BR112014029015A2 - derivados de ariletinila - Google Patents
derivados de ariletinilaInfo
- Publication number
- BR112014029015A2 BR112014029015A2 BR112014029015A BR112014029015A BR112014029015A2 BR 112014029015 A2 BR112014029015 A2 BR 112014029015A2 BR 112014029015 A BR112014029015 A BR 112014029015A BR 112014029015 A BR112014029015 A BR 112014029015A BR 112014029015 A2 BR112014029015 A2 BR 112014029015A2
- Authority
- BR
- Brazil
- Prior art keywords
- derivatives
- arylethynyl
- formula
- arylethynyl derivatives
- mglur5
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
resumo patente de invenção: derivados de ariletinila. a presente invenção refere-se a derivados de etinila da fórmula (i), em que r1 é fenila, que é opcionalmente substituída por 1-2 átomos de halogênio; selecionados de flúor ou cloro; ou a um sal de adição de ácido farmaceuticamente aceitável na forma enantiomericamente pura. foi descoberto que os compostos da fórmula geral i são moduladores alostéricos do receptor de glutamato de metabotrópico subtipo 5 (mglur5).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12176662 | 2012-07-17 | ||
| PCT/EP2013/064747 WO2014012851A1 (en) | 2012-07-17 | 2013-07-12 | Arylethynyl derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014029015A2 true BR112014029015A2 (pt) | 2017-06-27 |
Family
ID=48782352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014029015A BR112014029015A2 (pt) | 2012-07-17 | 2013-07-12 | derivados de ariletinila |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US20150133505A1 (pt) |
| EP (1) | EP2875000B1 (pt) |
| JP (1) | JP6089104B2 (pt) |
| KR (1) | KR101631041B1 (pt) |
| CN (1) | CN104364233B (pt) |
| AR (1) | AR091764A1 (pt) |
| AU (1) | AU2013292142B2 (pt) |
| BR (1) | BR112014029015A2 (pt) |
| CA (1) | CA2871389C (pt) |
| CL (1) | CL2014003160A1 (pt) |
| CO (1) | CO7111256A2 (pt) |
| CR (1) | CR20140531A (pt) |
| CY (1) | CY1118205T1 (pt) |
| DK (1) | DK2875000T3 (pt) |
| EA (1) | EA026593B1 (pt) |
| ES (1) | ES2600133T3 (pt) |
| HK (1) | HK1202544A1 (pt) |
| HR (1) | HRP20161691T1 (pt) |
| HU (1) | HUE030177T2 (pt) |
| IL (1) | IL236362A (pt) |
| LT (1) | LT2875000T (pt) |
| MA (1) | MA20150280A2 (pt) |
| MX (1) | MX358998B (pt) |
| MY (1) | MY167810A (pt) |
| NZ (1) | NZ701849A (pt) |
| PE (1) | PE20150184A1 (pt) |
| PH (1) | PH12014502695B1 (pt) |
| PL (1) | PL2875000T3 (pt) |
| PT (1) | PT2875000T (pt) |
| RS (1) | RS55313B1 (pt) |
| SG (1) | SG11201407050UA (pt) |
| SI (1) | SI2875000T1 (pt) |
| TW (1) | TWI473799B (pt) |
| UA (1) | UA114911C2 (pt) |
| WO (1) | WO2014012851A1 (pt) |
| ZA (1) | ZA201408514B (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA113223C2 (xx) * | 2012-08-13 | 2016-12-26 | Арилетинілпіримідини | |
| MY171517A (en) * | 2012-10-18 | 2019-10-16 | Hoffmann La Roche | Ethynyl derivatives as modulators of mglur5 receptor activity |
| PL3303316T3 (pl) | 2015-06-03 | 2020-06-29 | F. Hoffmann-La Roche Ag | Pochodne etynylu |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19546462A1 (de) * | 1995-12-13 | 1997-06-19 | Bayer Ag | Diarylacetylenketone |
| DK1354875T3 (da) | 2003-05-19 | 2005-03-14 | Servier Lab | Ny syntesefremgangsmåde for (2S, 3aS, 7aS)-perhydroindol-2-carboxylsyre og estere heraf samt anvendelse ved syntese af perindopril |
