CS241070B2 - Method of cepheme derivatives' crystalline acid-forming addition salts' production - Google Patents

Method of cepheme derivatives' crystalline acid-forming addition salts' production Download PDF

Info

Publication number
CS241070B2
CS241070B2 CS839974A CS997483A CS241070B2 CS 241070 B2 CS241070 B2 CS 241070B2 CS 839974 A CS839974 A CS 839974A CS 997483 A CS997483 A CS 997483A CS 241070 B2 CS241070 B2 CS 241070B2
Authority
CS
Czechoslovakia
Prior art keywords
formula
acid
compound
anion
water
Prior art date
Application number
CS839974A
Other languages
Czech (cs)
English (en)
Other versions
CS997483A2 (en
Inventor
Walter Duerckheimer
Rudolf Lattrell
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of CS997483A2 publication Critical patent/CS997483A2/cs
Publication of CS241070B2 publication Critical patent/CS241070B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CS839974A 1982-12-28 1983-12-27 Method of cepheme derivatives' crystalline acid-forming addition salts' production CS241070B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823248281 DE3248281A1 (de) 1982-12-28 1982-12-28 Kristalisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
CS997483A2 CS997483A2 (en) 1985-07-16
CS241070B2 true CS241070B2 (en) 1986-03-13

Family

ID=6181953

Family Applications (2)

Application Number Title Priority Date Filing Date
CS839974A CS241070B2 (en) 1982-12-28 1983-12-27 Method of cepheme derivatives' crystalline acid-forming addition salts' production
CS914157A CS415791A3 (en) 1982-12-28 1991-12-30 Crystallizing acid addition salts of cephem

Family Applications After (1)

Application Number Title Priority Date Filing Date
CS914157A CS415791A3 (en) 1982-12-28 1991-12-30 Crystallizing acid addition salts of cephem

Country Status (28)

