DK1601689T3 - Oprensningsfremgangsmåde for bakterielt cytolysin - Google Patents
Oprensningsfremgangsmåde for bakterielt cytolysinInfo
- Publication number
- DK1601689T3 DK1601689T3 DK04719447T DK04719447T DK1601689T3 DK 1601689 T3 DK1601689 T3 DK 1601689T3 DK 04719447 T DK04719447 T DK 04719447T DK 04719447 T DK04719447 T DK 04719447T DK 1601689 T3 DK1601689 T3 DK 1601689T3
- Authority
- DK
- Denmark
- Prior art keywords
- purification procedure
- bacterial cytolysin
- cytolysin purification
- bacterial
- procedure
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0305791A GB0305791D0 (en) | 2003-03-13 | 2003-03-13 | Detoxification process |
GB0305792A GB0305792D0 (en) | 2003-03-13 | 2003-03-13 | Purification Process |
PCT/EP2004/002641 WO2004081515A2 (en) | 2003-03-13 | 2004-03-11 | Purification process for bacterial cytolysin |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1601689T3 true DK1601689T3 (da) | 2008-03-25 |
Family
ID=32992596
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04719447T DK1601689T3 (da) | 2003-03-13 | 2004-03-11 | Oprensningsfremgangsmåde for bakterielt cytolysin |
Country Status (23)
Country | Link |
---|---|
US (3) | US8084235B2 (da) |
EP (1) | EP1601689B1 (da) |
JP (2) | JP4597123B2 (da) |
KR (1) | KR101052996B1 (da) |
CN (1) | CN101818185B (da) |
AU (2) | AU2004219910B2 (da) |
BR (1) | BRPI0408094A (da) |
CA (2) | CA2518669C (da) |
CY (1) | CY1107134T1 (da) |
DE (1) | DE602004010376T2 (da) |
DK (1) | DK1601689T3 (da) |
EG (1) | EG24449A (da) |
ES (1) | ES2295836T3 (da) |
HK (1) | HK1086013A1 (da) |
IL (1) | IL210984A0 (da) |
IS (1) | IS2587B (da) |
MA (1) | MA27666A1 (da) |
MX (1) | MXPA05009579A (da) |
NO (1) | NO336672B1 (da) |
NZ (1) | NZ541969A (da) |
PT (1) | PT1601689E (da) |
RU (1) | RU2340627C2 (da) |
WO (1) | WO2004081515A2 (da) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE602004010376T2 (de) | 2003-03-13 | 2008-10-23 | Glaxosmithkline Biologicals S.A. | Verfahren zur reinigung von bakteriellem cytolysin |
GB0421083D0 (en) * | 2004-09-22 | 2004-10-27 | Glaxosmithkline Biolog Sa | Purification process |
KR101532778B1 (ko) | 2005-03-23 | 2015-06-30 | 오클루스 이노바티브 사이언시즈 인코포레이티드 | 산화 환원 전위 수용액을 사용한 2도 및 3도 화상의 치료방법 |
CA2611960C (en) | 2005-06-27 | 2015-05-05 | Glaxosmithkline Biologicals S.A. | Immunogenic compositions comprising n.meningitidis capsular saccharide conjugates |
GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
AR058707A1 (es) | 2005-12-22 | 2008-02-20 | Glaxosmithkline Biolog Sa | Vacuna, procedimiento para fabricarla y su uso |
JP2009523832A (ja) | 2006-01-20 | 2009-06-25 | オキュラス イノヴェイティヴ サイエンシズ、インコーポレイテッド | 酸化還元電位水溶液を用いた腹膜炎の治療又は予防方法 |
ES2387582T3 (es) | 2006-09-07 | 2012-09-26 | Glaxosmithkline Biologicals S.A. | Vacuna de combinación con cantidades reducidas del antígeno del virus de la polio |
CA2684494C (en) * | 2007-04-16 | 2016-07-05 | Lunds Universitets Utvecklingsaktiebolag | Fusion protein capable of eliciting protective immunity against group b streptococcus |
CA2685506A1 (en) | 2007-05-02 | 2008-11-13 | Glaxosmithkline Biologicals S.A. | Vaccine |
EA200901578A1 (ru) | 2007-06-26 | 2010-08-30 | Глаксосмитклайн Байолоджикалс С.А. | Вакцина, содержащая конъюгаты капсульных полисахаридов streptococcus pneumoniae |
WO2009127676A1 (en) | 2008-04-16 | 2009-10-22 | Glaxosmithkline Biologicals S.A. | Vaccine |
EA201100268A1 (ru) * | 2008-08-28 | 2011-10-31 | Глаксосмитклайн Байолоджикалс С.А. | Вакцина |
KR101450958B1 (ko) | 2009-04-30 | 2014-10-15 | 콜레이 파마시티컬 그룹, 인코포레이티드 | 폐렴구균 백신 및 그의 용도 |
US8668911B2 (en) | 2009-05-14 | 2014-03-11 | The Regents Of The University Of Michigan | Streptococcus vaccine compositions and methods of using the same |
MX348304B (es) | 2009-06-15 | 2017-06-02 | Invekra S A P I De C V | Solucion que contiene acido hipocloroso y metodos para usar la misma. |
AU2010290931B2 (en) | 2009-09-03 | 2014-02-06 | Pfizer Vaccines Llc | PCSK9 vaccine |
EP3199177A1 (en) | 2009-10-30 | 2017-08-02 | GlaxoSmithKline Biologicals S.A. | Purification of staphylococcus aureus type 5 and type 8 capsular saccharides |
GB201003924D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Immunogenic composition |
US20140004142A1 (en) | 2011-03-02 | 2014-01-02 | Pfizer Inc. | Pcsk9 vaccine |
BR122019017005B1 (pt) * | 2011-04-22 | 2022-03-29 | Wyeth Llc | Composições que se relacionam a uma toxina de clostridium difficile mutante |
AR086405A1 (es) * | 2011-05-17 | 2013-12-11 | Glaxosmithkline Biolog Sa | Vacuna de streptococcus pneumoniae |
CN109289045A (zh) * | 2012-09-19 | 2019-02-01 | 国立大学法人大阪大学 | 含有肺炎球菌表面蛋白a的肺炎球菌疫苗 |
CN104884606B (zh) * | 2012-11-30 | 2020-07-10 | 株式会社百奥尼 | 自动化制备无细胞蛋白的设备及其制备蛋白质的方法 |
US11708411B2 (en) | 2013-12-20 | 2023-07-25 | Wake Forest University Health Sciences | Methods and compositions for increasing protective antibody levels induced by pneumococcal polysaccharide vaccines |
KR102049826B1 (ko) | 2014-01-21 | 2019-12-03 | 화이자 인코포레이티드 | 스트렙토코쿠스 뉴모니아에 피막 폴리사카라이드 및 그의 접합체 |
EP4286000A3 (en) | 2014-01-21 | 2024-02-14 | Pfizer Inc. | Streptococcus pneumoniae capsular polysaccharides and conjugates thereof |
US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
EP3096785B1 (en) | 2014-01-21 | 2020-09-09 | Pfizer Inc | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
EP3443983B1 (en) | 2014-02-14 | 2022-07-20 | Pfizer Inc. | Immunogenic glycoprotein conjugates |
HRP20230416T1 (hr) | 2015-01-15 | 2023-07-07 | Pfizer Inc. | Imunogeni pripravci, namijenjeni upotrebi u cjepivima protiv pneumokoka |
US9218427B1 (en) * | 2015-01-21 | 2015-12-22 | Maana, Inc. | Dynamic semantic models having multiple indices |
US10076563B2 (en) * | 2015-04-16 | 2018-09-18 | Inventprise, Llc | Bordetella pertussis immunogenic vaccine compositions |
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US20190360013A1 (en) * | 2016-12-02 | 2019-11-28 | President And Fellows Of Harvard College | Processive Template Independent DNA Polymerase Variants |
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KR102486891B1 (ko) | 2018-02-05 | 2023-01-10 | 사노피 파스퇴르 인코포레이티드 | 다가 폐렴구균성 다당류-단백질 접합체 조성물 |
CA3096358A1 (en) | 2018-04-18 | 2019-10-24 | Sk Bioscience Co., Ltd. | Streptococcus pneumoniae capsular polysaccharide and immunogenic conjugate thereof |
US11260119B2 (en) | 2018-08-24 | 2022-03-01 | Pfizer Inc. | Escherichia coli compositions and methods thereof |
EP3894431A2 (en) | 2018-12-12 | 2021-10-20 | GlaxoSmithKline Biologicals SA | Modified carrier proteins for o-linked glycosylation |
WO2020121159A1 (en) | 2018-12-12 | 2020-06-18 | Pfizer Inc. | Immunogenic multiple hetero-antigen polysaccharide-protein conjugates and uses thereof |
TWI788610B (zh) | 2018-12-19 | 2023-01-01 | 美商默沙東有限責任公司 | 包含肺炎鏈球菌多醣-蛋白質結合物之組合物及其使用方法 |
JP7239509B6 (ja) | 2019-02-22 | 2023-03-28 | ファイザー・インク | 細菌多糖類を精製するための方法 |
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AU2020323498A1 (en) | 2019-07-31 | 2022-03-03 | Sk Bioscience Co., Ltd. | Multivalent pneumococcal polysaccharide-protein conjugate compositions and methods of using the same |
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JP2021132644A (ja) | 2020-02-21 | 2021-09-13 | ファイザー・インク | 糖の精製 |
JP2023514697A (ja) | 2020-02-23 | 2023-04-07 | ファイザー・インク | 大腸菌組成物およびその方法 |
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TW202245835A (zh) | 2021-02-04 | 2022-12-01 | 美商默沙東有限責任公司 | 用於肺炎球菌結合物疫苗之奈米乳化液佐劑組合物 |
WO2022234416A1 (en) | 2021-05-03 | 2022-11-10 | Pfizer Inc. | Vaccination against pneumoccocal and covid-19 infections |
JP2024517780A (ja) | 2021-05-03 | 2024-04-23 | ファイザー・インク | 細菌およびベータコロナウイルス感染症に対するワクチン接種 |
CA3221075A1 (en) | 2021-05-28 | 2022-12-01 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
TW202304503A (zh) | 2021-05-28 | 2023-02-01 | 美商輝瑞大藥廠 | 包含結合之莢膜醣抗原的免疫原組合物及其用途 |
WO2023135515A1 (en) | 2022-01-13 | 2023-07-20 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
WO2023161817A1 (en) | 2022-02-25 | 2023-08-31 | Pfizer Inc. | Methods for incorporating azido groups in bacterial capsular polysaccharides |
WO2023218322A1 (en) | 2022-05-11 | 2023-11-16 | Pfizer Inc. | Process for producing of vaccine formulations with preservatives |
WO2024084397A1 (en) | 2022-10-19 | 2024-04-25 | Pfizer Inc. | Vaccination against pneumoccocal and covid-19 infections |
Family Cites Families (14)
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GB8807860D0 (en) * | 1988-04-05 | 1988-05-05 | Connaught Lab | Pertussis vaccine |
WO1990006951A1 (en) * | 1988-12-16 | 1990-06-28 | De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur | Pneumolysin mutants and pneumococcal vaccines made therefrom |
DE4133707A1 (de) | 1991-10-11 | 1993-04-15 | Behringwerke Ag | Verfahren zur reinigung von streptolysin o, intaktes streptolysin o erhaeltlich nach diesem verfahren und seine verwendung |
GB9216351D0 (en) * | 1992-07-31 | 1992-09-16 | Wellcome Found | Vaccine production |
US5565204A (en) | 1994-08-24 | 1996-10-15 | American Cyanamid Company | Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections |
ATE355363T1 (de) | 1995-01-27 | 2006-03-15 | Genencor Int | Verfahren zur extraktion von enzymen unter verwendung von tensiden |
US5877298A (en) * | 1995-05-04 | 1999-03-02 | Connaught Lab | Acellular pertussis vaccines and methods of preparing thereof |
