CS88091A2 - Pharmaceuticals - Google Patents
Pharmaceuticals Download PDFInfo
- Publication number
- CS88091A2 CS88091A2 CS91880A CS88091A CS88091A2 CS 88091 A2 CS88091 A2 CS 88091A2 CS 91880 A CS91880 A CS 91880A CS 88091 A CS88091 A CS 88091A CS 88091 A2 CS88091 A2 CS 88091A2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- pharmaceutical composition
- composition according
- lecithin
- biologically active
- phospholipid
- Prior art date
Links
- 239000003814 drug Substances 0.000 title description 7
- 239000000203 mixture Substances 0.000 claims abstract description 95
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims abstract description 48
- 235000010445 lecithin Nutrition 0.000 claims abstract description 47
- 239000000787 lecithin Substances 0.000 claims abstract description 47
- 150000003904 phospholipids Chemical class 0.000 claims abstract description 44
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 33
- 229940125396 insulin Drugs 0.000 claims abstract description 25
- 102000004877 Insulin Human genes 0.000 claims abstract description 23
- 108090001061 Insulin Proteins 0.000 claims abstract description 23
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 claims abstract description 23
- 102000018997 Growth Hormone Human genes 0.000 claims abstract description 9
- 108010051696 Growth Hormone Proteins 0.000 claims abstract description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol Substances OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 6
- 102000003951 Erythropoietin Human genes 0.000 claims abstract description 5
- 108090000394 Erythropoietin Proteins 0.000 claims abstract description 5
- 229940105423 erythropoietin Drugs 0.000 claims abstract description 5
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims abstract description 5
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 46
- 229940067606 lecithin Drugs 0.000 claims description 46
- 229940067631 phospholipid Drugs 0.000 claims description 42
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 32
- 239000002243 precursor Substances 0.000 claims description 30
- 239000013543 active substance Substances 0.000 claims description 27
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- 235000012000 cholesterol Nutrition 0.000 claims description 17
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- 239000003381 stabilizer Substances 0.000 claims description 8
- 125000004432 carbon atom Chemical group C* 0.000 claims description 7
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- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 claims description 5
- 102000002265 Human Growth Hormone Human genes 0.000 claims description 5
- 108010000521 Human Growth Hormone Proteins 0.000 claims description 5
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- 239000003963 antioxidant agent Substances 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 5
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- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims description 3
- NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 claims description 3
- BIABMEZBCHDPBV-MPQUPPDSSA-N 1,2-palmitoyl-sn-glycero-3-phospho-(1'-sn-glycerol) Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCCCC BIABMEZBCHDPBV-MPQUPPDSSA-N 0.000 claims description 3
- 229960005160 dimyristoylphosphatidylglycerol Drugs 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 238000011321 prophylaxis Methods 0.000 claims description 3
- 238000005507 spraying Methods 0.000 claims description 3
- 108091005804 Peptidases Proteins 0.000 claims description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 2
- 125000002252 acyl group Chemical group 0.000 claims description 2
- 239000004599 antimicrobial Substances 0.000 claims description 2
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims description 2
- 229960001231 choline Drugs 0.000 claims description 2
- 229960003724 dimyristoylphosphatidylcholine Drugs 0.000 claims description 2
- BPHQZTVXXXJVHI-AJQTZOPKSA-N ditetradecanoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCC BPHQZTVXXXJVHI-AJQTZOPKSA-N 0.000 claims description 2
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- 230000002335 preservative effect Effects 0.000 claims 3
- SLKDGVPOSSLUAI-PGUFJCEWSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine zwitterion Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCN)OC(=O)CCCCCCCCCCCCCCC SLKDGVPOSSLUAI-PGUFJCEWSA-N 0.000 claims 2
- LVNGJLRDBYCPGB-UHFFFAOYSA-N 1,2-distearoylphosphatidylethanolamine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(COP([O-])(=O)OCC[NH3+])OC(=O)CCCCCCCCCCCCCCCCC LVNGJLRDBYCPGB-UHFFFAOYSA-N 0.000 claims 2
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims 2
- NEZDNQCXEZDCBI-UHFFFAOYSA-N 2-azaniumylethyl 2,3-di(tetradecanoyloxy)propyl phosphate Chemical compound CCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCCN)OC(=O)CCCCCCCCCCCCC NEZDNQCXEZDCBI-UHFFFAOYSA-N 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- CITHEXJVPOWHKC-UUWRZZSWSA-N 1,2-di-O-myristoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCC CITHEXJVPOWHKC-UUWRZZSWSA-N 0.000 claims 1
- OZSITQMWYBNPMW-GDLZYMKVSA-N 1,2-ditetradecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCC OZSITQMWYBNPMW-GDLZYMKVSA-N 0.000 claims 1
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909007052A GB9007052D0 (en) | 1990-03-29 | 1990-03-29 | Pharmaceutical formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS88091A2 true CS88091A2 (en) | 1991-11-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS91880A CS88091A2 (en) | 1990-03-29 | 1991-03-29 | Pharmaceuticals |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5665700A (no) |
| EP (1) | EP0521994B1 (no) |
| JP (1) | JPH05505192A (no) |
| KR (1) | KR100197915B1 (no) |
| AT (1) | ATE154515T1 (no) |
| AU (1) | AU656134B2 (no) |
| CA (1) | CA2079233A1 (no) |
| CS (1) | CS88091A2 (no) |
| DE (1) | DE69126609T2 (no) |
| DK (1) | DK0521994T3 (no) |
| ES (1) | ES2104697T3 (no) |
| FI (1) | FI101043B (no) |
| GB (1) | GB9007052D0 (no) |
| GR (1) | GR3024745T3 (no) |
| HK (1) | HK1004531A1 (no) |
| HU (2) | HUT63341A (no) |
| IE (1) | IE911086A1 (no) |
| NO (1) | NO923768D0 (no) |
| NZ (1) | NZ237667A (no) |
| PT (1) | PT97199B (no) |
| RU (1) | RU2104715C1 (no) |
| SG (1) | SG54998A1 (no) |
| WO (1) | WO1991014454A1 (no) |
| ZA (1) | ZA912411B (no) |
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| GB1180996A (en) * | 1967-08-30 | 1970-02-11 | Inst Rech S Chimiques Et Biolo | Solubilised Cytochrome C-phospholipid Complexes |
| US4164573A (en) * | 1975-06-13 | 1979-08-14 | Galinsky Alvin M | Composition and method for making a suppository for introducing a hypoglycemic agent into a mammal |
| JPS5517328A (en) * | 1978-07-21 | 1980-02-06 | Tanabe Seiyaku Co Ltd | Insulin-containing emulsion and its preparation |
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| NL193099C (nl) * | 1981-10-30 | 1998-11-03 | Novo Industri As | Gestabiliseerde insuline-oplossing. |
