CY1105243T1 - Συστατικα αυξησης διεισδυσης δερματος - Google Patents
Συστατικα αυξησης διεισδυσης δερματοςInfo
- Publication number
- CY1105243T1 CY1105243T1 CY20061101341T CY061101341T CY1105243T1 CY 1105243 T1 CY1105243 T1 CY 1105243T1 CY 20061101341 T CY20061101341 T CY 20061101341T CY 061101341 T CY061101341 T CY 061101341T CY 1105243 T1 CY1105243 T1 CY 1105243T1
- Authority
- CY
- Cyprus
- Prior art keywords
- skin penetration
- penetration enhancing
- macrolide
- enhancing ingredients
- prodrug
- Prior art date
Links
- 230000035515 penetration Effects 0.000 title abstract 3
- 230000002708 enhancing effect Effects 0.000 title 1
- 239000004615 ingredient Substances 0.000 title 1
- 239000003120 macrolide antibiotic agent Substances 0.000 abstract 3
- 230000001506 immunosuppresive effect Effects 0.000 abstract 2
- 150000002596 lactones Chemical class 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 230000003115 biocidal effect Effects 0.000 abstract 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 abstract 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 abstract 1
- 229960002930 sirolimus Drugs 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 239000012049 topical pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Η παρούσα εφεύρεση αφορά μία τοπική συνταγοποίηση για τη θεραπεία μιας δερματολογικής κατάστασης η οποία περιλαμβάνει αντιβιοτικό μακροκυκλικής λακτόνης, ανοσοκατασταλτικό μακρολίδιο ή βιολογικώς δραστικό ανάλογο, παράγωγο ή προφάρμακο αυτού, που χαρακτηρίζεται από το ότι περαιτέρω περιλαμβάνει ένα ρυθμιστή διείσδυσης και ο ρυθμιστής διείσδυσης και η μακροκυκλική λακτόνη ή μακρολίδιο ή το βιολογικώς δραστικό ανάλογο παράγωγο ή προφάρμακο αυτών υπάρχουν σε σχετικές ποσότητες έτσι ώστε όταν εφαρμόζεται μία θεραπευτική ποσότητα στο δέρμα παράγεται ένα ελάχιστο συστημικό αποτέλεσμα. Το ανοσοκατασταλτικό μακρολίδιο μπορεί να είναι sirolimus.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9723669.9A GB9723669D0 (en) | 1997-11-07 | 1997-11-07 | Skin penetration enhancing components |
PCT/GB1998/003317 WO1999024036A1 (en) | 1997-11-07 | 1998-11-05 | Skin penetration enhancing components |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1105243T1 true CY1105243T1 (el) | 2010-03-03 |
Family
ID=10821813
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061101341T CY1105243T1 (el) | 1997-11-07 | 2006-09-20 | Συστατικα αυξησης διεισδυσης δερματος |
Country Status (33)
Country | Link |
---|---|
US (2) | US6958153B1 (el) |
EP (2) | EP1028727B1 (el) |
JP (1) | JP2001522801A (el) |
KR (1) | KR20010031741A (el) |
CN (1) | CN1115148C (el) |
AR (1) | AR014011A1 (el) |
AT (1) | ATE332134T1 (el) |
AU (1) | AU759326B2 (el) |
BG (1) | BG104370A (el) |
BR (1) | BR9815264A (el) |
CA (1) | CA2309159C (el) |
CY (1) | CY1105243T1 (el) |
DE (1) | DE69835163T2 (el) |
DK (1) | DK1028727T3 (el) |
EA (1) | EA003616B1 (el) |
EE (1) | EE04390B1 (el) |
ES (1) | ES2268795T3 (el) |
GB (1) | GB9723669D0 (el) |
GE (2) | GEP20032884B (el) |
HR (1) | HRP20000233A2 (el) |
HU (1) | HUP0003675A3 (el) |
ID (1) | ID24662A (el) |
IL (1) | IL135978A0 (el) |
NO (1) | NO20002078L (el) |
NZ (3) | NZ520449A (el) |
PL (1) | PL340710A1 (el) |
PT (1) | PT1028727E (el) |
SK (1) | SK6622000A3 (el) |
TR (1) | TR200001238T2 (el) |
TW (1) | TW557218B (el) |
UA (1) | UA73274C2 (el) |
WO (1) | WO1999024036A1 (el) |
ZA (1) | ZA9810111B (el) |
Families Citing this family (64)
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GB9826656D0 (en) | 1998-12-03 | 1999-01-27 | Novartis Ag | Organic compounds |
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EP1133987A1 (en) * | 2000-03-09 | 2001-09-19 | Ian Whitcroft | Treatment of inflammatory dermatoses with combinations of erythromycin or clarythromycin, metronidazole and a hydrogen pump inhibitor |
DE60231868D1 (de) * | 2001-04-24 | 2009-05-20 | Purdue Research Foundation | Folat-mimetika und deren folatrezeptorbindende konjugate |
HRP20010301A2 (en) * | 2001-04-27 | 2001-12-31 | Pliva D D | New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases |
ATE429947T1 (de) | 2001-08-29 | 2009-05-15 | Pharmakodex Ltd | Vorrichtung zur topischen verabreichung |
AU2002347541A1 (en) * | 2001-12-13 | 2003-06-23 | Ranbaxy Laboratories Limited | Stable topical formulation of clarithromycin |
DE60326833D1 (de) * | 2002-05-15 | 2009-05-07 | Endocyte Inc | Vitamin-mitomycin-konjugate |
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GB0307869D0 (en) * | 2003-04-04 | 2003-05-14 | Novartis Ag | Pharmaceutical composition |
