CS205025B2 - Process for preparing derivatives of glukosamine - Google Patents

Process for preparing derivatives of glukosamine Download PDF

Info

Publication number
CS205025B2
CS205025B2 CS768063A CS806376A CS205025B2 CS 205025 B2 CS205025 B2 CS 205025B2 CS 768063 A CS768063 A CS 768063A CS 806376 A CS806376 A CS 806376A CS 205025 B2 CS205025 B2 CS 205025B2
Authority
CS
Czechoslovakia
Prior art keywords
benzyl
deoxy
solution
water
acid
Prior art date
Application number
CS768063A
Other languages
Czech (cs)
English (en)
Inventor
Gerhard Baschang
Albert Hartmann
Jaroslav Stanek
Alex Sele
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of CS205025B2 publication Critical patent/CS205025B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CS768063A 1975-12-10 1976-12-09 Process for preparing derivatives of glukosamine CS205025B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1604275A CH613709A5 (en) 1975-12-10 1975-12-10 Process for the preparation of glucosamine derivatives

Publications (1)

Publication Number Publication Date
CS205025B2 true CS205025B2 (en) 1981-04-30

Family

ID=4414012

Family Applications (4)

Application Number Title Priority Date Filing Date
CS768063A CS205025B2 (en) 1975-12-10 1976-12-09 Process for preparing derivatives of glukosamine
CS768063A CS205026B2 (en) 1975-12-10 1976-12-09 Method of producing glocosamine derivatives
CS768063A CS205027B2 (en) 1975-12-10 1976-12-09 Method of producing glucosamine derivatives
CS768063A CS205028B2 (en) 1975-12-10 1976-12-09 Method of producing glucosamine derivatives

Family Applications After (3)

Application Number Title Priority Date Filing Date
CS768063A CS205026B2 (en) 1975-12-10 1976-12-09 Method of producing glocosamine derivatives
CS768063A CS205027B2 (en) 1975-12-10 1976-12-09 Method of producing glucosamine derivatives
CS768063A CS205028B2 (en) 1975-12-10 1976-12-09 Method of producing glucosamine derivatives

Country Status (30)