| JPS6058915A (ja) * | 1983-09-12 | 1985-04-05 | Fujisawa Pharmaceut Co Ltd | 薬物含有脂質小胞体製剤 |
| FR2581543B1 (fr) * | 1985-05-09 | 1989-07-07 | Tressens Dominique | Pharmacotechnie permettant la realisation d'une preparation insulinique active par voie orale |
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| NZ222907A (en) * | 1986-12-16 | 1990-08-28 | Novo Industri As | Preparation for intranasal administration containing a phospholipid absorption enhancing system |
| AU598958B2 (en) * | 1987-11-12 | 1990-07-05 | Vestar, Inc. | Improved amphotericin b liposome preparation |
-
1990
- 1990-03-29 GB GB909007052A patent/GB9007052D0/en active Pending
-
1991
- 1991-03-28 IE IE108691A patent/IE911086A1/en unknown
- 1991-03-28 PT PT97199A patent/PT97199B/pt not_active IP Right Cessation
- 1991-03-28 ZA ZA912411A patent/ZA912411B/xx unknown
- 1991-03-29 CS CS91880A patent/CS88091A2/cs unknown
- 1991-04-02 DK DK91907052.4T patent/DK0521994T3/da active
- 1991-04-02 SG SG1996000854A patent/SG54998A1/en unknown
- 1991-04-02 ES ES91907052T patent/ES2104697T3/es not_active Expired - Lifetime
- 1991-04-02 AU AU75842/91A patent/AU656134B2/en not_active Ceased
- 1991-04-02 DE DE69126609T patent/DE69126609T2/de not_active Revoked
- 1991-04-02 JP JP3506507A patent/JPH05505192A/ja active Pending
- 1991-04-02 AT AT91907052T patent/ATE154515T1/de not_active IP Right Cessation
- 1991-04-02 CA CA002079233A patent/CA2079233A1/en not_active Abandoned
- 1991-04-02 HU HU9330A patent/HUT63341A/hu unknown
- 1991-04-02 WO PCT/GB1991/000510 patent/WO1991014454A1/en not_active Ceased
- 1991-04-02 KR KR1019920070234A patent/KR100197915B1/ko not_active Expired - Lifetime
- 1991-04-02 EP EP91907052A patent/EP0521994B1/en not_active Revoked
- 1991-04-02 HK HK98103678A patent/HK1004531A1/en not_active IP Right Cessation
- 1991-04-02 RU SU5053188A patent/RU2104715C1/ru active
- 1991-04-03 NZ NZ237667A patent/NZ237667A/en unknown
-
1992
- 1992-09-28 NO NO923768A patent/NO923768D0/no unknown
- 1992-09-28 FI FI924340A patent/FI101043B/fi active
-
1994
- 1994-08-15 US US08/290,293 patent/US5665700A/en not_active Expired - Fee Related
-
1995
- 1995-06-30 HU HU95P/P00724P patent/HU211962A9/hu unknown
-
1997
- 1997-09-17 GR GR970402390T patent/GR3024745T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU7584291A (en) | 1991-10-21 |
| FI924340A0 (fi) | 1992-09-28 |
| NO923768L (no) | 1992-09-28 |
| FI924340L (fi) | 1992-09-28 |
| ES2104697T3 (es) | 1997-10-16 |
| US5665700A (en) | 1997-09-09 |
| RU2104715C1 (ru) | 1998-02-20 |
| SG54998A1 (en) | 1998-12-21 |
| EP0521994A1 (en) | 1993-01-13 |
| PT97199B (pt) | 1998-07-31 |
| IE911086A1 (en) | 1991-10-09 |
| NZ237667A (en) | 1994-01-26 |
| ZA912411B (en) | 1992-11-25 |
| AU656134B2 (en) | 1995-01-27 |
| GB9007052D0 (en) | 1990-05-30 |
| NO923768D0 (no) | 1992-09-28 |
| JPH05505192A (ja) | 1993-08-05 |
| PT97199A (pt) | 1991-11-29 |
| HK1004531A1 (en) | 1998-11-27 |
| HUT63341A (en) | 1993-08-30 |
| HU9203093D0 (en) | 1992-12-28 |
| DE69126609D1 (de) | 1997-07-24 |
| KR100197915B1 (ko) | 1999-06-15 |
| FI101043B (fi) | 1998-04-15 |
| HU211962A9 (en) | 1996-01-29 |
| DK0521994T3 (da) | 1997-07-07 |
| WO1991014454A1 (en) | 1991-10-03 |
| CA2079233A1 (en) | 1991-09-30 |
| GR3024745T3 (en) | 1997-12-31 |
| DE69126609T2 (de) | 1998-01-02 |
| ATE154515T1 (de) | 1997-07-15 |
| EP0521994B1 (en) | 1997-06-18 |
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