WO2004043443A3 - Drugs for sexual dysfunctions - Google Patents

Drugs for sexual dysfunctions Download PDF

Info

Publication number
WO2004043443A3
WO2004043443A3 PCT/EP2003/050779 EP0350779W WO2004043443A3 WO 2004043443 A3 WO2004043443 A3 WO 2004043443A3 EP 0350779 W EP0350779 W EP 0350779W WO 2004043443 A3 WO2004043443 A3 WO 2004043443A3
Authority
WO
WIPO (PCT)
Prior art keywords
drugs
sexual dysfunctions
compounds
formula
preparation
Prior art date
Application number
PCT/EP2003/050779
Other languages
French (fr)
Other versions
WO2004043443A2 (en
Inventor
Giuseppe Cirino
Vincenzo Mirone
Louis J Ignarro
Soldato Piero Del
Original Assignee
Nicox Sa
Giuseppe Cirino
Vincenzo Mirone
Louis J Ignarro
Soldato Piero Del
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa, Giuseppe Cirino, Vincenzo Mirone, Louis J Ignarro, Soldato Piero Del filed Critical Nicox Sa
Priority to AU2003301950A priority Critical patent/AU2003301950A1/en
Publication of WO2004043443A2 publication Critical patent/WO2004043443A2/en
Publication of WO2004043443A3 publication Critical patent/WO2004043443A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Use for the preparation of drugs for treating sexual dysfunctions, in particular male impotence, of compounds or salts thereof of formula: (I) wherein z is R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, p, q, and X, k, y and W have the meanings mentioned in the specification. Another aspect or the preparation of drugs for treating sexual dysfunctions of derivatives of the compounds of formula (I) containing one or more -ON (O)s groups.
PCT/EP2003/050779 2002-11-12 2003-11-03 Drugs for sexual dysfunctions WO2004043443A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003301950A AU2003301950A1 (en) 2002-11-12 2003-11-03 Drugs for sexual dysfunctions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT002389A ITMI20022389A1 (en) 2002-11-12 2002-11-12 DRUGS FOR SEXUAL DYSFUNCTIONS.
ITMI2002A002389 2002-11-12

Publications (2)

Publication Number Publication Date
WO2004043443A2 WO2004043443A2 (en) 2004-05-27
WO2004043443A3 true WO2004043443A3 (en) 2004-07-15

Family

ID=32310156

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/050779 WO2004043443A2 (en) 2002-11-12 2003-11-03 Drugs for sexual dysfunctions

Country Status (3)

Country Link
AU (1) AU2003301950A1 (en)
IT (1) ITMI20022389A1 (en)
WO (1) WO2004043443A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2861298B1 (en) * 2003-10-24 2006-02-17 Lmd ACETOXYACETATE OF CHAVICOL AND ITS DERIVATIVES AS AN EPAPHRODISIAC
JP2006160721A (en) * 2004-11-09 2006-06-22 Kao Corp Agent for recovery from fatigue of cerebrum
TW200740779A (en) 2005-07-22 2007-11-01 Mitsubishi Pharma Corp Intermediate compound for synthesizing pharmaceutical agent and production method thereof
HUE057970T2 (en) 2018-03-08 2022-06-28 Incyte Corp Aminopyrazine diol compounds as pi3k-y inhibitors
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997046556A1 (en) * 1996-06-07 1997-12-11 Merck & Co., Inc. OXADIAZOLE BENZENESULFONAMIDES AS SELECTIVE β3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY
WO2002011706A2 (en) * 2000-08-08 2002-02-14 Nicox S.A. Drugs for sex dysfunctions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997046556A1 (en) * 1996-06-07 1997-12-11 Merck & Co., Inc. OXADIAZOLE BENZENESULFONAMIDES AS SELECTIVE β3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY
WO2002011706A2 (en) * 2000-08-08 2002-02-14 Nicox S.A. Drugs for sex dysfunctions

