AR091764A1 - Derivados de ariletinilo - Google Patents
Derivados de ariletiniloInfo
- Publication number
- AR091764A1 AR091764A1 ARP130102507A AR091764A1 AR 091764 A1 AR091764 A1 AR 091764A1 AR P130102507 A ARP130102507 A AR P130102507A AR 091764 A1 AR091764 A1 AR 091764A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivatives
- aryletinyl
- formula
- mglur5
- subtype
- Prior art date
Links
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 102000016193 Metabotropic glutamate receptors Human genes 0.000 abstract 1
- 108010010914 Metabotropic glutamate receptors Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000003281 allosteric effect Effects 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente se refiere a derivados de etinilo de la fórmula (1) en la que: R¹ es fenilo, que está opcionalmente sustituido por 1 - 2 átomos de halógeno, elegidos entre flúor y cloro; o una sal de adición de ácido farmacéuticamente aceptable, en forma enantioméricamente pura. Se ha encontrado que los compuestos de la fórmula general (1) son moduladores alostéricos del receptor metabotrópico de glutamato del subtipo 5 (mGluR5).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12176662 | 2012-07-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR091764A1 true AR091764A1 (es) | 2015-02-25 |
Family
ID=48782352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130102507 AR091764A1 (es) | 2012-07-17 | 2013-07-15 | Derivados de ariletinilo |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US20150133505A1 (es) |
| EP (1) | EP2875000B1 (es) |
| JP (1) | JP6089104B2 (es) |
| KR (1) | KR101631041B1 (es) |
| CN (1) | CN104364233B (es) |
| AR (1) | AR091764A1 (es) |
| AU (1) | AU2013292142B2 (es) |
| BR (1) | BR112014029015A2 (es) |
| CA (1) | CA2871389C (es) |
| CL (1) | CL2014003160A1 (es) |
| CO (1) | CO7111256A2 (es) |
| CR (1) | CR20140531A (es) |
| CY (1) | CY1118205T1 (es) |
| DK (1) | DK2875000T3 (es) |
| EA (1) | EA026593B1 (es) |
| ES (1) | ES2600133T3 (es) |
| HK (1) | HK1202544A1 (es) |
| HR (1) | HRP20161691T1 (es) |
| HU (1) | HUE030177T2 (es) |
| IL (1) | IL236362A (es) |
| LT (1) | LT2875000T (es) |
| MA (1) | MA20150280A2 (es) |
| MX (1) | MX358998B (es) |
| MY (1) | MY167810A (es) |
| NZ (1) | NZ701849A (es) |
| PE (1) | PE20150184A1 (es) |
| PH (1) | PH12014502695A1 (es) |
| PL (1) | PL2875000T3 (es) |
| PT (1) | PT2875000T (es) |
| RS (1) | RS55313B1 (es) |
| SG (1) | SG11201407050UA (es) |
| SI (1) | SI2875000T1 (es) |
| TW (1) | TWI473799B (es) |
| UA (1) | UA114911C2 (es) |
| WO (1) | WO2014012851A1 (es) |
| ZA (1) | ZA201408514B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA113223C2 (xx) * | 2012-08-13 | 2016-12-26 | Арилетинілпіримідини | |
| CN104603110B (zh) * | 2012-10-18 | 2016-08-31 | 霍夫曼-拉罗奇有限公司 | 作为mGluR5受体活性的调节剂的乙炔基衍生物 |
| AU2016273751B2 (en) | 2015-06-03 | 2020-04-02 | F. Hoffmann-La Roche Ag | Ethynyl derivatives |
| CN107580598B (zh) | 2015-07-15 | 2020-11-13 | 豪夫迈·罗氏有限公司 | 作为代谢型谷氨酸受体调节剂的乙炔基衍生物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19546462A1 (de) * | 1995-12-13 | 1997-06-19 | Bayer Ag | Diarylacetylenketone |
| ATE283258T1 (de) | 2003-05-19 | 2004-12-15 | Servier Lab | Verfahren zur synthese von (2s,3as,7as)- perhydroindol-2-carbonsäure und seiner estern, und verwendung in der synthese von perindopril |
| GB0325956D0 (en) | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
| EP1809620B1 (en) | 2004-11-04 | 2010-12-29 | Addex Pharma SA | Novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors |
| GB0510139D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
| KR20100033981A (ko) | 2007-06-03 | 2010-03-31 | 벤더르빌트 유니버시티 | 벤즈아미드 대사성 글루타민산염 수용체5 양성 알로스테릭 조절자 및 이의 제조 및 사용방법 |
| CN101544892B (zh) * | 2009-05-07 | 2012-10-03 | 石家庄诚志永华显示材料有限公司 | 一种合成二芳基乙炔类单体液晶的方法 |
| US8420661B2 (en) * | 2010-04-13 | 2013-04-16 | Hoffmann-La Roche Inc. | Arylethynyl derivatives |
| CA2829170C (en) * | 2011-04-26 | 2019-02-26 | F. Hoffmann-La Roche Ag | Ethynyl derivatives as positive allosteric modulators of the mglur5 |
-
2013
- 2013-07-12 MY MYPI2014003059A patent/MY167810A/en unknown
- 2013-07-12 RS RS20160979A patent/RS55313B1/sr unknown
- 2013-07-12 LT LTEP13735315.7T patent/LT2875000T/lt unknown
- 2013-07-12 DK DK13735315.7T patent/DK2875000T3/en active
- 2013-07-12 PE PE2014002231A patent/PE20150184A1/es active IP Right Grant
- 2013-07-12 NZ NZ701849A patent/NZ701849A/en not_active IP Right Cessation
- 2013-07-12 UA UAA201500231A patent/UA114911C2/uk unknown
- 2013-07-12 SI SI201330415A patent/SI2875000T1/sl unknown
- 2013-07-12 PL PL13735315T patent/PL2875000T3/pl unknown
- 2013-07-12 BR BR112014029015A patent/BR112014029015A2/pt not_active Application Discontinuation
- 2013-07-12 EP EP13735315.7A patent/EP2875000B1/en active Active
- 2013-07-12 AU AU2013292142A patent/AU2013292142B2/en not_active Ceased
- 2013-07-12 CN CN201380031736.9A patent/CN104364233B/zh active Active
- 2013-07-12 CA CA2871389A patent/CA2871389C/en not_active Expired - Fee Related
- 2013-07-12 JP JP2015521004A patent/JP6089104B2/ja active Active
- 2013-07-12 HU HUE13735315A patent/HUE030177T2/en unknown
- 2013-07-12 ES ES13735315.7T patent/ES2600133T3/es active Active
- 2013-07-12 PT PT137353157T patent/PT2875000T/pt unknown
- 2013-07-12 MA MA37795A patent/MA20150280A2/fr unknown
- 2013-07-12 KR KR1020157001019A patent/KR101631041B1/ko active IP Right Grant
- 2013-07-12 EA EA201492274A patent/EA026593B1/ru not_active IP Right Cessation
- 2013-07-12 SG SG11201407050UA patent/SG11201407050UA/en unknown
- 2013-07-12 MX MX2014014950A patent/MX358998B/es active IP Right Grant
- 2013-07-12 WO PCT/EP2013/064747 patent/WO2014012851A1/en active Application Filing
- 2013-07-15 AR ARP130102507 patent/AR091764A1/es not_active Application Discontinuation
- 2013-07-16 TW TW102125419A patent/TWI473799B/zh not_active IP Right Cessation
-
2014
- 2014-10-23 CO CO14235289A patent/CO7111256A2/es unknown
- 2014-11-19 ZA ZA2014/08514A patent/ZA201408514B/en unknown
- 2014-11-20 CR CR20140531A patent/CR20140531A/es unknown
- 2014-11-21 CL CL2014003160A patent/CL2014003160A1/es unknown
- 2014-12-03 PH PH12014502695A patent/PH12014502695A1/en unknown
- 2014-12-18 IL IL236362A patent/IL236362A/en active IP Right Grant
-
2015
- 2015-01-15 US US14/597,375 patent/US20150133505A1/en not_active Abandoned
- 2015-03-31 HK HK15103216.5A patent/HK1202544A1/zh unknown
- 2015-10-26 US US14/923,308 patent/US9328090B2/en active Active
-
2016
- 2016-11-04 CY CY20161101133T patent/CY1118205T1/el unknown
- 2016-12-12 HR HRP20161691TT patent/HRP20161691T1/hr unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1119422T1 (el) | Παραγωγα μπετουλινης | |
| CR20150078A (es) | Análogos de piridazina 1,4-disustituida y métodos para el tratamiento de condiciones relacionadas con la deficiencia de smn | |
| PE20160862A1 (es) | Polimorfo de los inhibidores de la syk | |
| CY1118678T1 (el) | Παραγωγα καρβοξαμιδιου χλωρο-πυραζινης χρησιμα για την θεραπευτικη αντιμετωπιση ασθενειων που ευνοουνται απο την ανεπαρκη ενυδατωση του βλεννογονου | |
| CY1118365T1 (el) | Διαμορφωτες διυδροπυραζολης του gpr40 | |
| CR20130369A (es) | Novedosos derivados heterocíclicos | |
| EA201500875A1 (ru) | СОЛИ ПРОИЗВОДНЫХ 2-АМИНО-1-ГИДРОКСИЭТИЛ-8-ГИДРОКСИХИНОЛИН-2-(1Н)-ОНА, ОБЛАДАЮЩИЕ АГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К β2 АДРЕНЕРГИЧЕСКОМУ РЕЦЕПТОРУ И АНТАГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К МУСКАРИНОВОМУ РЕЦЕПТОРУ М3 | |
| DOP2013000181A (es) | Moduladores del receptor de glucagon | |
| CY1117105T1 (el) | Ενωσεις πυριδαζινονης και χρηση τους ως αναστολεις του daao | |
| EA201591815A1 (ru) | Бицикло [2.2.2] кислоты - модуляторы gpr120 | |
| MA40281A (fr) | Composés de pyrazole et leur utilisation en tant qu' agents de blocage des canaux calciques de type t | |
| CR20150419A (es) | Derivados sustituidos del ácido bisfenil butanóico fosfónico como inhibidores de la nep | |
| AR095097A1 (es) | Compuestos de fenoxietoxi | |
| AR093042A1 (es) | Derivados de etinilo | |
| CR20150325A (es) | Compuestos trcíclicos para inhibir el canal cftr | |
| AR105821A1 (es) | COMPUESTOS ÚTILES PARA INHIBIR ROR-g-T | |
| AR091764A1 (es) | Derivados de ariletinilo | |
| AR096824A1 (es) | Derivados de etinilo | |
| CL2019000045A1 (es) | Derivados etinilo. | |
| CL2017002651A1 (es) | Derivados de aminohidrotiazina fusionados con tetrahidrofurano los cuales son útiles en el tratamiento de la enfermedad de alzheimer | |
| AR093029A1 (es) | Derivados de etilino | |
| AR092673A1 (es) | Derivados de ariletinilo | |
| CO7180198A2 (es) | Ariletinilo pirimidinas | |
| AR092627A1 (es) | Derivados glucopiranosidos de urea | |
| PE20151557A1 (es) | Derivados de 3-(4'-sustituido)-bencil-eter de pregnenolona |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |