CS235334B2 - Method of 1,4-dihydropyridines production - Google Patents

Method of 1,4-dihydropyridines production Download PDF

Info

Publication number
CS235334B2
CS235334B2 CS835483A CS548383A CS235334B2 CS 235334 B2 CS235334 B2 CS 235334B2 CS 835483 A CS835483 A CS 835483A CS 548383 A CS548383 A CS 548383A CS 235334 B2 CS235334 B2 CS 235334B2
Authority
CS
Czechoslovakia
Prior art keywords
methyl
formula
residue
radical
compounds
Prior art date
Application number
CS835483A
Other languages
Czech (cs)
English (en)
Inventor
Simon F Campbell
Peter E Cross
John K Stubbs
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CS235334B2 publication Critical patent/CS235334B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Manufacture Of Tobacco Products (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
CS835483A 1982-07-22 1983-07-21 Method of 1,4-dihydropyridines production CS235334B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8221214 1982-07-22

Publications (1)

Publication Number Publication Date
CS235334B2 true CS235334B2 (en) 1985-05-15

Family

ID=10531838

Family Applications (1)

Application Number Title Priority Date Filing Date
CS835483A CS235334B2 (en) 1982-07-22 1983-07-21 Method of 1,4-dihydropyridines production

Country Status (25)

Country Link
US (1) US4616024A (ru)
EP (1) EP0100189B1 (ru)
JP (1) JPS5942380A (ru)
KR (1) KR840005425A (ru)
AT (1) ATE20064T1 (ru)
AU (1) AU542962B2 (ru)
CA (1) CA1248961A (ru)
CS (1) CS235334B2 (ru)
DD (1) DD211340A5 (ru)
DE (1) DE3363743D1 (ru)
DK (1) DK333683A (ru)
ES (1) ES8504126A1 (ru)
FI (1) FI79103C (ru)
GR (1) GR78880B (ru)
HU (1) HU190725B (ru)
IE (1) IE55797B1 (ru)
IL (1) IL69284A (ru)
NO (1) NO832632L (ru)
NZ (1) NZ204964A (ru)
PH (1) PH30061A (ru)
PL (1) PL139905B1 (ru)
PT (1) PT77072B (ru)
SU (1) SU1279528A3 (ru)
YU (1) YU156783A (ru)
ZA (1) ZA835310B (ru)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3363743D1 (en) * 1982-07-22 1986-07-03 Pfizer Ltd Dihydropyridine anti-ischaemic and antihypertensive agents
PL140573B1 (en) * 1982-12-21 1987-05-30 Pfizer Method of obtaining new dihydropyridine derivatives
US4568677A (en) * 1983-07-23 1986-02-04 Pfizer Inc. 2-(4-Pyrimidone alkoxyalkyl) dihydropyridine anti-ischaemic and antihypertensive agents
GB8401288D0 (en) * 1984-01-18 1984-02-22 Pfizer Ltd Therapeutic agents
GB8412208D0 (en) * 1984-05-12 1984-06-20 Pfizer Ltd Quinolone inotropic agents
DE3567460D1 (en) * 1984-06-07 1989-02-16 Pfizer Ltd Dihydropyridines
GB8414518D0 (en) * 1984-06-07 1984-07-11 Pfizer Ltd Therapeutic agents
GB8415386D0 (en) * 1984-06-15 1984-07-18 Pfizer Ltd Therapeutic agents
GB8421039D0 (en) * 1984-08-17 1984-09-19 Wyeth John & Brother Ltd Heterocyclic compounds
GR851819B (ru) * 1984-08-17 1985-11-26 Wyeth John & Brother Ltd
GB8601382D0 (en) * 1986-01-21 1986-02-26 Pfizer Ltd Dihydropyridine antiischaemic & antihypertensive agents
EP0225175A3 (en) * 1985-11-28 1988-12-28 FISONS plc Dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions thereof
DE3601196A1 (de) * 1986-01-17 1987-07-23 Merck Patent Gmbh 1,4-dihydropyridine
GB8602518D0 (en) * 1986-02-01 1986-03-05 Wyeth John & Brother Ltd 1 4-dihydropyridines
GB8620880D0 (en) * 1986-08-29 1986-10-08 Pfizer Ltd Therapeutic agents
NO874194L (no) * 1986-11-07 1988-05-09 Pfizer Ltd Fremgangsmaate ved fremstilling av dihydro-pyridinderivater
GB8712747D0 (en) * 1987-05-30 1987-07-01 Pfizer Ltd Therapeutic agents
MY104933A (en) 1987-09-30 1994-07-30 Pfizer Ltd Platelet activating factor antagonists
GB2233974A (en) * 1989-07-22 1991-01-23 Pfizer Ltd Dihydropyridine antiinflammatory agent
US5739333A (en) * 1995-05-16 1998-04-14 Tanabe Seiyaku Co., Ltd. Sulfonamide derivative and process for preparing the same
US5977369A (en) * 1995-12-28 1999-11-02 Napp Technologies, Inc. Process to prepare dihydropyridine and derivatives thereof
IT1283793B1 (it) * 1996-08-23 1998-04-30 Lusochimica Spa Processo per la preparazione di diidropiridine
IT1310933B1 (it) 1999-11-16 2002-02-27 Luigi Benatti Macchina multifunzionale per il monitoraggio ed il controllo diterapie locoregionali in oncologia.