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ADAIKAN P G ET AL: "ADRENO RECEPTORS IN THE HUMAN PENIS", JOURNAL OF AUTONOMIC PHARMACOLOGY, vol. 1, no. 3, 1981, pages 199 - 204, XP009027592, ISSN: 0144-1795 *
ANDERSSON K-E: "The pharmacological perspective: Role for the sympathetic nervous system in micturition and sexual function", PROSTATE CANCER AND PROSTATIC DISEASES 1999 UNITED KINGDOM, vol. 2, no. SUPPL. 4, 1999, pages S5 - S8, XP009027596, ISSN: 1365-7852 *
BROCKUNIER LINDA L ET AL: "Human beta3 adrenergic receptor agonists containing cyanoguanidine and nitroethylenediamine moieties", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 11, no. 3, 12 February 2001 (2001-02-12), pages 379 - 382, XP002273723, ISSN: 0960-894X *
CIRINO GIUSEPPE ET AL: "Involvement of beta3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 100, no. 9, 29 April 2003 (2003-04-29), April 29, 2003, pages 5531 - 5536, XP002273722, ISSN: 0027-8424 (ISSN print) *
HIEBLE J P: "Drugs targeting adrenergic receptors: Does interaction with a specific subtype confer therapeutic advantage?", CURRENT OPINION IN DRUG DISCOVERY AND DEVELOPMENT 2000 UNITED KINGDOM, vol. 3, no. 4, 2000, pages 370 - 382, XP009027587, ISSN: 1367-6733 *

Also Published As

Publication number Publication date
WO2004043443A2 (en) 2004-05-27
AU2003301950A8 (en) 2004-06-03
ITMI20022389A1 (en) 2004-05-13
AU2003301950A1 (en) 2004-06-03

Similar Documents

Publication Publication Date Title
GEP20084329B (en) 5,7-diaminopyrazolo [4,3-d] pyrimidines useful in the treatment of hypertension
UA103873C2 (en) Urea heteroaryl derivatives as p38 inhibitors and use thereof
AP2002002455A0 (en) 5-(2-substituted-5-heterocyclylsulphonylpyrid-3-yl)-dIhydropyrazolo[4,3-D] pyrimidin-7-ones as phosphodiesterase inhibitors.
MY132106A (en) New pyridazin-3(2h)-one derivatives
JO2311B1 (en) Alkyne-aryl phosphodiesterase-4 inhibitors
MY126862A (en) Purine derivatives inhibitors of tyrosine protein kinase syk
WO2004060882A8 (en) Cb 1/cb 2 receptor ligands and their use in the treatment of pain
UA84712C2 (en) N-substituted pyrazolyl-amidyl-benzimidazolyl c-kit inhibitors
ATE248837T1 (en) QUINUCLIDINE-ACRYLAMIDE
GEP20084391B (en) Pyrazoles and methods of making and using the same
CA2414095A1 (en) Novel compounds
MXPA04001685A (en) Sulfonylamino derivatives useful as herbicides.
MXPA05007296A (en) (2-carboxamido) (3-amino) thiophene compounds.
MY138737A (en) N3-substituted imidazopyridine c-kit inhibitors
TW200504029A (en) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
TW200604197A (en) New compounds
MXPA02009552A (en) Alkylated imidazopyridine derivatives.
ATE311389T1 (en) PRECURSOR OF IMIDAZOPYRIDINE DERIVATIVES
MXPA04006041A (en) Pyridoquinoxaline antivirals.
TW200626581A (en) Compounds, compositions containing them, preparation thereof and uses thereof
TW200504030A (en) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
MXPA04001419A (en) Isoxazolopyridinones and use thereof in the treatment of parkinson's disease.
WO2004043443A3 (en) Drugs for sexual dysfunctions
TW200505926A (en) 1,4-diazabicyclo [3.2.2] nonanecarboxamide derivatives, preparation thereof and therapeutic use thereof
NO20053805L (en) Diarylmethylindenepiperidine derivatives, processes for their preparation, and use thereof

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP