CS199522B2 - Method of producing morphine derivatives - Google Patents

Method of producing morphine derivatives Download PDF

Info

Publication number
CS199522B2
CS199522B2 CS781847A CS184778A CS199522B2 CS 199522 B2 CS199522 B2 CS 199522B2 CS 781847 A CS781847 A CS 781847A CS 184778 A CS184778 A CS 184778A CS 199522 B2 CS199522 B2 CS 199522B2
Authority
CS
Czechoslovakia
Prior art keywords
formula
alkyl
group
carbon atoms
solution
Prior art date
Application number
CS781847A
Other languages
Czech (cs)
English (en)
Inventor
Ryszard J Kobylecki
Ian G Guest
John W Lewis
Gordon W Kirby
Original Assignee
Reckitt & Colmann Prod Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reckitt & Colmann Prod Ltd filed Critical Reckitt & Colmann Prod Ltd
Publication of CS199522B2 publication Critical patent/CS199522B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
CS781847A 1977-03-23 1978-03-22 Method of producing morphine derivatives CS199522B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB12342/77A GB1587831A (en) 1977-03-23 1977-03-23 Morphine derivatives

Publications (1)

Publication Number Publication Date
CS199522B2 true CS199522B2 (en) 1980-07-31

Family

ID=10002756

Family Applications (1)

Application Number Title Priority Date Filing Date
CS781847A CS199522B2 (en) 1977-03-23 1978-03-22 Method of producing morphine derivatives

Country Status (25)

Country Link
US (1) US4241067A (ru)
JP (1) JPS53121798A (ru)
AR (1) AR218296A1 (ru)
AT (1) AT360664B (ru)
AU (1) AU518614B2 (ru)
BE (1) BE865182A (ru)
CA (1) CA1089455A (ru)
CH (1) CH630629A5 (ru)
CS (1) CS199522B2 (ru)
DD (1) DD135081A5 (ru)
DE (1) DE2812581A1 (ru)
DK (1) DK149753C (ru)
ES (1) ES468170A1 (ru)
FR (1) FR2384775A1 (ru)
GB (1) GB1587831A (ru)
HU (1) HU177722B (ru)
IE (1) IE46442B1 (ru)
IT (1) IT1105172B (ru)
LU (1) LU79295A1 (ru)
NL (1) NL7803084A (ru)
NZ (1) NZ186693A (ru)
PL (1) PL111722B1 (ru)
SE (1) SE436132B (ru)
SU (1) SU856381A3 (ru)
ZA (1) ZA781525B (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4362870A (en) * 1980-01-16 1982-12-07 Regents Of The University Of Minnesota Selective opioid receptor alkylating agents
US4401672A (en) * 1981-10-13 1983-08-30 Regents Of The University Of Minnesota Non-addictive narcotic antitussive preparation
EP0103636B1 (en) * 1982-03-16 1990-09-12 Rockefeller University Use of opium antagonists for the manufacture of medicaments for controlling gastrointestinal dysmotility
GB8711558D0 (en) * 1987-05-15 1987-06-17 Reckitt & Colmann Prod Ltd Derivative of codeine
WO1993015081A1 (fr) 1992-01-23 1993-08-05 Toray Industries, Inc. Derive de morphinane et utilisation en medicine
JP3948026B2 (ja) * 1993-07-19 2007-07-25 東レ株式会社 脳細胞保護剤
JP3843456B2 (ja) * 1993-07-23 2006-11-08 東レ株式会社 モルヒナン誘導体および医薬用途
US20060063792A1 (en) * 2004-09-17 2006-03-23 Adolor Corporation Substituted morphinans and methods of their use
CA2610859C (en) 2005-06-16 2013-11-12 Peter Xianqi Wang A synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs
ES2784690T3 (es) 2013-12-05 2020-09-29 Univ Bath Nuevos compuestos opioides y sus usos

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3332950A (en) * 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
IL26896A (en) * 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
BE788478A (fr) * 1971-09-08 1973-03-06 Bristol Myers Co Procede de preparation de composes analgesiques
US4017497A (en) * 1975-11-18 1977-04-12 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives

Also Published As

Publication number Publication date
AT360664B (de) 1981-01-26
BE865182A (fr) 1978-09-22
US4241067A (en) 1980-12-23
HU177722B (en) 1981-12-28
PL111722B1 (en) 1980-09-30
AU3435678A (en) 1979-09-27
NZ186693A (en) 1979-10-25
IT1105172B (it) 1985-10-28
GB1587831A (en) 1981-04-08
SE436132B (sv) 1984-11-12
FR2384775A1 (fr) 1978-10-20
IE46442B1 (en) 1983-06-15
NL7803084A (nl) 1978-09-26
CA1089455A (en) 1980-11-11
SU856381A3 (ru) 1981-08-15
AU518614B2 (en) 1981-10-08
PL205497A1 (pl) 1979-06-04
ATA204378A (de) 1980-06-15
IE780514L (en) 1978-09-23
JPS53121798A (en) 1978-10-24
DD135081A5 (de) 1979-04-11
DK129978A (da) 1978-09-24
AR218296A1 (es) 1980-05-30
ZA781525B (en) 1979-04-25
ES468170A1 (es) 1979-01-01
DK149753C (da) 1987-07-06
DE2812581A1 (de) 1978-09-28
IT7848545A0 (it) 1978-03-22
SE7803329L (sv) 1978-09-24
FR2384775B1 (ru) 1981-04-30
CH630629A5 (fr) 1982-06-30
JPS6259112B2 (ru) 1987-12-09
LU79295A1 (fr) 1979-10-29
DK149753B (da) 1986-09-22

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