CY1106048T1 - Αναστολεiς διαyλων ασβεστiου - Google Patents

Αναστολεiς διαyλων ασβεστiου

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Publication number
CY1106048T1
CY1106048T1 CY20051101207T CY051101207T CY1106048T1 CY 1106048 T1 CY1106048 T1 CY 1106048T1 CY 20051101207 T CY20051101207 T CY 20051101207T CY 051101207 T CY051101207 T CY 051101207T CY 1106048 T1 CY1106048 T1 CY 1106048T1
Authority
CY
Cyprus
Prior art keywords
alkyl
group
independently
calcium channel
channel blockers
Prior art date
Application number
CY20051101207T
Other languages
English (en)
Inventor
Terrance Preston Snutch
Gerald Werner Zamponi
Original Assignee
Neuromed Technologies, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuromed Technologies, Inc. filed Critical Neuromed Technologies, Inc.
Publication of CY1106048T1 publication Critical patent/CY1106048T1/el

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
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Abstract

Ενώσεις του τύπου (1) όπου το m είναι 0, 1 ή 2, όπου όταν το m είναι 0, το Ζ είναι 0, όταν το m είναι 1, το Ζ είναι Ν, και όταν το m είναι 2, το Ζ είναι C, το Υ είναι Η, ΟΗ, ΝΗ2, ή ένα οργανικό τμήμα από 1-20C, το οποίο προαιρετικά περιλαμβάνει επιπλέον 1-8 ετεροάτομα, που επιλέγονται από την ομάδα που αποτελείται από Ν, Ρ, Ο, S και αλογονομάδες, τα I1 και I2 είναι ανεξάρτητα 0-5, το I3 είναι 0 ή 1, καθένα από τα R1, R2 και R3 είναι ανεξάρτητα αλκύλιο (1-6C), αρύλιο (6-10C) ή αραλκύλιο (7-16C), που περιλαμβάνει προαιρετικά 1-4 ετεροάτομα, που επιλέγονται από την ομάδα που αποτελείται από αλογόνο, Ν, Ρ, Ο και S ή καθένα από τα R1 και R2 μπορεί ανεξάρτητα να είναι αλογόνο, COOR, CONR2, CF3, CN ή ΝO2, όπου το R είναι Η ή κατώτερο αλκύλιο (1-4C) ή αλκύλιο (1-6C), το n είναι 0 ή 1, το Χ είναι μία συνδετική ομάδα, με την προϋπόθεση, ότι το Υ δεν είναι τροπολόνη, κουμαρίνη ή ένα αντι-οξειδωτικό που περιέχει μία αρωματική ομάδα και με την περαιτέρω προϋπόθεση, ότι αν το I3 είναι 0, ούτε το R1 ούτε το R2 μπορούν να παριστούν F στην πάρα θέση, και είναι χρήσιμες ως αναστολείς των διαύλων ασβεστίου. Μπορούν επίσης να χρησιμοποιηθούν και βιβλιοθήκες αυτών των ενώσεων, για την αναγνώριση ανταγωνιστών και άλλων στόχων.
