CU20170029A7 - Indazoles sustituidos con bencilo en calidad de inhibidores de bub1, útiles para el tratamiento o profilaxis de una enfermedad hiperproliferativa y/o un trastorno que responde a la inducción de la muerte celular, un procedimiento para la preparación de estos compuestos, y compuestos intermediarios - Google Patents
Indazoles sustituidos con bencilo en calidad de inhibidores de bub1, útiles para el tratamiento o profilaxis de una enfermedad hiperproliferativa y/o un trastorno que responde a la inducción de la muerte celular, un procedimiento para la preparación de estos compuestos, y compuestos intermediariosInfo
- Publication number
- CU20170029A7 CU20170029A7 CUP2017000029A CU20170029A CU20170029A7 CU 20170029 A7 CU20170029 A7 CU 20170029A7 CU P2017000029 A CUP2017000029 A CU P2017000029A CU 20170029 A CU20170029 A CU 20170029A CU 20170029 A7 CU20170029 A7 CU 20170029A7
- Authority
- CU
- Cuba
- Prior art keywords
- composition
- preparation
- disorder
- induction
- useful
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14185604 | 2014-09-19 | ||
EP15176903 | 2015-07-15 | ||
PCT/EP2015/071340 WO2016042084A1 (fr) | 2014-09-19 | 2015-09-17 | Indazoles à substituants benzyle utilisés comme inhibiteurs de bub1 |
Publications (1)
Publication Number | Publication Date |
---|---|
CU20170029A7 true CU20170029A7 (es) | 2017-08-08 |
Family
ID=54140475
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CUP2017000029A CU20170029A7 (es) | 2014-09-19 | 2015-09-17 | Indazoles sustituidos con bencilo en calidad de inhibidores de bub1, útiles para el tratamiento o profilaxis de una enfermedad hiperproliferativa y/o un trastorno que responde a la inducción de la muerte celular, un procedimiento para la preparación de estos compuestos, y compuestos intermediarios |
Country Status (27)
Country | Link |
---|---|
US (1) | US10350206B2 (fr) |
EP (1) | EP3194379A1 (fr) |
JP (1) | JP6664385B2 (fr) |
KR (1) | KR20170049604A (fr) |
CN (1) | CN107001331A (fr) |
AP (1) | AP2017009803A0 (fr) |
AU (1) | AU2015316796A1 (fr) |
BR (1) | BR112017005444A2 (fr) |
CA (1) | CA2961589A1 (fr) |
CL (1) | CL2017000654A1 (fr) |
CO (1) | CO2017002532A2 (fr) |
CR (1) | CR20170100A (fr) |
CU (1) | CU20170029A7 (fr) |
DO (1) | DOP2017000078A (fr) |
EA (1) | EA032401B1 (fr) |
EC (1) | ECSP17016797A (fr) |
IL (1) | IL251071A0 (fr) |
MA (1) | MA39484A (fr) |
MX (1) | MX2017003664A (fr) |
NI (1) | NI201700034A (fr) |
PE (1) | PE20170697A1 (fr) |
PH (1) | PH12017500509A1 (fr) |
SG (1) | SG11201702082VA (fr) |
TN (1) | TN2017000092A1 (fr) |
TW (1) | TW201615636A (fr) |
UY (1) | UY36311A (fr) |
WO (1) | WO2016042084A1 (fr) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA111754C2 (uk) | 2011-10-06 | 2016-06-10 | Байєр Фарма Акцієнгезелльшафт | Заміщені бензиліндазоли для застосування як інгібіторів bub1-кінази для лікування гіперпроліферативних захворювань |
EP3822273B1 (fr) | 2012-06-13 | 2024-04-10 | Incyte Holdings Corporation | Composés tricycliques substitués servant d'inhibiteurs des fgfr |
TWI649318B (zh) | 2013-04-19 | 2019-02-01 | 英塞特控股公司 | 作為fgfr抑制劑之雙環雜環 |
US9745285B2 (en) | 2013-06-21 | 2017-08-29 | Bayer Pharma Aktiengesellschaft | Heteroaryl substituted pyrazoles |
JP2016525076A (ja) | 2013-06-21 | 2016-08-22 | バイエル ファーマ アクチエンゲゼルシャフト | 置換されたベンジルピラゾール類 |
JP2016536311A (ja) | 2013-10-30 | 2016-11-24 | バイエル ファーマ アクチエンゲゼルシャフト | ヘテロアリール置換ピラゾール類 |
CN109851610B (zh) | 2014-02-06 | 2021-09-21 | 赫普泰雅治疗有限公司 | 作为毒蕈碱m1和/或m4受体激动剂的双环氮杂化合物 |
AR100886A1 (es) | 2014-06-17 | 2016-11-09 | Bayer Pharma AG | 3-amino-1,5,6,7-tetrahidro-4h-indol-4-onas |
