CS208735B2 - Method of making the pure heparine - Google Patents
Method of making the pure heparine Download PDFInfo
- Publication number
- CS208735B2 CS208735B2 CS777263A CS726377A CS208735B2 CS 208735 B2 CS208735 B2 CS 208735B2 CS 777263 A CS777263 A CS 777263A CS 726377 A CS726377 A CS 726377A CS 208735 B2 CS208735 B2 CS 208735B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- heparin
- solution
- pharmacopoeia
- water
- units
- Prior art date
Links
- 229920000669 heparin Polymers 0.000 title claims abstract description 29
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title claims abstract description 28
- 238000004519 manufacturing process Methods 0.000 title description 3
- 229960002897 heparin Drugs 0.000 claims abstract description 27
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 18
- 241001465754 Metazoa Species 0.000 claims abstract description 8
- 239000011780 sodium chloride Substances 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 210000000936 intestine Anatomy 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 7
- 238000009938 salting Methods 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 2
- 239000012267 brine Substances 0.000 abstract description 7
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 6
- 230000000968 intestinal effect Effects 0.000 abstract description 4
- 238000004321 preservation Methods 0.000 abstract description 3
- 238000007796 conventional method Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 21
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 239000002244 precipitate Substances 0.000 description 10
- 235000002639 sodium chloride Nutrition 0.000 description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- 239000002994 raw material Substances 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 238000003756 stirring Methods 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 210000003097 mucus Anatomy 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 241001494479 Pecora Species 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000012266 salt solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 241000238876 Acari Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000005909 Kieselgur Substances 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000005349 anion exchange Methods 0.000 description 1
- 239000003957 anion exchange resin Substances 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 159000000009 barium salts Chemical class 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- -1 from the lungs Chemical compound 0.000 description 1
- 239000002565 heparin fraction Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials Engineering (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2652272A DE2652272C2 (de) | 1976-11-12 | 1976-11-12 | Verfahren zur Herstellung von Heparin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS208735B2 true CS208735B2 (en) | 1981-09-15 |
Family
ID=5993323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS777263A CS208735B2 (en) | 1976-11-12 | 1977-11-07 | Method of making the pure heparine |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US4283530A (de) |
| JP (1) | JPS5844082B2 (de) |
| AR (1) | AR214759A1 (de) |
| AT (1) | AT354633B (de) |
| AU (1) | AU515671B2 (de) |
| BE (1) | BE860729A (de) |
| BG (1) | BG28425A3 (de) |
| BR (1) | BR7707493A (de) |
| CA (1) | CA1088522A (de) |
| CS (1) | CS208735B2 (de) |
| DD (1) | DD134352A5 (de) |
| DE (1) | DE2652272C2 (de) |
| DK (1) | DK142059C (de) |
| FI (1) | FI62104C (de) |
| FR (1) | FR2370757A1 (de) |
| GB (1) | GB1592806A (de) |
| GR (1) | GR65226B (de) |
| HU (1) | HU174644B (de) |
| IE (1) | IE47041B1 (de) |
| IL (1) | IL53254A (de) |
| IS (1) | IS2410A7 (de) |
| IT (1) | IT1088965B (de) |
| LU (1) | LU78488A1 (de) |
| NL (1) | NL179481C (de) |
| PL (1) | PL108607B1 (de) |
| RO (1) | RO78597A (de) |
| SE (1) | SE432875B (de) |
| SU (1) | SU1028237A3 (de) |
| YU (1) | YU260677A (de) |
| ZA (1) | ZA776753B (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2800943C2 (de) * | 1978-01-06 | 1984-09-27 | Schering AG, 1000 Berlin und 4709 Bergkamen | Verwendung von Darm-Salzlake zur Gewinnung von reinem Heparin |
| HU177887B (en) * | 1979-03-21 | 1982-01-28 | Richter Gedeon Vegyeszet | Process for preparing a raw material containing heparin |
| EP0066908B1 (de) * | 1981-05-21 | 1985-08-28 | Akzo N.V. | Antithrombotikum auf Basis von Polysacchariden, Verfahren zur dessen Herstellung und medizinale Zusammensetzungen |