CY20051101207T 1998-06-30 2005-09-30 Αναστολεiς διαyλων ασβεστiου CY1106048T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/107,037 US6011035A (en) 1998-06-30 1998-06-30 Calcium channel blockers
PCT/CA1999/000612 WO2000001375A2 (en) 1998-06-30 1999-06-30 Calcium channel blockers

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Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6492375B2 (en) 1998-06-30 2002-12-10 Neuromed Technologies, Inc. Partially saturated calcium channel blockers
US20040266784A1 (en) * 1998-06-30 2004-12-30 Snutch Terrance P. Calcium channel inhibitors comprising benzhydril spaced from piperazine
US7186726B2 (en) * 1998-06-30 2007-03-06 Neuromed Pharmaceuticals Ltd. Preferentially substituted calcium channel blockers
US6943168B2 (en) * 1998-06-30 2005-09-13 Neuromed Technologies Inc. Calcium channel inhibitors comprising benzhydril spaced from piperazine
WO2004089922A2 (en) * 1998-06-30 2004-10-21 Neuromed Technologies, Inc. Calcium channel inhibitors comprising benzhydril spaced from piperazine
US20040259866A1 (en) * 1998-06-30 2004-12-23 Snutch Terrance P. Calcium channel blockers comprising two benzhydril moieties
US6951862B2 (en) * 1998-06-30 2005-10-04 Neuromed Technologies, Inc. Calcium channel blockers comprising two benzhydril moieties
US6387897B1 (en) * 1998-06-30 2002-05-14 Neuromed Technologies, Inc. Preferentially substituted calcium channel blockers
US6011035A (en) * 1998-06-30 2000-01-04 Neuromed Technologies Inc. Calcium channel blockers
US20060084660A1 (en) * 1998-06-30 2006-04-20 Neuromed Technologies Inc. Calcium channel blockers comprising two benzhydril moieties
EP1242398A2 (en) * 1999-12-20 2002-09-25 Neuromed Technologies, Inc. Partially saturated calcium channel blockers
AU2001282886A1 (en) * 2000-07-13 2002-01-30 Pharmacia Corporation Combination of a cox-2 inhibitor and a vasomodulator for treating pain and headache pain
US7151102B2 (en) * 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
KR100915263B1 (ko) 2001-05-18 2009-09-03 아스트라제네카 아베 4(페닐-피페라지닐-메틸)벤즈아미드 유도체 및 통증, 불안증 또는 위장관 장애 치료를 위한 이들의 용도
JP4337138B2 (ja) 2001-08-31 2009-09-30 味の素株式会社 新規ジアリールアルケン誘導体及び新規ジアリールアルカン誘導体
US20030199523A1 (en) * 2002-02-28 2003-10-23 Snutch Terrance P. Heterocyclic calcium in channel blockers
US20040204404A1 (en) * 2002-09-30 2004-10-14 Robert Zelle Human N-type calcium channel blockers
SE0203303D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203302D0 (sv) * 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
WO2004072615A2 (en) * 2003-02-11 2004-08-26 Scion Pharmaceuticals, Inc. Methods for identifying ion channel modulators
EP1611116A2 (en) * 2003-04-08 2006-01-04 Neuromed Technologies, Inc. Calcium channel inhibitors comprising benzhydril spaced from piperazine
MXPA05012899A (es) * 2003-05-30 2006-06-23 Neuromed Tech Inc 3-aminometil-pirrolidinas como bloqueadores del canal de calcio tipo n.
WO2005015159A2 (en) * 2003-08-08 2005-02-17 The Regents Of The University Of California. Methods for modulating a drug-related effect or behavior
GB0320983D0 (en) * 2003-09-08 2003-10-08 Biofocus Plc Compound libraries
US7507760B2 (en) * 2004-01-22 2009-03-24 Neuromed Pharmaceuticals Ltd. N-type calcium channel blockers
JP2007532492A (ja) * 2004-04-09 2007-11-15 ニューロメッド ファーマシューティカルズ リミテッド カルシウムチャネルブロッカーとしてのジアリールアミン誘導体
US20050227999A1 (en) * 2004-04-09 2005-10-13 Neuromed Technologies Inc. Diarylamine derivatives as calcium channel blockers
MX2007001240A (es) 2004-08-02 2007-03-23 Astrazeneca Ab Derivados de diarilmetil-piperazina, preparaciones y usos de las mismas.
GB0419072D0 (en) * 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
KR20070063526A (ko) * 2004-08-30 2007-06-19 뉴로메드 파머큐티칼즈 리미티드 칼슘 채널 차단제인 우레아 유도체
KR101277520B1 (ko) * 2004-09-10 2013-06-21 뉴론 파마슈티칼즈 에스. 피. 에이. （할로벤질옥시）벤질아미노－프로판아미드를 포함하는 선택적 나트륨 및／또는 칼슘 채널 조절제로서 유용한 약제학적 조성물
TW200630337A (en) 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
US7511077B2 (en) * 2005-02-09 2009-03-31 Neuromed Pharmaceuticals Ltd. Diamine calcium channel blockers
JP2008534630A (ja) * 2005-04-08 2008-08-28 ニューロメッド ファーマシューティカルズ リミテッド 疼痛の軽減のためのｎ型カルシウムチャネルブロッカーを含む組み合わせ治療の方法
CA2605587A1 (en) * 2005-04-22 2006-11-02 Wyeth Chromane and chromene derivatives and uses thereof
US8022177B2 (en) * 2005-09-30 2011-09-20 The Board Of Trustees Of The University Of Illinois Peptides and calcium regulation in mammalian cells
US8299211B2 (en) * 2005-09-30 2012-10-30 The Board Of Trustees Of The University Of Illinois Peptides and regulation of calcium channels
CA2633457A1 (en) * 2005-12-19 2007-06-28 Neuromed Pharmaceuticals Ltd. Heterocyclic amide derivatives as calcium channel blockers
CA2629065C (en) * 2005-12-22 2013-08-06 Newron Pharmaceuticals S.P.A. 2 -phenylethylamino derivatives as calcium and/or sodium channel modulators
WO2007110449A1 (en) * 2006-03-29 2007-10-04 Euro-Celtique S.A. Benzenesulfonamide compounds and their use
WO2007118853A1 (en) * 2006-04-13 2007-10-25 Euro-Celtique S.A. Benzenesulfonamide compounds and their use as blockers of calcium channels
WO2007118854A1 (en) * 2006-04-13 2007-10-25 Euro-Celtique S.A. Benzenesulfonamide compounds and the use thereof
US20090286806A1 (en) * 2006-04-17 2009-11-19 Hassan Pajouhesh Isoxazole derivatives as calcium channel blockers
WO2007133481A2 (en) * 2006-05-11 2007-11-22 Neuromed Pharmaceuticals Ltd. Method for increasing the bioavailability of benzhydryl piperazine containing compounds
US20100029681A1 (en) * 2006-05-26 2010-02-04 Hassan Pajouhesh Heterocyclic compounds as calcium channel blockers
WO2008008398A2 (en) * 2006-07-14 2008-01-17 Shionogi & Co., Ltd. Oxime compounds and the use thereof
US20100168103A1 (en) * 2006-09-14 2010-07-01 Neuromed Pharmaceuticals Ltd. Diaryl piperidine compounds as calcium channel blockers
US20100105682A1 (en) * 2006-10-13 2010-04-29 Hassan Pajouhesh Cyclopropyl-piperazine compounds as calcium channel blockers
UY30639A1 (es) * 2006-10-17 2008-05-31 Kudos Pharm Ltd Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones
US20080139578A1 (en) * 2006-11-30 2008-06-12 Catherine Abbadie Substituted piperizines for the treatment of pain
WO2008124118A1 (en) * 2007-04-09 2008-10-16 Purdue Pharma L.P. Benzenesulfonyl compounds and the use therof
US20090012010A1 (en) * 2007-05-18 2009-01-08 Neuromed Phramaceuticals Ltd. Amino acid derivatives as calcium channel blockers
JP5323063B2 (ja) * 2007-05-31 2013-10-23 塩野義製薬株式会社 オキシイミノ化合物およびその使用
MX2009013119A (es) 2007-06-15 2010-03-04 Newron Pharm Spa Derivados de 2-[2-(fenil)etilamino]alcanamida sustituidos y su uso como moduladores del canal de sodio y/o potasio.