Country Link
JP (1) JPS5273820A (fr)
AR (2) AR224091A1 (fr)
AT (1) AT365607B (fr)
AU (1) AU508764B2 (fr)
BE (1) BE849214A (fr)
CA (1) CA1262400A (fr)
CH (2) CH613709A5 (fr)
CS (4) CS205025B2 (fr)
DD (1) DD129781A5 (fr)
DE (1) DE2655500A1 (fr)
DK (1) DK154654C (fr)
ES (2) ES454118A1 (fr)
FI (1) FI64164C (fr)
FR (1) FR2361902A1 (fr)
GB (1) GB1570625A (fr)
GR (1) GR61647B (fr)
HK (1) HK32883A (fr)
HU (1) HU177970B (fr)
IE (1) IE44190B1 (fr)
IL (1) IL51076A (fr)
MY (1) MY8400123A (fr)
NL (1) NL7613666A (fr)
NO (1) NO144850C (fr)
NZ (1) NZ182837A (fr)
PL (4) PL110794B1 (fr)
PT (1) PT65946B (fr)
SE (1) SE445923B (fr)
SG (1) SG11083G (fr)
SU (3) SU660589A3 (fr)
ZA (1) ZA767333B (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186194A (en) * 1973-10-23 1980-01-29 Agence Nationale De Valorisation De La Recherche (Anvar) Water soluble agents effective as immunological adjuvants for stimulating, in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents
US4370265A (en) * 1974-10-22 1983-01-25 Agence Nationale De Valorisation Water soluble agents effective as immunological adjuvants for stimulating in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents
GB1571133A (en) * 1976-04-26 1980-07-09 Syntex Inc Immuniological adjuvant peptidoglycans compounds and methods of preparation thereof
EP0002677B1 (fr) 1977-12-02 1982-10-13 Takeda Chemical Industries, Ltd. Dérivés de glucosamine-peptides et leurs compositions pharmaceutiques
EP0003833B2 (fr) * 1978-02-24 1990-12-19 Ciba-Geigy Ag Dérivés d'antigène, procédé pour leur préparation, compositions pharmaceutiques les contenant
US4397844A (en) * 1978-02-24 1983-08-09 Ciba-Geigy Corporation Antigen derivatives and processes for their preparation
FR2420545A1 (fr) * 1978-03-20 1979-10-19 Anvar Nouveaux esters de l'acide n-acetyl-muramyl-aminoacyl-glutamique ou des derives de substitution de celui-ci a proprietes anti-infectieuses et/ou d'adjuvants immunologiques
FR2442241A2 (fr) * 1978-03-20 1980-06-20 Anvar Nouveaux composes esters de muramyl-peptide, leur preparation et les compositions pharmaceutiques les contenant, notamment sous forme de liposomes
FR2428051A1 (fr) * 1978-06-05 1980-01-04 Anvar Nouveaux composes du type muramyl-peptide et medicaments les contenant
FR2428050A1 (fr) * 1978-06-05 1980-01-04 Anvar Oligomeres de composes du type muramyl-peptide et medicaments les contenant
FR2446292A1 (fr) * 1979-01-12 1980-08-08 Anvar Muramyl-peptides fixes sur polymeres peptidiques et medicaments les contenant
US4256735A (en) 1979-01-29 1981-03-17 Merck & Co., Inc. Immunologically active dipeptidyl saccharides and methods of preparation
FR2449697A1 (fr) 1979-02-20 1980-09-19 Anvar Nouveaux muramyl-peptides substitues sur un azote peptidique et medicaments les contenant
JPS55111499A (en) * 1979-02-21 1980-08-28 Takeda Chem Ind Ltd Glucosamine derivative and its preparation
JPS5618996A (en) * 1979-06-21 1981-02-23 Dai Ichi Seiyaku Co Ltd Muramyldipeptide derivative
FI75578C (fi) * 1979-07-25 1988-07-11 Ciba Geigy Ag Analogifoerfarande foer framstaellning av farmakologiskt verkande lipofila fosfatidylmuramylpeptider.
JPS5649396A (en) * 1979-09-28 1981-05-02 Dai Ichi Seiyaku Co Ltd Novel muramyldipeptide derivative
EP0026746B1 (fr) * 1979-10-02 1985-04-10 Ciba-Geigy Ag Compositions combinées utilisables dans un procédé pour augmenter l'activité des antibiotiques, compositions antibiotiques ayant une efficacité accrue et procédé pour leur préparation
FI803077A (fi) 1979-10-12 1981-04-13 Ciba Geigy Ag Foerfarande foer framstaellning av myramylpeptider
US4409209A (en) * 1979-10-12 1983-10-11 Ciba-Geigy Corporation Novel phosphorylmuramyl peptides and processes for the manufacture thereof
US4406889A (en) * 1980-02-15 1983-09-27 Ciba-Geigy Corporation Derivatives of aldohexoses, intermediates, processes for their manufacture, preparations containing such compounds, and their use
US4368190A (en) * 1980-04-17 1983-01-11 Merck & Co., Inc. Immunologically active dipeptidyl 4-O-,6-O-acyl-2-amino-2-deoxy-D-glucose derivatives and methods for their preparation
US4310514A (en) 1980-05-05 1982-01-12 Merck & Co., Inc. Immunologically active dipeptidyl 5-0,6-0-acyl-2-amino-2-deoxy-D-glucofuranose derivatives and methods of preparation
EP0056560A1 (fr) * 1981-01-19 1982-07-28 Ciba-Geigy Ag Préparations antibiotiques à effet accru, procédé pour leur obtention et procédé pour augmenter l'effet antibiotique des antibiotiques
GR78246B (fr) * 1981-01-23 1984-09-26 Ciba Geigy Ag
JPS6042398A (ja) * 1983-08-18 1985-03-06 Toshiyuki Hamaoka ムラミルジペプチド活性エステル誘導体
EP0541486A1 (fr) * 1991-11-07 1993-05-12 Ciba-Geigy Ag Conjugates polycycliques
WO2006118327A1 (fr) * 2005-04-27 2006-11-09 Oxygenix Co Ltd Lipide de type acide aminé cationique
WO2016138286A1 (fr) 2015-02-26 2016-09-01 Stc.Unm Irgm et commandes de l'autophagie de précision contre des maladies bactériennes et inflammatoires et procédés de détection de l'autophagie
US10927147B2 (en) 2015-12-10 2021-02-23 Bharat Biotech International Limited Muramyl peptide derivative compound, synthesis and uses thereof
CN108883080B (zh) * 2015-12-15 2021-12-21 巴拉特生物技术国际有限公司 胞壁酰肽衍生物化合物、其合成及其用途
MX2020002010A (es) 2017-08-21 2020-07-13 Celgene Corp Procesos para la preparacion de 4,5-diamino-5-oxopentanoato de (s)-terc-butilo.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186194A (en) * 1973-10-23 1980-01-29 Agence Nationale De Valorisation De La Recherche (Anvar) Water soluble agents effective as immunological adjuvants for stimulating, in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents

Also Published As

Publication number Publication date
AR220686A1 (es) 1980-11-28
PT65946A (en) 1977-01-01
AT365607B (de) 1982-02-10
PT65946B (en) 1978-06-14
HU177970B (en) 1982-02-28
NZ182837A (en) 1978-07-28
NO144850B (no) 1981-08-17
AU508764B2 (en) 1980-04-03
NO144850C (no) 1981-11-25
DD129781A5 (de) 1978-02-08
SE445923B (sv) 1986-07-28
SE7613851L (sv) 1977-06-11
SG11083G (en) 1983-09-16
CS205027B2 (en) 1981-04-30
PL194291A1 (pl) 1978-10-23
BE849214A (fr) 1977-06-09
PL110353B1 (en) 1980-07-31
HK32883A (en) 1983-09-02
PL110787B1 (en) 1980-07-31
CH613709A5 (en) 1979-10-15
IE44190L (en) 1977-06-10
ES465514A1 (es) 1978-09-16
NL7613666A (nl) 1977-06-14
DK154654B (da) 1988-12-05
JPS638118B2 (fr) 1988-02-19
AR224091A1 (es) 1981-10-30
SU660589A3 (ru) 1979-04-30
IL51076A0 (en) 1977-02-28
CA1262400A (fr) 1989-10-17
MY8400123A (en) 1984-12-31
DK552476A (da) 1977-06-11
IL51076A (en) 1980-09-16
ES454118A1 (es) 1978-03-01
FR2361902A1 (fr) 1978-03-17
FI64164C (fi) 1983-10-10
DE2655500A1 (de) 1977-06-23
PL112672B1 (en) 1980-10-31
ZA767333B (en) 1977-11-30
DK154654C (da) 1989-05-08
NO764191L (fr) 1977-06-13
FI763541A (fr) 1977-06-11
PL110794B1 (en) 1980-07-31
SU747430A3 (ru) 1980-07-23
GB1570625A (en) 1980-07-02
GR61647B (en) 1978-12-05
CS205028B2 (en) 1981-04-30
FR2361902B1 (fr) 1980-11-07
CH614718A5 (en) 1979-12-14
ATA909276A (de) 1981-06-15
FI64164B (fi) 1983-06-30
DE2655500C2 (fr) 1988-12-22
CS205026B2 (en) 1981-04-30
IE44190B1 (en) 1981-09-09
AU2042276A (en) 1978-06-15
SU1060118A3 (ru) 1983-12-07
JPS5273820A (en) 1977-06-21

Similar Documents

Publication Publication Date Title
CS205025B2 (en) Process for preparing derivatives of glukosamine
FI75578B (fi) Analogifoerfarande foer framstaellning av farmakologiskt verkande lipofila fosfatidylmuramylpeptider.
US4101536A (en) Muramyldipeptide derivatives and process for the preparation thereof
CA1183525A (fr) Peptides phosphorylmuranyliques et methode de preparation
US4368190A (en) Immunologically active dipeptidyl 4-O-,6-O-acyl-2-amino-2-deoxy-D-glucose derivatives and methods for their preparation
US4369178A (en) Glucosamine peptide derivatives, their production and use
EP0015468B1 (fr) Dérivés peptidiques de la 6-déoxyglucosamine, leur préparation et leur utilisation
US4315913A (en) Immunologically active dipeptidyl 2-amino-1,2-dideoxy-D-glucose derivatives and methods of preparation
NO152904B (no) Analogifremgangsmaate til fremstilling av farmakologisk virksomme heksapyranoseforbindelser
FI72733C (fi) Foerfarande foer framstaellning av farmakologiskt verkande glukosderivat samt mellanprodukter anvaenda vid foerfarandet.
US4310514A (en) Immunologically active dipeptidyl 5-0,6-0-acyl-2-amino-2-deoxy-D-glucofuranose derivatives and methods of preparation
US4256735A (en) Immunologically active dipeptidyl saccharides and methods of preparation
US4391800A (en) Immunologically active peptidyl disaccharides and methods of preparation
US4377570A (en) Immunologically active dipeptidyl saccharides and methods of preparation
CS221505B2 (en) Method of making the compounds of the type of n-acetylmuramyle