CS231955B2 - Manufacturing process of 8 alfa-substituted 6-methyl-ergolines - Google Patents

Manufacturing process of 8 alfa-substituted 6-methyl-ergolines Download PDF

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Publication number
CS231955B2
CS231955B2 CS8171A CS7181A CS231955B2 CS 231955 B2 CS231955 B2 CS 231955B2 CS 8171 A CS8171 A CS 8171A CS 7181 A CS7181 A CS 7181A CS 231955 B2 CS231955 B2 CS 231955B2
Authority
CS
Czechoslovakia
Prior art keywords
methyl
substituted
ergolines
alpha
8alpha
Prior art date
Application number
CS8171A
Other languages
Czech (cs)
English (en)
Inventor
Gerhard Sauer
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of CS231955B2 publication Critical patent/CS231955B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CS8171A 1980-01-16 1981-01-05 Manufacturing process of 8 alfa-substituted 6-methyl-ergolines CS231955B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803001752 DE3001752A1 (de) 1980-01-16 1980-01-16 Verfahren zur herstellung von 8(alpha)-substituierten 6-methylergolinen

Publications (1)

Publication Number Publication Date
CS231955B2 true CS231955B2 (en) 1985-01-16

Family

ID=6092409

Family Applications (1)

Application Number Title Priority Date Filing Date
CS8171A CS231955B2 (en) 1980-01-16 1981-01-05 Manufacturing process of 8 alfa-substituted 6-methyl-ergolines

Country Status (12)

Country Link
US (1) US4417051A (fr)
EP (1) EP0032684B1 (fr)
JP (1) JPH0631232B2 (fr)
AT (1) ATE16592T1 (fr)
CS (1) CS231955B2 (fr)
DD (1) DD156973A5 (fr)
DE (2) DE3001752A1 (fr)
DK (1) DK163995C (fr)
HU (1) HU183285B (fr)
RO (1) RO81385A (fr)
SU (1) SU971101A3 (fr)
YU (1) YU42111B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH644606A5 (de) * 1980-09-23 1984-08-15 Sandoz Ag Verfahren zur isomerisierung von 9,10-dihydrolysergsaeurederivaten.
DE3101535A1 (de) * 1981-01-14 1982-08-12 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue (2-halogen-ergolinyl)-n'.n'-diethyl-harnstoffderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
US4526892A (en) * 1981-03-03 1985-07-02 Farmitalia Carlo Erba, S.P.A. Dimethylaminoalkyl-3-(ergoline-8'βcarbonyl)-ureas
DE3216870A1 (de) * 1982-05-03 1983-11-03 Schering AG, 1000 Berlin und 4709 Bergkamen Pharmazeutische zubereitungen mit zytostatischer wirkung
PH21123A (en) * 1983-04-28 1987-07-27 Erba Farmitalia Ergoline derivatives
DE3445784A1 (de) * 1984-12-13 1986-06-26 Schering AG, Berlin und Bergkamen, 1000 Berlin Verfahren zur herstellung von ergolin-derivaten
DE3533675A1 (de) * 1985-09-19 1987-03-26 Schering Ag Neue 12- und 13-brom-ergolinderivate
HU196598B (en) * 1986-04-25 1988-12-28 Richter Gedeon Vegyeszet Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds
DE3623438C2 (de) * 1986-07-10 1998-04-09 Schering Ag In 2-Stellung mit radioaktivem Iod markierte Ergolinylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Diagnostika
US5242678A (en) * 1986-07-10 1993-09-07 Schering Aktiengesellschaft BR*-diagnostics for monoamine receptors
JP4835153B2 (ja) * 2005-12-22 2011-12-14 富士電機リテイルシステムズ株式会社 自動販売機の商品送出装置

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH386439A (de) * 1961-01-31 1965-01-15 Sandoz Ag Verfahren zur Herstellung von neuen Dihydrolysergsäure-Derivaten
CH477447A (de) * 1962-07-13 1969-08-31 Farmaceutici Italia Verfahren zur Herstellung neuer Derivate von Dihydro-D-lysergsäure- und 1-Methyl-dihydro-D-lysergsäure-a-hydroxyäthylamid
ES290275A2 (es) * 1962-07-26 1964-03-01 Farm Italia Procedimiento para preparar nuevos compuestos de la 6-metil y la 1,6-dimetil-er-golina ii
CH507248A (de) * 1967-03-16 1971-05-15 Spofa Vereinigte Pharma Werke Verfahren zur Herstellung von D-6-Methylergolin(I)ylessigsäure
US3901893A (en) * 1970-05-18 1975-08-26 Richter Gedeon Vegyeszet New dihydro-lysergic acid derivative
SE396753B (sv) * 1970-05-18 1977-10-03 Richter Gedeon Vegyeszet Analogiforfarande for framstellning av en forening tillhorande dihydrolysergsyraserien
CH573936A5 (fr) * 1971-08-05 1976-03-31 Spofa Vereinigte Pharma Werke
US3968111A (en) * 1974-12-06 1976-07-06 Eli Lilly And Company 8,8-Disubstituted-6-methylergolines and related compounds

Also Published As

Publication number Publication date
EP0032684B1 (fr) 1985-11-21
JPH0631232B2 (ja) 1994-04-27
DK163995C (da) 1992-10-12
US4417051A (en) 1983-11-22
SU971101A3 (ru) 1982-10-30
YU8181A (en) 1983-10-31
ATE16592T1 (de) 1985-12-15
RO81385A (fr) 1983-07-07
DD156973A5 (de) 1982-10-06
DE3172932D1 (en) 1986-01-02
DE3001752A1 (de) 1981-07-30
EP0032684A1 (fr) 1981-07-29
YU42111B (en) 1988-04-30
DK163995B (da) 1992-04-27
JPS56100782A (en) 1981-08-12
DK11981A (da) 1981-07-17
RO81385B (ro) 1983-06-30
HU183285B (en) 1984-04-28

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