CS991A2 - Azaoxindole derivatives and method of their production - Google Patents

Azaoxindole derivatives and method of their production Download PDF

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Publication number
CS991A2
CS991A2 CS919A CS991A CS991A2 CS 991 A2 CS991 A2 CS 991A2 CS 919 A CS919 A CS 919A CS 991 A CS991 A CS 991A CS 991 A2 CS991 A2 CS 991A2
Authority
CS
Czechoslovakia
Prior art keywords
carbon atoms
alkyl
phenyl
formula
mmol
Prior art date
Application number
CS919A
Other languages
Czech (cs)
English (en)
Inventor
Ralph P Robison
Anthony Marfat
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CS991A2 publication Critical patent/CS991A2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CS919A 1990-01-05 1991-01-04 Azaoxindole derivatives and method of their production CS991A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1990/000107 WO1991009598A1 (fr) 1990-01-05 1990-01-05 Derives de l'azaoxindole

Publications (1)

Publication Number Publication Date
CS991A2 true CS991A2 (en) 1991-09-15

Family

ID=22220612

Family Applications (1)

Application Number Title Priority Date Filing Date
CS919A CS991A2 (en) 1990-01-05 1991-01-04 Azaoxindole derivatives and method of their production

Country Status (19)

Country Link
EP (1) EP0436333A3 (fr)
JP (1) JPH0826018B2 (fr)
KR (1) KR930005447B1 (fr)
CN (1) CN1031053C (fr)
AU (1) AU635593B2 (fr)
BR (1) BR9100046A (fr)
CA (1) CA2033531C (fr)
CS (1) CS991A2 (fr)
FI (1) FI922347A0 (fr)
IE (1) IE910022A1 (fr)
IL (1) IL96819A0 (fr)
MY (1) MY109722A (fr)
NO (1) NO922634D0 (fr)
NZ (1) NZ236582A (fr)
PL (2) PL166512B1 (fr)
PT (1) PT96411B (fr)
WO (1) WO1991009598A1 (fr)
YU (1) YU47728B (fr)
ZA (1) ZA9172B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1625192A (en) * 1991-05-31 1992-12-03 Zeneca Limited Heterocyclic derivatives
GB9226855D0 (en) * 1992-12-23 1993-02-17 Erba Carlo Spa Vinylene-azaindole derivatives and process for their preparation
US5618819A (en) * 1994-07-07 1997-04-08 Adir Et Compagnie 1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-(3H)-one compounds
FR2722196B1 (fr) * 1994-07-07 1996-08-23 Adir Nouveaux derives amines de 1,3-dihydro-2h-pyrrolo(2,3-b) pyridin-2-ones et oxazolo(4,5-b) pyridin-2 (3h)-ones, leur procede de preparation et les compositions pharmaceutique qui les contiennent
FR2722195B1 (fr) * 1994-07-07 1996-08-23 Adir Nouveaux derives de 1,3-dihydro-2h-pyrrolo(2,3-b) pyridin-2-ones et oxazolo(4,5-b) pyridin-2(3h)-ones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5939069A (en) 1996-08-23 1999-08-17 University Of Florida Materials and methods for detection and treatment of immune system dysfunctions
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
DK1157019T3 (da) * 1998-12-17 2003-07-14 Hoffmann La Roche 4-alkenyl- (og alkynyl-)oxindoler som inhibitorer af cyklinafhængige kinaser, især CDK2
AU760039B2 (en) 1998-12-17 2003-05-08 F. Hoffmann-La Roche Ag 4-aryloxindoles as inhibitors of JNK protein kinases
WO2000035921A1 (fr) 1998-12-17 2000-06-22 F. Hoffmann-La Roche Ag 4,5-pyrazinoxindoles comme inhibiteurs de proteine kinase
US6153634A (en) * 1998-12-17 2000-11-28 Hoffmann-La Roche Inc. 4,5-azolo-oxindoles
GB9904933D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US6492398B1 (en) 1999-03-04 2002-12-10 Smithkline Beechman Corporation Thiazoloindolinone compounds
US6624171B1 (en) 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
US6313310B1 (en) 1999-12-15 2001-11-06 Hoffmann-La Roche Inc. 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles
ATE299881T1 (de) 1999-12-21 2005-08-15 Sugen Inc 4-substituierte 7-aza-indolin-2-one und ihre anwendung als protein kinase inhibitoren
US6620818B1 (en) 2000-03-01 2003-09-16 Smithkline Beecham Corporation Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
TWI262920B (en) 2000-10-27 2006-10-01 Elbion Ag New 7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them
DE10053275A1 (de) * 2000-10-27 2002-05-02 Dresden Arzneimittel Neue 7-Azaindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
US7186745B2 (en) 2001-03-06 2007-03-06 Astrazeneca Ab Indolone derivatives having vascular damaging activity
JP2005534619A (ja) * 2002-03-28 2005-11-17 エーザイ株式会社 Ｃ−ｊｕｎｎ−末端キナーゼ阻害剤としてのアザインドール
RU2006147278A (ru) 2004-06-09 2008-07-20 Глэксо Груп Лимитед (GB) Производные пирролопиридина
US7906528B2 (en) * 2004-10-05 2011-03-15 Novartis International Pharmaceutical Ltd. Pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds
WO2009147476A1 (fr) * 2008-06-02 2009-12-10 Matrix Laboratories Ltd. Nouveaux inhibiteurs de phosphodiestérases, compositions pharmaceutiques les contenant et leurs procédés de préparation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
US4569942A (en) * 1984-05-04 1986-02-11 Pfizer Inc. N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
EP0208510B1 (fr) * 1985-07-09 1991-09-11 Pfizer Inc. Oxindole-3-carboxamines substituées utilisées analgésiques et anti-inflammatoires
EP0419561A1 (fr) * 1988-06-14 1991-04-03 Schering Corporation Composes heterobicycliques presentant une activite anti-inflammatoire

Also Published As

Publication number Publication date
CA2033531C (fr) 1998-06-23
KR910014375A (ko) 1991-08-31
PT96411A (pt) 1991-10-15
PL165653B1 (pl) 1995-01-31
YU47728B (sh) 1996-01-08
IE910022A1 (en) 1991-07-17
PT96411B (pt) 1999-04-30
YU791A (sh) 1994-01-20
AU635593B2 (en) 1993-03-25
MY109722A (en) 1997-05-31
CN1031053C (zh) 1996-02-21
NO922634L (no) 1992-07-03
ZA9172B (en) 1992-10-28
IL96819A0 (en) 1991-09-16
JPH0826018B2 (ja) 1996-03-13
PL288598A1 (en) 1991-12-02
FI922347A (fi) 1992-05-22
AU6860691A (en) 1992-03-05
NZ236582A (en) 1993-10-26
FI922347A0 (fi) 1992-05-22
BR9100046A (pt) 1991-10-22
PL166512B1 (pl) 1995-05-31
CN1053065A (zh) 1991-07-17
JPH04210981A (ja) 1992-08-03
EP0436333A2 (fr) 1991-07-10
WO1991009598A1 (fr) 1991-07-11
NO922634D0 (no) 1992-07-03
CA2033531A1 (fr) 1991-07-06
EP0436333A3 (en) 1992-05-27
KR930005447B1 (ko) 1993-06-22

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