CR20170107A - Alfa-glucosidasa ácida muy potente con hidratos de carbono potenciados - Google Patents
Alfa-glucosidasa ácida muy potente con hidratos de carbono potenciadosInfo
- Publication number
- CR20170107A CR20170107A CR20170107A CR20170107A CR20170107A CR 20170107 A CR20170107 A CR 20170107A CR 20170107 A CR20170107 A CR 20170107A CR 20170107 A CR20170107 A CR 20170107A CR 20170107 A CR20170107 A CR 20170107A
- Authority
- CR
- Costa Rica
- Prior art keywords
- glucosidase
- potentiated
- carbon hydrates
- rhgaa
- powerful acid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2465—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/0102—Alpha-glucosidase (3.2.1.20)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Abstract
Composición de alfa glucosidasa humana recombinante (rhGAA) derivada de células CHO que contiene una composición de glicano más optimizada que consiste en una cantidad de rhGAA que contiene N-glicanos que llevan manosa-6-fosfato (M6P) o bis-M6P mayor que las rhGAAs convencionales, junto con una baja cantidad de glicanos de alto contenido en manosa no fosforilados y una baja cantidad de galactosa terminal en oligosacáridos complejos.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462057842P | 2014-09-30 | 2014-09-30 | |
US201462057847P | 2014-09-30 | 2014-09-30 | |
US201562112463P | 2015-02-05 | 2015-02-05 | |
US201562135345P | 2015-03-19 | 2015-03-19 | |
PCT/US2015/053252 WO2016054231A1 (en) | 2014-09-30 | 2015-09-30 | Highly potent acid alpha-glucosidase with enhanced carbohydrates |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20170107A true CR20170107A (es) | 2017-09-01 |
Family
ID=55631441
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20170107A CR20170107A (es) | 2014-09-30 | 2015-09-30 | Alfa-glucosidasa ácida muy potente con hidratos de carbono potenciados |
Country Status (33)
Country | Link |
---|---|
US (5) | US10208299B2 (es) |
EP (2) | EP4273241A3 (es) |
JP (3) | JP6851964B2 (es) |
KR (3) | KR102306577B1 (es) |
CN (2) | CN107075468B (es) |
AU (2) | AU2015325028B2 (es) |
BR (1) | BR112017005810A2 (es) |
CA (2) | CA3228032A1 (es) |
CL (1) | CL2017000722A1 (es) |
CO (1) | CO2017002776A2 (es) |
CR (1) | CR20170107A (es) |
DK (1) | DK3201320T3 (es) |
DO (1) | DOP2017000079A (es) |
EA (1) | EA038986B1 (es) |
EC (1) | ECSP17019103A (es) |
FI (2) | FI3201320T3 (es) |
HR (1) | HRP20240041T1 (es) |
IL (4) | IL289383B2 (es) |
LT (1) | LT3201320T (es) |
MX (2) | MX2017003989A (es) |
MY (1) | MY186336A (es) |
NI (1) | NI201700039A (es) |
PE (1) | PE20170906A1 (es) |
PH (1) | PH12017500455A1 (es) |
PL (1) | PL3201320T3 (es) |
PT (1) | PT3201320T (es) |
RS (1) | RS65066B1 (es) |
SG (2) | SG10202003753PA (es) |
SI (1) | SI3201320T1 (es) |
SV (1) | SV2017005416A (es) |
TN (1) | TN2017000082A1 (es) |
WO (1) | WO2016054231A1 (es) |
ZA (2) | ZA201701945B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT3201320T (pt) | 2014-09-30 | 2024-01-12 | Amicus Therapeutics Inc | Alfa-glucosidase ácida altamente potente com hidratos de carbono intensificados |
KR20230041833A (ko) * | 2015-12-30 | 2023-03-24 | 아미쿠스 세라퓨틱스, 인코포레이티드 | 폼페병 치료용의 강화된 산 알파-글루코시다제 |
LT3957320T (lt) * | 2015-12-30 | 2023-12-11 | Amicus Therapeutics, Inc. | Patobulinta rūgštinė alfa-gliukozidazė pompe ligos gydymui |
TWI823272B (zh) * | 2016-03-30 | 2023-11-21 | 美商阿米庫斯醫療股份有限公司 | 用於選擇高m6p重組蛋白之方法 |
