligonucleótidos inmunomoduladores.
|
US6207646B1
(en)
|
1994-07-15 |
2001-03-27 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
US6239116B1
(en)
|
1994-07-15 |
2001-05-29 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
AUPM873294A0
(en)
|
1994-10-12 |
1994-11-03 |
Csl Limited |
Saponin preparations and use thereof in iscoms
|
ES2200059T3
(es)
|
1995-03-22 |
2004-03-01 |
Henry M. Jackson Foundation For The Advancement Of Military Medicine |
Produccion de construcciones inmunogenicas usando carbohidratos solubles activados mediante reactivos cianilados organicos.
|
GB9513261D0
(en)
|
1995-06-29 |
1995-09-06 |
Smithkline Beecham Biolog |
Vaccines
|
AUPO517897A0
(en)
|
1997-02-19 |
1997-04-11 |
Csl Limited |
Chelating immunostimulating complexes
|
CA2281838A1
(en)
|
1997-02-28 |
1998-09-03 |
University Of Iowa Research Foundation |
Use of nucleic acids containing unmethylated cpg dinucleotide in the treatment of lps-associated disorders
|
US6299881B1
(en)
|
1997-03-24 |
2001-10-09 |
Henry M. Jackson Foundation For The Advancement Of Military Medicine |
Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts
|
US6339068B1
(en)
|
1997-05-20 |
2002-01-15 |
University Of Iowa Research Foundation |
Vectors and methods for immunization or therapeutic protocols
|
GB9712347D0
(en)
|
1997-06-14 |
1997-08-13 |
Smithkline Beecham Biolog |
Vaccine
|
GB9713156D0
(en)
|
1997-06-20 |
1997-08-27 |
Microbiological Res Authority |
Vaccines
|
ES2298316T3
(es)
|
1997-09-05 |
2008-05-16 |
Glaxosmithkline Biologicals S.A. |
Emulsiones de aceite en agua que contienen saponinas.
|
US6303114B1
(en)
|
1998-03-05 |
2001-10-16 |
The Medical College Of Ohio |
IL-12 enhancement of immune responses to T-independent antigens
|
CA2323929C
(en)
|
1998-04-03 |
2004-03-09 |
University Of Iowa Research Foundation |
Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines
|
PL354714A1
(en)
|
1998-04-09 |
2004-02-09 |
Smithkline Beecham Biologicals S.A. |
Adjuvant compositions
|
GB9817052D0
(en)
|
1998-08-05 |
1998-09-30 |
Smithkline Beecham Biolog |
Vaccine
|
EP2266604A3
(en)
|
1998-10-16 |
2011-05-11 |
GlaxoSmithKline Biologicals S.A. |
Adjuvant systems and vaccines
|
EP2050464B1
(en)
|
1998-12-21 |
2019-08-07 |
Medimmune, Inc. |
Streptococcus pneumoniae proteins and immunogenic fragments for vaccines
|
EA007409B1
(ru)
|
1998-12-23 |
2006-10-27 |
Шайе Биокем Инк. |
Антигенные полипептиды стрептококков, способы их получения и применения
|
AUPP807399A0
(en)
|
1999-01-08 |
1999-02-04 |
Csl Limited |
Improved immunogenic lhrh composition and methods relating thereto
|
JP5084984B2
(ja)
|
1999-02-17 |
2012-11-28 |
シーエスエル、リミテッド |
免疫原複合体およびそれに関する方法
|
CA2365296A1
(en)
|
1999-03-19 |
2000-09-28 |
Pierre Michel Desmons |
Vaccine
|
US6936258B1
(en)
|
1999-03-19 |
2005-08-30 |
Nabi Biopharmaceuticals |
Staphylococcus antigen and vaccine
|
WO2000061761A2
(en)
|
1999-04-09 |
2000-10-19 |
Techlab, Inc. |
Recombinant clostridium toxin a protein carrier for polysaccharide conjugate vaccines
|
KR100922031B1
(ko)
|
1999-04-19 |
2009-10-19 |
글락소스미스클라인 바이오로지칼즈 에스.에이. |
백신
|
EP1221971A2
(en)
|
1999-09-24 |
2002-07-17 |
SmithKline Beecham Biologics SA |
Use of the combination of polyoxyethylene sorbitan ester and octoxynol as adjuvant and its use in vaccines
|
BR0014285A
(pt)
|
1999-09-24 |
2002-05-21 |
Smithkline Beecham Biolog |
Adjuvantes compreendendo um éster ou éter de alquila de polioxietileno e pelo menos um tensoativo não-iÈnico
|
GB0007432D0
(en)
|
2000-03-27 |
2000-05-17 |
Microbiological Res Authority |
Proteins for use as carriers in conjugate vaccines
|
EP1303612A2
(en)
|
2000-06-20 |
2003-04-23 |
Shire Biochem Inc. |
Streptococcus antigens
|
AU2002309706A1
(en)
|
2001-05-11 |
2002-11-25 |
Aventis Pasteur, Inc. |
Novel meningitis conjugate vaccine
|
US20030091593A1
(en)
|
2001-09-14 |
2003-05-15 |
Cytos Biotechnology Ag |
In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles
|
WO2003054007A2
(en)
|
2001-12-20 |
2003-07-03 |
Shire Biochem Inc. |
Streptococcus antigens
|
ES2295836T3
(es)
|
2003-03-13 |
2008-04-16 |
Glaxosmithkline Biologicals S.A. |
Procedimiento de purificacion de citolisina bacteriana.
