CO7310522A2 - Compuestos de bis (fluoroalquil)-1,4-benzodiazepinona como inhibidores de notch - Google Patents

Compuestos de bis (fluoroalquil)-1,4-benzodiazepinona como inhibidores de notch

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Publication number
CO7310522A2
CO7310522A2 CO15057524A CO15057524A CO7310522A2 CO 7310522 A2 CO7310522 A2 CO 7310522A2 CO 15057524 A CO15057524 A CO 15057524A CO 15057524 A CO15057524 A CO 15057524A CO 7310522 A2 CO7310522 A2 CO 7310522A2
Authority
CO
Colombia
Prior art keywords
compounds
fluoroalkyl
bis
notch inhibitors
benzodiazepinone compounds
Prior art date
Application number
CO15057524A
Other languages
English (en)
Inventor
Ashvinikumar V Gavai
George V Delucca
Malley Daniel O
Patrice Gill
Claude Quesnelle
Brian E Fink
Yufen Zhao
Francis Lee
Original Assignee
Bristol Myers Squibb Co
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Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CO7310522A2 publication Critical patent/CO7310522A2/es

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    • C07ORGANIC CHEMISTRY
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    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/13Amines
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    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/55131,4-Benzodiazepines, e.g. diazepam or clozapine
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    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
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    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
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    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

La presente invención se refiere a compuestos de laFórmula (I) y/o sus sales:en donde R1 es -CH2CH2CF3; R2 es -CH2CH2CF3 o -CH2CH2CH2CF3; R3 es H, -CH3 o Rx; R4 es H o Ry; el anillo A esfenilo o piridinilo; y Rx, Ry, Ra, Rb, y e z son como sedefinen en la presente. También se describen métodos parausar tales compuestos con el fin de inhibir el receptor deNotch, y composiciones farmacéuticas que comprenden talescompuestos. Estos compuestos son útiles para el tratamiento,la prevención o el enlentecimiento de la progresión deenfermedades o trastornos en varias áreas terapéuticas, talescomo el cáncer; o como profármacos de tales compuestos
CO15057524A 2012-09-21 2015-03-12 Compuestos de bis (fluoroalquil)-1,4-benzodiazepinona como inhibidores de notch CO7310522A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261703912P 2012-09-21 2012-09-21

Publications (1)

Publication Number Publication Date
CO7310522A2 true CO7310522A2 (es) 2015-06-30

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CO15057524A CO7310522A2 (es) 2012-09-21 2015-03-12 Compuestos de bis (fluoroalquil)-1,4-benzodiazepinona como inhibidores de notch

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US (2) US8999918B2 (es)
EP (1) EP2897945B1 (es)
JP (1) JP6165255B2 (es)
KR (1) KR102155588B1 (es)
CN (1) CN104703976B (es)
AR (1) AR093767A1 (es)
AU (1) AU2013317923B2 (es)
BR (1) BR112015005817B1 (es)
CA (1) CA2885574C (es)
CL (1) CL2015000711A1 (es)
CO (1) CO7310522A2 (es)
CY (1) CY1118739T1 (es)
DK (1) DK2897945T3 (es)
EA (1) EA027281B1 (es)
ES (1) ES2617591T3 (es)
HR (1) HRP20170352T8 (es)
HU (1) HUE032038T2 (es)
IL (1) IL237782A (es)
LT (1) LT2897945T (es)
MA (1) MA37929B1 (es)
MX (1) MX367474B (es)
MY (1) MY185233A (es)
NZ (1) NZ707171A (es)
PE (1) PE20150622A1 (es)
PH (1) PH12015500414B1 (es)
PL (1) PL2897945T3 (es)
PT (1) PT2897945T (es)
RS (1) RS55779B1 (es)
SG (1) SG11201501573UA (es)
SI (1) SI2897945T1 (es)
TN (1) TN2015000102A1 (es)
TW (1) TWI614238B (es)
UY (1) UY35041A (es)
WO (1) WO2014047372A1 (es)

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