Country Link
US (1) US4609653A (da)
EP (1) EP0112550B1 (da)
JP (1) JPH0723382B2 (da)
KR (1) KR910000420B1 (da)
AR (1) AR245133A1 (da)
AT (1) ATE50261T1 (da)
AU (1) AU562714B2 (da)
CA (1) CA1235690A (da)
CS (2) CS241070B2 (da)
DD (1) DD215552A5 (da)
DE (2) DE3248281A1 (da)
DK (1) DK166211C (da)
DZ (1) DZ592A1 (da)
ES (1) ES8407495A1 (da)
FI (1) FI76094C (da)
GR (1) GR79444B (da)
HU (1) HU191385B (da)
IE (1) IE56488B1 (da)
IL (1) IL70544A (da)
MA (1) MA19990A1 (da)
NO (1) NO834824L (da)
NZ (1) NZ206704A (da)
OA (1) OA07622A (da)
PH (1) PH19269A (da)
PT (1) PT77896B (da)
SU (1) SU1292668A3 (da)
YU (1) YU43200B (da)
ZA (1) ZA839593B (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
JPS60142987A (ja) * 1983-12-29 1985-07-29 Mochida Pharmaceut Co Ltd セフアロスポリン誘導体
DE3485860T2 (de) * 1983-12-29 1993-01-14 Mochida Pharm Co Ltd Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate.
JPS60169486A (ja) * 1984-02-10 1985-09-02 Yamanouchi Pharmaceut Co Ltd ７−アミノ−３−置換メチル−３−セフエム−４−カルボン酸およびその低級アルキルシリル誘導体の製造法
JPH0649707B2 (ja) * 1985-03-01 1994-06-29 第一製薬株式会社 ３−ピリジニウムメチルセフエム誘導体
US4840945A (en) * 1985-04-01 1989-06-20 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
US5244891A (en) * 1985-08-05 1993-09-14 Bristol-Myers Squibb Company Injectable compositions of cefepime dihydrochloride hydrate
US4880798A (en) * 1986-11-25 1989-11-14 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
JPS63132893A (ja) * 1986-11-25 1988-06-04 Mochida Pharmaceut Co Ltd 新規セフアロスポリン誘導体、その製法およびそれらを有効成分とする抗菌剤
DE3706020A1 (de) * 1987-02-25 1988-09-08 Hoechst Ag Kristallisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung
DE4440141A1 (de) * 1994-11-10 1996-05-15 Hoechst Ag Neue kristalline Cephem-Säureadditionssalze und Verfahren zu ihrer Herstellung
TW526202B (en) 1998-11-27 2003-04-01 Shionogi & Amp Co Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity
BR0209065A (pt) * 2001-04-23 2004-08-10 Shionogi & Co Sulfato de composto de cefemo
AU2003275682A1 (en) * 2002-10-29 2004-05-25 Shionogi And Co., Ltd. Crystal of inorganic acid salt of cephem compound
CN101172982B (zh) * 2006-11-03 2011-06-08 河北凯盛医药科技有限公司 一种硫酸头孢匹罗的制备方法
WO2008056221A2 (en) * 2006-11-06 2008-05-15 Orchid Chemicals & Pharmaceuticals Limited Crystalline sulfate salt of cephalosporin antibiotic
CN101104621A (zh) * 2007-05-08 2008-01-16 深圳信立泰药业股份有限公司 制备高纯度硫酸头孢匹罗的工艺
CN101284840B (zh) * 2008-05-29 2012-07-04 管小明 硫酸头孢匹罗的合成方法
CN103044455B (zh) * 2011-10-17 2015-04-01 苏州中联化学制药有限公司 硫酸头孢匹罗混粉的返工方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS523091A (en) * 1975-06-23 1977-01-11 Takeda Chem Ind Ltd A prcess for preparing cephalosporins
FR2457295A1 (fr) * 1979-05-25 1980-12-19 Glaxo Group Ltd Composes intermediaires pour la preparation de cephalosporines
SE449996B (sv) * 1979-10-02 1987-06-01 Glaxo Group Ltd (6r,7r)-7-/(z)-2-(2-aminotiazol-4-yl)-2-(2-karboxiprop-2-oxiimino)acetamidol/-3-(1-pyridiniummetyl)cef-3-em-4-karboxylat i form av en kristallin bishydroklorid farmaceutisk komposition derav samt anvendning som mellanpr
ES8306160A1 (es) * 1981-04-03 1983-05-01 Fujisawa Pharmaceutical Co "procedimiento para preparar un nuevo compuesto de cefem".
DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
AU562714B2 (en) 1987-06-18
IL70544A (en) 1987-01-30
NO834824L (no) 1984-06-29
FI76094B (fi) 1988-05-31
IE833045L (en) 1984-06-28
ES528401A0 (es) 1984-09-16
HUT34211A (en) 1985-02-28
ES8407495A1 (es) 1984-09-16
AR245133A1 (es) 1993-12-30
DK166211C (da) 1993-08-16
DK600183A (da) 1984-06-29
FI834771A0 (fi) 1983-12-23
DD215552A5 (de) 1984-11-14
FI76094C (fi) 1988-09-09
CA1235690A (en) 1988-04-26
JPS59130888A (ja) 1984-07-27
ATE50261T1 (de) 1990-02-15
PT77896B (de) 1986-04-21
FI834771A (fi) 1984-06-29
EP0112550A3 (en) 1985-09-18
DZ592A1 (fr) 2004-09-13
GR79444B (da) 1984-10-30
KR840007016A (ko) 1984-12-04
ZA839593B (en) 1984-08-29
EP0112550B1 (de) 1990-02-07
OA07622A (fr) 1985-03-31
US4609653A (en) 1986-09-02
IE56488B1 (en) 1991-08-14
YU43200B (en) 1989-04-30
IL70544A0 (en) 1984-03-30
PT77896A (de) 1984-01-01
JPH0723382B2 (ja) 1995-03-15
DK166211B (da) 1993-03-22
DE3381201D1 (de) 1990-03-15
SU1292668A3 (ru) 1987-02-23
DE3248281A1 (de) 1984-06-28
PH19269A (en) 1986-02-21
DK600183D0 (da) 1983-12-27
HU191385B (en) 1987-02-27
MA19990A1 (fr) 1984-07-01
EP0112550A2 (de) 1984-07-04
KR910000420B1 (ko) 1991-01-25
YU251183A (en) 1986-06-30
NZ206704A (en) 1986-04-11
AU2289383A (en) 1984-07-05
CS997483A2 (en) 1985-07-16
CS415791A3 (en) 1992-07-15

Similar Documents

Publication Publication Date Title
CS241070B2 (en) Method of cepheme derivatives' crystalline acid-forming addition salts' production
AU615509B2 (en) Temperature stable crystalline salts of 7-(alpha-(2- aminothiazol-4-yl)-alpha-(Z)-methoxyiminoacetamidol)-3- ((1-methyl-1-pyrrolidino)methyl)-3-cephem-4-carboxylate
SU1367858A3 (ru) Способ получени производных цефалоспорина
US4845087A (en) Crystallized cephem-acid addition salts, and a process for the preparation thereof
DE3233377A1 (de) Cephalosporinisochinoliniumbetaine und sie enthaltende pharmazeutische mittel
EP0157538A2 (en) Improvements in or relating to crystalline ceftazidime salts
IE862078L (en) Cephalosporin salts
CS247168B2 (en) Method of new carbapenem derivatives production
GB2062640A (en) Fosfomycin salt
EP0449515B1 (en) Novel cephalosporin intermediates and process for preparing the intermediates and their end products
DE3783048T2 (de) Verfahren zur herstellung von cephalosporinverbindungen.
US5332731A (en) Cephalosporin derivatives
US4668782A (en) Anhydrous crystalline or crystalline hemihydrate monohydrate or trihydrate of cephalosporin derivative
EP0261990B1 (en) Crystalline cephem carboxylic acid addition salt
US4857521A (en) Trialkylsilyl pyridinium cephalosporin antibiotics
US4626533A (en) 7-(2-thienylacetamido)-3-acylaminomethyl-cephalosporins
CH562253A5 (en) 3-(5-mercapto-thiadiazolyl thiomethyl)-7-tetrazolylalkanamido - -3-cephem-4-carboxylic acids - useful as antibacterial agents