CS229938B2 - Production method imidazoline derivative - Google Patents

Production method imidazoline derivative

Info

Publication number
CS229938B2
CS229938B2 CS825668A CS566882A CS229938B2 CS 229938 B2 CS229938 B2 CS 229938B2 CS 825668 A CS825668 A CS 825668A CS 566882 A CS566882 A CS 566882A CS 229938 B2 CS229938 B2 CS 229938B2
Authority
CS
Czechoslovakia
Prior art keywords
methyl
hydrogen
compound
formula
adrenoreceptor
Prior art date
Application number
CS825668A
Other languages
Czech (cs)
English (en)
Inventor
Christopher B Chapleo
Peter L Myers
Original Assignee
Reckitt & Colmann Prod Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reckitt & Colmann Prod Ltd filed Critical Reckitt & Colmann Prod Ltd
Publication of CS229938B2 publication Critical patent/CS229938B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
CS825668A 1981-07-28 1982-07-27 Production method imidazoline derivative CS229938B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8123271 1981-07-28

Publications (1)

Publication Number Publication Date
CS229938B2 true CS229938B2 (en) 1984-07-16

Family

ID=10523561

Family Applications (1)

Application Number Title Priority Date Filing Date
CS825668A CS229938B2 (en) 1981-07-28 1982-07-27 Production method imidazoline derivative

Country Status (24)

Country Link
US (1) US4411908A (ja)
EP (1) EP0071368B1 (ja)
JP (1) JPS5826884A (ja)
AT (1) ATE12769T1 (ja)
AU (1) AU549166B2 (ja)
CA (1) CA1171864A (ja)
CS (1) CS229938B2 (ja)
DD (1) DD211349A5 (ja)
DE (1) DE3263123D1 (ja)
DK (1) DK160275C (ja)
ES (1) ES8307796A1 (ja)
FI (1) FI67545C (ja)
GR (1) GR76210B (ja)
HU (1) HU190023B (ja)
IE (1) IE53389B1 (ja)
IL (1) IL66353A (ja)
NO (1) NO157215C (ja)
NZ (1) NZ201219A (ja)
PH (1) PH18878A (ja)
PL (1) PL139439B1 (ja)
PT (1) PT75329B (ja)
SU (1) SU1204134A3 (ja)
ZA (1) ZA825164B (ja)
ZW (1) ZW13782A1 (ja)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2539415B1 (fr) * 1983-01-14 1985-09-13 Adir Derives de la d-2 imidazoline, leur preparation et leur application en therapeutique
ATE29494T1 (de) * 1983-08-11 1987-09-15 Synthelabo Indol-derivate, verfahren zu deren herstellung und deren therapeutische anwendung.
EP0139584B1 (fr) * 1983-10-17 1988-05-18 Synthelabo Dérivés d'imidazoline, leur préparation et leur application en thérapeutique
KR910005851B1 (ko) * 1983-12-12 1991-08-05 신 떼라보 피롤로[3,2,1-hi]인돌유도체 및 약학적으로 허용되는 그의 산부가염을 제조하는 방법
FR2621486B1 (fr) * 1987-10-07 1990-01-26 Synthelabo Utilisation de derives de pyrrolo(3,2,1-hi)indole pour obtenir un medicament destine au traitement du diabete
GB2167408B (en) * 1984-11-23 1988-05-25 Farmos Oy Substituted imidazole derivatives and their preparation and use
US4666931A (en) * 1984-12-29 1987-05-19 Kaken Pharmaceutical Co., Ltd. Benzofuran derivatives useful in treating diabetic complications
US4895867A (en) * 1986-06-26 1990-01-23 Norwich Eaton Pharmaceuticals, Inc. 2-(5-phenyl-2-furanyl)imidazoles useful as cardiotonic agents
US4882343A (en) * 1987-08-28 1989-11-21 G. D. Searle & Co. Biarylalkylimidazole derivatives as anti-depressants
DK344489D0 (da) * 1989-07-12 1989-07-12 Novo Nordisk As Substituerede 2-imidazoliner og fremstilling og anvendelse deraf
GB9020128D0 (en) * 1990-09-14 1990-10-24 Reckitt & Colmann Prod Ltd Imidazoline derivatives
GB9127050D0 (en) * 1991-12-20 1992-02-19 Orion Yhtymae Oy Substituted imidazole derivatives and their preparation and use
GB9127430D0 (en) * 1991-12-27 1992-02-19 Scras Benzofuranylimidazole derivatives
FR2706303B1 (fr) * 1993-06-18 1995-09-08 Pf Medicament Utilisation de l'Efaroxan et de ses dérivés pour la préparation d'un médicament destiné au traitement de la maladie de Parkinson.
FR2707166B1 (fr) * 1993-07-09 1995-09-29 Pf Medicament Utilisation de l'efaroxan et de ses dérivés pour la fabrication de médicaments destinés au traitement de maladies neurodégénératives et leur progression .
CA2315226A1 (en) * 1997-12-19 1999-07-01 Eli Lilly And Company Hypoglycemic imidazoline compounds
FR2784989B1 (fr) * 1998-09-10 2002-09-27 Fabre Pierre Sante Derive d'ester d'acide 2-ethyl-2,3-dihydrobenzofurane- carboxylique, procede de preparation et utilisation pour la preparation de derives de l'efaroxan
WO2000073269A2 (en) * 1999-06-02 2000-12-07 Regents Of The University Of Minnesota Nicotine receptor ligands
SE9902267D0 (sv) * 1999-06-16 1999-06-16 Astra Ab New compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2168216A1 (en) * 1972-01-21 1973-08-31 Labaz Substd imidazolines - with vasoconstrictor activity
US3927023A (en) * 1974-05-24 1975-12-16 Warner Lambert Co Imidazolyl benzofurans
DE2933962A1 (de) * 1979-08-22 1981-03-26 Hoechst Ag, 65929 Frankfurt Verfahren zur herstellung von 4,5-dichlor-imidazolen.

Also Published As

Publication number Publication date
PT75329B (en) 1984-07-31
ES514359A0 (es) 1983-08-01
FI67545C (fi) 1985-04-10
PH18878A (en) 1985-10-22
CA1171864A (en) 1984-07-31
NO157215B (no) 1987-11-02
FI822551A0 (fi) 1982-07-20
IE53389B1 (en) 1988-10-26
FI822551L (fi) 1983-01-29
DD211349A5 (de) 1984-07-11
IL66353A0 (en) 1982-11-30
DE3263123D1 (de) 1985-05-23
DK160275B (da) 1991-02-18
IL66353A (en) 1985-08-30
DK335682A (da) 1983-01-29
FI67545B (fi) 1984-12-31
ES8307796A1 (es) 1983-08-01
ATE12769T1 (de) 1985-05-15
PT75329A (en) 1982-08-01
JPS5826884A (ja) 1983-02-17
ZW13782A1 (en) 1982-10-06
PL139439B1 (en) 1987-01-31
JPH0233038B2 (ja) 1990-07-25
EP0071368B1 (en) 1985-04-17
NO157215C (no) 1988-02-10
SU1204134A3 (ru) 1986-01-07
AU8643882A (en) 1983-06-02
ZA825164B (en) 1983-05-25
IE821789L (en) 1983-01-28
EP0071368A1 (en) 1983-02-09
GR76210B (ja) 1984-08-03
DK160275C (da) 1991-07-22
PL237655A1 (en) 1983-03-28
HU190023B (en) 1986-08-28
NZ201219A (en) 1984-10-19
NO822568L (no) 1983-01-31
US4411908A (en) 1983-10-25
AU549166B2 (en) 1986-01-16

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