US8765736B2 (en) * 2007-09-28 2014-07-01 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
ES2428326T3 (es) 2007-10-04 2013-11-07 Merck Sharp & Dohme Corp. Derivados de aril sulfona sustituida como bloqueadores de canales de calcio
CA2702429A1 (en) * 2007-10-17 2009-04-23 Kudos Pharmaceuticals Limited Crystalline form l 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2h-phthalazin-1-one
CA2722704A1 (en) * 2008-04-28 2009-11-05 Zalicus Pharmaceuticals Ltd. Cyclylamine derivatives as calcium channel blockers
ES2408159T3 (es) * 2008-06-11 2013-06-18 Shionogi & Co., Ltd. Compuestos de oxicarbamoilo y su utilización
GB0812680D0 (en) * 2008-07-10 2008-08-20 Sec Dep For Innovation Univers Fluid decontamination method and apparatus
EP2344450A1 (en) * 2008-09-29 2011-07-20 Merck Sharp & Dohme Corp. Substituted aryl sulfone derivatives as calcium channel blockers
EA020783B1 (ru) 2008-10-07 2015-01-30 Астразенека Юк Лимитед Фармацевтическая композиция, содержащая 4-[3-(4-циклопропанкарбонилпиперазин-1-карбонил)-4-фторбензил]-2н-фталазин-1-он и коповидон
US8629149B2 (en) 2009-09-04 2014-01-14 Zalicus Pharmaceuticals Ltd. Oxopiperazine derivatives for the treatment of pain and epilepsy
US8609672B2 (en) 2010-08-27 2013-12-17 University Of The Pacific Piperazinylpyrimidine analogues as protein kinase inhibitors
US8409560B2 (en) 2011-03-08 2013-04-02 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
JP2014507424A (ja) 2011-03-08 2014-03-27 ザリカス ファーマスーティカルズ リミテッド 固体分散物製剤およびその使用方法
DK2723710T3 (en) 2011-06-27 2016-11-21 Newron Pharm Spa Flour ready arylalkylaminocarboxamidderivater
EP2961403A4 (en) 2013-03-01 2016-11-30 Zalicus Pharmaceuticals Ltd HETEROCYCLIC INHIBITORS OF SODIUM CHANNEL
TR202021399A2 (tr) * 2020-12-23 2021-01-21 Atatuerk Ueniversitesi Rektoerluegue Bilimsel Arastirma Projeleri Bap Koordinasyon Birimi Beni̇di̇pi̇ni̇n epi̇lepsi̇ hastaliğinin tedavi̇si̇ne yöneli̇k kullanimi

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1051527A (el) * 1964-07-31
NL131192C (el) * 1965-06-16
GB1218591A (en) * 1968-04-03 1971-01-06 Delalande Sa Derivatives of n-(3,4,5-trimethoxy cennamoyl) piperazine and their process of preparation
JPS50117784A (el) * 1974-03-05 1975-09-16
US3997539A (en) * 1974-05-31 1976-12-14 American Hoechst Corporation 3-(4-Acylaminopiperazin-1-yl alkyl)indoles, precursors and processes for the preparation thereof
JPS5198281A (en) * 1975-02-25 1976-08-30 nn * 3*33 jifuenirupuropiru * n** ararukiruchikanpiperajin oyobi sonoenno seiho
US4188485A (en) * 1978-06-16 1980-02-12 G. D. Searle & Co. 1-[(10,11-Dihydro-5H-dibenzo[a,d]-cyclohepten-5-yl)methyl]-4-substituted piperidines and related compounds
JPS59110690A (ja) * 1982-12-16 1984-06-26 Dai Ichi Seiyaku Co Ltd ベンゾピラン誘導体
JPS59225188A (ja) * 1983-06-02 1984-12-18 Takeda Chem Ind Ltd 縮合ピリミジン誘導体
JPS61155358A (ja) * 1984-12-21 1986-07-15 Suntory Ltd ジアリール酪酸誘導体
JPS61148144A (ja) * 1984-12-21 1986-07-05 Suntory Ltd フエニル酪酸誘導体
JPH0645600B2 (ja) * 1985-12-25 1994-06-15 大日本製薬株式会社 １，４−ジアザシクロアルカン誘導体
DE3600390A1 (de) * 1986-01-09 1987-07-16 Hoechst Ag Diarylalkyl-substituierte alkylamine, verfahren zu ihrer herstellung, ihre verwendung sowie sie enthaltende arzneimittel
JPH07100688B2 (ja) * 1986-02-12 1995-11-01 大日本製薬株式会社 環状アミン誘導体
