MX2013010530A - Combinacion de oligonucleotido anti-clusterina con antagonistas del receptor de androgeno para el tratamiento de cancer de prostata. - Google Patents

Combinacion de oligonucleotido anti-clusterina con antagonistas del receptor de androgeno para el tratamiento de cancer de prostata.

Info

Publication number
MX2013010530A
MX2013010530A MX2013010530A MX2013010530A MX2013010530A MX 2013010530 A MX2013010530 A MX 2013010530A MX 2013010530 A MX2013010530 A MX 2013010530A MX 2013010530 A MX2013010530 A MX 2013010530A MX 2013010530 A MX2013010530 A MX 2013010530A
Authority
MX
Mexico
Prior art keywords
combination
prostate cancer
receptor antagonist
androgen receptor
treatment
Prior art date
Application number
MX2013010530A
Other languages
English (en)
Inventor
Martin Gleave
Amina Zoubeidi
Original Assignee
Univ British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ British Columbia filed Critical Univ British Columbia
Publication of MX2013010530A publication Critical patent/MX2013010530A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describe un método para tratar un sujeto mamífero que padece de cáncer de próstata que comprende i) un oligonucleótido que reduce la expresión de clusterina y ii) un antagonista del receptor de andrógeno que tiene la estructura (Ver Formula) o una sal farmacéuticamente aceptable del mismo, cada uno en una cantidad que cuando en combinación con el otro es efectivo para tratar el sujeto mamífero.
MX2013010530A 2011-03-14 2012-03-14 Combinacion de oligonucleotido anti-clusterina con antagonistas del receptor de androgeno para el tratamiento de cancer de prostata. MX2013010530A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161452583P 2011-03-14 2011-03-14
US201161453309P 2011-03-16 2011-03-16
US201161453885P 2011-03-17 2011-03-17
US201161493336P 2011-06-03 2011-06-03
PCT/IB2012/000609 WO2012123820A1 (en) 2011-03-14 2012-03-14 Combination of anti-clusterin oligonucleotide with androgen receptor antagonist for the treatment of prostate cancer

Publications (1)

Publication Number Publication Date
MX2013010530A true MX2013010530A (es) 2014-05-01

Family

ID=46830100

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013010530A MX2013010530A (es) 2011-03-14 2012-03-14 Combinacion de oligonucleotido anti-clusterina con antagonistas del receptor de androgeno para el tratamiento de cancer de prostata.

Country Status (12)

Country Link
US (1) US20140088178A1 (es)
EP (1) EP2685989A4 (es)
JP (1) JP2014509607A (es)
KR (1) KR20140048106A (es)
AU (1) AU2012228007B2 (es)
CA (1) CA2830191A1 (es)
IL (1) IL227718A0 (es)
MX (1) MX2013010530A (es)
RU (1) RU2013145551A (es)
SG (1) SG192952A1 (es)
WO (1) WO2012123820A1 (es)
ZA (1) ZA201307558B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1163254T3 (da) 1999-02-26 2008-06-09 Univ British Columbia TRPM-2 antisense-behandling
US7569551B2 (en) 2000-02-25 2009-08-04 The University Of British Columbia Chemo- and radiation-sensitization of cancer by antisense TRPM-2 oligodeoxynucleotides
AU2012228010B2 (en) 2011-03-15 2016-08-25 The University Of British Columbia Combination of anti-clusterin oligonucleotide with Hsp90 inhibitor for the treatment of prostate cancer
CN106442992A (zh) * 2016-08-03 2017-02-22 上海延安药业有限公司 阿比特龙衍生物的药代动力学评估方法
CA3138197A1 (en) * 2019-05-14 2020-11-19 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
JP2022542013A (ja) 2019-07-25 2022-09-29 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム エアロゾル発生物品のための自動販売装置
EP4058464A1 (en) 2019-11-13 2022-09-21 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
US11834458B2 (en) 2021-03-23 2023-12-05 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005094899A1 (en) * 2004-04-02 2005-10-13 The University Of British Columbia Clusterin antisense therapy for treatment of cancer
CA2753425A1 (en) * 2009-02-24 2010-09-02 Medivation Prostate Therapeutics, Inc. Specific diarylhydantoin and diarylthiohydantoin compounds

Also Published As

Publication number Publication date
ZA201307558B (en) 2015-08-26
AU2012228007B2 (en) 2016-09-08
US20140088178A1 (en) 2014-03-27
SG192952A1 (en) 2013-09-30
IL227718A0 (en) 2013-09-30
CA2830191A1 (en) 2012-09-20
RU2013145551A (ru) 2015-04-20
AU2012228007A1 (en) 2013-10-31
NZ616465A (en) 2015-08-28
KR20140048106A (ko) 2014-04-23
JP2014509607A (ja) 2014-04-21
WO2012123820A1 (en) 2012-09-20
EP2685989A4 (en) 2014-12-10
EP2685989A1 (en) 2014-01-22

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