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PL203917B1 (pl) * | 1999-03-19 | 2009-11-30 | Glaxosmithkline Biolog Sa | Kompozycja immunogenna, sposób jej wytwarzania oraz zastosowanie |
JP4132694B2 (ja) * | 2000-03-10 | 2008-08-13 | 独立行政法人科学技術振興機構 | 受容体認識部位が保存された生理活性物質の誘導体及びその使用方法 |
GB0022742D0 (en) * | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
DE602004010376T2 (de) | 2003-03-13 | 2008-10-23 | Glaxosmithkline Biologicals S.A. | Verfahren zur reinigung von bakteriellem cytolysin |
GB0421083D0 (en) | 2004-09-22 | 2004-10-27 | Glaxosmithkline Biolog Sa | Purification process |
-
2004
- 2004-03-11 DE DE602004010376T patent/DE602004010376T2/de not_active Expired - Lifetime
- 2004-03-11 AU AU2004219910A patent/AU2004219910B2/en not_active Ceased
- 2004-03-11 ES ES04719447T patent/ES2295836T3/es not_active Expired - Lifetime
- 2004-03-11 CN CN201010157455.6A patent/CN101818185B/zh not_active Expired - Fee Related
- 2004-03-11 WO PCT/EP2004/002641 patent/WO2004081515A2/en active Application Filing
- 2004-03-11 PT PT04719447T patent/PT1601689E/pt unknown
- 2004-03-11 KR KR1020057017163A patent/KR101052996B1/ko not_active IP Right Cessation
- 2004-03-11 EP EP04719447A patent/EP1601689B1/en not_active Expired - Lifetime
- 2004-03-11 NZ NZ541969A patent/NZ541969A/en not_active IP Right Cessation
- 2004-03-11 JP JP2006504684A patent/JP4597123B2/ja not_active Expired - Fee Related
- 2004-03-11 BR BRPI0408094-7A patent/BRPI0408094A/pt not_active Application Discontinuation
- 2004-03-11 US US10/549,064 patent/US8084235B2/en not_active Expired - Fee Related
- 2004-03-11 DK DK04719447T patent/DK1601689T3/da active
- 2004-03-11 RU RU2005125832/13A patent/RU2340627C2/ru not_active IP Right Cessation
- 2004-03-11 MX MXPA05009579A patent/MXPA05009579A/es active IP Right Grant
- 2004-03-11 CA CA2518669A patent/CA2518669C/en not_active Expired - Fee Related
- 2004-03-11 CA CA2812817A patent/CA2812817C/en not_active Expired - Fee Related
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2005
- 2005-08-18 IS IS7993A patent/IS2587B/is unknown
- 2005-08-22 EG EGNA2005000491 patent/EG24449A/xx active
- 2005-09-06 NO NO20054134A patent/NO336672B1/no not_active IP Right Cessation
- 2005-09-09 MA MA28487A patent/MA27666A1/fr unknown
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2006
- 2006-05-24 HK HK06105983.2A patent/HK1086013A1/xx not_active IP Right Cessation
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2008
- 2008-01-10 CY CY20081100036T patent/CY1107134T1/el unknown
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2010
- 2010-08-10 AU AU2010212257A patent/AU2010212257B2/en not_active Ceased
- 2010-08-11 JP JP2010180165A patent/JP5683866B2/ja not_active Expired - Fee Related
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2011
- 2011-02-01 IL IL210984A patent/IL210984A0/en unknown
- 2011-08-31 US US13/222,066 patent/US8309327B2/en not_active Expired - Fee Related
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2012
- 2012-09-27 US US13/628,632 patent/US8815254B2/en not_active Expired - Fee Related
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