US5386025A (en) 1990-02-20 1995-01-31 The Salk Institute Biotechnology/Industrial Associates Calcium channel compositions and methods
DE3831993A1 (de) * 1988-09-21 1990-03-29 Basf Ag 2-hydroxy-3-phenoxy-propyl-substituierte piperazine und homo-piperazine, ihre herstellung und verwendung
FR2636946B1 (fr) * 1988-09-23 1990-11-02 Lipha ((diarylmethoxy)alcoyl)-1 pyrrolidines et piperidines, procedes de preparation et medicaments les contenant
IE73232B1 (en) * 1990-05-25 1997-05-21 Akzo Nv Isochromane derivatives
IE912759A1 (en) * 1990-08-06 1992-02-12 Smith Kline French Lab Compounds
US5703071A (en) * 1990-08-29 1997-12-30 Pharmacia & Upjohn Company Tropolone derivatives and pharmaceutical composition thereof for preventing and treating ischemic diseases
TW205034B (el) * 1990-09-13 1993-05-01 Pola Kasei Kogyo Kk
DE4111861A1 (de) * 1991-04-11 1992-10-15 Schwabe Willmar Gmbh & Co Benzopyranone, verfahren zu ihrer herstellung und verwendung
US5985880A (en) * 1996-06-05 1999-11-16 Delta Pharmaceuticals Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds
US5681830A (en) * 1992-02-03 1997-10-28 Delta Pharmaceuticals, Inc. Opioid compounds
GB9202238D0 (en) * 1992-02-03 1992-03-18 Wellcome Found Compounds
BR9406080A (pt) * 1993-12-08 1996-02-06 Alcon Lab Inc Compostos que tem tanto antividade de anaonista potente de calcio como de antioxidante e uso dos mesmos como agentes citoprotetores
US5623051A (en) 1994-11-10 1997-04-22 University Of Washington Methods and compositions for screening for presynaptic calcium channel blockers
US5624677A (en) 1995-06-13 1997-04-29 Pentech Pharmaceuticals, Inc. Controlled release of drugs delivered by sublingual or buccal administration
JP3668291B2 (ja) * 1995-06-16 2005-07-06 久光製薬株式会社 新規なピペリジン誘導体
SE9504661D0 (sv) * 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
CA2304503A1 (en) * 1997-09-23 1999-04-01 Graham Johnson Selective cpla2 inhibitors
HUP0004200A3 (en) * 1997-11-18 2001-04-28 Dupont Pharmaceuticals Res Lab Cyclic amine derivatives and their use as drugs
GB9804734D0 (en) * 1998-03-05 1998-04-29 Pfizer Ltd Compounds
US6011035A (en) * 1998-06-30 2000-01-04 Neuromed Technologies Inc. Calcium channel blockers

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ES2249894T3 (es) 2006-04-01
JP2002519372A (ja) 2002-07-02
AU2004216601A1 (en) 2004-11-11
US6294533B1 (en) 2001-09-25
PT1091737E (pt) 2005-11-30
EP1466605A2 (en) 2004-10-13
IL140260A0 (en) 2002-02-10
SI1091737T1 (sl) 2006-02-28
DE69942131D1 (de) 2010-04-22
US6011035A (en) 2000-01-04
CA2335461A1 (en) 2000-01-13
EP1091737A2 (en) 2001-04-18
EP1466605B1 (en) 2010-03-10
IL140260A (en) 2007-02-11
WO2000001375A2 (en) 2000-01-13
JP3856646B2 (ja) 2006-12-13
ATE304357T1 (de) 2005-09-15
EP1091737B1 (en) 2005-09-14
DK1091737T3 (da) 2006-01-30
EP1466605A3 (en) 2004-11-17
AU4494799A (en) 2000-01-24
AU774482B2 (en) 2004-07-01
HK1034456A1 (en) 2001-10-26
KR100517672B1 (ko) 2005-09-28
WO2000001375A3 (en) 2000-08-31
DE69927266T2 (de) 2006-06-14
CA2335461C (en) 2010-02-23
ATE460165T1 (de) 2010-03-15
DE69927266D1 (de) 2005-10-20
KR20010071696A (ko) 2001-07-31
JP2006182786A (ja) 2006-07-13
AU2004216601B2 (en) 2007-08-09

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