CS197276B2 - Method of producing new 1,5,10,10a-tetrahydrothiazolo/3,4-b/isoquinolines - Google Patents

Method of producing new 1,5,10,10a-tetrahydrothiazolo/3,4-b/isoquinolines Download PDF

Info

Publication number
CS197276B2
CS197276B2 CS765082A CS508276A CS197276B2 CS 197276 B2 CS197276 B2 CS 197276B2 CS 765082 A CS765082 A CS 765082A CS 508276 A CS508276 A CS 508276A CS 197276 B2 CS197276 B2 CS 197276B2
Authority
CS
Czechoslovakia
Prior art keywords
formula
hydrogen
pyridyl
tetrahydroisoquinoline
tetrahydrothiazolo
Prior art date
Application number
CS765082A
Other languages
Czech (cs)
English (en)
Inventor
Daniel Farge
Alain Jossin
Gerard Ponsinet
Daniel Reisdorf
Original Assignee
Rhone Poulenc Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7524523A external-priority patent/FR2320098A1/fr
Priority claimed from FR7614935A external-priority patent/FR2351655A1/fr
Application filed by Rhone Poulenc Ind filed Critical Rhone Poulenc Ind
Priority to CS776704A priority Critical patent/CS197277B2/cs
Priority to CS778474A priority patent/CS197278B2/cs
Publication of CS197276B2 publication Critical patent/CS197276B2/cs

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CS765082A 1975-08-06 1976-08-03 Method of producing new 1,5,10,10a-tetrahydrothiazolo/3,4-b/isoquinolines CS197276B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CS776704A CS197277B2 (cs) 1975-08-06 1977-10-14 Zpustli) výroby nových l,5,19,10a-tetrahydroihiazolo- [ 3,4-b jisochinolinových derivátů
CS778474A CS197278B2 (cs) 1975-08-06 1977-10-14 Způsob výroby derivátů l,5,13,10a-t3traIiydroUiiazoIn- [ 3,4-b 1 isochinolinu

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7524523A FR2320098A1 (fr) 1975-08-06 1975-08-06 Nouveaux derives de la thiazilo (3,4-b) isoquinoleine, leur preparation et les compositions qui les contiennent
FR7614935A FR2351655A1 (fr) 1976-05-18 1976-05-18 Nouveau derive de la thiazolo (3,4-b) isoquinoleine, sa preparation et les compositions qui le contiennent

Publications (1)

Publication Number Publication Date
CS197276B2 true CS197276B2 (en) 1980-04-30

Family

ID=26219017

Family Applications (1)

Application Number Title Priority Date Filing Date
CS765082A CS197276B2 (en) 1975-08-06 1976-08-03 Method of producing new 1,5,10,10a-tetrahydrothiazolo/3,4-b/isoquinolines

Country Status (26)

