CS228921B2 - Method of preparing diesters of 6-beta-/hydroxymethyl/penicillanic acid and 6-beta-/acylamino/penicillanic acid with methandiol - Google Patents

Method of preparing diesters of 6-beta-/hydroxymethyl/penicillanic acid and 6-beta-/acylamino/penicillanic acid with methandiol Download PDF

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Publication number
CS228921B2
CS228921B2 CS822016A CS201682A CS228921B2 CS 228921 B2 CS228921 B2 CS 228921B2 CS 822016 A CS822016 A CS 822016A CS 201682 A CS201682 A CS 201682A CS 228921 B2 CS228921 B2 CS 228921B2
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CS
Czechoslovakia
Prior art keywords
formula
beta
acid
hydroxymethyl
penicillanic acid
Prior art date
Application number
CS822016A
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Czech (cs)
English (en)
Inventor
Michael S Kellogg
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CS228921B2 publication Critical patent/CS228921B2/cs

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CS822016A 1981-03-23 1982-03-23 Method of preparing diesters of 6-beta-/hydroxymethyl/penicillanic acid and 6-beta-/acylamino/penicillanic acid with methandiol CS228921B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/246,505 US4342768A (en) 1979-10-22 1981-03-23 Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide and beta-lactam antibiotics

Publications (1)

Publication Number Publication Date
CS228921B2 true CS228921B2 (en) 1984-05-14

Family

ID=22930958

Family Applications (1)

Application Number Title Priority Date Filing Date
CS822016A CS228921B2 (en) 1981-03-23 1982-03-23 Method of preparing diesters of 6-beta-/hydroxymethyl/penicillanic acid and 6-beta-/acylamino/penicillanic acid with methandiol

Country Status (26)

Country Link
US (1) US4342768A (xx)
EP (1) EP0061313B1 (xx)
JP (1) JPS57169492A (xx)
KR (1) KR860000425B1 (xx)
AT (1) ATE11291T1 (xx)
AU (1) AU527895B2 (xx)
CA (1) CA1201709A (xx)
CS (1) CS228921B2 (xx)
DD (1) DD203723A5 (xx)
DE (1) DE3261898D1 (xx)
DK (1) DK126982A (xx)
ES (1) ES510656A0 (xx)
FI (1) FI74285C (xx)
GR (1) GR76107B (xx)
GT (1) GT198274394A (xx)
HU (1) HU186487B (xx)
IE (1) IE52812B1 (xx)
IL (1) IL65306A (xx)
NO (1) NO820897L (xx)
NZ (1) NZ200068A (xx)
PH (1) PH18040A (xx)
PL (1) PL130110B1 (xx)
PT (1) PT74624B (xx)
SU (1) SU1122230A3 (xx)
YU (1) YU61882A (xx)
ZA (1) ZA821901B (xx)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU559689B2 (en) * 1981-09-22 1987-03-19 Kureha Kagaku Kogyo K.K. Penicillin derivative
US4452796A (en) * 1982-06-14 1984-06-05 Pfizer Inc. 6-Aminoalkylpenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
EP0084730A1 (en) * 1982-01-22 1983-08-03 Beecham Group Plc Esters of penicillin derivatives with beta-lactamase inhibitors, their preparation and their use
DE3302335A1 (de) * 1982-01-26 1983-07-28 Leo Pharmaceutical Products Ltd. A/S (Loevens kemiske Fabrik Produktionsaktieselskab), 2750 Ballerup Ss-lactamverbindungen, ihre herstellung und sie enthaltendes arzneimittel
US4462934A (en) 1983-03-31 1984-07-31 Pfizer Inc. Bis-esters of dicarboxylic acids with amoxicillin and certain hydroxymethylpenicillanate 1,1-dioxides
US4536393A (en) * 1983-06-06 1985-08-20 Pfizer Inc. 6-(Aminomethyl)penicillanic acid 1,1-dioxide esters and intermediates therefor
US4503040A (en) * 1984-02-27 1985-03-05 Pfizer Inc. 6-(Aminoacyloxymethyl)penicillanic acid 1,1-dioxides as beta-lactamase inhibitors
US4591459A (en) * 1984-12-03 1986-05-27 Pfizer Inc. Intermediates for 6-(aminoacyloxymethyl) penicillanic acid 1,1-dioxides
US4675186A (en) 1985-04-18 1987-06-23 Pfizer Inc. 6-(1-acyl-1-hydroxymethyl)penicillanic acid derivatives
US4762921A (en) * 1985-04-18 1988-08-09 Pfizer Inc. 6-(1-acyl-1-hydroxymethyl)penicillanic acid derivatives
JPS63144296U (xx) * 1987-03-12 1988-09-22
CN108107120B (zh) * 2017-12-12 2020-12-01 山东鑫泉医药有限公司 采用高效液相法测定中间产物6,6-二溴青霉烷酸的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4207323A (en) * 1975-11-21 1980-06-10 Merck & Co., Inc. 6-Substituted methyl penicillins, derivatives and analogues thereof
IE49881B1 (en) 1979-02-13 1986-01-08 Leo Pharm Prod Ltd B-lactam intermediates
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide

Also Published As

Publication number Publication date
PH18040A (en) 1985-03-08
GT198274394A (es) 1983-09-08
IE52812B1 (en) 1988-03-16
FI820992L (fi) 1982-09-24
SU1122230A3 (ru) 1984-10-30
ZA821901B (en) 1983-01-26
AU8176182A (en) 1982-11-04
KR860000425B1 (ko) 1986-04-19
HU186487B (en) 1985-08-28
DE3261898D1 (en) 1985-02-28
NZ200068A (en) 1985-08-16
AU527895B2 (en) 1983-03-31
PL130110B1 (en) 1984-07-31
DD203723A5 (de) 1983-11-02
PT74624B (en) 1984-11-26
US4342768A (en) 1982-08-03
GR76107B (xx) 1984-08-03
KR830009110A (ko) 1983-12-17
PT74624A (en) 1982-04-01
IL65306A0 (en) 1982-05-31
YU61882A (en) 1985-03-20
FI74285C (fi) 1988-01-11
ATE11291T1 (de) 1985-02-15
PL235576A1 (en) 1983-03-14
EP0061313A3 (en) 1982-12-08
JPS6325593B2 (xx) 1988-05-26
EP0061313A2 (en) 1982-09-29
CA1201709A (en) 1986-03-11
JPS57169492A (en) 1982-10-19
IL65306A (en) 1986-02-28
DK126982A (da) 1982-09-24
ES8305769A1 (es) 1983-04-16
EP0061313B1 (en) 1985-01-16
NO820897L (no) 1982-09-24
ES510656A0 (es) 1983-04-16
IE820656L (en) 1982-09-23
FI74285B (fi) 1987-09-30

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