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2248150A1 (de) * 1972-09-30 1974-04-04 Bayer Ag Dihydropyridinpolyester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US3946028A (en) * 1972-09-30 1976-03-23 Bayer Aktiengesellschaft 2,3,5,6-Tetracarboxy-4-pyridyl-1,4-dihydropyridine derivatives
US3946027A (en) * 1972-09-30 1976-03-23 Bayer Aktiengesellschaft 3,5,6-Tricarboxy-4-pyridyl-1,4-dihydropyridine derivatives
US3943140A (en) * 1972-09-30 1976-03-09 Bayer Aktiengesellschaft 2,3,5,6-Tetracarboxy-1,4-dihydropyridine derivatives
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof
DE2658183A1 (de) * 1976-12-22 1978-07-06 Bayer Ag In 2-position substituierte 1,4- dihydropyridin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4177278A (en) * 1977-04-05 1979-12-04 Bayer Aktiengesellschaft 2-Alkyleneaminodihydropyridines compounds, their production and their medicinal use
US4307103A (en) * 1978-09-08 1981-12-22 Fujisawa Pharmaceutical Co., Ltd. Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same
JPS5547656A (en) * 1978-09-29 1980-04-04 Dainippon Pharmaceut Co Ltd 2-(2-substituted aminoethyl)-1,4-dihydropyridine derivative and its derivative
SE7910521L (sv) * 1979-12-20 1981-06-21 Haessle Ab Nya 2-metyl-6-substituerade-4-(2,3-disubstituerad fenyl)-1,4-dihydropyridin-3,5-diestrar med hypotesiva egenskaper, samt forfarande for deras framstellning, och farmaceutiska beredningar innehallande desamma
FR2472567A1 (fr) * 1979-12-28 1981-07-03 Cerm Cent Europ Rech Mauvernay Ethers de 1- (2-propynyloxy)-2-amino-3-propanol, leur preparation et leur application en therapeutique
CS228917B2 (en) * 1981-03-14 1984-05-14 Pfizer Method of preparing substituted derivatives of 1,4-dihydropyridine
JPS57175166A (en) * 1981-04-23 1982-10-28 Banyu Pharmaceut Co Ltd Carbamoyloxyalkyl-1,4-dihydropyridine derivative and its preparation
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
DE3363743D1 (en) * 1982-07-22 1986-07-03 Pfizer Ltd Dihydropyridine anti-ischaemic and antihypertensive agents