Country Link
US (1) US4064247A (es)
JP (1) JPS5219699A (es)
AR (2) AR211868A1 (es)
AT (2) AT350054B (es)
AU (1) AU505316B2 (es)
CA (1) CA1073909A (es)
CH (1) CH612682A5 (es)
CS (1) CS197276B2 (es)
DE (1) DE2635516C3 (es)
DK (1) DK141069B (es)
ES (2) ES450530A1 (es)
FI (1) FI60214C (es)
GB (1) GB1503091A (es)
HU (1) HU173003B (es)
IE (1) IE44379B1 (es)
IL (1) IL50208A (es)
LU (1) LU75540A1 (es)
MX (1) MX3639E (es)
NL (1) NL169076C (es)
NO (1) NO762729L (es)
NZ (1) NZ181693A (es)
OA (1) OA05403A (es)
PL (2) PL108413B1 (es)
PT (1) PT65442B (es)
SE (1) SE422065B (es)
SU (2) SU629881A3 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7800383A (nl) * 1977-01-20 1978-07-24 Rhone Poulenc Ind Nieuwe isochinolinederivaten, de bereiding ervan en preparaten die de isochinolinederivaten bevatten.
FR2412545A1 (fr) * 1977-12-23 1979-07-20 Rhone Poulenc Ind Nouveaux derives de l'isoquinoleine, leur preparation et les compositions pharmaceutiques qui les contiennent
NL7800385A (nl) * 1977-02-04 1978-08-08 Rhone Poulenc Ind Nieuwe indoolderivaten, werkwijzen ter berei- ding ervan en preparaten die de nieuwe deriva- ten bevatten.
FR2412554A2 (fr) * 1977-12-23 1979-07-20 Rhone Poulenc Ind Nouveaux derives de l'indole, leur preparation et les compositions qui les contiennent
FR2433023A2 (fr) * 1978-08-09 1980-03-07 Rhone Poulenc Ind Nouveaux derives de l'isoquinoleine, leur preparation et les compositions qui les contiennent
FR2408615A1 (fr) * 1977-11-10 1979-06-08 Rhone Poulenc Ind Nouveaux derives de l'isoquinoleine, leur preparation et les compositions qui les contiennent
SU797580A3 (ru) * 1977-11-10 1981-01-15 Рон-Пуленк Эндюстри (Фирма) Способ получени производных изохино-лиНА, иХ СОлЕй, РАцЕМАТОВ или ОпТичЕС-КиХ изОМЕРОВ
FR2456110A2 (fr) * 1979-05-09 1980-12-05 Rhone Poulenc Ind Nouveaux derives de l'isoquinoleine, leur preparation et les compositions qui les contiennent
FR2468613A2 (fr) * 1979-10-29 1981-05-08 Rhone Poulenc Ind Nouveaux derives de la thienopyridine, leur preparation et les medicaments qui les contiennent
NL7908655A (nl) * 1978-12-07 1980-06-10 Rhone Poulenc Ind Nieuwe thienopyridine-derivaten, de bereiding ervan, alsmede farmaceutische preparaten, die de nieuwe derivaten bevatten.
NL8002540A (nl) * 1979-05-09 1980-11-11 Rhone Poulenc Ind Nieuwe isochinoline derivaten, werkwijzen ter bereiding ervan en farmaceutische preparaten, die de nieuwe derivaten bevatten.
HU181232B (en) * 1979-12-04 1983-06-28 Rhone Poulenc Ind Process for preparing new derivatives of thiazolo-isoquinoline
US4269842A (en) * 1979-12-05 1981-05-26 Rhone-Poulenc Industries Method for treating rhinoviral complaints
FR2624861B1 (fr) * 1987-12-21 1990-06-01 Delalande Sa Carbamates tricycliques, leur procede de preparation et leur application en therapeutique
US5059692A (en) * 1989-09-01 1991-10-22 Hiroyoshi Hidaka Novel compounds exhibiting a vasodilating activity and inhibitory activity for platelet aggregation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3455933A (en) * 1966-11-15 1969-07-15 American Home Prod Thiazolo and thiazino isoquinoline derivatives
HU170680B (es) * 1973-05-30 1977-08-28

Also Published As

Publication number Publication date
AU1661576A (en) 1978-02-09
CH612682A5 (es) 1979-08-15
CA1073909A (fr) 1980-03-18
ATA586476A (de) 1978-10-15
DE2635516B2 (de) 1980-07-24
FI60214B (fi) 1981-08-31
SU635874A3 (ru) 1978-11-30
PT65442B (fr) 1978-02-09
IE44379L (en) 1977-02-06
GB1503091A (en) 1978-03-08
DK141069B (da) 1980-01-07
AU505316B2 (en) 1979-11-15
AT351544B (de) 1979-07-25
AT350054B (de) 1979-05-10
LU75540A1 (es) 1977-04-20
DK353876A (es) 1977-02-07
MX3639E (es) 1981-04-13
IL50208A (en) 1978-10-31
PL108413B1 (en) 1980-04-30
OA05403A (fr) 1981-02-28
JPS566435B2 (es) 1981-02-10
DK141069C (es) 1980-08-11
SE7608808L (sv) 1977-02-07
NL7608444A (nl) 1977-02-08
PT65442A (fr) 1976-09-01
ES450530A1 (es) 1977-11-16
FI762256A (es) 1977-02-07
SE422065B (sv) 1982-02-15
IE44379B1 (en) 1981-11-04
NO762729L (es) 1977-02-08
ATA397778A (de) 1979-01-15
US4064247A (en) 1977-12-20
NZ181693A (en) 1978-06-20
SU629881A3 (ru) 1978-10-25
PL191674A1 (pl) 1978-12-18
PL108034B1 (pl) 1980-03-31
HU173003B (hu) 1979-01-28
ES452987A1 (es) 1977-12-01
DE2635516A1 (de) 1977-02-17
FI60214C (fi) 1981-12-10
AR211170A1 (es) 1977-10-31
NL169076B (nl) 1982-01-04
DE2635516C3 (de) 1981-04-16
JPS5219699A (en) 1977-02-15
NL169076C (nl) 1982-06-01
IL50208A0 (en) 1976-10-31
AR211868A1 (es) 1978-03-31

Similar Documents

Publication Publication Date Title
CS197276B2 (en) Method of producing new 1,5,10,10a-tetrahydrothiazolo/3,4-b/isoquinolines
SU999972A3 (ru) Способ получени производных пиридо-(1,2-а) пиримидина или их фармацевтически приемлемых солей,или их оптически активных изомеров
MXPA03001337A (es) Preparacion de risperidona.
PL92086B1 (es)
RU2129546C1 (ru) 6,9-бис(аминозамещенные)-бензо(g)изохинолин-5,10-дионы, способ их получения, фармацевтическая композиция на их основе и способ ингибирования опухолей у млекопитающих
JPS582948B2 (ja) コウウイルスセイチカン 1 3− ジメチル −1h− ピラゾロ ( 3,4d ) キノリンルイ
JPH03145469A (ja) 置換イソキノリン及びその利用法
EP0061149A1 (en) Alkylenedioxybenzene derivatives and acid addition salts thereof and a process for their preparation
US4124587A (en) 4-Hydroxy-3-sulfinyl-quinolin-2(1H)-ones
JPH0377867A (ja) 新規オキサゾロピリジン誘導体
IL22791A (en) Tetrahydro indenopyridine compounds
JPS5825678B2 (ja) オキサゾ−ルユウドウタイ ノ セイゾウホウ
US4302458A (en) Phthalidyl-isoquinoline derivatives
US4273780A (en) Anti-allergic anti-9,10-dihydro-4-(1-methyl-4-piperidylidene)-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one oxime
CS203934B2 (en) Process for preparing new derivatives of 1,3 thiazino/ /3,4-b/isoquinolines
JP2875605B2 (ja) 3―エキソメチレンピロロ[2,1―b]チアゾール誘導体
US3207759A (en) Isoquinoline acetamides and acetonitriles
JPS5810387B2 (ja) 4,5,6,7テトラヒドロイミダゾ〔4,5−c〕ピリジン誘導体及びその製法
JPS633866B2 (es)
JPS5924992B2 (ja) ピリド〔2,3−d〕ピリミジン誘導体およびその製法
US3146266A (en) Novel ketone compounds
JPS6058919B2 (ja) フタリジル−イソキノリン誘導体、その製造法及びそれを含有する医薬
KR800000304B1 (ko) 티아졸로[3, 4-b] 이소퀴놀린 유도체의 제법
RU2036924C1 (ru) Способ получения производных имидазо (1,2-b)пиридазина или их солей и производные имидазо (1,2-b)пиридазина или их соли
JPH05306284A (ja) インドロキノリン誘導体