CY1106488T1 - Παραγωγα εναμιδιου φαινυλαλανινης που εχουν ομαδα κυκλοβουτενιου, για χρηση σαν αναστολεις ιντεγκρινης - Google Patents

Παραγωγα εναμιδιου φαινυλαλανινης που εχουν ομαδα κυκλοβουτενιου, για χρηση σαν αναστολεις ιντεγκρινης

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Publication number
CY1106488T1
CY1106488T1 CY20071100477T CY071100477T CY1106488T1 CY 1106488 T1 CY1106488 T1 CY 1106488T1 CY 20071100477 T CY20071100477 T CY 20071100477T CY 071100477 T CY071100477 T CY 071100477T CY 1106488 T1 CY1106488 T1 CY 1106488T1
Authority
CY
Cyprus
Prior art keywords
phenylalanine
derivatives
enamel
integrin inhibitors
cyclobutene group
Prior art date
Application number
CY20071100477T
Other languages
English (en)
Inventor
Stuart Bailey
Julien Alistair Brown
Stephen Brand
James Andrew Johnson
John Robert Porter
John Clifford Head
Original Assignee
Celltech R & D Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0104418A external-priority patent/GB0104418D0/en
Priority claimed from GB0114000A external-priority patent/GB0114000D0/en
Priority claimed from GB0127562A external-priority patent/GB0127562D0/en
Application filed by Celltech R & D Limited filed Critical Celltech R & D Limited
Publication of CY1106488T1 publication Critical patent/CY1106488T1/el

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
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    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
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Abstract

Περιγράφονται παράγωγα εναμιδίου φαινυλαλανίνης του τύπου (1): όπου τα R1, RX, RY, RZ, Χ και V είναι ως ορίζονται στην αξίωση 1. Οι ενώσεις είναι ικανές να αναστείλουν τη σύνδεση ιντεγκρινών προς τους συνδετήρες αυτών και έχουν χρήση στην προφύλαξη και θεραπεία άνοσων ή φλεγμονωδών διαταραχών ή διαταραχών που περιλαμβάνουν την ακατάλληλη ανάπτυξη ή μετανάστευση κυττάρων.
CY20071100477T 2001-02-22 2007-04-04 Παραγωγα εναμιδιου φαινυλαλανινης που εχουν ομαδα κυκλοβουτενιου, για χρηση σαν αναστολεις ιντεγκρινης CY1106488T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0104418A GB0104418D0 (en) 2001-02-22 2001-02-22 Chemical compounds
GB0114000A GB0114000D0 (en) 2001-06-08 2001-06-08 Chemical compounds
GB0127562A GB0127562D0 (en) 2001-11-16 2001-11-16 Chemical compounds
PCT/GB2002/000206 WO2002068393A1 (en) 2001-02-22 2002-01-18 Phenylalanine enamide derivatives possessing a cyclobutene group, for use as integrin inhibitors

Publications (1)

Publication Number Publication Date
CY1106488T1 true CY1106488T1 (el) 2011-04-06

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EP (2) EP1370531B1 (el)
JP (2) JP4340064B2 (el)
KR (3) KR100899921B1 (el)
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BG (1) BG107991A (el)
BR (1) BR0207166A (el)
CA (1) CA2434666A1 (el)
CY (1) CY1106488T1 (el)
CZ (1) CZ20032259A3 (el)
DE (1) DE60218436T2 (el)
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PT (1) PT1370531E (el)
SI (1) SI1370531T1 (el)
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WO (1) WO2002068393A1 (el)

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IL156915A0 (en) * 2001-02-22 2004-02-08 Celltech R&D Ltd Phenylalanine enamide derivatives possessing a cyclobutene group, for use as integrin inhibitors
WO2003011815A1 (en) * 2001-07-26 2003-02-13 Celltech R & D Limited Bicyclic heteroaromatic alanines
GB0216568D0 (en) 2002-07-17 2002-08-28 Celltech R&D Ltd Chemical compounds
GB0216574D0 (en) * 2002-07-17 2002-08-28 Celltech R&D Ltd Chemical compounds
GB0216571D0 (en) 2002-07-17 2002-08-28 Celltech R&D Ltd Chemical compounds
WO2008103378A2 (en) 2007-02-20 2008-08-28 Merrimack Pharmaceuticals, Inc. Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist
JP5639039B2 (ja) 2008-04-11 2014-12-10 メリマック ファーマシューティカルズ インコーポレーティッド ヒト血清アルブミンリンカーおよびそのコンジュゲート
WO2010059315A1 (en) * 2008-11-18 2010-05-27 Merrimack Pharmaceuticals, Inc. Human serum albumin linkers and conjugates thereof
US9273028B2 (en) 2010-10-29 2016-03-01 Biogen Ma Inc. Heterocyclic tyrosine kinase inhibitors
AU2012325017A1 (en) 2011-10-17 2014-04-17 Westfaelische Wilhelms-Universitaet Muenster Assessment of PML risk and methods based thereon
CA2854658A1 (en) * 2011-11-09 2013-05-16 Aestus Therapeutics, Inc. Methods of treating schizophrenia with phenylalanine enamide derivative inhibitors of .alpha.4 integrin possessing a cyclobutene group
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