CR10188A - Antagonistas de receptor de factor de crecimiento de tipo insulina (igf-ir) como auxiliares para tratamiento de cancer de prostata - Google Patents
Antagonistas de receptor de factor de crecimiento de tipo insulina (igf-ir) como auxiliares para tratamiento de cancer de prostataInfo
- Publication number
- CR10188A CR10188A CR10188A CR10188A CR10188A CR 10188 A CR10188 A CR 10188A CR 10188 A CR10188 A CR 10188A CR 10188 A CR10188 A CR 10188A CR 10188 A CR10188 A CR 10188A
- Authority
- CR
- Costa Rica
- Prior art keywords
- prostate cancer
- igf
- growth factor
- assistants
- cancer treatment
- Prior art date
Links
- 206010060862 Prostate cancer Diseases 0.000 title abstract 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 239000003102 growth factor Substances 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
- 239000003098 androgen Substances 0.000 abstract 2
- 238000009167 androgen deprivation therapy Methods 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000004584 Somatomedin Receptors Human genes 0.000 abstract 1
- 108010017622 Somatomedin Receptors Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000001934 delay Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000007704 transition Effects 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
Abstract
La presente invención se refiere a un método para tratar cáncer de próstata con terapia de privación de andrógeno y un antagonista de receptor de factor de crecimiento de tipo insulina (IGF-IR). Aunque la velocidad de respuesta de cáncer de próstata a la terapia de privación de andrógeno (ADT) es alta, las células de cáncer que sobreviven invariablemente se vuelven independientes de andrógeno (AI) y sigue el crecimiento del tumor. La invención inhibe o retrasa la transición de andrógeno, significativamente reduce el riesgo de recurrencia, y mejora el resultado del tratamiento.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76507206P | 2006-02-03 | 2006-02-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
CR10188A true CR10188A (es) | 2008-11-18 |
Family
ID=38345750
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR10188A CR10188A (es) | 2006-02-03 | 2008-08-01 | Antagonistas de receptor de factor de crecimiento de tipo insulina (igf-ir) como auxiliares para tratamiento de cancer de prostata |
Country Status (17)
Country | Link |
---|---|
US (1) | US7972600B2 (es) |
EP (1) | EP1984011A4 (es) |
JP (1) | JP5198289B2 (es) |
KR (1) | KR101353706B1 (es) |
CN (1) | CN101484587B (es) |
AP (1) | AP2008004569A0 (es) |
AU (1) | AU2007212447B2 (es) |
CA (1) | CA2641310C (es) |
CR (1) | CR10188A (es) |
EA (1) | EA017265B1 (es) |
EC (1) | ECSP088706A (es) |
IL (1) | IL193203A0 (es) |
MX (1) | MX2008009977A (es) |
NO (1) | NO20083444L (es) |
UA (1) | UA95945C2 (es) |
WO (1) | WO2007092453A2 (es) |
ZA (1) | ZA200807012B (es) |
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WO2009052379A2 (en) * | 2007-10-19 | 2009-04-23 | Pharma Mar, S.A. | Improved antitumoral treatments |
US9084770B2 (en) * | 2008-10-14 | 2015-07-21 | Antisense Therapeutics, Ltd. | Modulation of insulin like growth factor I receptor expression in cancer |
MX2011006055A (es) | 2008-12-12 | 2011-07-04 | Boehringer Ingelheim Int | Anticuerpos anti-igf. |
US20100214282A1 (en) | 2009-02-24 | 2010-08-26 | Dolby Laboratories Licensing Corporation | Apparatus for providing light source modulation in dual modulator displays |
US20100316639A1 (en) | 2009-06-16 | 2010-12-16 | Genentech, Inc. | Biomarkers for igf-1r inhibitor therapy |
WO2011057064A1 (en) * | 2009-11-05 | 2011-05-12 | Brian Long | Igf1r inhibitor based treatment of prostate cancer |
KR101426134B1 (ko) * | 2011-09-26 | 2014-08-06 | 한화케미칼 주식회사 | 항 igf-1r 단일클론 항체와 il-2를 포함하는 융합 단일클론 항체 및 이를 포함하는 암치료용 조성물 |
US9532972B2 (en) * | 2012-02-07 | 2017-01-03 | University Of Central Florida Research Foundation, Inc. | Increasing taxane sensitivity in cancer cells |
US10799473B2 (en) * | 2013-03-04 | 2020-10-13 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Methods of inhibiting IGF-1R activation or downtream signalling thereof to reduce radiation-induced cellular senescence |
US20140255413A1 (en) | 2013-03-07 | 2014-09-11 | Boehringer Ingelheim International Gmbh | Combination therapy for neoplasia treatment |
WO2015042029A1 (en) * | 2013-09-19 | 2015-03-26 | Glaxosmithkline Llc | Combination drug therapy |
US20230005594A1 (en) * | 2019-12-06 | 2023-01-05 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Clinical decision support for personalized adaptive prostate cancer therapy |
CN113512116B (zh) | 2020-04-10 | 2022-09-20 | 苏州普乐康医药科技有限公司 | 一种抗igf-1r抗体及其应用 |
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2007
- 2007-02-03 CA CA2641310A patent/CA2641310C/en not_active Expired - Fee Related
- 2007-02-03 AU AU2007212447A patent/AU2007212447B2/en not_active Ceased
- 2007-02-03 EA EA200870231A patent/EA017265B1/ru not_active IP Right Cessation
- 2007-02-03 KR KR1020087021466A patent/KR101353706B1/ko not_active IP Right Cessation
- 2007-02-03 CN CN200780012266.6A patent/CN101484587B/zh not_active Expired - Fee Related
- 2007-02-03 AP AP2008004569A patent/AP2008004569A0/xx unknown
- 2007-02-03 MX MX2008009977A patent/MX2008009977A/es active IP Right Grant
- 2007-02-03 UA UAA200810850A patent/UA95945C2/ru unknown
- 2007-02-03 EP EP07763681A patent/EP1984011A4/en not_active Withdrawn
- 2007-02-03 JP JP2008553410A patent/JP5198289B2/ja not_active Expired - Fee Related
- 2007-02-03 WO PCT/US2007/003164 patent/WO2007092453A2/en active Application Filing
- 2007-02-05 US US11/702,838 patent/US7972600B2/en not_active Expired - Fee Related
-
2008
- 2008-08-01 CR CR10188A patent/CR10188A/es unknown
- 2008-08-03 IL IL193203A patent/IL193203A0/en not_active IP Right Cessation
- 2008-08-07 NO NO20083444A patent/NO20083444L/no not_active Application Discontinuation
- 2008-08-14 ZA ZA200807012A patent/ZA200807012B/xx unknown
- 2008-08-28 EC EC2008008706A patent/ECSP088706A/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN101484587A (zh) | 2009-07-15 |
EA200870231A1 (ru) | 2009-12-30 |
MX2008009977A (es) | 2009-02-27 |
NO20083444L (no) | 2008-10-31 |
IL193203A0 (en) | 2009-08-03 |
EP1984011A4 (en) | 2010-08-18 |
KR20080090566A (ko) | 2008-10-08 |
US7972600B2 (en) | 2011-07-05 |
ZA200807012B (en) | 2009-12-30 |
CA2641310A1 (en) | 2007-08-16 |
JP2009525348A (ja) | 2009-07-09 |
UA95945C2 (ru) | 2011-09-26 |
CA2641310C (en) | 2013-08-20 |
AU2007212447A1 (en) | 2007-08-16 |
JP5198289B2 (ja) | 2013-05-15 |
AU2007212447B2 (en) | 2013-02-21 |
AP2008004569A0 (en) | 2008-08-31 |
EP1984011A2 (en) | 2008-10-29 |
US20090175868A1 (en) | 2009-07-09 |
EA017265B1 (ru) | 2012-11-30 |
WO2007092453A3 (en) | 2008-12-24 |
KR101353706B1 (ko) | 2014-02-18 |
WO2007092453A2 (en) | 2007-08-16 |
CN101484587B (zh) | 2014-02-12 |
ECSP088706A (es) | 2008-10-31 |
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