Also Published As

Publication number Publication date
FI832648A0 (fi) 1983-07-20
IL69284A (en) 1986-08-31
GR78880B (ru) 1984-10-02
PT77072B (en) 1986-04-09
NZ204964A (en) 1986-02-21
DD211340A5 (de) 1984-07-11
NO832632L (no) 1984-01-23
ES524236A0 (es) 1985-04-16
AU1716583A (en) 1984-01-26
ATE20064T1 (de) 1986-06-15
EP0100189B1 (en) 1986-05-28
PL243130A1 (en) 1984-10-22
EP0100189A3 (en) 1984-05-23
JPS5942380A (ja) 1984-03-08
DK333683D0 (da) 1983-07-20
PT77072A (en) 1983-08-01
FI79103B (fi) 1989-07-31
IL69284A0 (en) 1983-11-30
DE3363743D1 (en) 1986-07-03
HU190725B (en) 1986-10-28
ES8504126A1 (es) 1985-04-16
PH30061A (en) 1996-11-08
DK333683A (da) 1984-01-23
YU156783A (en) 1986-06-30
EP0100189A2 (en) 1984-02-08
FI832648A (fi) 1984-01-23
SU1279528A1 (ru) 1986-12-23
JPS6348271B2 (ru) 1988-09-28
IE55797B1 (en) 1991-01-16
IE831713L (en) 1984-01-22
US4616024A (en) 1986-10-07
FI79103C (fi) 1989-11-10
CA1248961A (en) 1989-01-17
SU1279528A3 (ru) 1986-12-23
ZA835310B (en) 1984-04-25
AU542962B2 (en) 1985-03-28
KR840005425A (ko) 1984-11-12
PL139905B1 (en) 1987-03-31

Similar Documents

Publication Publication Date Title
CS235334B2 (en) Method of 1,4-dihydropyridines production
US5021436A (en) 2-thiomethyl-substituted-1,4-dihydropyridines, and pharmaceutical compositions containing same and antihypertensive properties
EP0634169B1 (en) Quinoline or quinazoline derivatives and their use in the manufacture of a medicament for the treatment of osteoporosis
EP0100200B1 (en) 2-substituted 4-amino-6,7-dimethoxyquinolines
EP0116769B1 (en) Dihydropyridines
HU187868B (en) Process for producing dihydropyridine derivatives
CZ277698B6 (en) Racemic or optically active bis-aza-bicyclic compounds, process for preparing thereof, intermediates and use thereof
US4847379A (en) 3,6-dihydro-1,5(2H)-pyrimidinecarboxylic acid esters
CZ396591A3 (en) Enantiomers of 1,4-dihydropyridine process of their preparation and pharmaceutical compositions prepared therefrom
EP0172029B1 (en) 1,4-dihydropyridines
US4618609A (en) Anti-ischaemic and antihypertensive 2-[pyrimidyloxy alhoxymethyl]-1,4-dihydropyridines
JPS61257983A (ja) １，４−ジヒドロピリジン及びこれを有効成分とする医薬組成物
KR920008819B1 (ko) 옥사디아졸릴-1,4-디히드로피리딘 유도체 및 그의 산부가염의 제조방법
US4883872A (en) 3-oxo-1,2,4-triazolo(4,3-A) pyrimidine-6-carboxylic acid esters
JP3776203B2 (ja) Ｉｃａｍ−１産生阻害剤
EP0150939A1 (en) Dihydropyridine anti-ischaemic and antihypertensive agents
US4547502A (en) Dihydropyridines and their use in treating cardiac conditions and hypertension
JP2005530799A (ja) ２−チオ−置換イミダゾール誘導体および薬学におけるその使用
JPH0769890A (ja) キノリンまたはキナゾリン誘導体を含んでなる医薬組成物
US6166035A (en) 1,4-dihydropyridine derivatives and their use in therapy
JP2003502374A (ja) Ｎｐｙ拮抗薬としてのジヒドロピラジン誘導体
US6339083B1 (en) Multiheterocyclic pharmAceuticals
EP0189254A1 (en) Dihydropyridine anti-ischaemic and antihypertensive agents
CS249525B2 (cs) Způsob výroby dihydropyridinů
IE56384B1 (en) Dihydropyridines