PE20170697A1 (es) | 2014-09-19 | 2017-06-24 | Bayer Pharma AG | Indazoles sustituidos con benzilo como inhibidores de bub1 |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
PE20171514A1 (es) | 2015-02-20 | 2017-10-20 | Incyte Corp | Heterociclos biciclicos como inhibidores de fgfr |
MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
WO2018122168A1 (fr) | 2016-12-29 | 2018-07-05 | Bayer Pharma Aktiengesellschaft | Combinaisons d'inhibiteurs de kinase bub1 et d'inhibiteurs de parp |
WO2018158175A1 (fr) | 2017-02-28 | 2018-09-07 | Bayer Pharma Aktiengesellschaft | Combinaison d'inhibiteurs de bub1 |
KR102615821B1 (ko) | 2017-04-11 | 2023-12-21 | 선샤인 레이크 파르마 컴퍼니 리미티드 | 불소-치환된 인다졸 화합물 및 이의 용도 |
WO2018206547A1 (fr) | 2017-05-12 | 2018-11-15 | Bayer Pharma Aktiengesellschaft | Combinaison d'inhibiteurs de bub1 et d'atr |
WO2018215282A1 (fr) | 2017-05-26 | 2018-11-29 | Bayer Pharma Aktiengesellschaft | Combinaison d'inhibiteurs de bub1 et de pi3k |
AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
AU2019262195A1 (en) | 2018-05-04 | 2020-12-24 | Incyte Corporation | Solid forms of an FGFR inhibitor and processes for preparing the same |
CR20200591A (es) | 2018-05-04 | 2021-03-31 | Incyte Corp | Sales de un inhibidor de fgfr |
WO2020185532A1 (fr) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Méthodes de traitement du cancer au moyen d'un inhibiteur de fgfr |
US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
MX2022004513A (es) | 2019-10-14 | 2022-07-19 | Incyte Corp | Heterociclos biciclicos como inhibidores de los receptores del factor de crecimiento de fibroblastos (fgfr). |
US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
PE20221504A1 (es) | 2019-12-04 | 2022-09-30 | Incyte Corp | Derivados de un inhibidor de fgfr |
EP4069696A1 (fr) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Hétérocycles tricycliques en tant qu'inhibiteurs de fgfr |
WO2022261160A1 (fr) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Hétérocycles tricycliques en tant qu'inhibiteurs de fgfr |
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BR0314196A (pt) | 2002-09-10 | 2005-07-26 | Scios Inc | Inibidores de tgf-beta |
DE10244810A1 (de) | 2002-09-26 | 2004-04-08 | Bayer Ag | Neue Morpholin-überbrückte Indazolderivate |
US8748601B2 (en) | 2003-04-11 | 2014-06-10 | The Regents Of The University Of California | Selective serine/threonine kinase inhibitors |
EP1709007A1 (fr) | 2004-01-22 | 2006-10-11 | Altana Pharma AG | N-4-(6-(hetero)aryle-pyrimidine-4-ylaminophenyle)-bezenesulfonamides en tant qu'inhibiteurs de kinase |
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DE102006043443A1 (de) | 2006-09-15 | 2008-03-27 | Bayer Healthcare Ag | Neue aza-bicyclische Verbindungen und ihre Verwendung |
AU2008253311A1 (en) | 2007-05-18 | 2008-11-27 | Bayer Schering Pharma Aktiengesellshaft | Inhibitors of hypoxia inducible factor (HIF) useful for treating hyper-proliferative disorders and diseases associated with angiogenesis |
JP2010111624A (ja) | 2008-11-06 | 2010-05-20 | Shionogi & Co Ltd | Ttk阻害作用を有するインダゾール誘導体 |
ES2630026T3 (es) | 2008-12-18 | 2017-08-17 | Nerviano Medical Sciences S.R.L. | Derivados indazólicos sustituidos activos como inhibidores de cinasa |
EP2491033A4 (fr) | 2009-10-20 | 2013-03-13 | Eiger Biopharmaceuticals Inc | Azaindazoles pour traiter une infection par le virus flaviviridae |
AU2010323227B2 (en) | 2009-11-27 | 2015-11-19 | Adverio Pharma Gmbh | Method for producing methyl-{4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridino-3-yl]pyrimidino-5-yl}methyl carbamate and its purification for use thereof as pharmaceutical substance |
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KR101813931B1 (ko) | 2010-06-30 | 2018-01-02 | 아이언우드 파마슈티컬스, 인코포레이티드 | Sgc 자극제 |
UA111754C2 (uk) | 2011-10-06 | 2016-06-10 | Байєр Фарма Акцієнгезелльшафт | Заміщені бензиліндазоли для застосування як інгібіторів bub1-кінази для лікування гіперпроліферативних захворювань |
EP2794596B1 (fr) | 2011-12-21 | 2017-05-31 | Bayer Intellectual Property GmbH | Benzylpyrazoles substitués |
CA2861804C (fr) | 2011-12-27 | 2021-10-26 | Ironwood Pharmaceuticals, Inc. | Pyrazoles 2-benzyle, 3-(pyrimidin-2-yle)-substitues utiles comme stimulateurs de scg |
US20150141372A1 (en) | 2012-05-11 | 2015-05-21 | Bayer Pharma Aktiengesellschaft | Substituted cycloalkenopyrazoles as bub1 inhibitors for the treatment of cancer |
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US9487508B2 (en) | 2012-09-19 | 2016-11-08 | Ironwood Pharmaceuticals, Inc. | SGC stimulators |
US9738610B2 (en) | 2012-09-24 | 2017-08-22 | Whitehead Institute For Biomedical Research | Indazole derivatives and uses thereof |
EP2976334A1 (fr) | 2013-03-21 | 2016-01-27 | Bayer Pharma Aktiengesellschaft | Indazoles substitués par diaminohétéroaryle |
US20160046610A1 (en) | 2013-03-21 | 2016-02-18 | Bayer Pharma Aktiengesellschaft | 3-heteroaryl substituted indazoles |
EP2976335A1 (fr) | 2013-03-21 | 2016-01-27 | Bayer Pharma Aktiengesellschaft | Indazoles substitués par hétéroaryle |
JP2016525076A (ja) | 2013-06-21 | 2016-08-22 | バイエル ファーマ アクチエンゲゼルシャフト | 置換されたベンジルピラゾール類 |
CN105452236A (zh) | 2013-06-21 | 2016-03-30 | 拜耳制药股份公司 | 取代的苄基吡唑 |
US9745285B2 (en) | 2013-06-21 | 2017-08-29 | Bayer Pharma Aktiengesellschaft | Heteroaryl substituted pyrazoles |
JP2016522232A (ja) | 2013-06-21 | 2016-07-28 | バイエル ファーマ アクチエンゲゼルシャフト | ヘテロアリール置換されたピラゾール類 |
CA2916103A1 (fr) | 2013-06-21 | 2014-12-24 | Bayer Pharma Aktiengesellschaft | Pyrazoles a substitution diaminoheteroaryle |
JP2016536311A (ja) | 2013-10-30 | 2016-11-24 | バイエル ファーマ アクチエンゲゼルシャフト | ヘテロアリール置換ピラゾール類 |
PE20170697A1 (es) | 2014-09-19 | 2017-06-24 | Bayer Pharma AG | Indazoles sustituidos con benzilo como inhibidores de bub1 |
PT3447050T (pt) | 2014-09-19 | 2020-09-17 | Forma Therapeutics Inc | Derivados da piridin-2(1h)-ona-quinolinona como inibidores da isocitrato-desidrogenase mutante |
EP3194381A1 (fr) | 2014-09-19 | 2017-07-26 | Bayer Pharma Aktiengesellschaft | Indazoles substitués par benzyle comme inhibiteurs de bub1 kinase |
CA2960347A1 (fr) | 2014-09-19 | 2016-03-24 | Yuanlong Pan | Traitement d'un cancer avec un inhibiteur de l'alpha-amylase chez les animaux de compagnie |
EP3194384A1 (fr) | 2014-09-19 | 2017-07-26 | GlaxoSmithKline Intellectual Property Development Limited | Nouveaux activateurs de la guanylate cyclase soluble et leur utilisation |
WO2016042080A1 (fr) | 2014-09-19 | 2016-03-24 | Bayer Pharma Aktiengesellschaft | Indazoles substitués par benzyle comme inhibiteurs de bub1 kinase |
US20170275270A1 (en) | 2014-09-19 | 2017-09-28 | Bayer Pharma Aktiengesellschaft | Benzyl substituted indazoles |
WO2017148995A1 (fr) | 2016-03-04 | 2017-09-08 | Bayer Pharma Aktiengesellschaft | 1-(pyrimidin-2-yl)-1h-indazoles possédant une activité d'inhibition de la kinase bub1 |
WO2017157991A1 (fr) | 2016-03-18 | 2017-09-21 | Bayer Pharma Aktiengesellschaft | 1-alkyl-pyrazoles et 1-alkyl-indazoles utilisés en tant qu'inhibiteurs de bub1 pour le traitement de maladies hyperprolifératives |
WO2017157992A1 (fr) | 2016-03-18 | 2017-09-21 | Bayer Pharma Aktiengesellschaft | Pyrazoles annelés utilisés en tant qu'inhibiteurs de kinase bub1 pour le traitement de troubles prolifératifs |