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US20050079228A1 (en) * | 2003-05-30 | 2005-04-14 | Ashish Jaiswal | Clear, stable topical compositions of clarithromycin and processes for their preparation |
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CA1165240A (en) * | 1980-07-09 | 1984-04-10 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions |
AU618517B2 (en) * | 1986-12-23 | 1992-01-02 | Eugene J. Van Scott | Additives enhancing topical actions of therapeutic agents |
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CA2033725C (en) * | 1990-01-24 | 2001-05-29 | Folker Pittrof | Pharmaceutical and cosmetic compositions containing a salt of cholanic acid |
ATE150304T1 (de) * | 1990-09-04 | 1997-04-15 | Fujisawa Pharmaceutical Co | Tricyclische verbindungen enthaltende salben |
ATE182786T1 (de) | 1992-08-04 | 1999-08-15 | Rhone Poulenc Rorer Gmbh | Pharmazeutische und/oder kosmetische zubereitung |
US5462746A (en) * | 1992-11-02 | 1995-10-31 | Lts Lohmann Therapie-Systeme Gmbh & Co. Kg | Patch for transdermal administration of volatile pharmaceutically active ingredients of chemically basic nature and a process for preparation |
FI90649C (fi) | 1993-02-01 | 1994-03-10 | Pauli Groenberg | Menetelmä hevosen satulan sovittamiseksi hevosen selkään |
CH686761A5 (de) * | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
JPH06345646A (ja) * | 1993-06-08 | 1994-12-20 | Fujisawa Pharmaceut Co Ltd | ローション剤 |
JPH08133979A (ja) * | 1994-09-16 | 1996-05-28 | Sando Yakuhin Kk | 局所適用薬剤組成物 |
EP0786986B1 (en) * | 1994-10-26 | 2002-03-20 | Novartis AG | Use of an unsaturated fatty alcohol |
US5648389A (en) * | 1995-10-27 | 1997-07-15 | Medicis Pharmaceutical, Inc. | Compositions for the treatment of dermatological disorders and methods for their use |
-
1997
- 1997-11-07 GB GBGB9723669.9A patent/GB9723669D0/en not_active Ceased
-
1998
- 1998-05-11 UA UA2000063310A patent/UA73274C2/uk unknown
- 1998-10-23 TW TW087117554A patent/TW557218B/zh not_active IP Right Cessation
- 1998-11-04 AR ARP980105560A patent/AR014011A1/es unknown
- 1998-11-05 HU HU0003675A patent/HUP0003675A3/hu unknown
- 1998-11-05 EP EP98952860A patent/EP1028727B1/en not_active Expired - Lifetime
- 1998-11-05 PT PT98952860T patent/PT1028727E/pt unknown
- 1998-11-05 NZ NZ520449A patent/NZ520449A/en unknown
- 1998-11-05 NZ NZ504076A patent/NZ504076A/xx unknown
- 1998-11-05 EA EA200000461A patent/EA003616B1/ru not_active IP Right Cessation
- 1998-11-05 KR KR1020007004806A patent/KR20010031741A/ko not_active Application Discontinuation
- 1998-11-05 AT AT98952860T patent/ATE332134T1/de not_active IP Right Cessation
- 1998-11-05 BR BR9815264-5A patent/BR9815264A/pt active Search and Examination
- 1998-11-05 DE DE69835163T patent/DE69835163T2/de not_active Expired - Fee Related
- 1998-11-05 GE GEAP19985335A patent/GEP20032884B/en unknown
- 1998-11-05 TR TR2000/01238T patent/TR200001238T2/xx unknown
- 1998-11-05 DK DK98952860T patent/DK1028727T3/da active
- 1998-11-05 EE EEP200000279A patent/EE04390B1/xx not_active IP Right Cessation
- 1998-11-05 ID IDW20000846A patent/ID24662A/id unknown
- 1998-11-05 EP EP05007320A patent/EP1632231A3/en not_active Withdrawn
- 1998-11-05 SK SK662-2000A patent/SK6622000A3/sk unknown
- 1998-11-05 ES ES98952860T patent/ES2268795T3/es not_active Expired - Lifetime
- 1998-11-05 PL PL98340710A patent/PL340710A1/xx unknown
- 1998-11-05 GE GEAP19986193A patent/GEP20043171B/en unknown
- 1998-11-05 CN CN98810780A patent/CN1115148C/zh not_active Expired - Fee Related
- 1998-11-05 IL IL13597898A patent/IL135978A0/xx unknown
- 1998-11-05 CA CA002309159A patent/CA2309159C/en not_active Expired - Fee Related
- 1998-11-05 ZA ZA9810111A patent/ZA9810111B/xx unknown
- 1998-11-05 JP JP2000520128A patent/JP2001522801A/ja not_active Withdrawn
- 1998-11-05 WO PCT/GB1998/003317 patent/WO1999024036A1/en active IP Right Grant
- 1998-11-05 AU AU10408/99A patent/AU759326B2/en not_active Ceased
- 1998-11-05 US US09/530,375 patent/US6958153B1/en not_active Expired - Fee Related
- 1998-11-05 NZ NZ530752A patent/NZ530752A/en unknown
-
2000
- 2000-04-19 NO NO20002078A patent/NO20002078L/no unknown
- 2000-04-20 HR HR20000233A patent/HRP20000233A2/xx not_active Application Discontinuation
- 2000-04-24 BG BG104370A patent/BG104370A/xx unknown
-
2005
- 2005-06-16 US US11/153,318 patent/US20050239724A1/en not_active Abandoned
-
2006
- 2006-09-20 CY CY20061101341T patent/CY1105243T1/el unknown
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