IL301319A (en) | 2016-03-30 | 2023-05-01 | Amicus Therapeutics Inc | Formulations that include recombinant acid alpha-glucosidase |
JP7046003B2 (ja) | 2016-03-30 | 2022-04-01 | アミカス セラピューティックス インコーポレイテッド | 高m6p組換えタンパク質の選択方法 |
TW201829770A (zh) * | 2017-01-10 | 2018-08-16 | 美商阿米庫斯醫療股份有限公司 | 用於治療fabry氏病之重組α-半乳糖苷酶A |
EA202290114A1 (ru) * | 2017-03-30 | 2022-03-29 | Амикус Терапьютикс, Инк. | Способ отбора рекомбинантных белков с высоким содержанием m6p |
IL270530B1 (en) * | 2017-05-15 | 2024-03-01 | Amicus Therapeutics Inc | Recombinant human acid alpha-glucosidase |
JP2022546587A (ja) | 2019-09-06 | 2022-11-04 | アミカス セラピューティックス インコーポレイテッド | 生物製剤の捕捉及び精製のための方法 |
AU2022218792A1 (en) * | 2021-02-11 | 2023-08-24 | Amicus Therapeutics, Inc. | Recombinant human acid alpha-glucosidase and uses thereof |
WO2023150387A1 (en) * | 2022-02-07 | 2023-08-10 | M6P Therapeutics, Inc. | Compositions comprising acid alpha glucosidase and methods of use thereof |
TW202400212A (zh) | 2022-05-05 | 2024-01-01 | 美商阿米庫斯醫療股份有限公司 | 用於治療龐貝氏病之方法 |
Family Cites Families (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4837237A (en) | 1985-07-09 | 1989-06-06 | Fred Hutchinson Cancer Research Center | Therapy using glucosidase processing inhibitors |
US5879680A (en) | 1987-12-23 | 1999-03-09 | The United States Of America As Represented By The Department Of Health And Human Services | Cloned DNA for synthesizing unique glucocerebrosidase |
US4985445A (en) | 1988-02-12 | 1991-01-15 | Meiji Seika Kaisha, Ltd. | Cancer cell metastasis inhibitors and novel compounds |
US6451600B1 (en) | 1989-12-22 | 2002-09-17 | Genzyme Corporation | Enzymatically active recombinant glucocerebrosidase |
US5236838A (en) | 1988-12-23 | 1993-08-17 | Genzyme Corporation | Enzymatically active recombinant glucocerebrosidase |
US5179023A (en) | 1989-03-24 | 1993-01-12 | Research Corporation Technologies, Inc. | Recombinant α-galactosidase a therapy for Fabry disease |
US5011829A (en) | 1989-06-02 | 1991-04-30 | G. D. Searle & Co. | Pharmaceutical composition and method of inhibiting virus |
US5103008A (en) | 1989-08-17 | 1992-04-07 | Monsanto Company | Compound, N-butyl-deoxynojirimycin-6-phosphate |
US5401650A (en) | 1990-10-24 | 1995-03-28 | The Mount Sinai School Of Medicine Of The City University Of New York | Cloning and expression of biologically active α-galactosidase A |
US5399567A (en) | 1993-05-13 | 1995-03-21 | Monsanto Company | Method of treating cholera |
US6118045A (en) | 1995-08-02 | 2000-09-12 | Pharming B.V. | Lysosomal proteins produced in the milk of transgenic animals |
US6458574B1 (en) | 1996-09-12 | 2002-10-01 | Transkaryotic Therapies, Inc. | Treatment of a α-galactosidase a deficiency |
US6083725A (en) | 1996-09-13 | 2000-07-04 | Transkaryotic Therapies, Inc. | Tranfected human cells expressing human α-galactosidase A protein |
US6210666B1 (en) | 1997-10-21 | 2001-04-03 | Orphan Medical, Inc. | Truncated α-galactosidase A to treat fabry disease |
ATE258919T1 (de) | 1997-11-10 | 2004-02-15 | Searle & Co | Verwendung von alkylierten iminozuckern zur behandlung von multipler medikamentenresistenz |
US6465488B1 (en) | 1997-12-11 | 2002-10-15 | Chancellor, Masters & Scholars Of The University Of Oxford | Inhibition of glycolipid biosynthesis |
US6274597B1 (en) | 1998-06-01 | 2001-08-14 | Mount Sinai School Of Medicine Of New York University | Method of enhancing lysosomal α-Galactosidase A |
PT2020438T (pt) | 1998-12-07 | 2018-07-13 | Genzyme Corp | Tratamento da doença de pompe |
ES2311921T3 (es) | 1999-02-12 | 2009-02-16 | United Therapeutics Corporation | N-(8,8,8-trifluorooctil)1-5,-didesoxi-1,5-imino-d-glucitol para tratar infecciones por el virus de la hepatitis. |
EP1196190B1 (en) | 1999-07-26 | 2003-03-19 | G.D. SEARLE & CO. | Use of long-chain n-alkyl derivatives of deoxynojirimycin and a glucocerebrosidase enzyme for the manufacture of a medicament for the treatment of glycolipid storage diseases |
US6537785B1 (en) | 1999-09-14 | 2003-03-25 | Genzyme Glycobiology Research Institute, Inc. | Methods of treating lysosomal storage diseases |
WO2001097829A2 (en) | 2000-06-19 | 2001-12-27 | Genzyme Corporation | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
US20040204379A1 (en) | 2000-06-19 | 2004-10-14 | Cheng Seng H. | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
ES2799882T3 (es) | 2000-07-18 | 2020-12-22 | Univ Duke | Tratamiento de glucogenosis de tipo II |
CN1638739A (zh) | 2000-08-18 | 2005-07-13 | 法玛西雅厄普约翰美国公司 | 治疗成瘾性障碍的化合物 |
US7723296B2 (en) * | 2001-01-18 | 2010-05-25 | Genzyme Corporation | Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof |
US7560424B2 (en) | 2001-04-30 | 2009-07-14 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
WO2002087510A2 (en) | 2001-04-30 | 2002-11-07 | Symbiontics, Inc. | Subcellular targeting of therapeutic proteins |
JP2005523882A (ja) | 2001-10-16 | 2005-08-11 | アールエックスキネティックス,インコーポレイテッド | 高濃度タンパク質製剤および製造の方法 |
US20030072761A1 (en) | 2001-10-16 | 2003-04-17 | Lebowitz Jonathan | Methods and compositions for targeting proteins across the blood brain barrier |
WO2003086452A2 (en) | 2002-04-05 | 2003-10-23 | Genzyme Corporation | Methods of enhancing lysosomal storage disease therapy |
CA2814767C (en) | 2003-01-31 | 2016-03-15 | Mount Sinai School Of Medicine Of New York University | Combination therapy for treating protein deficiency disorders |
FR2861991B1 (fr) | 2003-11-07 | 2008-01-18 | Centre Nat Rech Scient | Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidose |
AU2005211775B2 (en) * | 2004-02-06 | 2009-10-08 | Biomarin Pharmaceutical Inc. | Manufacture of highly phosphorylated lysosomal enzymes and uses thereof |
JP4914224B2 (ja) | 2004-02-10 | 2012-04-11 | バイオマリン ファーマシューティカル インコーポレイテッド | 酸性αグルコシダーゼおよびそのフラグメント |
US20060142234A1 (en) | 2004-12-23 | 2006-06-29 | Guohua Chen | Injectable non-aqueous suspension |
MX2007014470A (es) | 2005-05-17 | 2008-02-06 | Amicus Therapeutics Inc | Metodo para el tratamiento de enfermedad de pompe usando derivados de 1-desoxinojirimicina. |
CA2669347A1 (en) | 2006-11-13 | 2008-05-29 | Zystor Therapeutics, Inc. | Methods for treating pompe disease |
CN101636200A (zh) * | 2006-11-13 | 2010-01-27 | 齐斯特治疗公司 | 用于治疗庞贝氏症的方法 |
US20100184803A1 (en) | 2007-03-09 | 2010-07-22 | Link Medicine Corporation | Treatment of Lysosomal Storage Diseases |
CA2685332A1 (en) | 2007-04-26 | 2008-11-06 | Amicus Therapeutics, Inc. | Dosing regimens for the treatment of lysosomal storage diseases using pharmacological chaperones |
US20100317690A1 (en) | 2007-11-21 | 2010-12-16 | Summit Corporation Plc | Treatment of protein folding disorders |
WO2009075815A1 (en) | 2007-12-07 | 2009-06-18 | Duke University | Immunomodulating gene therapy |
SI2252313T1 (sl) | 2008-02-12 | 2015-08-31 | Amicus Therapeutics, Inc. | Postopek napovedovanja odgovora na zdravljenje bolezni s farmakološkim spremljevalcem |
CA2718059A1 (en) | 2008-03-12 | 2009-09-17 | Amicus Therapeutics, Inc. | Assays for diagnosing and evaluating treatment options for pompe disease |
MX2010009874A (es) | 2008-03-12 | 2010-11-30 | Amicus Therapeutics Inc | Tratamiento para la enfermedad de pompe con chaperonas farmacologicas especificas y monitoreo del tratamiento usando marcadores subrogados. |
EP3187508A1 (en) * | 2008-05-07 | 2017-07-05 | BioMarin Pharmaceutical Inc. | Lysosomal targeting peptides and uses thereof |
WO2010015816A2 (en) | 2008-08-06 | 2010-02-11 | Summit Corporation Plc | Treatment of lysosomal storage disorders and other proteostatic diseases |
US20100119502A1 (en) | 2008-11-11 | 2010-05-13 | Amicus Therapeutics, Inc. | Therapy regimens, dosing regimens and stable medicaments for the treatment of pompe disease |
CA3040973A1 (en) * | 2008-12-16 | 2010-07-01 | Genzyme Corporation | Oligosaccharide-protein conjugates |
WO2010096369A1 (en) * | 2009-02-18 | 2010-08-26 | Amicus Therapeutics, Inc. | Mouse model for pompe disease and methods of use thereof |
ES2564093T3 (es) | 2009-04-09 | 2016-03-17 | Amicus Therapeutics, Inc. | Métodos para prevenir y/o tratar trastornos del almacenamiento lisosomal |
US8785168B2 (en) | 2009-06-17 | 2014-07-22 | Biomarin Pharmaceutical Inc. | Formulations for lysosomal enzymes |
JP5415170B2 (ja) | 2009-07-21 | 2014-02-12 | 富士フイルム株式会社 | 複眼撮像装置 |
KR101824743B1 (ko) | 2009-09-29 | 2018-02-05 | 유니버시테이트 젠트 | 만노스-1-포스포-6-만노스 결합의 포스포-6-만노스로의 가수분해 |
US20130196410A1 (en) | 2010-03-05 | 2013-08-01 | Alnylam Pharmaceuticals, Inc | Compositions and methods for modifying the glycosylation pattern of a polypeptide |
US9347050B2 (en) * | 2010-09-29 | 2016-05-24 | Oxyrane Uk Limited | Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated N-glycans and methods of facilitating mammalian cellular uptake of glycoproteins |
MX2013012345A (es) | 2011-04-22 | 2015-05-07 | Genzyme Corp | Alfa glucosidasa acida modificada con procesamiento acelerado. |
ES2660185T3 (es) * | 2011-05-27 | 2018-03-21 | Amicus Therapeutics, Inc. | Métodos para acoplar péptidos direccionadores a enzimas lisosomales recombinantes para optimizar los tratamientos de las enfermedades por depósito lisosomal |
WO2013013017A2 (en) | 2011-07-21 | 2013-01-24 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for modifying the glycosylation of lysosomal storage disorder therapeutics |
JP2014522105A (ja) * | 2011-07-22 | 2014-08-28 | インサイト フォトニック ソリューションズ,インコーポレイテッド | 波長連続及び規定された時間に対する波長掃引をレーザーから動的及び適応的に生成するシステム及び方法 |
AU2012359165A1 (en) | 2011-12-22 | 2014-07-10 | Centogene Ip Gmbh | Combination of a compound having the ability to rearrange a lysosomal enzyme and ambroxol and/or a derivative of ambroxol |
JP6236406B2 (ja) | 2012-03-07 | 2017-11-22 | アミカス セラピューティックス インコーポレイテッド | ポンペ病の処置のための高濃度α−グルコシダーゼ組成物 |
EP2844279B1 (en) * | 2012-05-03 | 2020-12-09 | Amicus Therapeutics, Inc. | Dosing regimens for the treatment of pompe disease |
US20150147309A1 (en) | 2012-06-06 | 2015-05-28 | Fondazione Telethon | Allosteric chaperones and uses thereof |
TWI529396B (zh) | 2014-07-18 | 2016-04-11 | Mpi Corp | Probe card and its transfer circuit board and signal feed structure |
