CR11106A - Inhibidores de cinasa p710 s6 - Google Patents

Inhibidores de cinasa p710 s6

Info

Publication number
CR11106A
CR11106A CR11106A CR11106A CR11106A CR 11106 A CR11106 A CR 11106A CR 11106 A CR11106 A CR 11106A CR 11106 A CR11106 A CR 11106A CR 11106 A CR11106 A CR 11106A
Authority
CR
Costa Rica
Prior art keywords
kinase inhibitors
formula
methods
relates
present
Prior art date
Application number
CR11106A
Other languages
English (en)
Spanish (es)
Inventor
Dean Dally Robert
Huang Jianping
Joseph Sajan
Alan Shepherd Timothy
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CR11106A publication Critical patent/CR11106A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CR11106A 2007-05-11 2009-11-10 Inhibidores de cinasa p710 s6 CR11106A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91733107P 2007-05-11 2007-05-11

Publications (1)

Publication Number Publication Date
CR11106A true CR11106A (es) 2010-04-12

Family

ID=39765082

Family Applications (1)

Application Number Title Priority Date Filing Date
CR11106A CR11106A (es) 2007-05-11 2009-11-10 Inhibidores de cinasa p710 s6

Country Status (33)

Country Link
US (2) US8093383B2 (cg-RX-API-DMAC10.html)
EP (1) EP2148880B1 (cg-RX-API-DMAC10.html)
JP (1) JP5503532B2 (cg-RX-API-DMAC10.html)
KR (1) KR101088219B1 (cg-RX-API-DMAC10.html)
CN (1) CN101679439B (cg-RX-API-DMAC10.html)
AR (1) AR066344A1 (cg-RX-API-DMAC10.html)
AU (1) AU2008251692B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI0811212A2 (cg-RX-API-DMAC10.html)
CA (1) CA2687265C (cg-RX-API-DMAC10.html)
CL (1) CL2008001230A1 (cg-RX-API-DMAC10.html)
CO (1) CO6241109A2 (cg-RX-API-DMAC10.html)
CR (1) CR11106A (cg-RX-API-DMAC10.html)
DK (1) DK2148880T3 (cg-RX-API-DMAC10.html)
DO (1) DOP2009000257A (cg-RX-API-DMAC10.html)
EA (1) EA016445B1 (cg-RX-API-DMAC10.html)
EC (1) ECSP099721A (cg-RX-API-DMAC10.html)
ES (1) ES2483726T3 (cg-RX-API-DMAC10.html)
GT (1) GT200900292A (cg-RX-API-DMAC10.html)
HR (1) HRP20140611T1 (cg-RX-API-DMAC10.html)
IL (1) IL201564A (cg-RX-API-DMAC10.html)
MA (1) MA31433B1 (cg-RX-API-DMAC10.html)
MX (1) MX2009012075A (cg-RX-API-DMAC10.html)
MY (1) MY154898A (cg-RX-API-DMAC10.html)
NZ (1) NZ580423A (cg-RX-API-DMAC10.html)
PE (1) PE20090887A1 (cg-RX-API-DMAC10.html)
PL (1) PL2148880T3 (cg-RX-API-DMAC10.html)
PT (1) PT2148880E (cg-RX-API-DMAC10.html)
RS (1) RS53451B (cg-RX-API-DMAC10.html)
SI (1) SI2148880T1 (cg-RX-API-DMAC10.html)
TN (1) TN2009000446A1 (cg-RX-API-DMAC10.html)
TW (1) TWI423805B (cg-RX-API-DMAC10.html)
UA (1) UA99284C2 (cg-RX-API-DMAC10.html)
WO (1) WO2008140947A1 (cg-RX-API-DMAC10.html)

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MX2015002887A (es) * 2012-09-06 2015-07-06 Plexxikon Inc Compuestos y metodos para la modulacion de cinasas, e indicaciones para ello.
AU2013203714B2 (en) 2012-10-18 2015-12-03 Signal Pharmaceuticals, Llc Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
CA2890345A1 (en) * 2012-11-16 2014-05-22 Merck Patent Gmbh Imidazol-piperidinyl derivatives as modulators of kinase activity
ES2620119T3 (es) 2012-11-16 2017-06-27 Merck Patent Gmbh Derivados heterocíclicos novedosos como moduladores de la actividad de quinasa
WO2014085528A1 (en) 2012-11-29 2014-06-05 Merck Patent Gmbh Azaquinazoline carboxamide derivatives
HK1218756A1 (zh) 2013-03-11 2017-03-10 默克专利有限公司 用作激酶活性调节剂的6-[4-(1h-咪唑-2-基)哌啶-1-基]嘧啶-4-胺衍生物
SG10201708111YA (en) 2013-04-17 2017-11-29 Signal Pharm Llc Combination therapy comprising a dihydropyrazino-pyrazine compound and an androgen receptor antagonist for treating prostate cancer
JP6382946B2 (ja) 2013-04-17 2018-08-29 シグナル ファーマシューティカルズ，エルエルシー ジヒドロピラジノ−ピラジンによる癌治療
TW201521725A (zh) 2013-04-17 2015-06-16 Signal Pharm Llc 使用ｔｏｒ激酶抑制劑組合療法以治療癌症之方法
CA2909629C (en) 2013-04-17 2022-12-13 Signal Pharmaceuticals, Llc Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one
WO2014172436A1 (en) 2013-04-17 2014-10-23 Signal Pharmaceuticals, Llc Combination therapy comprising a tor kinase inhibitor and a 5-substituted quinazolinone compound for treating cancer
MX377267B (es) 2013-04-17 2025-03-07 Signal Pharm Llc Tratamiento de cáncer con dihidropirazino-pirazinas.
TWI631949B (zh) 2013-04-17 2018-08-11 標誌製藥公司 使用ｔｏｒ激酶抑制劑組合療法以治療癌症之方法
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US9771369B2 (en) 2014-03-04 2017-09-26 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
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WO2016040078A1 (en) * 2014-09-10 2016-03-17 Eli Lilly And Company Substituted phenyl imidazolyl piperidyl compounds as p70s6k1 inhibitors
US10160755B2 (en) 2015-04-08 2018-12-25 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
CN106187899B (zh) * 2016-06-28 2019-07-16 绍兴文理学院 一种氟代氮杂芳烃的合成方法
BR112019027402A2 (pt) 2017-06-22 2020-07-07 Celgene Corporation tratamento de carcinoma hepatocelular caracterizado por infecção pelo vírus da hepatite b
EP4243819A1 (en) 2020-11-16 2023-09-20 Merck Patent GmbH Kinase inhibitor combinations for cancer treatment

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Also Published As

Publication number Publication date
CO6241109A2 (es) 2011-01-20
UA99284C2 (ru) 2012-08-10
TW200848053A (en) 2008-12-16
CN101679439B (zh) 2013-09-11
SI2148880T1 (sl) 2014-07-31
ECSP099721A (es) 2009-12-28
BRPI0811212A2 (pt) 2014-10-29
TWI423805B (zh) 2014-01-21
AU2008251692B2 (en) 2012-10-11
RS53451B (sr) 2014-12-31
WO2008140947A1 (en) 2008-11-20
EA016445B1 (ru) 2012-05-30
HRP20140611T1 (hr) 2014-08-15
ES2483726T3 (es) 2014-08-07
CN101679439A (zh) 2010-03-24
KR101088219B1 (ko) 2011-11-30
TN2009000446A1 (en) 2011-03-31
MX2009012075A (es) 2009-11-19
PT2148880E (pt) 2014-08-28
JP2010526814A (ja) 2010-08-05
DOP2009000257A (es) 2010-03-31
DK2148880T3 (da) 2014-06-16
AU2008251692A1 (en) 2008-11-20
EP2148880A1 (en) 2010-02-03
CA2687265C (en) 2012-12-04
HK1140767A1 (en) 2010-10-22
US20120071490A1 (en) 2012-03-22
JP5503532B2 (ja) 2014-05-28
GT200900292A (es) 2011-06-24
IL201564A0 (en) 2010-05-31
US8093383B2 (en) 2012-01-10
NZ580423A (en) 2012-02-24
AR066344A1 (es) 2009-08-12
MA31433B1 (fr) 2010-06-01
EA200971051A1 (ru) 2010-06-30
IL201564A (en) 2014-08-31
EP2148880B1 (en) 2014-05-28
CA2687265A1 (en) 2008-11-20
CL2008001230A1 (es) 2009-05-22
PE20090887A1 (es) 2009-07-13
US20090163714A1 (en) 2009-06-25
MY154898A (en) 2015-08-28
KR20100005710A (ko) 2010-01-15
PL2148880T3 (pl) 2014-10-31

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