CY1106888T1 - Μεθοδος δια την παρασκευη μπιπεριδενης - Google Patents

Μεθοδος δια την παρασκευη μπιπεριδενης

Info

Publication number
CY1106888T1
CY1106888T1 CY20071101233T CY071101233T CY1106888T1 CY 1106888 T1 CY1106888 T1 CY 1106888T1 CY 20071101233 T CY20071101233 T CY 20071101233T CY 071101233 T CY071101233 T CY 071101233T CY 1106888 T1 CY1106888 T1 CY 1106888T1
Authority
CY
Cyprus
Prior art keywords
biperiden
mixture
beverides
preparing
hept
Prior art date
Application number
CY20071101233T
Other languages
English (en)
Inventor
Peter Klein
Marco Thyes
Markus Grosse
Klus Dieter Weber
Original Assignee
Laboratorio Farmaceutico S.I.T. Specialita´ Igienico Terapeutiche S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorio Farmaceutico S.I.T. Specialita´ Igienico Terapeutiche S.R.L. filed Critical Laboratorio Farmaceutico S.I.T. Specialita´ Igienico Terapeutiche S.R.L.
Publication of CY1106888T1 publication Critical patent/CY1106888T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Separation By Low-Temperature Treatments (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)

Abstract

Η εφεύρεση σχετίζεται με μια μέθοδο για την παραγωγή της μπιπεριδένης με την αντίδραση ενός εξω/ενδο μείγματος 1-(δικυκλο[2.2.1]επτ-5-εν-2-υλ)-3-πιπεριδινο-1-προπανόνη με μια ένωση φαινυλ μαγνησίου δια να σχηματίσει ένα μείγμα ισομερών 1-(δικυκλο[2.2.1]επτ-5-εν-2-υλ)-1-φαινυλ-3-πιπεριδινο-1-προπανόλης, με τον οποίο η μπιπεριδένη λαμβάνει από την μετατροπή του αναφερόμενου μείγματος στο αντίστοιχο υδροχλωρίδιο, απομόνωση του αναφερόμενου υδροχλωριδίου, επαναφορά σε ελεύθερη βάση και κρυσταλλοποίηση της αναφερόμενης μπιπεριδένης.
CY20071101233T 2001-05-18 2007-09-26 Μεθοδος δια την παρασκευη μπιπεριδενης CY1106888T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10124451A DE10124451A1 (de) 2001-05-18 2001-05-18 Verfahren zur Herstellung von Biperiden
EP02743054A EP1392667B1 (de) 2001-05-18 2002-05-17 Verfahren zur herstellung von biperiden

Publications (1)

Publication Number Publication Date
CY1106888T1 true CY1106888T1 (el) 2012-09-26

Family

ID=7685403

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071101233T CY1106888T1 (el) 2001-05-18 2007-09-26 Μεθοδος δια την παρασκευη μπιπεριδενης

Country Status (14)

Country Link
US (1) US7030247B2 (el)
EP (1) EP1392667B1 (el)
JP (1) JP4338978B2 (el)
KR (1) KR100849756B1 (el)
CN (1) CN1240692C (el)
AT (1) ATE365726T1 (el)
BR (1) BRPI0209853C1 (el)
CY (1) CY1106888T1 (el)
DE (2) DE10124451A1 (el)
DK (1) DK1392667T3 (el)
ES (1) ES2290317T3 (el)
IL (2) IL158926A0 (el)
PT (1) PT1392667E (el)
WO (1) WO2002094800A1 (el)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10124451A1 (de) 2001-05-18 2002-11-21 Abbott Gmbh & Co Kg Verfahren zur Herstellung von Biperiden
ES2250678T3 (es) 2001-05-18 2006-04-16 Laboratorio Farmaceutico S.I.T. Specialita' Igienico Terapeutiche S.R.L. Procedimiento para la preparacion de biperideno i.
KR100975396B1 (ko) * 2007-11-23 2010-08-11 윤중원 분수용 안전노즐
CN101508628B (zh) * 2009-03-30 2011-12-28 南昌航空大学 一种1-苯基-1-(二环[2.2.1]-5-庚烯-2)-乙醇的制备方法
CN106187948B (zh) * 2016-08-02 2019-02-22 安徽省逸欣铭医药科技有限公司 盐酸比哌立登制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2789110A (en) * 1953-03-14 1957-04-16 Knoll Ag Amino alcohols substituted by bicycloalkyl residues and a process of making same
DE1005067B (de) * 1953-03-14 1957-03-28 Knoll Ag Verfahren zur Herstellung von bicyclisch substituierten Aminopropanolen
JPH11189729A (ja) 1997-12-26 1999-07-13 Chemiprokasei Kaisha Ltd 色素兼紫外線安定剤およびそれを含む高分子組成物
DE10124451A1 (de) 2001-05-18 2002-11-21 Abbott Gmbh & Co Kg Verfahren zur Herstellung von Biperiden
DE10124449A1 (de) * 2001-05-18 2002-11-21 Abbott Gmbh & Co Kg Verfahren zur Herstellung von Biperiden

Also Published As

Publication number Publication date
BRPI0209853B8 (pt) 2018-12-18
US20040147753A1 (en) 2004-07-29
IL158926A0 (en) 2004-05-12
BR0209853A (pt) 2004-06-15
BRPI0209853B1 (pt) 2018-06-19
CN1525964A (zh) 2004-09-01
DE10124451A1 (de) 2002-11-21
BRPI0209853C1 (pt) 2021-05-25
JP2004536067A (ja) 2004-12-02
EP1392667A1 (de) 2004-03-03
KR100849756B1 (ko) 2008-07-31
KR20040007579A (ko) 2004-01-24
EP1392667B1 (de) 2007-06-27
IL158926A (en) 2011-02-28
CN1240692C (zh) 2006-02-08
PT1392667E (pt) 2007-10-09
WO2002094800A1 (de) 2002-11-28
ATE365726T1 (de) 2007-07-15
DK1392667T3 (da) 2007-10-22
ES2290317T3 (es) 2008-02-16
JP4338978B2 (ja) 2009-10-07
US7030247B2 (en) 2006-04-18
DE50210384D1 (de) 2007-08-09

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