PT3201320T (pt) | 2014-09-30 | 2024-01-12 | Amicus Therapeutics Inc | Alfa-glucosidase ácida altamente potente com hidratos de carbono intensificados |
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2015
- 2015-09-30 PT PT158456640T patent/PT3201320T/pt unknown
- 2015-09-30 EA EA201790724A patent/EA038986B1/ru unknown
- 2015-09-30 MY MYPI2017000365A patent/MY186336A/en unknown
- 2015-09-30 KR KR1020177011346A patent/KR102306577B1/ko active Application Filing
- 2015-09-30 SG SG10202003753PA patent/SG10202003753PA/en unknown
- 2015-09-30 EP EP23191307.0A patent/EP4273241A3/en active Pending
- 2015-09-30 JP JP2017516917A patent/JP6851964B2/ja active Active
- 2015-09-30 US US15/515,808 patent/US10208299B2/en active Active
- 2015-09-30 HR HRP20240041TT patent/HRP20240041T1/hr unknown
- 2015-09-30 CN CN201580052512.5A patent/CN107075468B/zh active Active
- 2015-09-30 SG SG11201702114TA patent/SG11201702114TA/en unknown
- 2015-09-30 PE PE2017000507A patent/PE20170906A1/es unknown
- 2015-09-30 IL IL289383A patent/IL289383B2/en unknown
- 2015-09-30 SI SI201531983T patent/SI3201320T1/sl unknown
- 2015-09-30 RS RS20240027A patent/RS65066B1/sr unknown
- 2015-09-30 LT LTEPPCT/US2015/053252T patent/LT3201320T/lt unknown
- 2015-09-30 PL PL15845664.0T patent/PL3201320T3/pl unknown
- 2015-09-30 KR KR1020217030450A patent/KR102455814B1/ko active IP Right Grant
- 2015-09-30 CA CA3228032A patent/CA3228032A1/en active Pending
- 2015-09-30 EP EP15845664.0A patent/EP3201320B1/en active Active
- 2015-09-30 FI FIEP15845664.0T patent/FI3201320T3/fi active
- 2015-09-30 AU AU2015325028A patent/AU2015325028B2/en active Active
- 2015-09-30 DK DK15845664.0T patent/DK3201320T3/da active
- 2015-09-30 BR BR112017005810A patent/BR112017005810A2/pt not_active Application Discontinuation
- 2015-09-30 MX MX2017003989A patent/MX2017003989A/es unknown
- 2015-09-30 IL IL307587A patent/IL307587A/en unknown
- 2015-09-30 CN CN202111483006.5A patent/CN114540327A/zh active Pending
- 2015-09-30 CA CA2961762A patent/CA2961762C/en active Active
- 2015-09-30 TN TN2017000082A patent/TN2017000082A1/en unknown
- 2015-09-30 KR KR1020227035610A patent/KR20220146662A/ko not_active Application Discontinuation
- 2015-09-30 CR CR20170107A patent/CR20170107A/es unknown
- 2015-09-30 WO PCT/US2015/053252 patent/WO2016054231A1/en active Application Filing
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2017
- 2017-03-10 PH PH12017500455A patent/PH12017500455A1/en unknown
- 2017-03-14 IL IL251152A patent/IL251152B/en active IP Right Grant
- 2017-03-20 ZA ZA2017/01945A patent/ZA201701945B/en unknown
- 2017-03-20 DO DO2017000079A patent/DOP2017000079A/es unknown
- 2017-03-23 CO CONC2017/0002776A patent/CO2017002776A2/es unknown
- 2017-03-27 MX MX2021014565A patent/MX2021014565A/es unknown
- 2017-03-27 CL CL2017000722A patent/CL2017000722A1/es unknown
- 2017-03-28 EC ECIEPI201719103A patent/ECSP17019103A/es unknown
- 2017-03-28 SV SV2017005416A patent/SV2017005416A/es unknown
- 2017-03-28 NI NI201700039A patent/NI201700039A/es unknown
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2019
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2021
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2023
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2024
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