| WO2016137471A1 (en) * | 2015-02-26 | 2016-09-01 | Nantpharma, Llc | Method for enhanced heparin quality |
| RU2612813C1 (ru) * | 2015-12-07 | 2017-03-13 | Павел Андреевич Канаев | Способ получения гепарина |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2623001A (en) * | 1949-04-07 | 1952-12-23 | Bengt E G V Sylven | Preparing heparin |
| GB872214A (en) * | 1957-09-23 | 1961-07-05 | Upjohn Co | Extraction process for the recovery of heparin |
| DE1156938B (de) * | 1957-09-23 | 1963-11-07 | Upjohn Company Eine Ges Nach D | Verfahren zur Gewinnung von Heparin |
| US3058884A (en) * | 1959-09-14 | 1962-10-16 | Abbott Lab | Process for purifying heparin |
| NL301375A (de) * | 1962-12-10 | |||
| US4119774A (en) * | 1976-03-05 | 1978-10-10 | Ab Kabi | Heparin purification method |
-
1976
- 1976-11-12 DE DE2652272A patent/DE2652272C2/de not_active Expired
-
1977
- 1977-10-06 IS IS2410A patent/IS2410A7/is unknown
- 1977-10-19 SU SU772531003A patent/SU1028237A3/ru active
- 1977-10-26 NL NLAANVRAGE7711746,A patent/NL179481C/xx not_active IP Right Cessation
- 1977-10-28 IL IL53254A patent/IL53254A/xx unknown
- 1977-10-31 YU YU02606/77A patent/YU260677A/xx unknown
- 1977-11-01 DK DK486177A patent/DK142059C/da not_active IP Right Cessation
- 1977-11-02 FI FI773285A patent/FI62104C/fi not_active IP Right Cessation
- 1977-11-02 AU AU30265/77A patent/AU515671B2/en not_active Expired
- 1977-11-04 IE IE2248/77A patent/IE47041B1/en unknown
- 1977-11-05 BG BG037730A patent/BG28425A3/xx unknown
- 1977-11-07 CS CS777263A patent/CS208735B2/cs unknown
- 1977-11-09 RO RO7792068A patent/RO78597A/ro unknown
- 1977-11-09 AR AR269906A patent/AR214759A1/es active
- 1977-11-09 BR BR7707493A patent/BR7707493A/pt unknown
- 1977-11-10 GB GB46840/77A patent/GB1592806A/en not_active Expired
- 1977-11-10 PL PL1977202036A patent/PL108607B1/pl unknown
- 1977-11-10 BE BE182551A patent/BE860729A/xx not_active IP Right Cessation
- 1977-11-10 SE SE7712732A patent/SE432875B/sv unknown
- 1977-11-10 GR GR54768A patent/GR65226B/el unknown
- 1977-11-10 DD DD77202002A patent/DD134352A5/de unknown
- 1977-11-10 FR FR7733883A patent/FR2370757A1/fr active Granted
- 1977-11-10 LU LU78488A patent/LU78488A1/de unknown
- 1977-11-11 ZA ZA00776753A patent/ZA776753B/xx unknown
- 1977-11-11 JP JP52135592A patent/JPS5844082B2/ja not_active Expired
- 1977-11-11 IT IT29581/77A patent/IT1088965B/it active
- 1977-11-11 HU HU77SCHE629A patent/HU174644B/hu not_active IP Right Cessation
- 1977-11-11 AT AT806677A patent/AT354633B/de not_active IP Right Cessation
- 1977-11-14 CA CA290,824A patent/CA1088522A/en not_active Expired
-
1979
- 1979-07-02 US US06/054,071 patent/US4283530A/en not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US3770720A (en) | Process for the extraction of alkali salts of deoxyribonucleic acid from animal organs | |
| US3766167A (en) | Orally active anticoagulant | |
| JPS63503067A (ja) | 化学的に定義された再現性のあるポリデオキシリボヌクレオチドを得る方法 | |
| EP0056025B1 (de) | Heme-konzentrat und verfahren zu dessen herstellung | |
| CS208735B2 (en) | Method of making the pure heparine | |
| KR820001739B1 (ko) | 헤파린의 회수방법 | |
| US3342683A (en) | Heparin from whale tissue and method of preparing same | |
| FI65073B (fi) | Foerfarande foer framstaellning av heparin | |
| KR820000044B1 (ko) | 헤파린의 추출방법 | |
| US3262854A (en) | Method for the recovery of heparin | |
| FR2522266A1 (fr) | Procede de preparation d'un agent fibrinolytiquement actif et agent obtenu | |
| US3660237A (en) | Process for obtaining kallekrein from pancreas or submandibularis glands of pigs | |
| US2194677A (en) | Silver animal mucin and process for producing same | |
| US2921000A (en) | Thromboplastin | |
| SU738622A1 (ru) | Способ получени модифицированного глобина | |
| US2085768A (en) | Method of separating and isolating the thyreotropic and the gonadotropic hormone of the anterior lobe of the hypophysis | |
| RU2128512C1 (ru) | Способ выделения цитохрома с | |
| US2674560A (en) | Preparation of insulin from pancreas glands | |
| US2319902A (en) | Therapeutic pressor composition and method of preparing it | |
| EP0352090A2 (de) | Methode zur Herstellung von Nephritogenosid | |
| SU948384A1 (ru) | Способ получени средства дл диагностики заболеваний поджелудочной железы | |
| DE2660052A1 (de) | Verfahren zur herstellung von heparin | |
| NO129280B (de) | ||
| UA120089U (uk) | Спосіб отримання цитохрому-с | |
| JPH04136001A (ja) | β―シクロデキストリン・スルホンアミド誘導体のポリ硫酸エステル及びその製法 |