| GB0325956D0 (en) | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
| EP1809620B1 (en) | 2004-11-04 | 2010-12-29 | Addex Pharma SA | Novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors |
| GB0510139D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
| WO2008151184A1 (en) | 2007-06-03 | 2008-12-11 | Vanderbilt University | Benzamide mglur5 positive allosteric modulators and methods of making and using same |
| CN101544892B (zh) * | 2009-05-07 | 2012-10-03 | 石家庄诚志永华显示材料有限公司 | 一种合成二芳基乙炔类单体液晶的方法 |
| US8420661B2 (en) * | 2010-04-13 | 2013-04-16 | Hoffmann-La Roche Inc. | Arylethynyl derivatives |
| MY163164A (en) * | 2011-04-26 | 2017-08-15 | Hoffmann La Roche | Ethynyl derivatives as positive allosteric modulators of the mglur5 |
-
2013
- 2013-07-12 LT LTEP13735315.7T patent/LT2875000T/lt unknown
- 2013-07-12 CN CN201380031736.9A patent/CN104364233B/zh active Active
- 2013-07-12 ES ES13735315.7T patent/ES2600133T3/es active Active
- 2013-07-12 SG SG11201407050UA patent/SG11201407050UA/en unknown
- 2013-07-12 CA CA2871389A patent/CA2871389C/en not_active Expired - Fee Related
- 2013-07-12 PL PL13735315T patent/PL2875000T3/pl unknown
- 2013-07-12 EA EA201492274A patent/EA026593B1/ru not_active IP Right Cessation
- 2013-07-12 JP JP2015521004A patent/JP6089104B2/ja active Active
- 2013-07-12 UA UAA201500231A patent/UA114911C2/uk unknown
- 2013-07-12 NZ NZ701849A patent/NZ701849A/en not_active IP Right Cessation
- 2013-07-12 PE PE2014002231A patent/PE20150184A1/es active IP Right Grant
- 2013-07-12 EP EP13735315.7A patent/EP2875000B1/en active Active
- 2013-07-12 DK DK13735315.7T patent/DK2875000T3/en active
- 2013-07-12 MX MX2014014950A patent/MX358998B/es active IP Right Grant
- 2013-07-12 MY MYPI2014003059A patent/MY167810A/en unknown
- 2013-07-12 HU HUE13735315A patent/HUE030177T2/en unknown
- 2013-07-12 KR KR1020157001019A patent/KR101631041B1/ko active IP Right Grant
- 2013-07-12 PT PT137353157T patent/PT2875000T/pt unknown
- 2013-07-12 SI SI201330415A patent/SI2875000T1/sl unknown
- 2013-07-12 AU AU2013292142A patent/AU2013292142B2/en not_active Ceased
- 2013-07-12 RS RS20160979A patent/RS55313B1/sr unknown
- 2013-07-12 MA MA37795A patent/MA20150280A2/fr unknown
- 2013-07-12 BR BR112014029015A patent/BR112014029015A2/pt not_active Application Discontinuation
- 2013-07-12 WO PCT/EP2013/064747 patent/WO2014012851A1/en active Application Filing
- 2013-07-15 AR ARP130102507 patent/AR091764A1/es not_active Application Discontinuation
- 2013-07-16 TW TW102125419A patent/TWI473799B/zh not_active IP Right Cessation
-
2014
- 2014-10-23 CO CO14235289A patent/CO7111256A2/es unknown
- 2014-11-19 ZA ZA2014/08514A patent/ZA201408514B/en unknown
- 2014-11-20 CR CR20140531A patent/CR20140531A/es unknown
- 2014-11-21 CL CL2014003160A patent/CL2014003160A1/es unknown
- 2014-12-03 PH PH12014502695A patent/PH12014502695B1/en unknown
- 2014-12-18 IL IL236362A patent/IL236362A/en active IP Right Grant
-
2015
- 2015-01-15 US US14/597,375 patent/US20150133505A1/en not_active Abandoned
- 2015-03-31 HK HK15103216.5A patent/HK1202544A1/zh unknown
- 2015-10-26 US US14/923,308 patent/US9328090B2/en active Active
-
2016
- 2016-11-04 CY CY20161101133T patent/CY1118205T1/el unknown
- 2016-12-12 HR HRP20161691TT patent/HRP20161691T1/hr unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |