CO7111256A2 - Derivados de ariletinilo - Google Patents
Derivados de ariletiniloInfo
- Publication number
- CO7111256A2 CO7111256A2 CO14235289A CO14235289A CO7111256A2 CO 7111256 A2 CO7111256 A2 CO 7111256A2 CO 14235289 A CO14235289 A CO 14235289A CO 14235289 A CO14235289 A CO 14235289A CO 7111256 A2 CO7111256 A2 CO 7111256A2
- Authority
- CO
- Colombia
- Prior art keywords
- derivatives
- pharmaceutically acceptable
- ariletinyl
- formula
- metaboterous
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a derivados de etinilo de la fórmula I en la que: R1 es fenilo, que está opcionalmente sustituido por 1-2 átomos de halógeno, elegidos entre flúor y cloro; o una sal de adición de ácido farmacéuticamente aceptable, en forma enantioméri-camente pura. Se ha encontrado que los compuestos de la fórmula general I son moduladores alostéricos del receptor metabotrópico de glutamato del subtipo 5 (mGluR5).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12176662 | 2012-07-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO7111256A2 true CO7111256A2 (es) | 2014-11-10 |
Family
ID=48782352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO14235289A CO7111256A2 (es) | 2012-07-17 | 2014-10-23 | Derivados de ariletinilo |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US20150133505A1 (es) |
| EP (1) | EP2875000B1 (es) |
| JP (1) | JP6089104B2 (es) |
| KR (1) | KR101631041B1 (es) |
| CN (1) | CN104364233B (es) |
| AR (1) | AR091764A1 (es) |
| AU (1) | AU2013292142B2 (es) |
| BR (1) | BR112014029015A2 (es) |
| CA (1) | CA2871389C (es) |
| CL (1) | CL2014003160A1 (es) |
| CO (1) | CO7111256A2 (es) |
| CR (1) | CR20140531A (es) |
| CY (1) | CY1118205T1 (es) |
| DK (1) | DK2875000T3 (es) |
| EA (1) | EA026593B1 (es) |
| ES (1) | ES2600133T3 (es) |
| HK (1) | HK1202544A1 (es) |
| HR (1) | HRP20161691T1 (es) |
| HU (1) | HUE030177T2 (es) |
| IL (1) | IL236362A (es) |
| LT (1) | LT2875000T (es) |
| MA (1) | MA20150280A2 (es) |
| MX (1) | MX358998B (es) |
| MY (1) | MY167810A (es) |
| NZ (1) | NZ701849A (es) |
| PE (1) | PE20150184A1 (es) |
| PH (1) | PH12014502695B1 (es) |
| PL (1) | PL2875000T3 (es) |
| PT (1) | PT2875000T (es) |
| RS (1) | RS55313B1 (es) |
| SG (1) | SG11201407050UA (es) |
| SI (1) | SI2875000T1 (es) |
| TW (1) | TWI473799B (es) |
| UA (1) | UA114911C2 (es) |
| WO (1) | WO2014012851A1 (es) |
| ZA (1) | ZA201408514B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA113223C2 (xx) * | 2012-08-13 | 2016-12-26 | Арилетинілпіримідини | |
| MY171517A (en) * | 2012-10-18 | 2019-10-16 | Hoffmann La Roche | Ethynyl derivatives as modulators of mglur5 receptor activity |
| PL3303316T3 (pl) | 2015-06-03 | 2020-06-29 | F. Hoffmann-La Roche Ag | Pochodne etynylu |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19546462A1 (de) * | 1995-12-13 | 1997-06-19 | Bayer Ag | Diarylacetylenketone |
| DK1354875T3 (da) | 2003-05-19 | 2005-03-14 | Servier Lab | Ny syntesefremgangsmåde for (2S, 3aS, 7aS)-perhydroindol-2-carboxylsyre og estere heraf samt anvendelse ved syntese af perindopril |
| GB0325956D0 (en) | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
| EP1809620B1 (en) | 2004-11-04 | 2010-12-29 | Addex Pharma SA | Novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors |
| GB0510139D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
| WO2008151184A1 (en) | 2007-06-03 | 2008-12-11 | Vanderbilt University | Benzamide mglur5 positive allosteric modulators and methods of making and using same |
| CN101544892B (zh) * | 2009-05-07 | 2012-10-03 | 石家庄诚志永华显示材料有限公司 | 一种合成二芳基乙炔类单体液晶的方法 |
| US8420661B2 (en) * | 2010-04-13 | 2013-04-16 | Hoffmann-La Roche Inc. | Arylethynyl derivatives |
| MY163164A (en) * | 2011-04-26 | 2017-08-15 | Hoffmann La Roche | Ethynyl derivatives as positive allosteric modulators of the mglur5 |
-
2013
- 2013-07-12 LT LTEP13735315.7T patent/LT2875000T/lt unknown
- 2013-07-12 CN CN201380031736.9A patent/CN104364233B/zh active Active
- 2013-07-12 ES ES13735315.7T patent/ES2600133T3/es active Active
- 2013-07-12 SG SG11201407050UA patent/SG11201407050UA/en unknown
- 2013-07-12 CA CA2871389A patent/CA2871389C/en not_active Expired - Fee Related
- 2013-07-12 PL PL13735315T patent/PL2875000T3/pl unknown
- 2013-07-12 EA EA201492274A patent/EA026593B1/ru not_active IP Right Cessation
- 2013-07-12 JP JP2015521004A patent/JP6089104B2/ja active Active
- 2013-07-12 UA UAA201500231A patent/UA114911C2/uk unknown
- 2013-07-12 NZ NZ701849A patent/NZ701849A/en not_active IP Right Cessation
- 2013-07-12 PE PE2014002231A patent/PE20150184A1/es active IP Right Grant
- 2013-07-12 EP EP13735315.7A patent/EP2875000B1/en active Active
- 2013-07-12 DK DK13735315.7T patent/DK2875000T3/en active
- 2013-07-12 MX MX2014014950A patent/MX358998B/es active IP Right Grant
- 2013-07-12 MY MYPI2014003059A patent/MY167810A/en unknown
- 2013-07-12 HU HUE13735315A patent/HUE030177T2/en unknown
- 2013-07-12 KR KR1020157001019A patent/KR101631041B1/ko active IP Right Grant
- 2013-07-12 PT PT137353157T patent/PT2875000T/pt unknown
- 2013-07-12 SI SI201330415A patent/SI2875000T1/sl unknown
- 2013-07-12 AU AU2013292142A patent/AU2013292142B2/en not_active Ceased
- 2013-07-12 RS RS20160979A patent/RS55313B1/sr unknown
- 2013-07-12 MA MA37795A patent/MA20150280A2/fr unknown
- 2013-07-12 BR BR112014029015A patent/BR112014029015A2/pt not_active Application Discontinuation
- 2013-07-12 WO PCT/EP2013/064747 patent/WO2014012851A1/en active Application Filing
- 2013-07-15 AR ARP130102507 patent/AR091764A1/es not_active Application Discontinuation
- 2013-07-16 TW TW102125419A patent/TWI473799B/zh not_active IP Right Cessation
-
2014
- 2014-10-23 CO CO14235289A patent/CO7111256A2/es unknown
- 2014-11-19 ZA ZA2014/08514A patent/ZA201408514B/en unknown
- 2014-11-20 CR CR20140531A patent/CR20140531A/es unknown
- 2014-11-21 CL CL2014003160A patent/CL2014003160A1/es unknown
- 2014-12-03 PH PH12014502695A patent/PH12014502695B1/en unknown
- 2014-12-18 IL IL236362A patent/IL236362A/en active IP Right Grant
-
2015
- 2015-01-15 US US14/597,375 patent/US20150133505A1/en not_active Abandoned
- 2015-03-31 HK HK15103216.5A patent/HK1202544A1/zh unknown
- 2015-10-26 US US14/923,308 patent/US9328090B2/en active Active
-
2016
- 2016-11-04 CY CY20161101133T patent/CY1118205T1/el unknown
- 2016-12-12 HR HRP20161691TT patent/HRP20161691T1/hr unknown
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