WO2018122168A1 (fr) | 2016-12-29 | 2018-07-05 | Bayer Pharma Aktiengesellschaft | Combinaisons d'inhibiteurs de kinase bub1 et d'inhibiteurs de parp |
WO2018158175A1 (fr) | 2017-02-28 | 2018-09-07 | Bayer Pharma Aktiengesellschaft | Combinaison d'inhibiteurs de bub1 |
WO2018206547A1 (fr) | 2017-05-12 | 2018-11-15 | Bayer Pharma Aktiengesellschaft | Combinaison d'inhibiteurs de bub1 et d'atr |
WO2018215282A1 (fr) | 2017-05-26 | 2018-11-29 | Bayer Pharma Aktiengesellschaft | Combinaison d'inhibiteurs de bub1 et de pi3k |
-
2015
- 2015-09-17 PE PE2017000480A patent/PE20170697A1/es unknown
- 2015-09-17 EA EA201790649A patent/EA032401B1/ru not_active IP Right Cessation
- 2015-09-17 CR CR20170100A patent/CR20170100A/es unknown
- 2015-09-17 CU CUP2017000029A patent/CU20170029A7/xx unknown
- 2015-09-17 KR KR1020177010425A patent/KR20170049604A/ko unknown
- 2015-09-17 EP EP15763619.2A patent/EP3194379A1/fr not_active Withdrawn
- 2015-09-17 CN CN201580062951.4A patent/CN107001331A/zh active Pending
- 2015-09-17 BR BR112017005444A patent/BR112017005444A2/pt not_active IP Right Cessation
- 2015-09-17 TN TN2017000092A patent/TN2017000092A1/en unknown
- 2015-09-17 AP AP2017009803A patent/AP2017009803A0/en unknown
- 2015-09-17 MA MA039484A patent/MA39484A/fr unknown
- 2015-09-17 MX MX2017003664A patent/MX2017003664A/es unknown
- 2015-09-17 US US15/512,494 patent/US10350206B2/en not_active Expired - Fee Related
- 2015-09-17 WO PCT/EP2015/071340 patent/WO2016042084A1/fr active Application Filing
- 2015-09-17 JP JP2017514825A patent/JP6664385B2/ja not_active Expired - Fee Related
- 2015-09-17 SG SG11201702082VA patent/SG11201702082VA/en unknown
- 2015-09-17 AU AU2015316796A patent/AU2015316796A1/en not_active Abandoned
- 2015-09-17 CA CA2961589A patent/CA2961589A1/fr not_active Abandoned
- 2015-09-18 TW TW104131025A patent/TW201615636A/zh unknown
- 2015-09-18 UY UY0001036311A patent/UY36311A/es not_active Application Discontinuation
-
2017
- 2017-03-09 IL IL251071A patent/IL251071A0/en unknown
- 2017-03-16 PH PH12017500509A patent/PH12017500509A1/en unknown
- 2017-03-17 EC ECIEPI201716797A patent/ECSP17016797A/es unknown
- 2017-03-17 DO DO2017000078A patent/DOP2017000078A/es unknown
- 2017-03-17 CL CL2017000654A patent/CL2017000654A1/es unknown
- 2017-03-17 CO CONC2017/0002532A patent/CO2017002532A2/es unknown
- 2017-03-17 NI NI201700034A patent/NI201700034A/es unknown
Also Published As
Publication number | Publication date |
---|---|
MA39484A (fr) | 2016-03-24 |
WO2016042084A1 (fr) | 2016-03-24 |
CA2961589A1 (fr) | 2016-03-24 |
IL251071A0 (en) | 2017-04-30 |
EA201790649A1 (ru) | 2017-09-29 |
AU2015316796A1 (en) | 2017-03-30 |
CN107001331A (zh) | 2017-08-01 |
SG11201702082VA (en) | 2017-04-27 |
MX2017003664A (es) | 2017-07-13 |
NI201700034A (es) | 2017-06-16 |
TN2017000092A1 (en) | 2018-07-04 |
CO2017002532A2 (es) | 2017-07-11 |
US20170273980A1 (en) | 2017-09-28 |
EA032401B1 (ru) | 2019-05-31 |
DOP2017000078A (es) | 2017-06-30 |
JP2017530962A (ja) | 2017-10-19 |
US10350206B2 (en) | 2019-07-16 |
PH12017500509A1 (en) | 2017-08-30 |
ECSP17016797A (es) | 2017-05-31 |
CL2017000654A1 (es) | 2017-12-11 |
AP2017009803A0 (en) | 2017-03-31 |
KR20170049604A (ko) | 2017-05-10 |
PE20170697A1 (es) | 2017-06-24 |
JP6664385B2 (ja) | 2020-03-13 |
EP3194379A1 (fr) | 2017-07-26 |
TW201615636A (zh) | 2016-05-01 |
UY36311A (es) | 2016-04-29 |
CR20170100A (es) | 2017-04-24 |
BR112017005444A2 (pt) | 2018-04-24 |
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