|
CA2519511A1
(en)
|
2003-03-17 |
2004-09-30 |
Wyeth Holdings Corporation |
Mutant cholera holotoxin as an adjuvant and an antigen carrier protein
|
GB0323103D0
(en)
|
2003-10-02 |
2003-11-05 |
Chiron Srl |
De-acetylated saccharides
|
KR100958505B1
(ko)
|
2004-07-18 |
2010-05-17 |
씨에스엘 리미티드 |
면역자극 복합체 및 향상된 인터페론-감마 반응을 유도하기위한 올리고뉴클레오티드 제제
|
US20070129320A9
(en)
|
2004-07-18 |
2007-06-07 |
Coley Pharmaceutical Group, Ltd. |
Methods and compositions for inducing innate immune responses
|
GB0421083D0
(en)
|
2004-09-22 |
2004-10-27 |
Glaxosmithkline Biolog Sa |
Purification process
|
CN104815327A
(zh)
|
2005-04-08 |
2015-08-05 |
惠氏有限责任公司 |
多价肺炎球菌多糖-蛋白质缀合物组合物
|
US20070184072A1
(en)
|
2005-04-08 |
2007-08-09 |
Wyeth |
Multivalent pneumococcal polysaccharide-protein conjugate composition
|
PL1866342T3
(pl)
|
2005-04-08 |
2019-04-30 |
Wyeth Llc |
Oddzielanie zanieczyszczeń od polisacharydu Streptococcus pneumoniae przez manipulację pH
|
US7955605B2
(en)
|
2005-04-08 |
2011-06-07 |
Wyeth Llc |
Multivalent pneumococcal polysaccharide-protein conjugate composition
|
US7709001B2
(en)
|
2005-04-08 |
2010-05-04 |
Wyeth Llc |
Multivalent pneumococcal polysaccharide-protein conjugate composition
|
MX2009003730A
(es)
|
2006-10-10 |
2009-04-22 |
Wyeth Corp |
Purificacion de polisacaridos de streptococcus pneumoniae tipo 3.
|
SI2436700T1
(sl)
|
2007-03-23 |
2018-09-28 |
Wyeth Llc |
Skrajšan postopek čiščenja za proizvodnjo kapsularnih polisaharidov streptococcusa pneumoniae
|
DK2167121T3
(en)
|
2007-06-26 |
2015-11-23 |
Glaxosmithkline Biolog Sa |
A vaccine comprising Streptococcus pneumoniae kapselpolysaccharidkonjugater
|
KR101450958B1
(ko)
|
2009-04-30 |
2014-10-15 |
콜레이 파마시티컬 그룹, 인코포레이티드 |
폐렴구균 백신 및 그의 용도
|
US9517274B2
(en)
|
2012-08-16 |
2016-12-13 |
Pfizer Inc. |
Glycoconjugation processes and compositions
|
PT3363806T
(pt)
|
2012-12-20 |
2022-12-16 |
Pfizer |
Processo de glicoconjugação
|
CN103495161B
(zh)
|
2013-10-08 |
2019-06-18 |
江苏康泰生物医学技术有限公司 |
一种多元肺炎球菌荚膜多糖-蛋白质结合物的混合物及其制备方法
|
MX371453B
(es)
*
|
2014-01-21 |
2020-01-29 |
Pfizer |
Polisacaridos capsulares de streptococcus pneumoniae y conjugados de los mismos.
|
EP3436061A4
(en)
*
|
2016-03-31 |
2019-12-04 |
Liffey Biotech Limited |
Saccharide-polypeptide-conjugate compositions and methods of use thereof
|
KR20240018697A
(ko)
*
|
2017-06-10 |
2024-02-13 |
인벤트프라이즈 인크. |
면역원성과 항원항체 결합성이 개선된 2가 또는 다가 접합체 다당류를 가진 다가 접합체 백신
|
EP3720483A2
(en)
|
2017-12-06 |
2020-10-14 |
Merck Sharp&Dohme Corp. |
Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof
|
KR20210062669A
(ko)
*
|
2018-09-23 |
2021-05-31 |
바이오로지칼 이 리미티드 |
스트렙토코쿠스 뉴모니아에의 정제된 협막 다당류
|
JP2022528158A
(ja)
*
|
2019-04-10 |
2022-06-08 |
ファイザー・インク |
コンジュゲート化莢膜糖抗原を含む免疫原性組成物、それを含むキットおよびその使用
|